JPH0291022A - Ａｚｔまたはリバビリンと組み合わせたジデオキシ炭素環式ヌクレオシド - Google Patents

Ａｚｔまたはリバビリンと組み合わせたジデオキシ炭素環式ヌクレオシド

Info

Publication number
JPH0291022A
JPH0291022A JP1145534A JP14553489A JPH0291022A JP H0291022 A JPH0291022 A JP H0291022A JP 1145534 A JP1145534 A JP 1145534A JP 14553489 A JP14553489 A JP 14553489A JP H0291022 A JPH0291022 A JP H0291022A
Authority
JP
Japan
Prior art keywords
compound
formula
compounds
ribavirin
antiviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1145534A
Other languages
English (en)
Japanese (ja)
Inventor
Robert Vince
ロバート・ビンス
William M Shannon
ウイリアム・エム・シヤノン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Minnesota Twin Cities
Southern Research Institute
Original Assignee
University of Minnesota Twin Cities
Southern Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Minnesota Twin Cities, Southern Research Institute filed Critical University of Minnesota Twin Cities
Publication of JPH0291022A publication Critical patent/JPH0291022A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Formation And Processing Of Food Products (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP1145534A 1988-06-10 1989-06-09 Ａｚｔまたはリバビリンと組み合わせたジデオキシ炭素環式ヌクレオシド Pending JPH0291022A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20516388A 1988-06-10 1988-06-10
US205,163 1988-06-10

Publications (1)

Publication Number Publication Date
JPH0291022A true JPH0291022A (ja) 1990-03-30

Family

ID=22761073

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1145534A Pending JPH0291022A (ja) 1988-06-10 1989-06-09 Ａｚｔまたはリバビリンと組み合わせたジデオキシ炭素環式ヌクレオシド

Country Status (9)

Country Link
EP (1) EP0346132B1 (enExample)
JP (1) JPH0291022A (enExample)
AT (1) ATE73335T1 (enExample)
AU (1) AU627188B2 (enExample)
DE (1) DE68900961D1 (enExample)
DK (1) DK284189A (enExample)
GR (1) GR3004628T3 (enExample)
NZ (1) NZ229453A (enExample)
ZA (1) ZA894392B (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001519432A (ja) * 1997-10-14 2001-10-23 グラクソ グループ リミテッド クロロプリン中間体の合成法
WO2006137447A1 (ja) * 2005-06-24 2006-12-28 Yamasa Corporation シュードウリジン保護体の安定結晶
JP2008540454A (ja) * 2005-05-05 2008-11-20 アーディア・バイオサイエンシーズ・インコーポレイテッド Ｈｉｖの処置のための非ヌクレオシド逆転写酵素インヒビターとしてのジアリル−プリン、−アザプリンおよび−デアザプリン
US7582618B2 (en) 2002-06-28 2009-09-01 Idenix Pharmaceuticals, Inc. 2′-C-methyl-3′-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US9968628B2 (en) 2000-05-26 2018-05-15 Idenix Pharmaceuticals Llc Methods and compositions for treating flaviviruses and pestiviruses
US10363265B2 (en) 2000-05-23 2019-07-30 Idenix Pharmaceuticals Llc Methods and compositions for treating hepatitis C virus
US10525072B2 (en) 2002-11-15 2020-01-07 Idenix Pharmaceuticals Llc 2′-branched nucleosides and flaviviridae mutation

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2793825B2 (ja) * 1988-01-20 1998-09-03 リージヤンツ・オブ・ザ・ユニバーシテイ・オブ・ミネソタ ジデオキシジデヒドロ炭素環式ヌクレオシド
GB2243609B (en) * 1988-01-20 1992-03-11 Univ Minnesota Dideoxydidehydrocarbocyclic pyrimidines
US5631370A (en) 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
US5175292A (en) * 1988-01-20 1992-12-29 Regents Of The University Of Minnesota Intermediates for the preparation of dideoxycarbocyclic nucleosides
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
US4939252A (en) * 1989-04-20 1990-07-03 Hoffmann-La Roche Inc. Novel intermediates for the preparation of Carbovir
CA2246162C (en) * 1996-01-23 2000-04-04 Icn Pharmaceuticals, Inc. Modulation of th1/th2 cytokine expression by ribavirin.rtm. and ribavirin.rtm. analogs in activated t-lymphocytes
CN1253504A (zh) * 1997-01-17 2000-05-17 Icn药品公司 细胞因子相关的疾病治疗法
DK0991415T3 (da) * 1997-12-22 2003-06-16 Schering Corp Faste, oralt indgivelige dosisformer for ribavirin og fremgangsmåde til fremstilling af disse
US5916594A (en) * 1997-12-22 1999-06-29 Schering Corporation Process of making solid ribavirin dosage forms
GB9903091D0 (en) * 1999-02-12 1999-03-31 Glaxo Group Ltd Therapeutic nucleoside compound
US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
US20060084627A1 (en) * 2002-06-27 2006-04-20 Medivir Ab Synergistic interaction of abacavir and alovudine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4138562A (en) * 1977-02-09 1979-02-06 The Regents Of The University Of Minnesota Adenosine deaminase resistant antiviral purine nucleosides and method of preparation
US4362729A (en) * 1980-06-23 1982-12-07 The Regents Of The University Of Minnesota Alkoxyalkanoate esters of cyclaradine
US4636383A (en) * 1984-08-29 1987-01-13 Schering Corporation Interferon-cyclaradine combination
EP0374096B1 (de) * 1988-12-14 1992-12-02 Ciba-Geigy Ag 2',3'-Dideoxypurinnucleosid/Purinnucleosid-Phosphorylase-Inhibitor Kombinationstherapie und Zusammensetzungen dafür

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001519432A (ja) * 1997-10-14 2001-10-23 グラクソ グループ リミテッド クロロプリン中間体の合成法
US10363265B2 (en) 2000-05-23 2019-07-30 Idenix Pharmaceuticals Llc Methods and compositions for treating hepatitis C virus
US10758557B2 (en) 2000-05-23 2020-09-01 Idenix Pharmaceuticals Llc Methods and compositions for treating hepatitis C virus
US9968628B2 (en) 2000-05-26 2018-05-15 Idenix Pharmaceuticals Llc Methods and compositions for treating flaviviruses and pestiviruses
US7582618B2 (en) 2002-06-28 2009-09-01 Idenix Pharmaceuticals, Inc. 2′-C-methyl-3′-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US10525072B2 (en) 2002-11-15 2020-01-07 Idenix Pharmaceuticals Llc 2′-branched nucleosides and flaviviridae mutation
JP2008540454A (ja) * 2005-05-05 2008-11-20 アーディア・バイオサイエンシーズ・インコーポレイテッド Ｈｉｖの処置のための非ヌクレオシド逆転写酵素インヒビターとしてのジアリル−プリン、−アザプリンおよび−デアザプリン
WO2006137447A1 (ja) * 2005-06-24 2006-12-28 Yamasa Corporation シュードウリジン保護体の安定結晶
US7968521B2 (en) 2005-06-24 2011-06-28 Yamasa Corporation Stable cystal of protected pseudouridine
JP5192807B2 (ja) * 2005-06-24 2013-05-08 ヤマサ醤油株式会社 シュードウリジン保護体の安定結晶

Also Published As

Publication number Publication date
ZA894392B (en) 1990-08-29
AU627188B2 (en) 1992-08-20
EP0346132A1 (en) 1989-12-13
DK284189D0 (da) 1989-06-09
NZ229453A (en) 1991-08-27
AU3627289A (en) 1989-12-14
GR3004628T3 (enExample) 1993-04-28
ATE73335T1 (de) 1992-03-15
DK284189A (da) 1989-12-11
EP0346132B1 (en) 1992-03-11
DE68900961D1 (de) 1992-04-16

Similar Documents

Publication Publication Date Title
US4916224A (en) Dideoxycarbocyclic nucleosides
JPH0291022A (ja) Ａｚｔまたはリバビリンと組み合わせたジデオキシ炭素環式ヌクレオシド
US6072053A (en) Dideoxycarbocyclic nucleosides
AT397801B (de) Didesoxydehydrocarbocyclische nucleoside und deren verwendung
US5122517A (en) Antiviral combination comprising nucleoside analogs
EP0294114B1 (en) Antiviral compounds
DE3689976T2 (de) Therapeutische Nucleoside und deren Herstellung.
US5665709A (en) Polysubstituted benzimidazole nucleosides as antiviral agents
DE69232845T2 (de) 1,3-Oxathiolannukleosid-analoge Verbindungen
EP0215759A1 (en) Antiviral carbocyclic analogs of xylofuranosylpurines
US4950758A (en) Optically-active isomers of dideoxycarbocyclic nucleosides
US4931559A (en) Optically-active isomers of dideoxycarbocyclic nucleosides
JPS63297381A (ja) ９−〔２−（ヒドロキシメチル）シクロアルキルメチル〕グアニン類
EP0285432B1 (en) Therapeutic nucleosides
US20050222180A1 (en) Antiviral phosphonate analogs
WO1994001117A1 (en) Therapeutic nucleosides
US5567703A (en) Method for treating HIV infections with dideoxycarbocyclic nucleosides
US20030119762A1 (en) 5'-substituted-ribofuranosyl benzimidazoles as antiviral agents
US5175292A (en) Intermediates for the preparation of dideoxycarbocyclic nucleosides
Swayze et al. Synthesis, antiproliferative, and antiviral evaluation of certain acyclic 6-substituted pyrrolo [2, 3-d]-pyrimidine nucleoside analogs related to sangivamycin and toyocamycin
GB2243609A (en) Carbocyclic nucleosides