JPH0250885B2 - - Google Patents
Info
- Publication number
- JPH0250885B2 JPH0250885B2 JP5485281A JP5485281A JPH0250885B2 JP H0250885 B2 JPH0250885 B2 JP H0250885B2 JP 5485281 A JP5485281 A JP 5485281A JP 5485281 A JP5485281 A JP 5485281A JP H0250885 B2 JPH0250885 B2 JP H0250885B2
- Authority
- JP
- Japan
- Prior art keywords
- coating
- liquid
- fatty acid
- water
- acid ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 18
- 239000000194 fatty acid Substances 0.000 claims description 18
- 229930195729 fatty acid Natural products 0.000 claims description 18
- -1 sucrose fatty acid ester Chemical class 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 229930006000 Sucrose Natural products 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 14
- 239000005720 sucrose Substances 0.000 claims description 14
- 229920001577 copolymer Polymers 0.000 claims description 8
- 238000007720 emulsion polymerization reaction Methods 0.000 claims description 7
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims description 6
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 6
- 239000002702 enteric coating Substances 0.000 claims description 6
- 238000009505 enteric coating Methods 0.000 claims description 6
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims description 6
- 238000000576 coating method Methods 0.000 description 41
- 239000011248 coating agent Substances 0.000 description 40
- 239000007788 liquid Substances 0.000 description 36
- 239000008187 granular material Substances 0.000 description 14
- 229960004793 sucrose Drugs 0.000 description 13
- 238000002360 preparation method Methods 0.000 description 12
- 238000000034 method Methods 0.000 description 10
- 239000008213 purified water Substances 0.000 description 8
- 229920003138 Eudragit® L 30 D-55 Polymers 0.000 description 7
- GDCRSXZBSIRSFR-UHFFFAOYSA-N ethyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CCOC(=O)C=C GDCRSXZBSIRSFR-UHFFFAOYSA-N 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- 238000012812 general test Methods 0.000 description 6
- 238000010998 test method Methods 0.000 description 6
- 239000004014 plasticizer Substances 0.000 description 5
- 150000002148 esters Chemical class 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000006116 polymerization reaction Methods 0.000 description 3
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 2
- 229920003134 Eudragit® polymer Polymers 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 210000004051 gastric juice Anatomy 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 229940117841 methacrylic acid copolymer Drugs 0.000 description 2
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- SMTDFMMXJHYDDE-UHFFFAOYSA-N 2-prop-1-enylpyridine Chemical compound CC=CC1=CC=CC=N1 SMTDFMMXJHYDDE-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 238000003915 air pollution Methods 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5485281A JPS57169427A (en) | 1981-04-10 | 1981-04-10 | Enteric coating composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5485281A JPS57169427A (en) | 1981-04-10 | 1981-04-10 | Enteric coating composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57169427A JPS57169427A (en) | 1982-10-19 |
| JPH0250885B2 true JPH0250885B2 (enrdf_load_stackoverflow) | 1990-11-05 |
Family
ID=12982117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5485281A Granted JPS57169427A (en) | 1981-04-10 | 1981-04-10 | Enteric coating composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57169427A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0268332U (enrdf_load_stackoverflow) * | 1988-11-10 | 1990-05-23 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5877825A (ja) * | 1981-11-05 | 1983-05-11 | Eisai Co Ltd | 腸溶性固形製剤 |
| JPS6216432A (ja) * | 1985-07-05 | 1987-01-24 | Shin Etsu Chem Co Ltd | 腸溶性コ−テイング用組成物 |
| DE3920082A1 (de) * | 1989-06-20 | 1991-03-07 | Roehm Gmbh | Filmbildendes waessriges ueberzugsmittel fuer feste arzneimittel, verfahren zu seiner herstellung und verwendung |
| TW200633731A (en) * | 2004-12-06 | 2006-10-01 | Freund Corp | Film coating composition, and coating and tablet of the composition |
-
1981
- 1981-04-10 JP JP5485281A patent/JPS57169427A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0268332U (enrdf_load_stackoverflow) * | 1988-11-10 | 1990-05-23 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS57169427A (en) | 1982-10-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1199869A (en) | Preparation of aqueous alcoholic dispersions of ph sensitive polymers and plasticizing agents and a method of enteric coating dosage forms using same | |
| CA1214992A (en) | Enteric coating for pharmaceutical dosage forms | |
| US4683256A (en) | Dry edible film coating composition, method and coating form | |
| US3935326A (en) | Process for coating tablets with aqueous resin dispersions | |
| JPS61100527A (ja) | フイルム形成性の医薬用被覆剤水性分散液およびその製造法 | |
| DE3405378A1 (de) | Arzneimittelueberzug | |
| EP0088951A2 (de) | Verfahren zum Überziehen von Arzneiformen mittels eines in Wasser dispergierten Überzugsmittels | |
| EP0035780A1 (en) | Coating compositions for enterosoluble solid dosage forms | |
| KR900005795B1 (ko) | 피복 고형 제제의 제조방법 | |
| KR20080074083A (ko) | 난용성 약물을 포함하는 의약용 고형 제제와 그의 제조방법 | |
| JPH0250885B2 (enrdf_load_stackoverflow) | ||
| JPH08245423A (ja) | 水系腸溶性コーティング液 | |
| CA1236024A (en) | Enteric coating liquid | |
| JP2960482B2 (ja) | 固体医薬品形状物用の被膜形成性水性被覆剤、この製法及び医薬品形状物の被覆法 | |
| JPH0138091B2 (enrdf_load_stackoverflow) | ||
| JP2925346B2 (ja) | 腸溶性製剤およびその製法 | |
| Kane et al. | Technological evaluation of three enteric coating polymers I. with an insoluble drug | |
| JPH08333238A (ja) | 液体状ワックスを用いる無溶媒腸溶性コーティング剤で被覆した腸溶性製剤 | |
| JPH0559098B2 (enrdf_load_stackoverflow) | ||
| US4456628A (en) | Process for film-coating a particulate solid, and emulsions for conducting the process | |
| JPH07316077A (ja) | 腸溶性コーティング用組成物 | |
| Ortega | Latices of cellulosic polymers; manufacture, characterization and application as pharmaceutical film coatings | |
| JPS587607B2 (ja) | 腸溶性被覆製剤の製造方法 | |
| JP2003093000A (ja) | 食品用腸溶性皮膜、腸溶性食品及びその製法 | |
| JPS6291272A (ja) | フイルムコ−テイング方法 |