JPH02500183A - Pad printing equipment for transferring a clearly defined amount of printing medium per unit area - Google Patents

Abstract

In the printing pad device described, the surface of the pad (20) is recessed while retaining essentially the same external form and volume. Also described is the use of the pad for at least partially coating a substrate (22) with a predetermined pattern. The substrate (22) is a printed circuit board for manufacturing integrated circuits, a component of a pharmaceutical presentation and/or dosage form, a label with raised characters, a prepolymer or similar.

Description

[Detailed description of the invention] Pub for transporting a clearly defined amount of printing medium per unit area Printing device The present invention is capable of producing a clearly defined amount of printing per unit area. Pad printing equipment for transferring printing media and its applications Ru.

The band printing method has been known since 1968 and is used to print non-uniform surfaces. The flexible printing media transfer band is applied to non-uniform surfaces. It will be done. Pad printing is described, for example, in West German Publication No. 19 39 437. Are listed.

The pixels to be printed are etched in a concave manner into the block, i.e. the print.

Then follow the doctor blade method to meter the printing medium The printing medium is transferred to this block and the pads are left in the block. completely absorbs the printing medium and transfers the medium to the object to be printed. padpu An overview on the use and properties of linting methods is provided by Kornthal Müningen, Tambobrint GmbH (Geselschaf) located at Gwymlerstrafse 27/1 It is listed in Pants Left by Tomito Beschlenkterhaftsung. Details thereof are omitted to avoid unnecessary repetition in the specification.

Pad printers are particularly advantageous because they require limited space. The reason The reason is that pad printers can be difficult to incorporate (and cannot be enclosed) into production lines. This is because that. This enclosure is suitable for high-quality materials such as pharmaceuticals, etching inks, polymerization ink shakes, etc. Protects personnel and volatile materials when handling active or toxic printing media. Precisely controlled amounts of printing media to help reduce evaporation There was no attempt to use a pad printer before for carrying. amazing In particular, the band printing method allows the printing process to be completed with an error of less than ±2%. It was discovered that the weight per unit area of up to 26 g/d can be accurately measured. has been done.

Title of the invention: ``Manufacturing of administrations and dosage forms for pharmaceutically active substances by means of printing methods. As stated in the applicant's West German patent application filed on the same date, which is a method for Modulating membranes for highly sensitive pharmaceutical or active substance transport per unit area on corresponding substrates. Applied at a constant weight.

The use of hitherto known measures, i.e. changing the pad material (more printing material) transport when the printing medium is a soft band) and the viscosity of the printing medium. The modification also slightly increased supplying a constant amount of printing medium to the substrate. It merely increased the amount of transport. However, this amount is, for example, 100 glrd. It is insufficient for coatings with a large weight per unit area such as As a result, despite its excellent properties, pad printing methods are This method is unsuitable for applications such as manufacturing thick layers of material in patterns of Until now there has been no interest in applying coatings using. Instead, it is complicated expensive screen-process printing methods or complex multi-stage application methods. It was

The problem of the present invention is to transfer a larger amount of printing medium to the substrate than conventional bands. The object of the present invention is to improve a known device so as to be able to do the same.

According to the invention, this task is to maintain substantially the same external shape and shape volume. However, by increasing at least the printing contact surface of the entire surface of the band, The problem is solved by a device of the type described above.

Surface enlargement can be achieved by processing the finishing pad body or by using a suitable mold. By manufacturing an enlarged band surface during the forming of the band body within the band surface Screening, roughing, grooving, or knurling surfaces It consists of Compared to traditional pads with smooth surfaces, the new pads The printer is suitable for transporting more than three times the printing volume previously transportable. are doing.

As a result of the improvements of the present invention to known pad printers, a second and advantageous method It is possible to use these devices or methods in Therefore, thick paint Manufacture of fabric signboards, integrated circuits printed with photo lacquer or conductive materials or to systematically apply a polymerization initial shake to a prepolymer. Transfer the porcelain paint to apply the etching liquid to produce the engraved pattern. Pharmaceutical administration and/or medication, such as tablets or topicals, to Can be used to manufacture things.

Furthermore, dermal drugs deliver substances through the mucous membranes, i.e. rectal and vaginal administration. This also includes medicines. Particularly preferred applications are plaster-like and transdermal therapeutic agents. This is the manufacturing of

The present invention reduces the amount of printing media transferred during the printing process. It is possible to increase unexpectedly and obtain a constant metric within narrow limits. can.

The device of the invention can be used for surface coating treatments such as transdermal therapeutics. containing the active substance in the desired form without the loss of active substance that previously occurred. printing media and small active substance dosages; This saves expensive active substances and solves the problem of eliminating wasted active substances. can do.

In the case of plasters or therapeutic agents, e.g. several dyes, dyes and adhesives, adhesives and several printing media simultaneously, such as suppressor or active substance-containing products. and suitable blocks that can be applied spatially separated, thus saving manufacturing steps. This is possible in a single manufacturing step by using a Blocks and pads are heat sensitive materials that can only be processed under heat, such as adhesives or certain adhesives, must be processed. thermally regulated when necessary. If the heat-sensitive material is processed or It is also possible to cool the material and finishing equipment if necessary. Ru.

It is also possible to handle different requirements by choosing suitable pad materials. , natural rubber, synthetic rubber and especially silicone rubber. All elastomeric materials are passable and they are characterized by their processability, solvent resistance, thermal safety and can be selected according to desired properties such as elasticity at low temperatures.

The shape of the band is chosen according to the substrate to be processed. In this way, you can enlarge the any shape like frustum shape, flat shape or egg shape band with It is also possible to use conventional shapes.

With the device of the invention, the weight per unit area of approximately 200 g/m and its It is possible to transfer more than one printing medium in one printing process. Ru. Improvements to transportability include soft pads, modifications to methods known to experts. This can be achieved, for example, by using other printing media.

Other features and advantages of the invention will become apparent from the following description in conjunction with the drawings.

Figure 1 shows the side of the pad printer applying the printing media coating to the substrate. It is a front view.

Figure 2 shows the steps in Figure 1 when lifting new printing media from the block. FIG. 2 is a side view of the printer.

FIG. 3 is a side view of a band of the present invention with expanded surface area.

FIG. 4 is a side view of another band of the present invention having an expanded surface area.

Figure 5 shows the transdermal, plaster-like therapeutic agent produced by the device of the present invention. FIG.

FIG. 6 shows another example with two different active materials produced using the pad printer of the present invention. FIG. 2 is a plan view of an active substance coating.

FIG. 7 shows another preferred dosage form produced by the device ci of the invention, namely a dragee. FIG.

FIG. 1 illustrates flattening a printing medium with a band 20 constructed in accordance with the present invention. It is shown that the coating is applied to a substrate 22 having a similar shape. Oval elastic silicone rubber band 20 is formed according to the desired pattern for application of printing medium f (see Figure 2). from the cavity of the shaped block 24 onto the enlarged surface area 23 during the pre-working stage of the device. Receives printing media coating. Printing medium is a flat substrate 22, the pad leaves a uniform printing medium coating thickness. Then, the pad 20 is removed from a corrugated substrate such as a circular substrate or a tool-shaped substrate. It is likewise possible to print non-uniform substrates such as surfaces.

FIG. 3 shows a preferred modification of the oval pad 20 of the present invention, in which the printing medium The upper region 23 of the pad, which is used for the transfer of as a result, it is possible to absorb and transport large amounts of printing media. The amount of printing medium absorbed in the process of the invention is Depends on the etching depth and shape of the block 24 from which the medium is completely removed; The linting medium is uniformly coated on the block by doctor blade treatment. Pre-placed in thickness, removed and transported by band.

FIG. 4 shows another preferred refinement of the pad 20, which is substantially roller-like. The surface of the band is cup-shaped to enlarge the surface during feeding or application. It also acts to accommodate an increased amount of printing media.

FIG. 5 shows a plaster containing the active material gold that can be produced by the apparatus of the invention, which , covering a ring-shaped active substance impermeable acrylate tactile adhesive coating 16 It can be manufactured by uniformly pressing the film 15, and the cover film is made of this material. In some cases, the plaster is a siliconized paper that is removed before use. Also a certain thickness A circular regulatory coating that regulates the passage of substances through its physicochemical properties. The tag 18 is coated thereon with an active substance-containing container coat by means of a band printer according to the invention. 14 is printed, followed by aluminum polyester laminate in this case. A lamination with an opaque backing, which is the sheet 10, is printed. Its characteristics are thick Modulating coating 18 and its actives guaranteed only in the case of high constancy The thickness and surface height of the applied coating in a form that allows the quality content to pass through pharmaceutical applications. Both the active substance coating 140 and the device according to the invention guarantee only a high degree of constancy. Applied by placing.

FIG. 6 shows a plaster similar to FIG. 5 before application of the backing 10, which plaster This example has two active substances 14 and 14''. It can be manufactured in a single active substance application step using a multilayer printer. Also active substance impermeable tactile adhesive The agent ring 16 can also be seen.

FIG. 7 shows another pharmaceutical dosage form produced with the device of the invention, namely two coated cores. The two coated cores are coated with substrate material 34 or plastic, showing a dragee 30 with 34.36. Coating 36 on circular substrate 34 without wasting lint coating 36 It can be manufactured by printing.

Other modifications, combinations and uses of the device of the invention will be readily apparent to those skilled in the art. and shall fall within the protection scope of the claims of the specification.

Heisei Year Month Day Yoshi, Commissioner of the Patent Office 1) Takeshi Moon 1. Indication of case PCT/DE 8810 O3643, person making amendment Relationship to the case, applicant 4. Agent 5. Date of amendment order: Self-issued international search report international search report DE　8200364 SA　22752

Claims (6)

[Claims] 1. A pad that transports a well-defined amount of printing medium per unit area. In the doprinting device, the surfaces of the pads (20) have the same external shape and 12. A device characterized in that the device is expanded while substantially retaining its shape and volume. 2. The apparatus of claim 1, wherein the enlarged surface transports the printing medium. screening at least a portion (23) of the pad surface used for , characterized by consisting of roughening, grooving, or knotting A device that does this. 3. A device according to any one of claims 1 or 2, characterized in that the pad surface (23 ) is carried out by processing the finishing pad body (20). A device used as a sign. 4. A device according to any one of claims 1 or 2, in which the enlarged The surface portion (23) is manufactured in a suitable mold during the molding of the pad body (20). A device characterized by: 5. Claims for at least partially coating a substrate with a predetermined pattern The use of the apparatus described in any one of items 1 to 4 is for manufacturing integrated circuits. Printed circuit boards, pharmaceutical administration and/or medication components, signboards with raised letters. Applications characterized by being a board, prepolymer, etc. 6. The use according to claim 5, wherein the medicament administration and/or medication is trans. A use characterized by being a skin application such as a dermal treatment.