JPH0248516A - Hair tonic - Google Patents

Abstract

PURPOSE:To obtain a hair tonic, containing one or more extracts of crude drugs or further one or more surfactants and excellent in promoting effects on prevention of depilation, production, growth of hair, etc. CONSTITUTION:The objective substance obtained by containing one or more extracts of crude drugs selected from thyme, sage, lavender, juniper, cedarwood, lemon, geranium, spirulina, black soybean and longanae semen and further one or more anionic surfactants and one or more surfactants having nitrogen in the molecule other than the anionic surfactants as essential ingredients, mixing further normally used ingredients therewith and preparing a formulation according to a conventional method. A fatty acid soap, carboxy betaine, dimethyllaurylamine oxide, etc., are cited as the surfactants. The amounts of the blended ingredients are 0.005-10wt.% extracts of the crude drugs expressed in terms of dried substances and 0.001-10wt.% surfactants.

Description

Detailed Description of the Invention [Industrial Application Field] The present invention contains novel and safe crude drug extracts or crude drug extracts and surfactants to prevent hair loss, hair growth, The present invention relates to a hair nourishing agent that is highly effective in promoting hair growth.

[Conventional technology] BACKGROUND ART Hair nourishing agents containing various drugs have been known.

For example, vitamins such as vitamin B, amino acids such as methionine, vasodilators such as acetylcholine derivatives,
It contains anti-inflammatory agents such as purple root extract, female hormones such as estradiol, and skin function enhancers such as cephalanthine, and is used to prevent and treat alopecia.

However, although conventional hair restoration treatments are said to be effective in preventing and improving dandruff, itching, hair loss, and the like, and to promote hair growth and hair growth, no one has yet achieved satisfactory effects.

[Problems to be Solved by the Invention] The present inventors have conducted intensive research on hair nourishment that is effective in preventing hair loss, hair growth, etc. and has excellent safety.As a result, the present inventors have developed one or more specific crude drug extracts. The present inventors have discovered that this problem can be solved by containing one or more of these specific crude drug extracts and a specific surfactant, and have completed the present invention.

[Means for Solving the Problem 1 That is, the invention according to claim 1 is a crude drug extract selected from the group consisting of thyme, sage, lavender, juniper, cedarwood, lemon, geranium, spirulina, black bean, and currant; It is a hair-nourishing family that contains two or more species.

The invention according to claim 2 comprises one or more extracts of the crude drug according to claim 1, one or more anionic surfactants, and a nitrogen atom in the molecule other than the anionic surfactant. It is a hair nourishing agent characterized by containing one or more types of surfactants.

The invention according to claim 3 is characterized in that one or more extracts of the crude drug according to claim 1, one or more amphoteric surfactants and semipolar surfactants, and a nitrogen atom in the molecule. It is a hair-nourishing product characterized by containing one or more nonionic surfactants.

The invention according to claim 4 is a hair nourishing agent, characterized in that it contains one or more extracts of the crude drug according to claim 1 and an amine oxide.

Hereinafter, the configuration of the present invention will be explained in detail.

As the crude drug extract used in the present invention, the crude drug is used as a solvent,
For example, extracts obtained by extraction with hot water, lower alcohols such as methanol, ethanol, hydrous lower alcohols, polyhydric alcohols such as propylene glycol, 1-3 butylene glycol, or hydrous alcohols such as hydrous polyhydric alcohols, Examples include extracts obtained by concentrating and drying the extracted extract. The amount of the herbal medicine extract in the present invention is 0.005 to 10% by weight, preferably 0.01 to 5% by weight of the dry matter in the amount of hair nourishing material. If it is less than 0.005% by weight, the effects of the present invention will not be sufficiently exhibited, which is not preferable.

The anionic surfactant according to claim 1 includes anionic surfactants having one or more types of carboxylic acid group, sulfonic acid group, sulfuric acid ester group, and phosphoric acid ester group in the molecule. Those with carboxylic acid groups include fatty acid soaps, ether carboxylic acids and their salts, carboxylates such as condensates of amino acids and fatty acids, and those with sulfonates include alkyl sulfonates and sulfosuccinic acids. , ester sulfonates, alkylaryl and alkylnaphthalene sulfonates, N-
Acyl sulfonates, formalin condensation sulfonates, etc. have sulfate ester groups, such as sulfated oils,
Ester sulfates, alkyl sulfates, ether sulfates, alkyl allyl ether sulfates, amide sulfates, etc., those having a phosphoric acid ester group include alkyl phosphates, amide phosphates, ether phosphates, alkylaryl sulfates, etc. Ether phosphates and the like can be mentioned. One or more types are arbitrarily selected from these.

Examples of surfactants having a nitrogen atom in the molecule other than the anionic surfactant according to claim 1 include amphoteric surfactants having a nitrogen atom in the molecule, semipolar surfactants, nonionic surfactants, Examples include cationic surfactants. Examples of amphoteric surfactants include carboxybetaines such as N,t(-dimethyl-H-laurylrootcarboxymethylammonium betaine, N,N-dimethyl-N-oleyl-N-carboxymethylammoniumbetaine, 2-laurylrootcarboxyethyl -N-hydroxyethylimidazolinium betaine, 2-lauryl-N-
Imidacillin derivatives such as carboxymethyl-N-hydroxyethylimidazolinium betaine, aminocarboxylic acid salts such as toyashalkyl-β-aminopropionic acid sodium salt, toyashalkyl-β-iminodipropionic acid di-sodium salt, sulfobetaine, aminobetaine, etc. can be mentioned. Semipolar surfactants include (t, dimethyl lauryl amine oxide, bis=(2-hydroxyethyl) lauryl amine oxide, etc.) Nonionic surfactants include fatty acid alkanolamide, polyoxyethylene fatty acid amide, alkanol Examples of the cationic surfactants include esters of amines, polyoxyethylene alkyl amines, etc. Examples of the cationic surfactants include fatty acid amine salts, alkyl quaternary ammonium salts, aromatic quaternary ammonium salts, pyridium salts, and imidazolium salts. One or more types are arbitrarily selected from these.

The amphoteric surfactant according to claim 2 includes carboxylic surfactants such as N,N-dimethyl-N-lauryl-N-carboxymethylammonium betaine and N,N-dimethyl-N-oleyl-H-carboxymethylammonium betaine. imidacillin derivatives such as betaine, 2-lauryl-8-hydroxyethyl-H-hydroxyethylimidazolinium betaine, 2-lauryl-N-hydroxymethyl-8-hydroxyethylimidazolinium betaine, toysialkyl-β-aminopropionic acid sodium salt, Examples include aminocarboxylic acid salts such as toyashalkyl-β-iminodipropionic acid di-soda salt, sulfobetaine, aminobetaine, and the like.

Examples of the semipolar surfactant according to claim 2 include dimethyl lauryl amine oxide, bis-(2-and droxyethyl) lauryl amine oxide, and the like.

Examples of the nonionic surfactant according to claim 2 include fatty acid alkanolamide, polyoxyethylene fatty acid amide, alkanolamine ester, polyoxyethylene alkylamine, and the like.

The amine oxide according to claim 3 has the following general formula (
Examples are A) to (C).

R2N-+O(A) (wherein R1, R2 and R3 represent a straight chain or branched saturated or unsaturated hydrocarbon group having 1 to 24 carbon atoms, and at least one of R1, R2 and R3 is Represents a straight or branched saturated or unsaturated hydrocarbon group having 8 or more carbon atoms.) Specific examples of the amine oxide represented by the general formula (A) include dimethyl lauryl amine oxide, dimethyl myristyl amine oxide, Dimethylcetylamine oxide, dimethylstefurylamine oxide, dimethyloleylamine oxide, dimethylbehenylamine oxide,
Examples include methyl dilaurylamine oxide.

CH2CR20H R, -N→0 (B) Represents a branched saturated or unsaturated hydrocarbon group. ) H3 Rs-(OCH2CH2) n-N→0 (C
) R3 (In the formula, R5 represents a straight or branched saturated or unsaturated hydrocarbon group having 8 to 24 carbon atoms, and n represents an integer of 1 to 5.) In the present invention, these One or more amine oxides are arbitrarily selected and used.

The total amount of the anionic surfactant according to claim 1 and a surfactant other than the anionic surfactant having a nitrogen atom in the molecule is preferably 0.001 to 10% by weight based on the amount of hair nourishing fee. The content is preferably 0.01 to 5% by weight. Further, the ratio of the anionic surfactant to the surfactant other than the anionic surfactant having a nitrogen atom in the molecule is preferably 20:1 to 1:20, more preferably 10:1. ~1:10.

The total blending amount of one or more amphoteric surfactants and semipolar surfactants according to claim 2 and one or more nonionic surfactants having a nitrogen atom in the molecule is:
It is preferably 0.001 to 10% by weight, and more preferably 0.01 to 5% by weight based on the total amount of hair growth. In addition, one or more types of amphoteric surfactants and semipolar surfactants,
The ratio with one or more nonionic surfactants having a nitrogen atom in the molecule is 20:1 to 1:2 in molecular ratio.
The ratio is preferably 0, and more preferably 10:1 to 1:10.

The amount of the amine oxide according to claim 3 is preferably 0.0001 to 20% by weight based on the amount of hair nourishing material. Blend amount is 0
．． If it is less than 0001% by weight, sufficient hair nourishing effect cannot be obtained,
If it exceeds 20% by weight, it is undesirable from the standpoint of formulation and skin irritation.

In addition to the above-mentioned essential ingredients, the hair nourishing agent according to the present invention includes general-purpose ingredients normally used in hair nourishing products, such as vitamin B'6,
Vitamins such as vitamin E and its derivatives, biotin,
Hair growth agents or hair growth aids such as pantothenic acid and its derivatives, glycyrrhetinic acid and its derivatives, nicotinic acid esters such as benzyl nicotinate, cyclosporins, carpronium chloride, cepharanthine, oxendrone, diazoxide, minoxidil, and ethinyl estradiol. , hinokitiol, hexachlorophene, phenol, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, antibacterial agents such as trichlorocarbanilide and bithionol, cooling agents such as menthol, salicylic acid, zinc and its derivatives, lactic acid and its alkyl esters, etc. drugs, organic acids such as citric acid, amino acids such as arginine, oils such as olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids, higher alcohols, polyhydric alcohols such as glycerin and propylene glycol, fragrances, and antioxidants. Agents, ultraviolet absorbers, pigments, alcohols such as ethanol, benzyl alcohol, and isopropyl alcohol, water, humectants, thickeners, and the like can be appropriately blended within the range that does not impair the effects of the present invention.

The hair nourishment of the present invention may be in any form as long as it can be applied to the outer skin, such as liquid, emulsion, ointment, cream, gel, aerosol, etc., and may be in the form of tonic, conditioner, scalp treatment, shampoo, conditioner, etc. used.

[Example] Next, the present invention will be explained in detail with reference to Examples. The present invention is not limited to these. The blending amount is in weight%.

In order to investigate the hair growth effect of the hair growth agent according to the present invention, a tricogram test and a hair conversion test were conducted.

In both studies, 30 male subjects each received 10
The subjects were divided into three groups, each with a different name, and three different test solutions were given to each subject in each group for comparison.

The three types of test solutions are shown in Table 1.

Table 1: Each test solution was applied to the subject's scalp in two doses of 2 ml per coat.

(i) Trichogram Observe the hair roots under a microscope before and after using each of the above test solutions, calculate the number of telogen hair roots from the morphology of the hair roots, and determine the hair growth rate of each test solution based on the increase or decrease in the ratio. The effects were compared.

Here, the telogen hair root is a hair root that has stopped growing.

People who complain of hair loss have a greater number of telogen hair roots than normal people, so the hair-nourishing effect was evaluated based on the decrease in telogen hair roots. The application of each test solution to the scalp was continued for 3 months, and 6 hair roots per subject were removed immediately before and after the start of application.
I checked 0 books at a time.

The results are shown in Table 2 below.

At three locations, before and after applying each of the test liquids,
We compared the conversion rate from downy hair to the street.

Here, the term "road" refers to the length of 14 meters long.
It refers to hair that is longer than m, and the transition from downy hair to street hair means a hair-nourishing effect. Immediately after the start of application of each test solution and immediately after the completion of application of the four-day test liquid, the conversion rate was measured by directly taking a close-up photograph of the down hair region of the head. The conversion rate to the road is expressed as a percentage of the average over a month.

The results are shown in Table 3.

Table 3 From the results shown in Tables 2 and 3, it is understood that the herbal medicine cedarwood of the present invention has a sufficient hair-nourishing effect at 0.01% to o, ooi%.

(i [) Fluff conversion rate test Method for measuring the hair growth effect on the nape of the head of 30 subjects with male alopecia (Measurement of hair growth effect in mice) Using male C3H mice (60 days old), Ogawa et al. The method [(Norma
l and Abnormal Epidermal
Dif-ferentiation) M, 5eij
i and 1. The experiment was carried out according to A. Bernstein M Focusing University Publishing House]. In other words, the top of the mouse's back was shaved to a size of approximately 2 x 4 cm, and samples were applied once a day from the next day to determine changes in the area ratio of areas where hair regeneration had started, and to compare the speed of hair regeneration. I did it. Samples were obtained by stirring and dissolving the dried extracts of each herbal medicine in 75% ethanol, and adding and dissolving a surfactant thereto. 75% ethanol was used as a control in the test. Ten mice were used for each sample, and the average value of the rate of change was determined. The results of hair regeneration area after 20 days are shown in percentage in Table 4.

Comparative example 2 (1) 75% ethanol Comparative example 3 (1) 50% ethanol extract (dry product) of Oriental japonica 0.2 (2) 75%
Ethanol residual comparative example 4 (1) 70% ethanol extract of Japanese Angelica (dried material) (2) 75% ethanol 0.2 Residue comparative example 5 (1) Crane 50% ethanol extract (dried material) 0.2
(2) 75% ethanol Residue Example 3 (1) Thyme 50% ethanol extract (dried) (2) 75% ethanol 0.2 Residue Example 4 (1) Sage methanol extract (dry) (2 )75
% Ethanol 0.1 Remaining Example 5 (1) Dimethyllaurylamine oxide (2) Time 5
0% ethanol extract (dry product) (3) 75% ethanol 0.1 0.1 Residue (1) Dimethyl lauryl amine oxide (2) Sodium lauryl methyl taurate (3) 50% ethanol extract of lemon (dry product) (4) 75% ethanol 0.06 0.04 0.1 Remaining Example 6 (1) Dimethylstearylamine oxide (2) Methanol extract of sage (dried product) (3) 75% ethanol Example 7 (1) Dodecylbenzene sulfonate (2) Lauryldimethylamine oxide (3) 70% ethanol extract of lavender (dried product) (4) 75% ethanol Example 8 0.1 0.1 Remaining Example 9 (1) Betain lauryl aminoacetate (2) Lauroylgetanolamide (3) Geranium 1,3-butylene glycol extract (dry product) (4) 75% ethanol 0.03 0.02 0.1 Remaining 0.05 0, O5 0,1 Remaining Example 10 (1) Dimethyl laurylamine oxide (2) 70% ethanol extract of Spirulina (dry product) (3) Methanol extract of black bean (dry product) (4) 0.05 0.05 0° of Black Bean 05 Propatool extract (dried product) (5) 75% ethanol 0.05 Remaining Example 11 Hair tonic A tonic with the composition shown below was prepared and used to treat dandruff,
The effects on symptoms such as hair growth and hair loss were investigated.

4 doses of 1 to 5 ml once or twice a day to 20 men (age 24 to 60) exhibiting symptoms such as dandruff, hair growth, and hair loss.
The coating was applied for several months, and the results shown in Table 5 were obtained.

It was excellent in symptoms such as dandruff, hair growth and hair loss.

As is clear from Table 4, the effect on hair regeneration was observed in each Example.

(1) Thyme 70% ethanol extract (dried) (2)
Lavender 90% ethanol extract (dry) (3) Sage methanol extract (dry) (4) Dimethyl laurylamine oxide (5) Sodium lauryl sulfate (6) Propylene glycol (7) Sodium hyaluronate (8) 75 % Ethanol 0.05 1.0 0.5 0.3 0, O5 5.0 0.01 Residual Mourning -5 Materials Used ζ Remaining Rage In Table 5 above, the effectiveness was evaluated according to the following criteria.

1. Dandruff prevention effect test ``Ineffective'' means that no improvement is seen despite treatment.

"Effective" means that the occurrence of dandruff has been reduced.

"Remarkable effect" means that dandruff has stopped occurring.

2. Hair growth effect test ``Ineffective'' means that no improvement is seen despite treatment.

"Effective" means that new hair growth is observed in 2/3 or more of the hair loss area.

``Remarkable effect'' means that hair has grown in the hair removal area.

3. Hair removal effect test ``Ineffective'' means that no improvement is seen despite treatment.

"Effective" means that the progression of hair loss has been reduced.

"Remarkable response" means that hair loss has stopped.

Example 12 Hair tonic (1) Methanol extract of black bean (dried product) 0.05 (2) 80% ethanol extract of black bean (dried product) 0.05 (3
) 1,3-butylene glycol extract of thyme (dry product) O,0S (4) 90% ethanol extract of thyme (dry product) 0.05 (5
) Sage hot water extract (dried) 0.05 (
6) Cedarwood 70% ethanol extract (dry) 0.05 (7
) Polyoxyethylene (8 mol) Oleyl alcohol ether 0.05 (80,3-
Butylene glycol 0.05(9)60
% ethanol Remaining The effect of the cosmetic of Example 12 on hair growth was also effective.

Example 13 Shampoo (1) Sodium cocoyl methyl taurate 6.0 (2
) lauryldimethylaminoacetic acid betaine (3) lauric acid jetanolamide (4) ethylene glycol fatty acid ester (5) propylene glycol (6) 70% ethanol extract of lavender (dried product) (7) 50% ethanol extract of Juniva 2 Product (dried) (8) Methanol extract of lemon (dry) (9) Propylene glycol extract of geranium (dry) (10) 2-sodium edetate (11) Flavor (12) Purified water 8. 0 4.0 1.5 2.0 1.0 1.0 1.0 0.2 0.1 Appropriate amount Remainder Example 14 Rinse (1) Stearyltrimethylammonium chloride (2) Cetyl alcohol 1.5 2.0 ( 3) Silicone oil (4) Polyoxyethylene (10 moles) Oleyl alcohol ether (5) Glycerin (6) Methanol extract of black bean (dried) (7) Methanol extract of lavender (dry) (8) Cedarwood Hot water extract (dry product) (9) 70% ethanol extract of geranium (dry product) (10) Purified water (11) Preservative (12) Ultraviolet absorber 3.0 1.0 5.0 0.5 0.5 1.0 1.0 84.0 Appropriate amount Appropriate amount Example 15 Hair cream (1) Beeswax (2) Vaseline (3) Liquid paraffin (4) Polyoxyethylene (5 moles) 3.0 15.0 42. 0 Stearic acid ester (5) Polyoxyethylene (6 moles) Oleyl alcohol ether (6) 90% propatool extract of thyme (dry product) (7) 50% methanol extract of geranium (dry product) (8) Juniper , 70% ethanol extract (dry product) (9) Purified water (10) Flavor (11) Preservative 3.0 1.0 0.3 0.2 0.4 35.1 Appropriate amount Appropriate amount Examples 12-15 All of them had excellent hair growth effects.

[Effect of the invention] The hair nourishment of the present invention contains a specific crude drug extract or a specific crude drug extract and a specific surfactant, thereby achieving the following effects:
Various properties that are significantly superior to conventional hair care products (e.g.
hair growth, hair growth, hair loss prevention effects, etc.).

Claims (4)

[Claims] (1) A hair nourishing agent containing one or more herbal medicine extracts selected from the group consisting of thyme, sage, lavender, juniper, cedarwood, lemon, geranium, spirulina, black bean, and black bean. (2) One or more extracts of herbal medicine selected from the group consisting of thyme, sage, lavender, juniper, cedarwood, lemon, geranium, spirulina, black bean, and black bean, and one or more anionic surfactants. 1. A hair nourishing agent characterized by containing at least one type of surfactant, and one or more types of surfactant having a nitrogen atom in the molecule other than an anionic surfactant. (3) One or more extracts of herbal medicines selected from the group consisting of thyme, sage, lavender, juniper, cedarwood, lemon, geranium, spirulina, black bean, and black bean, an amphoteric surfactant, and a semipolar surfactant. 1. A hair nourishing agent comprising one or more types of surfactants and one or more types of nonionic surfactants having a nitrogen atom in the molecule. (4) It is characterized by containing one or more extracts of crude drugs selected from the group consisting of thyme, sage, lavender, juniper, cedarwood, lemon, geranium, spirulina, black bean, and black bean, and amine oxide. A hair nourishing agent.