JPH0233692B2 - - Google Patents

Info

Publication number
JPH0233692B2
JPH0233692B2 JP58073197A JP7319783A JPH0233692B2 JP H0233692 B2 JPH0233692 B2 JP H0233692B2 JP 58073197 A JP58073197 A JP 58073197A JP 7319783 A JP7319783 A JP 7319783A JP H0233692 B2 JPH0233692 B2 JP H0233692B2
Authority
JP
Japan
Prior art keywords
radioactive
carrier
chelate
radioactive metal
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP58073197A
Other languages
English (en)
Japanese (ja)
Other versions
JPS59199636A (ja
Inventor
Hiroyoshi Takahashi
Nobuo Ueda
Masaaki Hazue
Akira Yokoyama
Yoshiaki Oomomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nihon Medi Physics Co Ltd
Original Assignee
Nihon Medi Physics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Medi Physics Co Ltd filed Critical Nihon Medi Physics Co Ltd
Priority to JP58073197A priority Critical patent/JPS59199636A/ja
Priority to DE8484104617T priority patent/DE3479292D1/de
Priority to CA000452757A priority patent/CA1235063A/en
Priority to AT84104617T priority patent/ATE45288T1/de
Priority to EP84104617A priority patent/EP0123314B1/en
Priority to US06/604,261 priority patent/US4645660A/en
Priority to AU27273/84A priority patent/AU2727384A/en
Priority to KR1019840002235A priority patent/KR860001565B1/ko
Publication of JPS59199636A publication Critical patent/JPS59199636A/ja
Publication of JPH0233692B2 publication Critical patent/JPH0233692B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/081—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the protein being an albumin, e.g. human serum albumin [HSA], bovine serum albumin [BSA], ovalbumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/121—Solutions, i.e. homogeneous liquid formulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP58073197A 1983-04-26 1983-04-26 放射性診断剤 Granted JPS59199636A (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP58073197A JPS59199636A (ja) 1983-04-26 1983-04-26 放射性診断剤
DE8484104617T DE3479292D1 (en) 1983-04-26 1984-04-25 Radioactive diagnostic agent and its preparation
CA000452757A CA1235063A (en) 1983-04-26 1984-04-25 Increasing labeling efficiency by forming diagnostic agent in the presence of ascorbic acid of the like
AT84104617T ATE45288T1 (de) 1983-04-26 1984-04-25 Radiodiagnostik-agens und seine herstellung.
EP84104617A EP0123314B1 (en) 1983-04-26 1984-04-25 Radioactive diagnostic agent and its preparation
US06/604,261 US4645660A (en) 1983-04-26 1984-04-26 Increasing labeling efficiency by forming diagnostic agent in the presence of ascorbic acid or the like
AU27273/84A AU2727384A (en) 1983-04-26 1984-04-26 Radioactive diagnostic agent
KR1019840002235A KR860001565B1 (ko) 1983-04-26 1984-04-26 방사성 진단제의 제조방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58073197A JPS59199636A (ja) 1983-04-26 1983-04-26 放射性診断剤

Publications (2)

Publication Number Publication Date
JPS59199636A JPS59199636A (ja) 1984-11-12
JPH0233692B2 true JPH0233692B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1990-07-30

Family

ID=13511173

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58073197A Granted JPS59199636A (ja) 1983-04-26 1983-04-26 放射性診断剤

Country Status (8)

Country Link
US (1) US4645660A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0123314B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS59199636A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR860001565B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE45288T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU2727384A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1235063A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3479292D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0477390U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1990-11-13 1992-07-06
JPH0491189U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1990-12-25 1992-08-07

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
US5393512A (en) * 1985-01-14 1995-02-28 Vanderheyden; Jean-Luc Stable therapeutic radionuclide compositions and methods for preparation thereof
DE58906384D1 (de) * 1988-01-20 1994-01-27 Ciba Geigy Verfahren zur Herstellung von Komplexverbindungen.
US5011676A (en) * 1990-03-27 1991-04-30 Thomas Jefferson University Method to directly radiolabel antibodies for diagnostic imaging and therapy
CA2113995C (en) * 1991-08-29 2003-04-22 Edward A. Deutsch Use of gentisic acid or gentisyl alcohol for stabilising radiolabeled peptides and proteins
JP3051591B2 (ja) * 1993-03-05 2000-06-12 日本メジフィジックス株式会社 タリウム−２０１の容器に対する付着防止剤
GB9403855D0 (en) * 1994-03-01 1994-04-20 Scotia Holdings Plc Fatty acid derivatives
US6027710A (en) * 1996-09-18 2000-02-22 Nihon Medi-Physiscs Co., Ltd. Radiation-protecting agent
LT1585548T (lt) 2002-12-09 2018-09-25 Abraxis Bioscience, Llc Farmakologinių agentų kompozicijos ir įvedimo būdai
KR20190034694A (ko) * 2002-12-09 2019-04-02 아브락시스 바이오사이언스, 엘엘씨 약리학적 물질의 조성물 및 그 전달방법
CA2783275A1 (en) * 2003-07-24 2005-02-03 Bracco Imaging S.P.A. Stable radiopharmaceutical compositions and methods for their preparation
CA2997791A1 (en) 2015-09-30 2017-04-06 Duke University Ascorbate formulations and methods of use as contrast agents

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3740418A (en) * 1970-07-01 1973-06-19 Squibb & Sons Inc Radioactive scanning preparation
US4364920A (en) * 1975-04-30 1982-12-21 Medi-Physics, Inc. Stable diagnostic reagents
JPS56125317A (en) * 1980-03-08 1981-10-01 Nippon Mejifuijitsukusu Kk Stable radioactive diagnosticum with radioactive metallic mark
JPS5750928A (en) * 1980-09-13 1982-03-25 Nippon Mejifuijitsukusu Kk Diagnostic agent for scanning bone
JPS57102820A (en) * 1980-12-19 1982-06-26 Nippon Mejifuijitsukusu Kk Agent for radiodiagnosis
DE3171920D1 (en) * 1981-09-16 1985-09-26 Nihon Mediphysics Co Ltd Radioactive diagnostic agent and its preparation
FI82379C (fi) * 1981-10-27 1991-03-11 Univ California Radioaktivt maerkta monoklonala antikroppar samt en komposition innehaollande dessa och anvaendbar som diagnostiskt radiofarmaseutiskt medel.
JPS5896031A (ja) * 1981-12-03 1983-06-07 Nippon Mejifuijitsukusu Kk 放射性診断剤およびその製造用組成物
US4455291A (en) * 1982-01-22 1984-06-19 New England Nuclear Corporation Accelerators for forming cationic technetium complexes useful as radiodiagnostic agents
EP0096934B1 (en) * 1982-06-10 1986-11-26 Mallinckrodt, Inc. (a Delaware corporation) Radiographic imaging agents
US4504462A (en) * 1982-06-10 1985-03-12 Mallinckrodt, Inc. Process for making a lyophilized product for use in skeletal imaging
US4510125A (en) * 1982-12-08 1985-04-09 Mallinckrodt, Inc. Process for making lyophilized radiographic imaging kit
EP0111414A3 (en) * 1982-12-08 1985-05-02 Mallinckrodt, Inc. (a Delaware corporation) Radiographic imaging agents

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0477390U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1990-11-13 1992-07-06
JPH0491189U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1990-12-25 1992-08-07

Also Published As

Publication number Publication date
KR860001565B1 (ko) 1986-10-08
EP0123314B1 (en) 1989-08-09
DE3479292D1 (en) 1989-09-14
EP0123314A2 (en) 1984-10-31
ATE45288T1 (de) 1989-08-15
JPS59199636A (ja) 1984-11-12
US4645660A (en) 1987-02-24
KR840008291A (ko) 1984-12-14
AU2727384A (en) 1984-11-01
CA1235063A (en) 1988-04-12
EP0123314A3 (en) 1986-12-30

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