JPH02138107A - Skin cosmetic - Google Patents
Skin cosmeticInfo
- Publication number
- JPH02138107A JPH02138107A JP29052988A JP29052988A JPH02138107A JP H02138107 A JPH02138107 A JP H02138107A JP 29052988 A JP29052988 A JP 29052988A JP 29052988 A JP29052988 A JP 29052988A JP H02138107 A JPH02138107 A JP H02138107A
- Authority
- JP
- Japan
- Prior art keywords
- cyclodextrin
- weight
- cosmetic
- glycerin
- glycerol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 25
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 45
- 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 14
- -1 fatty acid ester Chemical class 0.000 claims abstract description 12
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 8
- 239000000194 fatty acid Substances 0.000 claims abstract description 8
- 229930195729 fatty acid Natural products 0.000 claims abstract description 8
- 125000002252 acyl group Chemical group 0.000 claims abstract description 6
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 claims abstract description 3
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract description 3
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract description 3
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract 2
- 235000011187 glycerol Nutrition 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 11
- 239000001116 FEMA 4028 Substances 0.000 claims description 6
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 6
- 229960004853 betadex Drugs 0.000 claims description 6
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 claims description 2
- 229940043377 alpha-cyclodextrin Drugs 0.000 claims description 2
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims description 2
- 229940080345 gamma-cyclodextrin Drugs 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 125000001419 myristoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 125000003910 behenoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 4
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract description 3
- 210000002615 epidermis Anatomy 0.000 abstract description 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000006003 cornification Effects 0.000 abstract 1
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 229920000223 polyglycerol Polymers 0.000 abstract 1
- 230000006641 stabilisation Effects 0.000 abstract 1
- 238000011105 stabilization Methods 0.000 abstract 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 10
- 239000008213 purified water Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 210000003491 skin Anatomy 0.000 description 6
- 229940075507 glyceryl monostearate Drugs 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 5
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 235000021355 Stearic acid Nutrition 0.000 description 4
- 239000003205 fragrance Substances 0.000 description 4
- 230000003020 moisturizing effect Effects 0.000 description 4
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 4
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 4
- 239000008117 stearic acid Substances 0.000 description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 3
- 229940032094 squalane Drugs 0.000 description 3
- DSSYKIVIOFKYAU-OIBJUYFYSA-N (S)-camphor Chemical compound C1C[C@]2(C)C(=O)C[C@H]1C2(C)C DSSYKIVIOFKYAU-OIBJUYFYSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- HYZPVMPQJVVJBP-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanol;propane-1,2,3-triol Chemical compound OCC(O)CO.OCCN(CCO)CCO HYZPVMPQJVVJBP-UHFFFAOYSA-N 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- KVYGGMBOZFWZBQ-UHFFFAOYSA-N benzyl nicotinate Chemical compound C=1C=CN=CC=1C(=O)OCC1=CC=CC=C1 KVYGGMBOZFWZBQ-UHFFFAOYSA-N 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 229940042585 tocopherol acetate Drugs 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 1
- SJLAFUFWXUJDDR-KTKRTIGZSA-N [3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]-2-hydroxypropyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)COCC(O)COCC(O)CO SJLAFUFWXUJDDR-KTKRTIGZSA-N 0.000 description 1
- NPTLAYTZMHJJDP-KTKRTIGZSA-N [3-[3-[3-[3-[3-[3-[3-[3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)CO NPTLAYTZMHJJDP-KTKRTIGZSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 229950004580 benzyl nicotinate Drugs 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000008341 cosmetic lotion Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 229940097362 cyclodextrins Drugs 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- ZLSFWAPBBIIMKI-KVINTPOGSA-M dipotassium;(2s,4as,6ar,6as,6br,8ar,10s,12as,14br)-2,4a,6a,6b,9,9,12a-heptamethyl-10-oxido-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1h-picene-2-carboxylate Chemical compound [K+].[K+].C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C([O-])=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H]([O-])C1(C)C ZLSFWAPBBIIMKI-KVINTPOGSA-M 0.000 description 1
- 229960000735 docosanol Drugs 0.000 description 1
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosanyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 125000005313 fatty acid group Chemical group 0.000 description 1
- FODTZLFLDFKIQH-FSVGXZBPSA-N gamma-Oryzanol (TN) Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)O[C@@H]2C([C@@H]3CC[C@H]4[C@]5(C)CC[C@@H]([C@@]5(C)CC[C@@]54C[C@@]53CC2)[C@H](C)CCC=C(C)C)(C)C)=C1 FODTZLFLDFKIQH-FSVGXZBPSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 description 1
- WNIFXKPDILJURQ-JKPOUOEOSA-N octadecyl (2s,4as,6ar,6as,6br,8ar,10s,12as,14br)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1h-picene-2-carboxylate Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@](C(=O)OCCCCCCCCCCCCCCCCCC)(C)C[C@H]5C4=CC(=O)[C@@H]3[C@]21C WNIFXKPDILJURQ-JKPOUOEOSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
撮肴五恋秤叩庫」
本発明は、グリセリンを高濃度に配合した皮膚化粧料に
関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a skin cosmetic containing a high concentration of glycerin.
従来の技術および課題
グリセリンが皮膚に対して高い保湿性を有することはよ
く知られている。しかしながら、グリセリンを用いた製
剤については、未だ製剤化技術の面で十分ではない。Prior Art and Problems It is well known that glycerin has high moisturizing properties for the skin. However, the formulation technology for formulations using glycerin is still insufficient.
すなわち、グリセリンを配合した製剤はグリセリン特有
のべたつきがあり、またグリセリン濃度が１０重量％を
超えると乳化が困難となり、化粧料として好ましくない
。That is, preparations containing glycerin have stickiness characteristic of glycerin, and if the glycerin concentration exceeds 10% by weight, emulsification becomes difficult, making them undesirable as cosmetics.
そこで本発明者は、グリセリンを高濃度に配合する製剤
化技術について検討を行った結果、グリセリンにポリグ
リセリン脂肪酸エステルを組み合わせることにより、保
湿性が高く、使用感、安定性にも優れた化粧料が得られ
ることを知り本発明を完成するに至った。Therefore, the present inventor investigated a formulation technology that incorporates glycerin at a high concentration, and found that by combining glycerin with polyglycerin fatty acid ester, a cosmetic product with high moisturizing properties, excellent usability, and stability. This led to the completion of the present invention.
課題を解決するための手段
即ち、本発明は、グリセリン、および
後記式（１）で表されるポリグリセリン脂肪酸エステル
を配合したことを特徴とする皮膚化粧料を提供するもの
である。Means for solving the problem, that is, the present invention provides a skin cosmetic product characterized by containing glycerin and a polyglycerin fatty acid ester represented by the formula (1) below.
本発明化粧料にはグリセ９２１０〜４０重量％が配合さ
れる。グリセリンが１０重量％未満では十分な保湿効果
が得られず、また４０重量％を超えると、べたつき感が
避けられず、安定性面にも問題が生ずる。The cosmetic composition of the present invention contains 10 to 40% by weight of Grise 92. If the glycerin content is less than 10% by weight, a sufficient moisturizing effect cannot be obtained, and if it exceeds 40% by weight, a sticky feeling is unavoidable and problems arise in terms of stability.
一力、本発明皮膚化粧料に配合されるポリグリセリン脂
肪酸エステルは、下式（■）：〔式中、ｎは２〜１３の
整数、Ｒ１〜Ｒｎ＋１は各々別個に水素または炭素数１
２〜２２のアシル基であり、平均置換アシル基数は３
（ｎ ＋ ２ ）／１０以下で０ではない〕
で表される。The polyglycerin fatty acid ester to be blended into the skin cosmetics of the present invention can be expressed by the following formula (■): [where n is an integer of 2 to 13, and R1 to Rn+1 are each independently hydrogen or carbon number 1]
2 to 22 acyl groups, and the average number of substituted acyl groups is 3.
(n + 2)/10 or less and not 0].
すなわち、ポリグリセリン脂肪酸エステルはグリセリン
重合度４〜１５のものが用いられる。また、各脂肪酸置
換基Ｒ１−い、４．は、ステアロイル、オレオイル、イ
ソステアロイル、バルミトイル、ミリストイル、または
ラウロイルの１種または２種以上であるのが好ましく、
その置換基の数は重合度の３０％以下であり０％ではな
い。That is, the polyglycerin fatty acid ester used has a glycerin polymerization degree of 4 to 15. In addition, each fatty acid substituent R1-, 4. is preferably one or more of stearoyl, oleoyl, isostearoyl, balmitoyl, myristoyl, or lauroyl,
The number of substituents is 30% or less of the degree of polymerization and not 0%.
かかるポリグリセリン脂肪酸エステルとしては、例えば
モノステアリン酸デカグリセリル、ジイソステアリン酸
デカグリセリル、トリオレイン酸デカグリセリル、モノ
ラウリン酸デカグリセリル、トリステアリン酸デカグリ
セリル、モノオレイン酸テトラグリセリル、モノミリス
チン酸へキサグリセリル、モノオレイン酸ヘキサグリセ
リルなどが挙げられる。Such polyglycerin fatty acid esters include, for example, decaglyceryl monostearate, decaglyceryl diisostearate, decaglyceryl trioleate, decaglyceryl monolaurate, decaglyceryl tristearate, tetraglyceryl monooleate, hexaglyceryl monomyristate, Examples include hexaglyceryl monooleate.
かかるポリグリセリン脂肪酸エステルの配合量は、化粧
料中１〜１０重量％であるのが好ましい。The amount of polyglycerin fatty acid ester blended in the cosmetic is preferably 1 to 10% by weight.
配合量が１重量％未満では、化粧料の安定性が充分でな
く、一方１０重量％を超えると、塗布時にべたつき感が
生じたり、塗布後に違和感を感じるなど使用感が低下す
る。If the amount is less than 1% by weight, the stability of the cosmetic composition will be insufficient, while if it exceeds 10% by weight, the feeling of use will deteriorate, such as a sticky feeling during application or an uncomfortable feeling after application.
本発明化粧料には、さらにシクロデキストリン類を配合
することにより安定性がさらに改良される。該シクロデ
キストリンとしては、α−シクロデキストリン、β−シ
クロデキストリン、γ−シクロデキストリンなどが挙げ
られ、これらの１種または２種以上が配合されてよい。The stability of the cosmetic composition of the present invention can be further improved by further incorporating cyclodextrins. Examples of the cyclodextrin include α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin, and one or more of these may be blended.
かかるデキストリンの配合量は０．１〜５重量％である
のが好ましい。配合量が０．１重量％未満では安定性改
善の効果が発現せず、一方、５重量％を超えると、水相
に溶解せず、結晶となって析出し、使用面で問題を生じ
る。The blending amount of such dextrin is preferably 0.1 to 5% by weight. If the amount is less than 0.1% by weight, the effect of improving stability will not be exhibited, while if it exceeds 5% by weight, it will not dissolve in the aqueous phase and will precipitate as crystals, causing problems in use.
さらに、本発明化粧料には、消炎作用を有する成分を配
合することができる。かかる成分としては、例えば、ア
ラントイン、アロエ末、イクタモールグアイアズレン及
びその誘導体、グリチルリチン酸及びその誘導体、グリ
チルレチン酸及びその誘導体、サリチル酸メチル、ステ
アリン酸グリチルレチニルヒノキヂオールなどが挙げら
れる。Furthermore, the cosmetic composition of the present invention may contain an ingredient having an anti-inflammatory effect. Examples of such ingredients include allantoin, aloe powder, ictamolguaiazulene and its derivatives, glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, methyl salicylate, glycyrrhetinylhinokidiol stearate, and the like.
また、本発明化粧料には、血行促進作用を有する成分を
配合することができる。かかる成分としては、例えば、
ビタミンＥアセテート、γ−オリザノール、ニコチン酸
、ニコチン酸アミド、ニコチン酸ベンジル、ｄ−カンフ
ル、ｃｔ（ｌ−カンフル、Ｑ−メントール、ｄ（１−メ
ントールなどが挙げられる。Furthermore, the cosmetic composition of the present invention may contain a component having a blood circulation promoting effect. Such ingredients include, for example,
Examples include vitamin E acetate, γ-oryzanol, nicotinic acid, nicotinamide, benzyl nicotinate, d-camphor, ct(l-camphor, Q-menthol, d(1-menthol), etc.
本発明の皮膚化粧料は公知の方法によりクリーム、乳液
、化粧液、パック、ゲル、洗浄剤などの形態に製造され
る。The skin cosmetics of the present invention are manufactured in the form of creams, emulsions, cosmetics, packs, gels, cleansers, etc. by known methods.
なお、本発明の化粧料には、さらにその種類に応じ、本
発明化粧料の性能を損なわない範囲において適宜公知の
成分が配合されてよい。In addition, the cosmetic composition of the present invention may further contain known ingredients as appropriate, depending on the type thereof, within a range that does not impair the performance of the cosmetic composition of the present invention.
笈嵐鯉
つぎに本発明を実施例にもとづきさらに具体的に説明す
る。Next, the present invention will be explained in more detail based on examples.
実施例ｔ （クリーム） 成 分 グリセリン トリエタノールアミン カルボキシビニルポリマー パラオキシ安息香酸エチル β−シクロデキストリン 精製水 モノオレイン酸デカグリセリル スクワラン ステアリン酸 セタノール トリ（カプリル・カプリン酸） グリセリン 親油型モノステアリン酸グリセリン 香 料 実施例２ （乳液） 成 分 グリセリン トリエタノールアミン カルボキンビニルポリマー 重量％ ０．５ ０．２ ０．２ 残部 ３．０ ４．０ ０．２ 重量％ ｌ ５，０ ０．７ ０．３ パラオキシ安息香酸エチル β−シクロデキストリン 精製水 ジイソステアリン酸デカグリセリル ステアリン酸 流動パラフィン トリオクタン酸グリセリル モノステアリン酸グリセリン 親油型モノステアリン酸グリセリン 香 料 実施例３ （化粧液） 成 分 グリセリン モノラウリン酸デカグリセリル β−シクロデキストリン パラオキシ安息香酸メチル エタノール 精製水 香 料 ０．２ ０．６ 残部 ２．５ ３．５ ２．５ １．０ 微量 重量％ ２０．０ １．５ ０．３ ０．１ １ Ｏｌｏ 残部 ０．１ 実施例４ （クレンジング・ゲル） 成 分 グリセリン ジイソステアリン酸デカグリセリル モノオレイン酸へキサグリセリル カルボキンビニルポリマー パラオキシ安息香酸エチル α−ンクロデキストリン プロピレングリコール 精製水 香 料 重量％ ３５．０ ６．０ ３．０ ０．２ ５．０ 残部 ０．２ 実施例５ （乳液） 成 分 グリセリン モノイソステアリン酸デカグリセリル α−ンクロデキストリン パラオキシ安息香酸メチル キサンタンガム 水酸化カリウム 重量％ ３５．０ １．２ ０．２ 精製水 トリオレイン酸デカグリセリル トリステアリン酸ヘキサグリセリル セスキステアリン酸ソルビタン ステアリン酸 ベヘニルアルコール オクタン酸セチル スクワラン パラオキシ安息香酸プロピル 香 料 実施例６（クリーム） 成 分 酢酸ｄＱ−α−トコフェロール グリチルレチン酸ステアリル スクワラン オリーブ油 ステアリン酸 セタノール 親油型モノステアリン酸グリセリン 残部 １．０ ３．５ １．５ １．５ １．０ ０．１ 重量％ ０．１０ ｔｏ、ｏ。Example t (cream) Component glycerin triethanolamine carboxyvinyl polymer Ethyl paraoxybenzoate β-cyclodextrin purified water Decaglyceryl monooleate Squalane stearic acid Setanol Tri (caprylic/capric acid) glycerin Lipophilic glyceryl monostearate fragrance Example 2 (emulsion) Component glycerin triethanolamine carboquine vinyl polymer weight% 0.5 0.2 0.2 remainder 3.0 4.0 0.2 weight% l 5,0 0.7 0.3 Ethyl paraoxybenzoate β-cyclodextrin purified water Decaglyceryl diisostearate stearic acid liquid paraffin Glyceryl trioctanoate glyceryl monostearate Lipophilic glyceryl monostearate fragrance Example 3 (cosmetics) Component glycerin Decaglyceryl monolaurate β-cyclodextrin Methyl paraoxybenzoate ethanol purified water Incense 0.2 0.6 remainder 2.5 3.5 2.5 1.0 Very small amount weight% 20.0 1.5 0.3 0.1 1 Olo remainder 0.1 Example 4 (Cleansing gel) Component glycerin Decaglyceryl diisostearate Hexaglyceryl monooleate carboquine vinyl polymer Ethyl paraoxybenzoate alpha-enclodextrin Propylene glycol purified water Incense weight% 35.0 6.0 3.0 0.2 5.0 remainder 0.2 Example 5 (emulsion) Component glycerin Decaglyceryl monoisostearate alpha-enclodextrin Methyl paraoxybenzoate xanthan gum potassium hydroxide weight% 35.0 1.2 0.2 purified water Decaglyceryl trioleate Hexaglyceryl tristearate Sorbitan sesquistearate stearic acid behenyl alcohol Cetyl octoate Squalane Propyl paraoxybenzoate fragrance Example 6 (cream) Component dQ-α-tocopherol acetate Stearyl glycyrrhetinate Squalane olive oil stearic acid Setanol Lipophilic glyceryl monostearate remainder 1.0 3.5 1.5 1.5 1.0 0.1 weight% 0.10 to, o.
８．００
４．００
２．００
３゜００
ポリオＮジエチレン（２０Ｅ、Ｏ，）グリセリルモノス
テアレートβ−シクロデキストリン
濃グリセリン
パラオキシ安息香酸エチル
精製水
２５．００
０．３０
残部
実施例７（化粧液）
成 分 重量％ｇ−メ
ントール ０．２０
グリチルレチン酸ジカリウム ０４０グリ
セリン １８．００ポリオキ
ンエチレン硬化ヒマシ油（４０Ｅ、Ｏ，） ０ 、８０
エタノール Ｉ Ｏ，０
０バラオキシ安息香酸エヂル ０．０５香
料 ０
．１０精製水 残部
発明の効果
本発明の皮膚化粧料は保湿効果に優れ、表皮の角化の抑
制、しわの抑止に顕著な効果を奏する。8.00 4.00 2.00 3゜00 PolyN diethylene (20E, O,) glyceryl monostearate β-cyclodextrin Concentrated glycerin Ethyl p-oxybenzoate Purified water 25.00 0.30 Remaining Example 7 (Cosmetic lotion ) Ingredients Weight% g-Menthol 0.20
Dipotassium glycyrrhetinate 040 Glycerin 18.00 Polyquine ethylene hydrogenated castor oil (40E, O,) 0,80
Ethanol I O,0
0 Rose oxybenzoic acid 0.05 Fragrance 0
．． 10 Purified water Remainder Effects of the Invention The skin cosmetic of the present invention has an excellent moisturizing effect and has a remarkable effect on suppressing keratinization of the epidermis and suppressing wrinkles.
Claims (4)
は各々別個に水素または炭素数１２〜２２のアシル基で
あり、平均置換アシル基数は３（ｎ＋２）／１０以下で
０ではない〕 で表されるポリグリセリン脂肪酸エステル を配合したことを特徴とする皮膚化粧料。(1) Glycerin 10 to 40% by weight, and the following formula: ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ (I) [In the formula, n is an integer from 2 to 13, R_1 to R_n_+_4
are each independently hydrogen or an acyl group having 12 to 22 carbon atoms, and the average number of substituted acyl groups is 3(n+2)/10 or less and not 0.] Skin cosmetics.
、オレオイル、イソステアロイル、パルミトイル、ミリ
ストイル、ラウロイルまたはベヘノイルである前記請求
項１記載の皮膚化粧料。(2) The skin cosmetic according to claim 1, wherein R_1_ to__(_n_+_4_) are stearoyl, oleoyl, isostearoyl, palmitoyl, myristoyl, lauroyl, or behenoyl.
０重量％である前記請求項１記載の皮膚化粧料。(3) The blending amount of polyglycerin fatty acid ester is 1 to 1
The skin cosmetic composition according to claim 1, wherein the content is 0% by weight.
ンおよびγ−シクロデキストリンの１種または２種以上
を０．１〜５重量％含有する前記請求項１記載の皮膚化
粧料。(4) The skin cosmetic according to claim 1, which contains 0.1 to 5% by weight of one or more of α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63290529A JP2603529B2 (en) | 1988-11-16 | 1988-11-16 | Skin cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63290529A JP2603529B2 (en) | 1988-11-16 | 1988-11-16 | Skin cosmetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02138107A true JPH02138107A (en) | 1990-05-28 |
| JP2603529B2 JP2603529B2 (en) | 1997-04-23 |
Family
ID=17757208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63290529A Expired - Fee Related JP2603529B2 (en) | 1988-11-16 | 1988-11-16 | Skin cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2603529B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994018943A1 (en) * | 1993-02-19 | 1994-09-01 | Beiersdorf Ag | Compositions against skin impurities containing di- or triglycerine esters as active principle |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58183608A (en) * | 1982-04-19 | 1983-10-26 | Shiseido Co Ltd | Transparent cosmetic |
| JPS58206905A (en) * | 1982-05-01 | 1983-12-02 | Yokogawa Hokushin Electric Corp | Method and device for measuring thickness of sheet-like object |
| JPS6112605A (en) * | 1984-06-28 | 1986-01-21 | Shiseido Co Ltd | Semi-transparent cosmetic |
| JPS6112602A (en) * | 1984-06-28 | 1986-01-21 | Shiseido Co Ltd | Semi-transparent cosmetic |
| JPS6185328A (en) * | 1984-10-02 | 1986-04-30 | Kao Corp | Percutaneous absorption promoter and external preparation for skin containing same |
| JPS62416A (en) * | 1985-06-27 | 1987-01-06 | Hoou Kk | Hair dye |
| JPS63419A (en) * | 1986-06-19 | 1988-01-05 | Nissan Motor Co Ltd | Surface hardening method for camshaft |
| JPS6357508A (en) * | 1986-08-28 | 1988-03-12 | Mikimoto Seiyaku Kk | Film-forming cosmetic pack |
| JPS6361050A (en) * | 1986-09-02 | 1988-03-17 | Nissan Motor Co Ltd | Plastic molding material |
-
1988
- 1988-11-16 JP JP63290529A patent/JP2603529B2/en not_active Expired - Fee Related
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58183608A (en) * | 1982-04-19 | 1983-10-26 | Shiseido Co Ltd | Transparent cosmetic |
| JPS58206905A (en) * | 1982-05-01 | 1983-12-02 | Yokogawa Hokushin Electric Corp | Method and device for measuring thickness of sheet-like object |
| JPS6112605A (en) * | 1984-06-28 | 1986-01-21 | Shiseido Co Ltd | Semi-transparent cosmetic |
| JPS6112602A (en) * | 1984-06-28 | 1986-01-21 | Shiseido Co Ltd | Semi-transparent cosmetic |
| JPS6185328A (en) * | 1984-10-02 | 1986-04-30 | Kao Corp | Percutaneous absorption promoter and external preparation for skin containing same |
| JPS62416A (en) * | 1985-06-27 | 1987-01-06 | Hoou Kk | Hair dye |
| JPS63419A (en) * | 1986-06-19 | 1988-01-05 | Nissan Motor Co Ltd | Surface hardening method for camshaft |
| JPS6357508A (en) * | 1986-08-28 | 1988-03-12 | Mikimoto Seiyaku Kk | Film-forming cosmetic pack |
| JPS6361050A (en) * | 1986-09-02 | 1988-03-17 | Nissan Motor Co Ltd | Plastic molding material |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994018943A1 (en) * | 1993-02-19 | 1994-09-01 | Beiersdorf Ag | Compositions against skin impurities containing di- or triglycerine esters as active principle |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2603529B2 (en) | 1997-04-23 |
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