JP3230579B2 - Cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic composition which has a moist, full-bodied, less sticky feel, an excellent feeling of use, and a high skin roughness preventing effect.

[0002]

2. Description of the Related Art Cosmetics have a function of keeping the skin moist and preventing rough skin. Hyaluronic acid has excellent moisturizing properties and is highly effective in keeping the skin moist, but on the other hand, sticky feel has been a problem.

[0003]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a cosmetic composition which has a moist, full-bodied, less sticky feel, an excellent feeling of use, and a high skin roughness preventing effect.

[0004]

The present inventors have made intensive studies to solve the above-mentioned problems and found that hyaluronic acid and 1,2
-Combination of pentanediol (containing one or two kinds selected from the group consisting of Talisman extract and vitamin E acetate, whey and serine, tranexamic acid and serine, alanine and trimethylglycine) It has been found that the above problems can be solved by combining and combining hyaluronic acid and polyoxypropylene diglyceryl ether, excluding the skin external preparation containing the above amino acids), and completed the present invention.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION Hyaluronic acid used in the cosmetics of the present invention is widely distributed in animal tissues, especially mesenchymal tissues, and has a structure in which the equimolar ratio of D-glucuronic acid and N-acetylglucosamine is 1 unit. Is a polysaccharide. The average molecular weight of the hyaluronic acid used in the present invention is 10,000 to 5,000,000, preferably 10,000 to 600,000. If the average molecular weight is less than 10,000, the moist feeling is insufficient, and if it is more than 600,000, it is somewhat difficult to suppress stickiness. The amount of the hyaluronic acid used in the present invention is preferably 0.001% to 1% by weight based on the total amount of the cosmetic. 0.
If it is less than 001%, the moist feeling is insufficient, and if it exceeds 1%, it is somewhat difficult to suppress stickiness.

[0006] The 1,2-pentanediol used in the present invention is a kind of dihydric aliphatic alcohol, and is a component usually incorporated in cosmetics as a humectant. The compounding amount of 1,2-pentanediol used in the present invention is 0.5 to 20.
% By weight is preferred, and 1 to 10% by weight is particularly preferred. The compounding ratio of hyaluronic acid and 1,2-pentanediol is preferably 1/10 to 1/20000 by weight. When the weight% ratio is larger than 1/10, the effect of suppressing the stickiness of hyaluronic acid becomes insufficient.

The polyglycerol used in the present invention is obtained by dehydrating and condensing glycerin. The average degree of polymerization of glycerin is 2 to 10. The amount of the polyglycerin used in the present invention is preferably 0.5 to 20% by weight,
A 0% by weight formulation is particularly preferred. The compounding ratio of hyaluronic acid and polyglycerin is 1/10 to 1/2000 by weight%.
0 is preferred. When the weight% ratio is larger than 1/10, the effect of suppressing the stickiness of hyaluronic acid becomes insufficient.

The polyoxypropylene diglyceryl ether used in the present invention is obtained by adding propylene oxide to diglycerin. The average degree of polymerization of propylene oxide is 5 to 15. The amount of the polyoxypropylene diglyceryl ether used in the present invention is preferably 0.5 to 20% by weight, and particularly preferably 1 to 10% by weight. The mixing ratio of hyaluronic acid and polyoxypropylene diglyceryl ether is 1/10 to 1/2000 by weight%.
0 is preferred. When the weight% ratio is larger than 1/10, the effect of suppressing the stickiness of hyaluronic acid becomes insufficient.

In the present invention, it goes without saying that a compounding agent which has been conventionally used as a cosmetic may be added as long as the effects of the present invention are not impaired. For example, as a humectant, glycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, xylitol, sorbit, lactose, sucrose, honey,
Glucose, D-mannitol, maltitol, maltose, urea, polyethylene glycol, polyoxyethylene methyl glucoside and the like can be blended.

[0010] Further, as an oil agent, avocado oil, diester adipate such as di-2-ethylhexyl adipate,
Anise oil, aralkyl alcohol, isostearic acid, isostearyl alcohol, isostearic acid ester such as isostearyl isostearate, isononanoic acid ester such as isodecyl isononanoate, isopalmitic acid ester such as octyl isopalmitate, undecylenic acid, 2-ethyl 2-ethylhexanoic acid ester such as cetyl hexanoate, erucic acid ester such as octyldodecyl erucate, octyldodecanol, oleic oil, oleic acid ester such as oleyl alcohol, phytosteryl oleate, and cyclic silicone such as decamethylcyclopentasiloxane , Octanoic acid esters such as isocetyl octoate, olive oil alcohol, orange laffy oil, cocoa butter, carnauba wax, caprylic esters such as cetyl caprylate, cap Acid, candelilla wax, volatile isoparaffin, cucumber oil, beef tallow, tallow fatty acid, citrate esters such as acetyltriethyl citrate, citrate esters such as tri-2-ethylhexyl citrate, kukui nut oil, light isoparaffin, and hardened oil , Sesame oil, cholesterol, hardened rapeseed oil alcohol, hardened castor oil, highly oxidized beeswax, hard lanolin fatty acid esters such as hard lanolin fatty acid cholesteryl, succinic esters such as di-2-ethylhexyl succinate, burdock seed oil, rice bran oil, rice germ Oil, safflower oil, sasanqua oil, safflower oil fatty acid, shark liver oil, salamon montan wax, diester of propylene glycol with fatty acid such as propylene glycol dioleate, hexyldecyl dimethyloctanoate, shea butter, di-2 Diesters of fatty acids such as neopentyl glycol ethylhexanoate and neopentyl glycol, diesters of fatty acids such as ethylene glycol dioctanoate and ethylene glycol, dimethyl octanoate such as octyl dodecyl dimethyl octanoate, squalane, stearyl alcohol, stearic acid, hydrogen jojoba oil, hydrogenated coconut oil, stearic acid esters such as isocetyl stearate, cetanol, sage oil, cetostearyl carboxymethyl polysiloxane side chain higher alcohol _{(C 32} ~C ₃₆₎ mixture, soybean oil, turtle oil, turtle oil Turtle oil fatty acid esters such as fatty acid ethyl ester, thyme oil, clove oil, camellia oil, evening primrose oil, decyl tetradecanol, fatty acid such as pentaerythritol tetra-2-ethylhexanoate and pentae Tetraester of slits, 7-dehydrocholesterol, turpentine oil, corn oil, fatty acids and triesters of glycerol, such as glyceryl tri-2-ethylhexanoate, rapeseed oil, cholesteryl nonanoate, nonanoic acid dihydrocholesteryl, persic oil, liquid paraffin,
Palmitic acid, palmitic acid esters such as isopropyl palmitate, palm kernel oil, palm oil, hydroxystearic acid, hydroxystearic acid esters such as cholesteryl hydroxystearate, hydroxylanolin,
Castor oil fatty acid esters such as castor oil fatty acid methyl, sunflower oil, phytosterol, hexyldecanol, behenic acid, hazelnut oil, heptanoic acid esters such as stearyl heptanoate, pelargonic acid esters such as octyl pelargonate, jojoba alcohol, jojoba oil, macadamia nut oil , Macadamia nut oil fatty acid phytosteryl and other macadamia nut oil fatty acid esters, beetle oil, beeswax, myristic acid esters such as myristic acid and isopropyl myristate, mink oil, myristyl alcohol, mink oil fatty acid esters such as mink oil fatty acid ethyl ester, mink wax, methyl Phenylpolysiloxane, methylpolysiloxane, mokuro, Mortierella oil, coconut oil, coconut oil fatty acid, eucalyptus oil, euglena oil, lauryl alcohol Lauric acid, lauric acid esters such as hexyl laurate, lanolin, lanolin alcohol, lanolin fatty acid, peanut oil, lanosterol, lavender oil, egg yolk fatty oil, egg yolk oil, ricinoleic acid esters such as cetyl ricinoleate, linoleic acid, linole Linoleic acid esters such as ethyl acid, rosemary oil, Roman chamomile oil, petrolatum and the like can be blended.

As vitamins, ascorbic acid, acetyl pantothenyl ethyl ether, inosit, ergocasiferol, β-carotene, DL-acetic acid
α-tocopherol, retinol acetate, ascorbyl dipalmitate, pyridoxine dipalmitate, pyridoxine, ascorbyl stearate, DL-α-tocopherol, nicotinamide, nicotinic acid, methyl nicotinate, D-pantothenyl alcohol, biotin, vitamin A Oil, pantothenyl ethyl ether and the like can be blended.

As the amino acid, L-aspartic acid, DL-alanine, glycine, L-cystine, L-threonine, L-serine, L-methionine, L-histidine, L-proline and the like can be blended.

As thickeners, gum arabic, sodium alginate, carrageenan, carboxyvinyl polymer, sodium carboxymethyl cellulose, sodium chondroitin sulfate, hydroxyethyl cellulose, sodium polyacrylate, guar gum, quince seed, xanthan gum, carboxymethyl chitosan,
Succinyl carboxymethyl chitosan and the like can be blended.

[0014] Further, as a roughening agent, allantoin, guaiazulene, glycyrrhizic acid, glycyrrhetinic acid, stearyl glycyrrhetinate, hinokitiol,
Bisabolol and the like can be blended.

[0015] Further, ethanol can be blended as a cooling agent.

Further, as a hydrogen ion concentration adjusting agent, citrate, tartrate, lactate, phosphate and the like can be blended.

The dosage form of the cosmetic of the present invention is arbitrary, and specific examples include lotions, emulsions, creams, packs, gels, beauty solutions, foundations, shampoos, rinses, and nutrients. And hair cosmetics.

[0018]

The present invention will be described more specifically with reference to examples and comparative examples. Examples 1 to 4 and Comparative Examples 1 to 4 Lotions were manufactured according to the composition shown in Table 1.

[0019]

[Table 1]

The following components in Table 1 are mixed and dissolved,
Got lotion. By 10 professional usability evaluators,
The feeling of use of Examples 1 to 4 and Comparative Examples 1 to 4 was evaluated. The evaluation criteria are as follows. ◎: Eight or more of the ten responded that they were good. ：: 6 or more respondents answered that they were good. B: 4 or more out of 10 responded that they were good. ×: Less than 4 out of 10 responded as good.

In addition, 20 women suffering from rough skin are divided into two groups of 10 women. The first group compares the effect of improving skin roughness between Example 1 and Comparative Example 1, and the second group compares Example 1 and Comparative Example 2. did. The continuous application period was 2 weeks, and Example 1 was applied to the left face and Comparative Example was applied to the right face once a day every morning and evening, and it was asked which of the skin roughness improving effects was higher after continuous application (Table 2). In both the first group and the second group, the number of persons who answered that the skin roughness improvement effect of the examples was high was remarkably large.

[0022]

[Table 2]

Examples 5 to 8 and Comparative Examples 5 to 8 Emulsions were prepared according to the composition shown in Table 3.

[0024]

[Table 3]

In Table 3, the components of 、 and ▲
The components of 11) were each heated, mixed and dissolved, and the former was added to the latter while stirring with a homomixer to emulsify. The mixture was cooled to room temperature, dissolved in a small amount of water, and mixed to obtain an emulsion. Example 5 by 10 professional usability evaluators
8, the feeling of use of Comparative Examples 5 to 8 was evaluated. The evaluation criteria are as follows. ◎: Eight or more of the ten responded that they were good. ：: 6 or more respondents answered that they were good. B: 4 or more out of 10 responded that they were good. ×: Less than 4 out of 10 responded as good.

Reference Examples 1 to 4 and Comparative Examples 9 to 12 Lotions were prepared according to the composition shown in Table 4.

[0027]

[Table 4]

The components (1) to (4) in Table 4 were mixed and dissolved.
Got lotion. By 10 professional usability evaluators,
The usability of Reference Examples 1 to 4 and Comparative Examples 9 to 12 was evaluated. The evaluation criteria are as follows. ◎: Eight or more of the ten responded that they were good. ：: 6 or more respondents answered that they were good. B: 4 or more out of 10 responded that they were good. ×: Less than 4 out of 10 responded as good.

Further, 20 women suffering from rough skin were divided into two groups of 10 women, and the first group compared the effect of improving skin roughness between Reference Example 1 and Comparative Example 9, and the second group compared between Reference Example 1 and Comparative Example 10. did.
The continuous use period was 2 weeks, and the reference example 1 and the comparative example were applied to the left face once daily in the morning and evening, respectively, and it was asked which of the skin roughness improvement effects was higher after continuous use (Table 5). In both the first group and the second group, the number of persons who answered that the skin roughness improvement effect of the reference example was high was remarkably large.

[0030]

[Table 5]

Reference Examples 5 to 8 and Comparative Examples 13 to 16 Emulsions were prepared according to the composition shown in Table 6.

[0032]

[Table 6]

In Table 6, the components of ~ and ~ 11
The components were heated, mixed and dissolved, and the mixture was stirred and emulsified with a homomixer while adding the former to the latter. The mixture was cooled to room temperature, dissolved in a small amount of water, and mixed to obtain an emulsion. Reference examples 5 to 8 by 10 professional usability evaluators,
The feeling of use of Comparative Examples 13 to 16 was evaluated. The evaluation criteria are as follows. ◎: 8 or more out of 10 responded that they were good. : 6 or more respondents answered that they were good. B: 4 or more out of 10 answered that they were good. ×: Less than 4 out of 10 responded as good.

[0034]

The present invention will be described more specifically with reference to examples and comparative examples. Examples 9 to 12 and Comparative Examples 17 to 20 Lotions were prepared according to the composition shown in Table 7.

[0035]

[Table 7]

The following components in Table 7 are mixed and dissolved.
Got lotion. By 10 professional usability evaluators,
The feeling of use of Examples 9 to 12 and Comparative Examples 17 to 20 was evaluated. The evaluation criteria are as follows. ◎: 8 or more out of 10 responded that they were good. : 6 or more respondents answered that they were good. B: 4 or more out of 10 answered that they were good. ×: Less than 4 out of 10 responded as good.

In addition, 20 women suffering from rough skin were divided into two groups of 10 women each.
The group compared the effect of improving skin roughness between Example 9 and Comparative Example 18. The continuous application period was 2 weeks, and Example 1 was applied to the left face and Comparative Example was applied to the right face once a day every morning and evening, and it was asked which of the skin roughness improving effects was higher after continuous application (Table 8). In both the first group and the second group, the number of persons who answered that the skin roughness improvement effect of the examples was high was remarkably large.

[0038]

[Table 8]

Examples 13 to 16 and Comparative Examples 21 to 24 Emulsions were prepared according to the composition shown in Table 9.

[0040]

[Table 9]

The components of and in Table 9 and ~ 11
The components were heated, mixed and dissolved, and the mixture was stirred and emulsified with a homomixer while adding the former to the latter. The mixture was cooled to room temperature, dissolved in a small amount of water, and mixed to obtain an emulsion. Examples 12 to 1 by 10 professional usability evaluators
6, the feeling of use of Comparative Examples 21 to 24 was evaluated. The evaluation criteria are as follows. ◎: 8 or more out of 10 responded that they were good. : 6 or more respondents answered that they were good. B: 4 or more out of 10 answered that they were good. ×: Less than 4 out of 10 responded as good.

Example 17 (Cream) (A) Purified water Residue 1,3-butylene glycol 5, 1,2-pentanediol 5 Dipotassium glycyrrhizinate 0.2 Glycine 0.2 (B) Squalane 3 Tri-2-ethylhexanoic acid Glyceryl 7 stearic acid 3 behenyl alcohol 1 methylpolysiloxane 1 licorice flavonoid 0.01 natural vitamin E 0.01 bisabolol 0.1 glyceryl monostearate 2 sorbitan monostearate 2 (C) sodium hyaluronate (average molecular weight 600,000) 01 Sodium carboxymethylcellulose 0.2 After each of (A) and (B) was heated and mixed and dissolved, (A) was added to (B), and the mixture was stirred with a homomixer and emulsified. After cooling to room temperature, (C) dissolved in a small amount of water was added and mixed to obtain a cream.

Reference Example 5 (Cream) (A) Purified water Residue 1,3-butylene glycol 5 Polyglycerin 5 Dipotassium glycyrrhizinate 0.2 Glycine 0.2 (B) Squalane 3 Glyceryl tri-2-ethylhexanoate 7 Stearic acid 3 behenyl alcohol 1 methyl polysiloxane 1 licorice flavonoid 0.01 natural vitamin E 0.01 bisabolol 0.1 glyceryl monostearate 2 sorbitan monostearate 2 (C) sodium hyaluronate (average molecular weight 600,000) 0.01 carboxymethyl cellulose sodium 0.2 The production method is in accordance with Example 17.

Example 18 (Cream) (A) Purified water Residue 1,3-butylene glycol 5 Polyoxypropylene diglyceryl ether 5 Dipotassium glycyrrhizinate 0.2 Glycine 0.2 (B) Squalane 3 Tri-2-ethylhexanoic acid Glyceryl 7 Stearic acid 3 Behenyl alcohol 1 Methylpolysiloxane 1 Licorice flavonoid 0.01 Natural vitamin E 0.01 Bisabolol 0.1 Glyceryl monostearate 2 Sorbitan monostearate 2 (C) Sodium hyaluronate (average molecular weight 600,000) 01 Sodium carboxymethylcellulose 0.2 The production method is according to Example 17.

Example 19 (Cleansing cream) (A) Purified water Residue 1,2-pentanediol 5 (B) Glyceryl tri-2-ethylhexanoate 40 Stearic acid 3 Behenyl alcohol 1 Methylpolysiloxane 1 Glyceryl monostearate 2 Monostearin Sorbitan acid 2 POE monostearate (20) Sorbitan 2 (C) Sodium hyaluronate (average molecular weight 600,000) 0.01 The production method is in accordance with Example 17.

Reference Example 6 (Cleansing cream) (A) Purified water Residue Polyglycerin 5 (B) Glyceryl tri-2-ethylhexanoate 40 Stearic acid 3 Behenyl alcohol 1 Methyl polysiloxane 1 Glyceryl monostearate 2 Sorbitan monostearate 2 Mono POE (20) sorbitan stearate 2 (C) Sodium hyaluronate (average molecular weight 600,000) 0.01 The production method is in accordance with Example 17.

Example 20 (Cleansing Cream) (A) Purified Water Residue Polyoxypropylene Diglyceryl Ether 5 (B) Glyceryl Tri-2-ethylhexanoate 40 Stearic Acid 3 Behenyl Alcohol 1 Methyl Polysiloxane 1 Glyceryl Monostearate 2 Monostearin Sorbitan acid 2 POE monostearate (20) Sorbitan 2 (C) Sodium hyaluronate (average molecular weight 600,000) 0.01 The production method is in accordance with Example 17.

Example 21 (Foundation) (A) Purified water Residue 1,2-pentanediol 5 Sodium chloride 0.5 L-arginine 0.01 Sodium hyaluronate (average molecular weight 600,000) 0.01 (B) Decamethyl Cyclopentasiloxane 30 Squalane 5 Methylpolysiloxane 1 Polyglyceryl diisostearate 4 Pigment 10 Sorbitan monostearate 2 POE (20) sorbitan monostearate 2 Vitamin A oil 0.01 Natural vitamin E 0.05 Heat-mixed (B) beforehand (A) that had been heated, mixed and dissolved was added and emulsified with a homomixer. After cooling to room temperature, a foundation was obtained.

Reference Example 7 (Foundation) (A) Purified water Residue Polyglycerin 5 Sodium chloride 0.5 L-arginine 0.01 Sodium hyaluronate (average molecular weight 600,000) 0.01 (B) Decamethylcyclopentasiloxane 30 Squalane 5 Methyl polysiloxane 1 Polyglyceryl diisostearate 4 Pigment 10 Sorbitan monostearate 2 POE (20) sorbitan monostearate 2 Vitamin A oil 0.01 Natural vitamin E 0.05 The production method is according to Example 21.

Example 22 (Foundation) (A) Purified water residue Polyoxypropylene diglyceryl ether 5 Sodium chloride 0.5 L-arginine 0.01 Sodium hyaluronate (average molecular weight 600,000) 0.01 (B) Decamethyl Cyclopentasiloxane 30 Squalane 5 Methylpolysiloxane 1 Polyglyceryl diisostearate 4 Pigment 10 Sorbitan monostearate 2 POE (20) sorbitan monostearate 2 Vitamin A oil 0.01 Natural vitamin E 0.05 The production method is according to Example 21. .

[0051]

EFFECT OF THE INVENTION By combining and combining hyaluronic acid and 1,2-pentanediol, it is possible to provide a cosmetic composition which has a moist, full-bodied, less sticky feel and a high skin roughness preventing effect. We were able to.

[Table 1]

[Table 2]

[Table 3]

[Table 4]

[Table 5]

[Table 6]

[Table 7]

[Table 8]

[Table 9]

────────────────────────────────────────────────── ─── Continuation of the front page (56) References JP-A-5-229916 (JP, A) JP-A-2000-86486 (JP, A) JP-A-2000-178165 (JP, A) JP-A-2000-256163 (JP, A) JP-A-2000-302668 (JP, A) JP-A-1-190614 (JP, A) JP-A-11-12137 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name ) A61K 7/00-7/50

Claims (3)

(57) [Claims] Claims: 1. A cosmetic comprising hyaluronic acid and 1,2-pentanediol (containing an extract of Paramecium officinalis and vitamin E acetate, containing whey and serine, tranexamic acid And a skin external preparation containing one or two or more amino acids selected from the group consisting of serine, alanine and trimethylglycine). 2. A cosmetic comprising hyaluronic acid and polyoxypropylene diglyceryl ether. 3. The cosmetic according to claim 1, wherein the molecular weight of hyaluronic acid is from 10,000 to 600,000.