JP2000264825A - Emulsion composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition which is effective for improving the skin conditions and also has a high safety and useful as a cosmetic by including galactosylceramide, etc., an oily component and a specific copolymer and no surfactant besides one such as galactosylceramide. SOLUTION: This composition is obtained by including (A) preferably 0.05-0.5 wt.% of at least one surfactant selected from galactosylceramide and glucosylceramide, (B) an oily component such as squalane, and (C) preferably 0.1-5 wt.% of a copolymer of acrylic acid with an alkyl methacrylate, and no surfactant besides galactosylceramide or glucosylceramide. This composition is useful for improving undesirable skin conditions such as dryness of the skin and an atopic dermatitis.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an emulsified composition having a high degree of safety and useful for improving undesired skin conditions such as dry skin and atopic dermatitis.

[0002]

2. Description of the Related Art Emulsion compositions used in cosmetics and the like are used for the purpose of replenishing water to the skin and suppressing the evaporation of water from the skin. Then, the emulsified composition usually emulsifies an oil component, a moisturizing component and water suitable for the skin using a surfactant. However, surfactants are undesirable for the skin, and attempts have been made to emulsify using alternatives to surfactants. For example,
JP-B-2-38253 proposes the use of cyclodextrin, and JP-A-7-149621 proposes the use of an alkyl-modified carboxyvinyl polymer. Although the primary purpose has been achieved by using these products, in recent years, the safety of so-called cosmetics, which has a higher degree of safety on the skin and has a long-term stability as an emulsion, has been further improved. Is expected.

[0003]

As a result of various studies to meet the above expectations, the present inventor has found that the use of galactosylceramide or glucosylceramide is effective in improving skin conditions and has a high degree of safety. It has been found that an emulsion is obtained, and the present invention has been completed. An object of the present invention is to provide a highly safe emulsified composition which does not use other surfactants by using galactosylceramide or glucosylceramide during emulsification. It is to be.

[0004]

That is, the gist of the present invention is to provide at least one of galactosylceramide and glucosylceramide, an oily component, and a copolymer of acrylic acid and alkyl methacrylate. It is an emulsified composition characterized by containing no surfactant other than galactosylceramide or glucosylceramide. It is known that galactosylceramide or glucosylceramide forms a liquid crystal state, retains moisture, and prevents evaporation of moisture. Galactosylceramide or glucosylceramide is a natural surfactant, but it is difficult to avoid creaming, although stable emulsion particles are formed by itself. However, in the present invention, a safe and stable emulsion composition could be obtained by blending acrylic acid and an alkyl methacrylate copolymer.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION Galactosylceramide used in the emulsified composition of the present invention is abundant in white matter of the brain, and glucosylceramide is a compound abundantly present in the spleen, and these can be obtained by ordinary extraction methods. (Lipid III,
Shinsei Chemistry Laboratory, Vol. 4, pp. 237-241, 199
0, edited by The Biochemical Society of Japan, Doujin Kagaku). The amount of galactosylceramide or glucosylceramide is preferably 0.05 to 0.5% by weight in the emulsified composition. If it is less than 0.05%, the emulsifying action is insufficient, and if it is 0.5% by weight or more, it is difficult to mix galactosylceramide or glucosylceramide due to low solubility.

[0006] The copolymer of acrylic acid and alkyl methacrylate used in the present invention is, for example, Pemulen (Pe).
mulen) TR-1, Pemulen
TR-2 (BF Goodrich Chemica)
l). The blending amount of the copolymer of acrylic acid and alkyl methacrylate is preferably 0.01 to 10% by weight, more preferably 0.1 to 5% by weight in the emulsion composition. If it is less than 0.01%, the emulsification stability is insufficient, and if it exceeds 10%, an increase in emulsion stability cannot be expected. Further, from the viewpoint of usability, the range of 0.1 to 5% by weight is most preferable.

[0007] The oil component used in the present invention is an oil component usually used as a cosmetic, such as avocado oil, diester adipic acid such as di-2-ethylhexyl adipate, anise oil, aralkyl alcohol, Isostearic acid esters such as isostearic acid, isostearyl alcohol, and isostearyl isostearate; isononanoic acid esters such as isodecyl isononanoate; isopalmitic acid esters such as octyl isopalmitate; undecylenic acid; Ethyl hexanoate, erucic acid esters such as octyldodecyl erucate, octyldodecanol, olive oil, oleyl alcohol, oleic acid esters such as phytosteryl oleate, cyclic silicones such as decamethylcyclopentasiloxane, Octanoic acid esters such as octane isocetyl, olive alcohol, orange roughy oil, cacao butter, carnauba wax, caprylic acid ester of cetyl caprylic acid, capric acid, candelilla wax,
Volatile isoparaffin, cucumber oil, beef tallow, tallow fatty acid, citrate acetyl ester such as acetyltriethyl citrate, citrate ester such as tri-2-ethylhexyl citrate, kukui nut oil, light isoparaffin, hydrogenated oil, sesame oil, cholesterol, hydrogenated rape Oil alcohol, hydrogenated castor oil, highly oxidized beeswax, hard lanolin fatty acid esters such as hard lanolin fatty acid cholesteryl, succinic esters such as di-2-ethylhexyl succinate, burdock seed oil, rice bran oil, rice germ oil, safflower oil, sasanqua Oil, safflower oil fatty acid, shark liver oil, salasimontan wax, diester of propylene glycol with fatty acid such as propylene glycol dioleate, hexyldecyl dimethyloctanoate, shea butter, neopen di-2-ethylhexanoate Diesters of fatty acids such as glycol and neopentyl glycol, diesters of fatty acids such as ethylene glycol dioctanoate and ethylene glycol, dimethyl octanoates such as octyl dodecyl dimethyl octanoate, squalane, stearyl alcohol, stearic acid, hydrogenated jojoba oil, Hydrogenated coconut oil, stearic esters such as isocetyl stearate, cetanol, sage oil, ethoxymethylpolysiloxane, side chain higher alcohol (C32-C36) mixture,
Turtle oil fatty acid esters such as soybean oil, turtle oil, and turtle oil fatty acid ethyl ester; Slit tetraester, 7-dehydrocholesterol, turpentine oil, corn oil, fatty acid such as glyceryl tri-2-ethylhexanoate and glycerin triester, rapeseed oil, cholesteryl nonanoate,
Dihydrocholesteryl nonanoate, persic oil, liquid paraffin, palmitic acid esters such as palmitic acid and isopropyl palmitate, palm stearic acid esters such as palm kernel oil, palm oil, hydroxystearic acid, cholesteryl hydroxystearate, hydroxylanolin and castor oil Castor oil fatty acid ester such as fatty acid methyl, sunflower oil, phytosterol, hexyldecanol, behenic acid, hazelnut oil, heptanoic acid ester such as stearyl heptanoate, pelargonic acid ester such as octyl pelargonate, jojoba alcohol, jojoba oil, macadamia nut oil, macadamia nut Macadamia nut oil fatty acid esters such as phytosteryl oil fatty acids, beetle oil, beeswax, myristic acid, isopropyl myristate, etc. Listin acid ester, mink oil, myristyl alcohol, mink oil fatty acid ester such as mink oil fatty acid ethyl, mink wax, methylphenylpolysiloxane, methylpolysiloxane, mokurou, Mortierella oil, coconut oil, coconut oil fatty acid, eucalyptus oil, euglena Oil, lauryl alcohol, lauric acid, lauric ester such as hexyl laurate, lanolin, lanolin alcohol, lanolin fatty acid, peanut oil, lanosterol, lavender oil, egg yolk fatty oil, egg yolk oil, ricinoleic acid ester such as cetyl ricinoleate, linole Acids, linoleic acid esters such as ethyl linoleate, rosemary oil, Roman chamomile oil, petrolatum, and the like. In the present invention, it goes without saying that a compounding agent conventionally used as an emulsion composition may be further added. For example, glycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol as a humectant,
1,2-pentanediol, xylit, sorbit,
Lactose, sucrose, honey, glucose, D-mannitol, maltitol, maltose, urea, polyethylene glycol and the like can be blended. As vitamins, ascorbic acid, acetyl pantothenyl ethyl ether,
Inosit, ergocasiferol, β-carotene, DL-α-tocopherol acetate, retinol acetate, ascorbyl dipalmitate, pyridoxine dipalmitate,
Pyridoxine, ascorbyl stearate, DL-α-
Tocopherol, nicotinamide, nicotinic acid, methyl nicotinate, D-pantoenyl alcohol, biotin, vitamin A oil, pantoenyl ethyl ether, and the like can be blended. As amino acids, L-aspartic acid, DL-alanine, glycine, L-cystine, L-cystine
-Threonine, L-serine, L-methionine, L-histidine, L-proline and the like can be blended. Also, gum arabic, sodium alginate, carrageenan, carboxyvinyl polymer, sodium carboxymethylcellulose, sodium chondroitin sulfate, hydroxyethylcellulose, sodium polyacrylate, guar gum, quince seed, xanthan gum, carboxymethyl chitosan, succinyl carboxymethyl chitosan, Compounding of sodium hyaluronate and the like is possible. In addition, allantoin,
Guaiazulene, glycyrrhizic acid, glycyrrhetinic acid, stearyl glycyrrhetinate, hinokitiol, bisabolol and the like can be blended. Ethanol can be added as a cooling agent. In addition, a citrate, a tartrate, a lactate, a phosphate, or the like can be blended as the hydrogen ion concentration regulator. The emulsion of the present invention can be obtained by a conventional method. That is, the mixture obtained by mixing and dissolving the aqueous phases is added to the mixture obtained by mixing and dissolving the oil phase components, and then subjected to a homomixer treatment and, if necessary, heated to obtain a uniform emulsion composition.

[0008]

Examples and Comparative Examples The present invention will be described more specifically with reference to Examples and Comparative Examples. Examples 1 to 4 and Comparative Examples 1 to 5 Cosmetic emulsions were manufactured according to the composition shown in Table 1.

[0009]

[Table 1]

[0010] The oil phase components in Table 1 are mixed and dissolved, while the aqueous phase components are dissolved in purified water, and both are treated with a homomixer to form a uniform emulsified composition. Comparative Examples 1 and 2 were prepared without blending a copolymer of acrylic acid and alkyl methacrylate and a thickener. In Comparative Example 3, the concentration of the copolymer of acrylic acid and alkyl methacrylate was reduced. In Comparative Examples 4 and 5, carboxyvinyl polymer and xanthan gum were used as stabilizers instead of the copolymer of acrylic acid and methacrylic acid, respectively. The stability of the obtained emulsified composition after one month in a thermostat at 40 ° C. was visually evaluated. The evaluation method is as follows. Evaluation criteria for emulsion stability based on appearance: ：: No oil separation was observed and uniform. Δ: No oil separation was observed, and creaming occurred. X: Oil separation is clearly recognized. The feeling of use was evaluated by a specialized panelist. The evaluation criteria for the usability are as follows. Usability evaluation criteria: ：: Rich. Δ: There is no richness. Or, it is a little sticky. ×: There is no body. Or sticky. As a result of these evaluations, all of the emulsified compositions of Examples 1 to 4 were stable at 40 ° C for one month, but creaming occurred in the emulsified compositions of Comparative Examples 1 and 3 to 5. In Comparative Example 2, oil separation occurred. As shown in Table 2, the emulsion composition of Example 2 was evaluated for skin roughness improvement effect and safety. Comparative Example 6 did not use galactosylceramide as an emulsifier, but instead emulsified with a polyoxyethylene (60 mol) hydrogenated castor oil as a surfactant.

[0011]

[Table 2]

The effect of improving skin roughness was as follows: 30 rough skin panels were divided into two groups, one group was coated with Example 2 and the other group with Comparative Example 6 twice on the cheeks twice a day and in the morning and continuously for four weeks. TWL (Transepider) of skin before and after continuous application
mal Water Loss, Undetectable Distillation)
METER TM210 (COURAGE + KHAZA
The measurement was carried out using KA Electronic GmbH). It can be seen that when Example 6 was continuously used, the permeation of moisture from the skin was smaller than before the continuous use, and the rough skin was improved.
The safety was evaluated by evaluating skin irritation by using 20 female subjects with sensitive skin who are susceptible to skin troubles due to changes in cosmetics, chemical substances, and external environment twice a day (morning / evening) for one week continuously. did. The skin irritation in the test results was indicated by the number of people who reported skin irritation. The number of persons complaining of skin irritation due to continuous use in Example 2 was 0, indicating that the safety was high.

Examples 5 and 6 The oil phase components in Table 3 were mixed and dissolved, while the aqueous phase component was dissolved in purified water, and these were made into a uniform emulsified composition in the same manner as in Example 1. Each of the obtained emulsified compositions was stable, and the skin roughness improvement effect was as good as in Examples 2 and 3.

[0014]

[Table 3]

[0015]

The present invention provides an emulsion composition having high stability and safety by combining at least one selected from galactosylceramide and glucosylceramide as a surfactant with a copolymer of acrylic acid and alkyl methacrylate. I was able to do it.

 ──────────────────────────────────────────────────続 き Continued on the front page F term (reference) 4C083 AC022 AC092 AC122 AC132 AC641 AC642 AD091 AD092 AD391 AD392 BB11 DD31 EE10 EE12 EE13

Claims (1)

[Claims] Claims: 1. A composition comprising at least one selected from galactosylceramide and glucosylceramide, an oily component, and a copolymer of acrylic acid and alkyl methacrylate,
An emulsified composition substantially free of a surfactant other than galactosylceramide or glucosylceramide.