JPH0210808B2 - - Google Patents
Info
- Publication number
- JPH0210808B2 JPH0210808B2 JP55183816A JP18381680A JPH0210808B2 JP H0210808 B2 JPH0210808 B2 JP H0210808B2 JP 55183816 A JP55183816 A JP 55183816A JP 18381680 A JP18381680 A JP 18381680A JP H0210808 B2 JPH0210808 B2 JP H0210808B2
- Authority
- JP
- Japan
- Prior art keywords
- kallidinogenase
- spray
- drying
- stable
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000001399 Kallikrein Human genes 0.000 claims description 27
- 108060005987 Kallikrein Proteins 0.000 claims description 27
- 229960003709 kallidinogenase Drugs 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 18
- 239000000843 powder Substances 0.000 claims description 13
- 238000001694 spray drying Methods 0.000 claims description 13
- 102000009027 Albumins Human genes 0.000 claims description 9
- 108010088751 Albumins Proteins 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 150000001720 carbohydrates Chemical class 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 description 12
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 235000010355 mannitol Nutrition 0.000 description 6
- 239000011812 mixed powder Substances 0.000 description 5
- 229930195725 Mannitol Natural products 0.000 description 4
- 239000000594 mannitol Substances 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 238000004108 freeze drying Methods 0.000 description 3
- 210000000496 pancreas Anatomy 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- GUBGYTABKSRVRQ-WFVLMXAXSA-N DEAE-cellulose Chemical compound OC1C(O)C(O)C(CO)O[C@H]1O[C@@H]1C(CO)OC(O)C(O)C1O GUBGYTABKSRVRQ-WFVLMXAXSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 229940015043 glyoxal Drugs 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 210000001138 tear Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
Landscapes
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55183816A JPS57108020A (en) | 1980-12-26 | 1980-12-26 | Stable kallidinogenase composition and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55183816A JPS57108020A (en) | 1980-12-26 | 1980-12-26 | Stable kallidinogenase composition and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57108020A JPS57108020A (en) | 1982-07-05 |
| JPH0210808B2 true JPH0210808B2 (xx) | 1990-03-09 |
Family
ID=16142357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55183816A Granted JPS57108020A (en) | 1980-12-26 | 1980-12-26 | Stable kallidinogenase composition and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57108020A (xx) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4684615A (en) * | 1983-06-06 | 1987-08-04 | Ciba Corning Diagnostics Corp. | Stabilized isoenzyme control products |
| JPS60161925A (ja) * | 1984-02-02 | 1985-08-23 | Sanwa Kagaku Kenkyusho:Kk | 安定なカリジノゲナーゼ打錠製剤の製法 |
| JPS61180723A (ja) * | 1985-02-06 | 1986-08-13 | Sanwa Kagaku Kenkyusho:Kk | 易吸収性カリジノゲナ−ゼ製剤用組成物 |
| US5051406A (en) * | 1987-03-04 | 1991-09-24 | Nippon Hypox Laboratories Incorporated | Pharmaceutical composition using albumin as a carrier and process for producing the same |
| FR2754269B1 (fr) * | 1996-10-04 | 1998-11-13 | Rhodia Chimie Sa | Procede de preparation d'une composition comprenant une substance thermosensible |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56115723A (en) * | 1980-02-15 | 1981-09-11 | Green Cross Corp:The | Medical kallikrein preparation |
-
1980
- 1980-12-26 JP JP55183816A patent/JPS57108020A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56115723A (en) * | 1980-02-15 | 1981-09-11 | Green Cross Corp:The | Medical kallikrein preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS57108020A (en) | 1982-07-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0302754B1 (en) | Stable aqueous thrombin solution | |
| US5874408A (en) | Stabilized albumin-free recombinant factor VII preparation having a low sugar content | |
| NL7905220A (nl) | Antitrombinepreparaat en werkwijze ter bereiding ervan. | |
| CA1322956C (en) | Process for the production of dried earthworm powder and antihyperlipemic, antidiabetic, antihypertensive and antihypotensive preparations containing dried earthworm powder as active ingredient | |
| US2834712A (en) | Urinary estrogen compositions and methods for preparing them | |
| JPS63243032A (ja) | トロンビンの加熱処理方法 | |
| US3933996A (en) | Composition comprising radioactive labeled-fibrinogen and albumin | |
| HUE026166T2 (en) | New epoprosthenol preparation and procedure | |
| US4769381A (en) | Nicorandil-containing preparation for injection | |
| JPH0210808B2 (xx) | ||
| EP0123375B1 (en) | Gamma-globulin preparation for intravenous administration | |
| JP2715104B2 (ja) | トロンビン乾燥製剤 | |
| Flippin et al. | Sulfapyridine and sulfathiazole therapy in pneumococcic pneumonia | |
| US3905870A (en) | Purification of kallikrein | |
| JPH0249720A (ja) | 難溶性薬剤組成物 | |
| JPH07157431A (ja) | 安定なプロスタグランジンｅ製剤 | |
| JPH0452252B2 (xx) | ||
| JPH0640909A (ja) | スーパーオキシド・ディスムターゼ様活性剤 | |
| JPH0479327B2 (xx) | ||
| US20030007959A1 (en) | Oral methods of treatment | |
| JP4146525B2 (ja) | アンチトロンビン−ｉｉｉの精製法 | |
| US5420124A (en) | Stable, painless piroxicam potassium injectable composition | |
| JPS629092B2 (xx) | ||
| JPS60193996A (ja) | 側柏葉から止血活性物質を抽出する方法、及びそれを含有する止血剤 | |
| JPH05310592A (ja) | 創傷治療剤及び医薬製剤 |