JPH0137115B2 - - Google Patents

Info

Publication number
JPH0137115B2
JPH0137115B2 JP57122799A JP12279982A JPH0137115B2 JP H0137115 B2 JPH0137115 B2 JP H0137115B2 JP 57122799 A JP57122799 A JP 57122799A JP 12279982 A JP12279982 A JP 12279982A JP H0137115 B2 JPH0137115 B2 JP H0137115B2
Authority
JP
Japan
Prior art keywords
medium
cells
serum
production
imr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP57122799A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5865219A (ja
Inventor
Bohatsuku Zubi
Kadori Abinoamu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
Publication of JPS5865219A publication Critical patent/JPS5865219A/ja
Publication of JPH0137115B2 publication Critical patent/JPH0137115B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP57122799A 1981-07-15 1982-07-14 プラスミノ−ゲン賦活体の製造法 Granted JPS5865219A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL63317A IL63317A (en) 1981-07-15 1981-07-15 Production of plasminogen activator
IL63317 1981-07-15

Publications (2)

Publication Number Publication Date
JPS5865219A JPS5865219A (ja) 1983-04-18
JPH0137115B2 true JPH0137115B2 (enExample) 1989-08-04

Family

ID=11052764

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57122799A Granted JPS5865219A (ja) 1981-07-15 1982-07-14 プラスミノ−ゲン賦活体の製造法

Country Status (6)

Country Link
JP (1) JPS5865219A (enExample)
DE (1) DE3226320A1 (enExample)
FR (1) FR2510604B1 (enExample)
GB (1) GB2104081B (enExample)
IL (1) IL63317A (enExample)
IT (1) IT1195939B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
JPS60158115A (ja) * 1984-01-30 1985-08-19 Meiji Milk Prod Co Ltd プラズミノーゲンアクチベーターの製造法
JPS60259187A (ja) * 1984-04-19 1985-12-21 マイルス・ラボラトリ−ス・インコ−ポレ−テツド プラスミノーゲン活性化因子を増収する方法
DE3479814D1 (en) * 1984-06-05 1989-10-26 Asahi Chemical Ind Process for the preparation of a plasminogen activator
US4550080A (en) * 1984-06-05 1985-10-29 Asahi Kasei Kogyo Kabushiki Kaisha Process for the preparation of a plasminogen activator
WO1989009257A1 (en) * 1988-03-22 1989-10-05 Invitron Corporation METHOD TO ENHANCE tPA PRODUCTION
US5210037A (en) * 1988-03-22 1993-05-11 Centocor Incorporated Method to enhance TPA production
DE4128953A1 (de) * 1991-08-30 1993-03-04 Basf Ag Verfahren zur kultivierung von saeugerzellen im fliessbettreaktor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232124A (en) * 1979-04-23 1980-11-04 Mann George F Method of producing plasminogen activator
JPS55144887A (en) * 1979-04-26 1980-11-12 Asahi Chem Ind Co Ltd Preparation of physiologically active substance

Also Published As

Publication number Publication date
DE3226320A1 (de) 1983-02-10
FR2510604A1 (fr) 1983-02-04
IL63317A0 (en) 1981-10-30
JPS5865219A (ja) 1983-04-18
IT1195939B (it) 1988-11-03
IL63317A (en) 1985-05-31
DE3226320C2 (enExample) 1989-08-17
GB2104081A (en) 1983-03-02
FR2510604B1 (fr) 1985-07-12
IT8222392A1 (it) 1984-01-14
GB2104081B (en) 1985-06-12
IT8222392A0 (it) 1982-07-14

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