JPH0127070B2 - - Google Patents

Info

Publication number
JPH0127070B2
JPH0127070B2 JP58063823A JP6382383A JPH0127070B2 JP H0127070 B2 JPH0127070 B2 JP H0127070B2 JP 58063823 A JP58063823 A JP 58063823A JP 6382383 A JP6382383 A JP 6382383A JP H0127070 B2 JPH0127070 B2 JP H0127070B2
Authority
JP
Japan
Prior art keywords
mixture
methanol
trifluoromethyl
bis
hydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP58063823A
Other languages
English (en)
Japanese (ja)
Other versions
JPS58188878A (ja
Inventor
Bemuhesu Herumuuto
Harudetsugaa Buruuno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JPS58188878A publication Critical patent/JPS58188878A/ja
Publication of JPH0127070B2 publication Critical patent/JPH0127070B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP58063823A 1982-04-14 1983-04-13 メフロキンの精製方法 Granted JPS58188878A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH225682 1982-04-14
CH2256/829 1982-04-14

Publications (2)

Publication Number Publication Date
JPS58188878A JPS58188878A (ja) 1983-11-04
JPH0127070B2 true JPH0127070B2 (enExample) 1989-05-26

Family

ID=4229522

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58063823A Granted JPS58188878A (ja) 1982-04-14 1983-04-13 メフロキンの精製方法

Country Status (5)

Country Link
US (1) US4507482A (enExample)
EP (1) EP0092185B1 (enExample)
JP (1) JPS58188878A (enExample)
AT (1) ATE33647T1 (enExample)
DE (1) DE3376320D1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE55387T1 (de) * 1983-10-07 1990-08-15 Hoffmann La Roche Mefloquin-hydrochlorid.
HUT54363A (en) * 1989-07-25 1991-02-28 Alkaloida Vegyeszeti Gyar Process for producing pyridyl-methyl-quinolin derivatives
US20030216426A1 (en) * 2002-05-17 2003-11-20 Regents Of The University Of California Treatment of cancer with mefloquine, its purified enantiomers, and mefloquine analogs
EP2233481A1 (de) 2009-03-27 2010-09-29 Cilag Ltd. Verfahren zur Herstellung von Mefloquin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2381044A1 (fr) * 1977-02-17 1978-09-15 Hoffmann La Roche Procede pour la preparation de mefloquine
DE2940443A1 (de) * 1979-10-05 1981-04-16 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von erythro-(alpha)-2-piperidyl-2,8-bis-(trifluormethyl)-4-chinolin-methanol

Also Published As

Publication number Publication date
US4507482A (en) 1985-03-26
EP0092185A3 (en) 1985-07-03
DE3376320D1 (en) 1988-05-26
EP0092185A2 (de) 1983-10-26
ATE33647T1 (de) 1988-05-15
EP0092185B1 (de) 1988-04-20
JPS58188878A (ja) 1983-11-04

Similar Documents

Publication Publication Date Title
NO171453B (no) Fremgangsmaate for fremstilling av krystallinsk paroxetin-hydroklorid-hemihydrat
JPS6160830B2 (enExample)
JPH09143180A (ja) （ｒ）−（−）−２−｛ｎ−［４−（１，１−ジオキシド−３−オキソ−２，３−ジヒドロベンズイソチアゾール−２−イル）−ブチル］−アミノメチル｝−クロマンの結晶塩酸塩
JPH0643400B2 (ja) トラセミドの安定な変態の製法
CN101341122B (zh) 生产高纯度多晶型（ⅰ）盐酸多奈哌齐的方法
JP6300277B2 (ja) （５−フルオロ−２−メチル−３−キノリン−２−イルメチル−インドール−１−イル）−酢酸エステルの製造のための方法
JP2727192B2 (ja) 新規の１，２，５，６−テトラヒドロピリジン誘導体、それらの製造方法、それらの薬剤としての使用及びそれらを含有する組成物
KR20070002101A (ko) (+)-시스-세르트랄린의 신규한 제조 방법
US3037031A (en) Derivatives of 3-(2-aminoalkyl)-5-indolol and process therefor
JPH0127070B2 (enExample)
TWI445697B (zh) 塔適那偉（ａｔａｚａｎａｖｉｒ）硫酸氫鹽之製法及其新穎的形式
AU748177B2 (en) Crystalline forms of osanetant
EP1581537B1 (en) Process for removing impurity S from olanzapine polymorphic form I
JP2011515453A (ja) 塩酸ドネペジルの製造方法
US4191828A (en) Process for preparing 2-(2,2-dicyclohexylethyl)piperidine
HUP0103651A2 (en) Paroxetine maleate and process for its preparation
HRP20050893A2 (en) Process for the preparation of a cyano-isobenzofuran
US4579855A (en) Melfloquin hydrochloride
JP4798728B2 (ja) ニフェジピンの製造法
AU627609B2 (en) New quinoline derivatives and process for the preparation thereof
HU188170B (en) Process for producing 3-square bracket-2-bracket-tetra-or hexahydro.4-pyridyl-bracket closed-ethyl-s uare bracket closed-indola derivatives
JP3160302B2 (ja) 水素化へテロ環式化合物
JPH05222041A (ja) アデニン誘導体の精製法
JP2007008918A (ja) パロキセチン塩酸塩半水和物の製造方法
JP3800356B2 (ja) エトポシドの異性体の生成を抑える方法