JPH0126024B2 - - Google Patents
Info
- Publication number
- JPH0126024B2 JPH0126024B2 JP56083050A JP8305081A JPH0126024B2 JP H0126024 B2 JPH0126024 B2 JP H0126024B2 JP 56083050 A JP56083050 A JP 56083050A JP 8305081 A JP8305081 A JP 8305081A JP H0126024 B2 JPH0126024 B2 JP H0126024B2
- Authority
- JP
- Japan
- Prior art keywords
- serum
- composition
- weight
- parts
- specific gravity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 claims description 57
- 210000002966 serum Anatomy 0.000 claims description 42
- 239000007788 liquid Substances 0.000 claims description 34
- 239000013008 thixotropic agent Substances 0.000 claims description 28
- 230000005484 gravity Effects 0.000 claims description 27
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 20
- 238000000926 separation method Methods 0.000 claims description 20
- -1 amine compound Chemical class 0.000 claims description 11
- 239000000377 silicon dioxide Substances 0.000 claims description 10
- 239000011521 glass Substances 0.000 claims description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 229920001083 polybutene Polymers 0.000 claims description 5
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- 229920000178 Acrylic resin Polymers 0.000 claims description 3
- 239000004925 Acrylic resin Substances 0.000 claims description 3
- 239000004593 Epoxy Substances 0.000 claims description 3
- 241001465754 Metazoa Species 0.000 claims description 3
- 239000010775 animal oil Substances 0.000 claims description 3
- 239000000440 bentonite Substances 0.000 claims description 3
- 229910000278 bentonite Inorganic materials 0.000 claims description 3
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 3
- 239000000454 talc Substances 0.000 claims description 3
- 229910052623 talc Inorganic materials 0.000 claims description 3
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 3
- 239000008158 vegetable oil Substances 0.000 claims description 3
- 210000002381 plasma Anatomy 0.000 description 26
- 238000012360 testing method Methods 0.000 description 20
- 238000005192 partition Methods 0.000 description 16
- 230000003993 interaction Effects 0.000 description 15
- 238000005119 centrifugation Methods 0.000 description 12
- 239000000306 component Substances 0.000 description 12
- 239000007787 solid Substances 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 11
- 239000008280 blood Substances 0.000 description 11
- 239000000843 powder Substances 0.000 description 10
- 210000000601 blood cell Anatomy 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 208000007536 Thrombosis Diseases 0.000 description 4
- 230000023555 blood coagulation Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000010908 decantation Methods 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- XTAZYLNFDRKIHJ-UHFFFAOYSA-N n,n-dioctyloctan-1-amine Chemical compound CCCCCCCCN(CCCCCCCC)CCCCCCCC XTAZYLNFDRKIHJ-UHFFFAOYSA-N 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- NAPSCFZYZVSQHF-UHFFFAOYSA-N dimantine Chemical compound CCCCCCCCCCCCCCCCCCN(C)C NAPSCFZYZVSQHF-UHFFFAOYSA-N 0.000 description 2
- 229950010007 dimantine Drugs 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229920000058 polyacrylate Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 235000012424 soybean oil Nutrition 0.000 description 2
- 239000003549 soybean oil Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000009974 thixotropic effect Effects 0.000 description 2
- FJLUATLTXUNBOT-UHFFFAOYSA-N 1-Hexadecylamine Chemical compound CCCCCCCCCCCCCCCCN FJLUATLTXUNBOT-UHFFFAOYSA-N 0.000 description 1
- YLZOPXRUQYQQID-UHFFFAOYSA-N 3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]propan-1-one Chemical compound N1N=NC=2CN(CCC=21)CCC(=O)N1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F YLZOPXRUQYQQID-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 description 1
- 239000005062 Polybutadiene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- PLZVEHJLHYMBBY-UHFFFAOYSA-N Tetradecylamine Chemical compound CCCCCCCCCCCCCCN PLZVEHJLHYMBBY-UHFFFAOYSA-N 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 238000010876 biochemical test Methods 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- JRBPAEWTRLWTQC-UHFFFAOYSA-N dodecylamine Chemical compound CCCCCCCCCCCCN JRBPAEWTRLWTQC-UHFFFAOYSA-N 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910001410 inorganic ion Inorganic materials 0.000 description 1
- 235000021388 linseed oil Nutrition 0.000 description 1
- 239000000944 linseed oil Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- YWFWDNVOPHGWMX-UHFFFAOYSA-N n,n-dimethyldodecan-1-amine Chemical compound CCCCCCCCCCCCN(C)C YWFWDNVOPHGWMX-UHFFFAOYSA-N 0.000 description 1
- SFBHPFQSSDCYSL-UHFFFAOYSA-N n,n-dimethyltetradecan-1-amine Chemical compound CCCCCCCCCCCCCCN(C)C SFBHPFQSSDCYSL-UHFFFAOYSA-N 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 229920002857 polybutadiene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 239000011163 secondary particle Substances 0.000 description 1
- 125000005624 silicic acid group Chemical group 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5002—Partitioning blood components
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56083050A JPS57197470A (en) | 1981-05-29 | 1981-05-29 | Composite for separation of blood serum or blood plasma |
| US06/292,029 US4457782A (en) | 1980-08-18 | 1981-08-11 | Composition for partitioning blood components |
| CA000383832A CA1174167A (en) | 1980-08-18 | 1981-08-13 | Composition for partitioning blood components |
| EP81303724A EP0046391B1 (en) | 1980-08-18 | 1981-08-14 | Composition for partitioning blood components |
| DE8181303724T DE3163080D1 (en) | 1980-08-18 | 1981-08-14 | Composition for partitioning blood components |
| US06/553,187 US4534798A (en) | 1980-08-18 | 1983-11-18 | Composition for partitioning blood components |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56083050A JPS57197470A (en) | 1981-05-29 | 1981-05-29 | Composite for separation of blood serum or blood plasma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57197470A JPS57197470A (en) | 1982-12-03 |
| JPH0126024B2 true JPH0126024B2 (cs) | 1989-05-22 |
Family
ID=13791358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56083050A Granted JPS57197470A (en) | 1980-08-18 | 1981-05-29 | Composite for separation of blood serum or blood plasma |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57197470A (cs) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56166956A (en) * | 1980-05-26 | 1981-12-22 | Terumo Corp | Liquid separating agent |
-
1981
- 1981-05-29 JP JP56083050A patent/JPS57197470A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56166956A (en) * | 1980-05-26 | 1981-12-22 | Terumo Corp | Liquid separating agent |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS57197470A (en) | 1982-12-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0046391B1 (en) | Composition for partitioning blood components | |
| EP2020599A1 (en) | Composition for separation of serum or plasma and container for blood test | |
| JPH0465981B2 (cs) | ||
| JP2550232B2 (ja) | 血液分離剤 | |
| CA1169744A (en) | Compositions able to separate the erythrocytes from the serum or plasma in blood analysis samples and the method which uses them | |
| JPH052015A (ja) | 血液分離剤 | |
| JPH06201682A (ja) | 血清分離用シーラント | |
| JPH0126024B2 (cs) | ||
| JPH0126501B2 (cs) | ||
| JPS6314782B2 (cs) | ||
| JPS64660B2 (cs) | ||
| JPH02271867A (ja) | 血清分離用シーラント及び血液分離方法 | |
| JP2734918B2 (ja) | 採血管 | |
| JPS61154541A (ja) | 真空採血管 | |
| JPH0510095B2 (cs) | ||
| JPS6367861B2 (cs) | ||
| EP0028842A2 (en) | Improved medium for the separation of human blood leucocytes | |
| JPH05288747A (ja) | 血液分離剤組成物およびそれを用いた血液分離管 | |
| JPS6116023B2 (cs) | ||
| JPS61195357A (ja) | 真空採血管 | |
| JPS61172061A (ja) | 真空採血管 | |
| JPS6129669B2 (cs) | ||
| JPS5835463A (ja) | 血液分離管 | |
| JPS636046B2 (cs) | ||
| JPS5837560A (ja) | 血清又は血漿分離用シ−ラント |