JPH01151512A - 齲蝕予防剤 - Google Patents
齲蝕予防剤Info
- Publication number
- JPH01151512A JPH01151512A JP18217988A JP18217988A JPH01151512A JP H01151512 A JPH01151512 A JP H01151512A JP 18217988 A JP18217988 A JP 18217988A JP 18217988 A JP18217988 A JP 18217988A JP H01151512 A JPH01151512 A JP H01151512A
- Authority
- JP
- Japan
- Prior art keywords
- dental caries
- preventive agent
- magnolol
- honokiol
- side effects
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000002925 dental caries Diseases 0.000 title claims abstract description 24
- 230000003449 preventive effect Effects 0.000 title claims abstract description 12
- VVOAZFWZEDHOOU-UHFFFAOYSA-N magnolol Chemical compound OC1=CC=C(CC=C)C=C1C1=CC(CC=C)=CC=C1O VVOAZFWZEDHOOU-UHFFFAOYSA-N 0.000 claims abstract description 31
- BYTORXDZJWWIKR-UHFFFAOYSA-N Hinokiol Natural products CC(C)c1cc2CCC3C(C)(CO)C(O)CCC3(C)c2cc1O BYTORXDZJWWIKR-UHFFFAOYSA-N 0.000 claims abstract description 8
- FVYXIJYOAGAUQK-UHFFFAOYSA-N honokiol Chemical compound C1=C(CC=C)C(O)=CC=C1C1=CC(CC=C)=CC=C1O FVYXIJYOAGAUQK-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims abstract 2
- 230000000694 effects Effects 0.000 abstract description 12
- 241000894006 Bacteria Species 0.000 abstract description 10
- 239000000284 extract Substances 0.000 abstract description 10
- 241000194019 Streptococcus mutans Species 0.000 abstract description 9
- 230000001013 cariogenic effect Effects 0.000 abstract description 5
- 210000000214 mouth Anatomy 0.000 abstract description 5
- 230000002401 inhibitory effect Effects 0.000 abstract description 4
- 208000019901 Anxiety disease Diseases 0.000 abstract description 3
- 230000036506 anxiety Effects 0.000 abstract description 3
- 239000000470 constituent Substances 0.000 abstract description 2
- 241001673966 Magnolia officinalis Species 0.000 abstract 2
- 241000768444 Magnolia obovata Species 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 230000002070 germicidal effect Effects 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 description 17
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 239000003795 chemical substances by application Substances 0.000 description 12
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 10
- 238000000034 method Methods 0.000 description 9
- 230000005764 inhibitory process Effects 0.000 description 8
- 239000003814 drug Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 229960003276 erythromycin Drugs 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 230000002378 acidificating effect Effects 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 229940126678 chinese medicines Drugs 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 3
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 3
- 229940093265 berberine Drugs 0.000 description 3
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 229940034610 toothpaste Drugs 0.000 description 3
- 239000000606 toothpaste Substances 0.000 description 3
- 208000002064 Dental Plaque Diseases 0.000 description 2
- 229920001503 Glucan Polymers 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000012259 ether extract Substances 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 241000269821 Scombridae Species 0.000 description 1
- 241000607768 Shigella Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241000194023 Streptococcus sanguinis Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000002815 broth microdilution Methods 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 239000010015 huanglian Substances 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 235000020640 mackerel Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000401 methanolic extract Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 229940098466 sublingual tablet Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001550 time effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18217988A JPH01151512A (ja) | 1988-07-21 | 1988-07-21 | 齲蝕予防剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18217988A JPH01151512A (ja) | 1988-07-21 | 1988-07-21 | 齲蝕予防剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55161091A Division JPS5785319A (en) | 1980-11-16 | 1980-11-16 | Agent for dental caries |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01151512A true JPH01151512A (ja) | 1989-06-14 |
| JPH0217524B2 JPH0217524B2 (enrdf_load_stackoverflow) | 1990-04-20 |
Family
ID=16113723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP18217988A Granted JPH01151512A (ja) | 1988-07-21 | 1988-07-21 | 齲蝕予防剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH01151512A (enrdf_load_stackoverflow) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5980870A (en) * | 1994-07-26 | 1999-11-09 | Aekyung Industrial Co., Ltd. | Herb medicine extract-containing non-bleeding striped dentifrice composition |
| US6500409B1 (en) * | 2000-05-10 | 2002-12-31 | Colgate Palmolive Company | Synergistic antiplaque/antigingivitis oral composition |
| WO2006065403A1 (en) * | 2004-12-10 | 2006-06-22 | Colgate-Palmolive Company | Tartar control oral care composition containing extract of magnolia |
| WO2007011504A1 (en) * | 2005-07-14 | 2007-01-25 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product comprising a magnolia bark extract and surfactant |
| US7595065B2 (en) | 2002-06-25 | 2009-09-29 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing products with synergistic combinations of magnolia bark extract and essential oils |
| WO2009148875A1 (en) * | 2008-05-30 | 2009-12-10 | Wm. Wrigley Jr. Company | Oral compositions containing enhanced antibacterial combinations of antioxidants and extracts of magnolia |
| EP2324821A1 (en) | 2001-02-28 | 2011-05-25 | Axiomedic Ltd. | Oral care compositions |
| US8012514B2 (en) | 2002-06-25 | 2011-09-06 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with Magnolia Bark Extract |
| JP2013501782A (ja) * | 2009-08-12 | 2013-01-17 | コルゲート・パーモリブ・カンパニー | 口腔ケア組成物 |
| JP2013532684A (ja) * | 2010-07-29 | 2013-08-19 | コルゲート・パーモリブ・カンパニー | モクレン由来抗細菌剤に基づくリン酸非含有オーラルケア組成物 |
| US8900644B2 (en) * | 2004-12-22 | 2014-12-02 | Colgate-Palmolive Company | Oral care compositions containing compounds from magnolia and hops extracts |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02131526U (enrdf_load_stackoverflow) * | 1989-04-01 | 1990-11-01 |
-
1988
- 1988-07-21 JP JP18217988A patent/JPH01151512A/ja active Granted
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5980870A (en) * | 1994-07-26 | 1999-11-09 | Aekyung Industrial Co., Ltd. | Herb medicine extract-containing non-bleeding striped dentifrice composition |
| US6500409B1 (en) * | 2000-05-10 | 2002-12-31 | Colgate Palmolive Company | Synergistic antiplaque/antigingivitis oral composition |
| EP2324821A1 (en) | 2001-02-28 | 2011-05-25 | Axiomedic Ltd. | Oral care compositions |
| US8012514B2 (en) | 2002-06-25 | 2011-09-06 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with Magnolia Bark Extract |
| US8163304B2 (en) | 2002-06-25 | 2012-04-24 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
| US7632525B2 (en) | 2002-06-25 | 2009-12-15 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
| US7595065B2 (en) | 2002-06-25 | 2009-09-29 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing products with synergistic combinations of magnolia bark extract and essential oils |
| WO2006065403A1 (en) * | 2004-12-10 | 2006-06-22 | Colgate-Palmolive Company | Tartar control oral care composition containing extract of magnolia |
| US8900644B2 (en) * | 2004-12-22 | 2014-12-02 | Colgate-Palmolive Company | Oral care compositions containing compounds from magnolia and hops extracts |
| WO2007011504A1 (en) * | 2005-07-14 | 2007-01-25 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product comprising a magnolia bark extract and surfactant |
| AU2009255317B2 (en) * | 2008-05-30 | 2013-07-11 | Wm. Wrigley Jr. Company | Oral compositions containing enhanced antibacterial combinations of antioxidants and extracts of magnolia |
| WO2009148875A1 (en) * | 2008-05-30 | 2009-12-10 | Wm. Wrigley Jr. Company | Oral compositions containing enhanced antibacterial combinations of antioxidants and extracts of magnolia |
| US9801919B2 (en) | 2008-05-30 | 2017-10-31 | Wm. Wrigley Jr. Company | Oral compositions containing enhanced antibacterial combinations of antioxidants and extracts of magnolia |
| JP2013501782A (ja) * | 2009-08-12 | 2013-01-17 | コルゲート・パーモリブ・カンパニー | 口腔ケア組成物 |
| US8906349B2 (en) | 2009-08-12 | 2014-12-09 | Colgate-Palmolive Company | Oral care composition |
| US9889077B2 (en) | 2009-08-12 | 2018-02-13 | Colgate-Palmolive Company | Oral care composition |
| JP2013532684A (ja) * | 2010-07-29 | 2013-08-19 | コルゲート・パーモリブ・カンパニー | モクレン由来抗細菌剤に基づくリン酸非含有オーラルケア組成物 |
| US9125860B2 (en) | 2010-07-29 | 2015-09-08 | Colgate-Palmolive Company | Phosphate free oral care compositions based on magnolia antibacterial agent |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0217524B2 (enrdf_load_stackoverflow) | 1990-04-20 |
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