JPH01100112A - External preparation for skin - Google Patents

Abstract

PURPOSE:To obtain external preparation for the skin, having beautifying action, good feeling in use, making the skin smooth and moist, providing the skin with tension, containing an amino acid or a derivative thereof and kojic acid or an ester thereof. CONSTITUTION:An external preparation is blended with one or more of amino acid and a derivative thereof or one or more of kojic acid and an ester thereof and pharmaceutically manufactured to give the aimed substance. The blending amounts of the substances are 0.01-20wt.% amino acids and 0.01-10wt.% kojic acids. The substance can be pharmaceutically manufactured into various shapes for external use of quasi-drugs such as emulsion, lotion, liniment or ointment besides cosmetic such as cream, cosmetic, pack or powder.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to an external skin preparation that has a whitening effect, is comfortable to use, gives smooth firmness to the skin, and moisturizes the skin.

[Prior Art] External skin preparations are used in cosmetics, emulsions, liniments, ointments, etc. in the form of lotions, milky lotions, creams, and powders. Since these external skin preparations are applied directly to the skin, their affinity with the skin and the feeling of use are considered important properties.

On the other hand, it is also known that kojic acid or its esters are safe and have strong whitening effects.

[Problems to be Solved by the Invention] The present invention was developed in view of the fact that the conventional formulation of external skin preparations using kojic acid or its esters does not necessarily provide a good feeling of use and skin condition. and
The object of the present invention is to provide a skin preparation for external use that does not leave the skin sticky when applied, smooths the skin, makes it irritating, and gives firmness.

[Means for Solving the Problems] This object is achieved by containing one or more amino acids or derivatives thereof and IPlIi or two or more kinds of kojic acid or its ester.

[Function and Examples] Kojic acid or its ester, which is one of the components in the present invention, has the general formula: ) are preferred.

As esters, monoesters such as kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamoate or kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, Diesters such as kojic acid distearate or kojic acid dioleate are preferred. The monoester is preferably one in which the hydroxyl group at the 5-position of kojic acid is esterified. When esterified, the melanin production inhibiting effect is equivalent to that of kojic acid, but the stability against pH and light is improved. These may be used alone or in combination.

It is also known to use amino acids or their derivatives, which are other ingredients, as a compounding ingredient in external skin preparations, but these may deteriorate over time and cause an unpleasant odor. However, even when such an amino acid or its derivative is blended with kojic acid or its ester, deterioration over time can be suppressed, and excellent affinity for the skin and feeling of use can be maintained for a long period of time.

Examples of amino acids include neutral amino acids such as glycine, serine, cystine, alanine, threonine, cysteine, valine, phenylalanine, methionine, leucine, tyrosine, proline, inleucine, tryptophan, and hydroxyproline; aspartic acid, asparagine, and glutamine. , acidic amino acids such as glutamic acid; and one or more types of basic amino acids such as arginine, histidine, and lysine. Examples of amino acid derivatives include acylglutamic acid or a salt thereof, acyl-β-alanine or a salt thereof, One or more types of pyrrolidone carboxylic acid or a salt thereof can be used. These amino acids or derivatives thereof may be used alone or in combination. The blending amount of kojic acid or its ester is usually 0.01 to 20% (Ili amount %, the same applies hereinafter) in the external preparation, preferably 0.1 to 2%, and the blending amount of the amino acid or its derivative is usually 0.601 to 20%. 1O%, preferably 0.1-5%.

External preparations of the present invention include, for example, creams, cosmetics,
In addition to cosmetics such as packs and powders, they can be formulated into various external forms such as emulsions, lotions, liniments, ointments, and other quasi-drugs, and the bases and excipients commonly used in each formulation. Agents, stabilizers, pigments, fragrances, ultraviolet absorbers, antioxidants, preservatives, metal sealants, organic acids, and the like may be added as appropriate.

Next, the skin external preparation of the present invention will be explained with reference to Examples, but the present invention is not limited to these Examples.

Example 1 (Cream) Part by weight (Δ) Polyoxyethylene glycol monostearate (40E, O,) 2.0
0 Self-emulsifying glycerin monostearate 5.00 Stearic acid 5600 Behenyl alcohol
1.00 liquid paraffin
1. OO glyceryl trioctanoate 10.0
0 Kojic acid dipalmitate 2.00 Preservatives
Appropriate amount of fragrance
Trace amount (B) 1,3-butylene glycol 5.00 Glycine
3.00 Purified water
Residue (manufacturing method) The components belonging to (A) are heated and dissolved (oil phase).

Separately, components belonging to (B) are dissolved by heating (aqueous phase). The water phase was added to the oil phase, emulsified by stirring, and then cooled to obtain a cream.

Example 2 (Lotion) Part by weight Polyoxyethylene hydrogenated castor oil (GOE, O,) 1.0
0 ethanol 15.00 citric acid 0゜10 sodium citrate 0.30 1.3-butylene glycol 4,00 kojic acid
1.00 Sodium pyrrolidone carboxylate 0.50 Preservatives Appropriate amount Flavoring
Micro-purified water Residue (manufacturing method) Each component was uniformly stirred, mixed, and dissolved to obtain a lotion.

Example 3 (emulsion) Part by weight (A) Polyoxyethylene behenyl ether (20E,
O,) 0.50 polyoxyethylene sorbitate tetraoleate (60E, O) 1,
00 Lipophilic glyceryl monostearate 1.00 Stearic acid 0.50 Behenyl alcohol 0.50 Avocado oil
1.00 natural vitamin E
' 0.02 Kojic acid monopalmitate 2.0
0 Preservatives Appropriate amount fragrance
Trace amount (B)
1.3-Butylene glycol 50 units 0 carboxyvinyl polymer 0.1 ON-sodium lauroyl-L-glutamate
0.50 aspartic acid
5.00 Purified water Residue (manufacturing method) Heat and dissolve the components belonging to (A) (oil phase).

Separately, components belonging to (B) are dissolved by heating (aqueous phase). The aqueous phase was added to the oil phase, emulsified by stirring, and then cooled to obtain a milky lotion.

Example 4 (jelly pack) Part by weight Citric acid 0.20 Propylene glycol 4.00 Concentrated glycerin
4.00 ethanol
2.00 carboxyvinyl polymer
1.00 potassium carbonate 0.
60 Kojic acid 0.50 Tryptophan 3.00 Preservatives
Appropriate amount of fragrance
micro purified water
Residue (manufacturing method) Each component was stirred, mixed, and dissolved to obtain a jelly-like pack.

Example 5 (Cream pack) Part by weight (A) Polyoxyethylene behenyl ether (20E,
O,) 1.00 Tetraoleic acid polyoxyethylene sorbitol (40E, 0.) 2.0
0 Lipophilic glycerin monostearate 2,00 Behenyl alcohol 3.00 Squalane
25.00 Glycerin octoate 10.00 Natural vitamin E
O,04 Kojic acid monocinnamoate 2.00 Preservative Appropriate amount
Trace amount (B)
1,3-butylene glycol 5.00
Sodium dl-pyrrolidonecarboxylate
1.50 citric acid
0,04 glutamic acid
3.00 Purified water remainder (
Manufacturing method) Components belonging to (A) are heated and dissolved (oil phase).

Separately, components belonging to (B) are dissolved by heating (aqueous phase). The aqueous phase was added to the oil phase, emulsified by stirring, and then cooled to obtain a cream pack.

Example 6 (Ointment) Parts by weight (A) Polyoxyethylene sorbitan monostearate (60E, O,) 1.00 Polyoxyethylene sorbitan tetraoleate (130B, 0.) 1.
50 Self-emulsifying glycerin monostearate ■, 50 White beeswax 2.00 Paraffin
2.00 stearic acid
3.00 behenyl alcohol
3.00 Shea butter 12.
OO Liquid Paraffin 5.00 Natural Vitamin E O,04 Methylpolysiloxane 0.01 Kojic Acid Monobenzoate 3.00 Preservative
Appropriate amount of fragrance
Trace amount (B) 1.3-butylene glycol 5.00 Citric acid
0.30 Sodium lauroyl monoglutamate 0.50 Arginine 5.00 Purified water
Residue (manufacturing method) The components belonging to (A) are heated and dissolved (oil phase).

Separately, components belonging to (B) are dissolved by heating (aqueous phase). The aqueous phase was added to the oil phase, emulsified by stirring, and then cooled to obtain an ointment.

Example 7 (whitening powder) Part by weight Octyldodecyl myristate 1.0 Kojic acid
2.0 aspartic acid
2.0 fragrance
trace maltitol
Residue (manufacturing method) Each ingredient was stirred and mixed uniformly to obtain a whitening powder.

Example 8 (panel test) The effectiveness of the external preparation of the present invention was confirmed by a panel test.

A panel of 20 women applied the topical preparation of the present invention to their right arm and the control topical preparation to their left arm, twice a day (morning and evening), three times a day.
Simple application was performed over a period of 0 days.

The test included the cream of Example 1, the lotion of Example 2,
The emulsion of Example 3 was used, and as a control product, the respective external preparations with kojic acid removed were used.

After the test, each test site was evaluated on a 5-point scale with 5 being the best and 1 being the worst in terms of stickiness when applied, skin smoothness, skin irritability, and skin firmness. The average values were taken and compared. The results are shown in Table 1.

[Effects of the invention] When using the skin external preparation of the present invention, stickiness during application,
It has a favorable effect on skin irritability and skin firmness, and is particularly effective in reducing stickiness and skin firmness.

Claims (1)

[Claims] 1. A skin external preparation containing one or more amino acids or derivatives thereof and one or more kojic acid or esters thereof.