JPH0228105A - Cosmetic - Google Patents

Abstract

PURPOSE:To obtain a whitening cosmetic, containing a compound selected from organic monocarboxylic, neutral amino acids, etc., or/and compound selected from organic dicarboxylic, high polymer polycarboxylic, acidic amino acids, etc., and kojic acid and good in stability, such as color and pH. CONSTITUTION:A cosmetic containing (A) 0.1-5wt.% compound selected from organic monocarboxylic acids (e.g., lactic, glycolic or acetic acid), neutral amino acids (e.g., glycine or alanine), basic amino acids (e.g., arginine or lysine) and salts thereof and 0.1-3wt.% kojic acid with a stable hue, a cosmetic containing (B) 0.1-5wt.% compound selected from organic dicarboxylic acids (e.g., succinic acid), organic tetracarboxylic acids [e.g., ethylenediaminetetraacetic acid(EDTA)], high polymer polycarboxylic acids (e.g., alginic acid), acidic amino acids (e.g., glutamic acid), etc., and 0.1-3wt.% kojic acid with a stable pH or a cosmetic containing both the ingredients (A) and (B) and the kojic acid with both stable hue and pH.

Description

DETAILED DESCRIPTION OF THE INVENTION Industrial Applications The present invention relates to stable cosmetics containing kojic acid.

BACKGROUND OF THE INVENTION Among conventional cosmetics, there are so-called fair-skinned cosmetics that whiten skin where melanin has been deposited due to sunburn. Vitamin C and its derivatives are used as active ingredients in skin-lightening cosmetics, but in recent years, =1-udic acid has attracted attention as a safe compound that has a high skin-lightening effect.

However, cosmetics containing kojic acid have a drawback in stability. In other words, the color/48 false pH of cosmetics containing kojic acid changes over time, making it impossible to obtain a satisfactory product.

Conventionally, no technology regarding cosmetics stably containing kojic acid has been reported.

The problem to be solved by the present invention is to stabilize cosmetics containing kojic acid.

Means and actions to solve the problem The above problems are solved by the present invention.

That is, the present invention relates to the following three types of kojic acid-containing cosmetics, all of which solve the above problems.

The first invention is for a cosmetic with stable hue, and is characterized by containing at least one selected from organic monocarboxylic acids, neutral amino acids, basic amino acids, and salts thereof and kojic acid. It is a cosmetic product that

The second invention relates to pH-stable cosmetics,
This cosmetic is characterized by containing kojic acid and at least one selected from organic dicarboxylic acids, organic tetracarboxylic acids, high-molecular polycarboxylic acids, acidic amino acids, and salts thereof.

The third invention relates to a cosmetic that is stable in both hue and pH, and includes (A) an organic monocarboxylic acid, a neutral amino acid,
(B) at least one selected from basic amino acids and salts thereof; (B) at least one selected from organic dicarboxylic acids, organic tricarboxylic acids, organic tetracarboxylic acids, high molecular weight polycarboxylic acids, acidic amino acids and salts thereof; and (C) A cosmetic product characterized by containing three components of kojic acid as essential components.

The kojic acid of the present invention is formally known as 5-hydroxy-2-(
It is called hydroxymethyl)-4-pyrone and is a compound obtained from fermentation metabolites of bacteria such as Aspergillus and Gluconobacter.

The organic monocarboxylic acid, neutral amino acid, and basic amino acid used in the first aspect of the present invention are the following compounds. That is, organic monocarboxylic acids include lactic acid, glycolic acid, acetic acid, propionic acid, urocanic acid, benzoic acid, pyrrolidonecarboxylic acid, glycyrrhetinic acid, nicotinic acid, orotic acid, vitamin A acid, α- or γ-lylunic acid, and the like. , neutral amino acids include alanine, β-alanine, γ-aminobutyric acid, ε-aminocaproic acid, cysteine, glycine, histidine, oxyproline, inleucine, leucine, methionine, phenylalanine, proline, threonine, tryptophan, etc. Examples of the amino acids include arginine, lysine, and ornithine. In the present invention, these salts are also effective in stabilizing kojic acid. Such salts include, in the case of organic monocarboxylic acids, their alkali metal salts, alkanolamine salts and basic amino acid salts, and in the case of neutral amino acids, their alkali metal salts, alkanolamine salts, and base Examples of amino acid salts include hydrochloride. Note that the neutral amino acid and basic amino acid used in the present invention may be either an optically active form or a racemic form.

The organic dicarboxylic acid, organic tetracarboxylic acid, high molecular weight polycarboxylic acid, and acidic amino acid used in the second invention of the present invention are the following compounds.

That is, organic dicarboxylic acids include succinic acid, oxalic acid, tartaric acid, malic acid, diglycolic acid, etc., organic tetracarboxylic acids include ethylenediaminetetraacetic acid, and polymeric polycarboxylic acids include alginic acid,
Hyaluronic acid, chondroitin sulfate, etc., and acidic amino acids include glutamic acid, aspartic acid, etc. 9 In the present invention, these salts are also effective in stabilizing kojic acid. Salts include organic dicarboxylic acids, organic tetracarboxylic acids, and polymeric polycarboxylic acids, such as their alkali metal salts, alkanolamine salts, and basic amino acid salts, and acidic amino acids, such as their alkali metal salts and alkanol salts. Amine salts and basic amino acid salts.

The organic monocarboxylic acid, neutral amino acid, basic amino acid of the component (A) of the third invention and the organic dicarboxylic acid, organic tetracarboxylic acid, polymeric polycarboxylic acid, and acidic amino acid of the component (B) are the first, Although the organic tricarboxylic acid used in the second invention can be used, the organic tricarboxylic acid in the component (B) of the third invention includes citric acid.

The amount of kojic acid blended in the cosmetic of the present invention is not particularly limited, but is usually 0.01 to 5% by weight, preferably 0.01 to 5% by weight.
It is 1 to 3% by weight.

In the first invention, the blending amount of at least one compound selected from organic monocarboxylic acids, neutral amino acids, basic amino acids, and salts thereof is 0.05-7% by weight,
Preferably it is 0.1 to 5%. If it is less than 0.05% by weight, the effect on stability will be poor (1-<), and even if it is added more than 7% by weight, the stability will change! -No.

In the second invention, the distribution ratio of at least one selected from organic dicarboxylic acids, organic dicarboxylic acids, polymeric polycarboxylic acids, acidic amino acids, and salts thereof is 0.05 to 7% by weight. , preferably 0.1 to 5% by weight
It is. If it is less than 0.05% by weight, the effect on stability is poor, and 7% by weight? Even if it is blended beyond the tongue, the stability does not change.

In the third invention, the Rh ratio of the component u (A) and the component (B) is such that the rheology ratio of the component (A) and the component (F3) is 1/9 to 1/9.
Q,,/l - Preferably in the range of 2/8 to 8/2, the total blending amount of both components is 0.05 to 7 per cosmetic.
% by weight, preferably from 0.1 to 5% by weight.

The dosage form of the cosmetic composition of the present invention can be appropriately selected depending on the purpose of use, such as cream, milky lotion, lotion, bag, lotion, etc.

The method for producing the cosmetic of the present invention is not particularly limited, and may be carried out in accordance with a conventional method for producing cosmetics. For example, in the case of emulsified cosmetics, kojic acid and various organic acids, amino acids, etc. of the present invention are dissolved in an aqueous phase, and thoroughly stirred with an emulsifier and oil phase components commonly used as cosmetic raw materials. Emulsification may be carried out by a common method used among manufacturers, and the emulsification state may be W/O1○/W.

In addition, the organic acids, amino acids, etc. in the present invention may be blended separately, or may be commercially available pre-blended with these components as the main ingredients.
Ajinomoto ■ “Prodew 100J, [Brodew 20]”
0J) may be used.

The cosmetics of the present invention may optionally contain anti-inflammatory agents, vitamins, astringents, hormones, etc., as long as they do not impair stability.
Auxiliary agents commonly used in cosmetics such as moisturizing agents, cooling agents, melanin formation inhibitors, and other animal and plant extracts, as well as special ingredients such as elastin, chitin, chitosan, and physiologically active substances, may be added. The present invention will be described in more detail below.9 笈-mxi- Each test sample was weighed to give the concentration shown in Table 1, and 2'5 g of a 2% aqueous solution of kojic acid was added. 3% hydroxide I-
The pH was adjusted to 5.5 using an aqueous solution of sodium chloride or hydrochloric acid. Furthermore, 25 g of distilled water was added.

After leaving this product in a constant temperature bath at 110° C. for 1 to 2 weeks, the absorbance at 7120 mm was measured to examine changes in hue. For the change in hue, the absorbance at the beginning is a, and 4
The absorbance after 1 week and 2 weeks at 0°C is b, and b l
It was evaluated based on the ratio of a. The results are shown in Table 1.

The smaller the number in the table, the less coloring.

Table 1 - Example 2 Cold cream (oil phase) wt%
Liquid paraffin 40.0, solid paraffin 10.0, beeswax 13.0, polyoxyethylene (2) cetyl ether 24, polyoxyethylene (5) oleyl ether 4.0, polyoxyethylene (20) sorbitan laurate
0.7・Butyl paraoxybenzoate 012 (water phase) ・Borax 1,3・Lactic acid 0.5・Kojic acid 1.0・Water
The residual oil phase was heated to 80° C. to melt it, the aqueous phase was separately heated to 80° C., the oil phase was added to the aqueous phase with stirring, and the mixture was cooled to 30° C. while stirring to prepare a cold cream.

Example 3 Cold cream (oil phase) wt%
Liquid paraffin 38.0, solid paraffin 120 beeswax
12.0. Polyoxyethylene (2) Cetyl ether 25. Polyoxyethylene (5) Oleyl ether 4. Topolyoxyethylene (20) sorbitan laurate 0.8 ・Butyl paraoxybenzoate 0.2 μm (aqueous phase) Nicotinic acid 0.3・γ-
Rilunic acid 0.2・vitamin A
Acid 0.2 Kojic acid
1,0・Wednesday
A cold cream was prepared according to Example 2 based on the above formulation.

4 Vanishing cream (oil phase) ・MC-stearin 1' ・Liquid paraffin ・Isobrobyl myristylate ・Tyrchol 2) ・Hydrogenated lanolin ・Glycerin monostearate ・Polyoxyethylene (20) Cetyl ether propyl paraoxybenzoate (water Phase) ・Kojic acid・PCA soda (50%) 31 ・ε-Aminocaproic acid・L-proline・L-lysine hydrochloride 1.3-Butylene glycol・Methyl paraoxybenzoate wt % 10.0 1.0 1. 0 1.5 0.2 1.5 3.0 0.5 0.5 0.3 4.0 0.1 ・Water Remaining note) 1 Nistearic acid Made by Yoken Fine Chemicals Note) 2: For cetyl octoate 3: Sodium DL-2-pyrrolidone-5-carboxylate Manufactured by Ajinomoto ■ Based on the above formulation, a vanishing cream was prepared according to Example 2.

Example 5 Emulsion (oil phase) wt%
Squalane 5.0, petrolatum 20, beeswax 0.5, sorbitan sesquioleate 0.8, polyoxyethylene (5) oleyl ether 1, 2, propyl paraoxybenzoate 0. Butyl toparaoxybenzoate Q, 1 (aqueous phase) ・Propylene glycol 5.0 ・Ethanol 5.0 ・Carboxyvinyl polymer (1%) 20.0 ・Kojic acid 0.75 ・Prodew 10041 10.0 ・L-Arginine 0 ．． ]・Fragrance
0. Methyl toparaoxybenzoate 0.1 Sodium hydroxide
Amount/water to adjust pH to 5.5
Remaining note) 4: L-proline, PCA soda, sodium lactate, protein hydrolyzate mixture (50% concentration), manufactured by Ajinomoto ■ Based on the above formulation, a milky lotion was prepared according to Example 2.

Example 6 Emulsion (oil phase) wt%
Liquid paraffin 10.0 Beeswax 1.0 stearyl alcohol 1.4 63-stearin 51 1.2 polyoxyethylene (10) glyceryl tristearate 2.4 polyoxyethylene (15) cetyl ether 0.8 Butyl paraoxybenzoate 0.1 (aqueous phase) PCA soda 4.0
L-Threonine 1.0・Kojic acid 2.0 Allantoin 0.2・Methyl paraoxybenzoate 0.1・Mixed plant extract 0.5・Water
Remaining note) 5 Nistearic acid, manufactured by Yoken Fine Chemicals ■ Based on the above formulation, a milky lotion was prepared according to Example 2.

Ufiig 7 -1-Ihi I- wt% Kojic acid 0.5・D
L-methionine 0.2・D L
-2-pyrrolidone-5-carboxylic acid triethanolamine 0.5・Aloe extract
0. Horse chestnut extract
0. Tohetima extract
0.1・Calcium carbonate
0.2・Ethanol
5.0・Glycerin
10,0-Methyl paraoxybenzoate 0
．． 1.Fragrance 0.1
・Sodium hydroxide 0.1・
Water After heating and dissolving all the remaining components above, the solution was stirred and cooled to prepare a lotion.

Example 8 Pack- (A) ・Kojic acid ・Sodium benzoate ・L-oxyproline ・L-leucine ・Begum ・Squalane ·Propylene glycol ・Vitamin A ・Vitamin C ・Shikon extract ・Methyl paraoxybenzoate ·water (B) ・Zinc oxide ・Kaolin (C) ·ethanol After dissolving and swelling the above component A, wt% 1.8 1.0 0, 5 0.8 5.0 5.0 0.01 0.01 0.1 0.1 10.0 10.0 5, O Add component B Then, component C was added and kneaded to prepare a pack.

When each of the cosmetics of Examples 2 to 8 was left at 45° C. for 2 months, there was only slight discoloration and the cosmetics could be used as commercial products.

Comparative Example 1.2 A cosmetic was prepared by removing organic acids (salts), neutral amino acids (salts), and basic amino acids (salts) from the formulations of Examples 2 and 5. The pH was adjusted with sodium hydroxide or hydrochloric acid. Comparative Example 1.2 (combined with Example 2.5) was used as Comparative Example 1.2. These were subjected to a coloring test at 45° C. for 2 months.

The sample before the test was measured using a color difference meter (“Color Meter 2-10” manufactured by Nippon Heavy Industries Ltd.).
01DPJ), L (brightness), a (redness), b (
Yellow) was measured, and the hue after the test was similarly measured, and ΔE was calculated from the following formula using L', ', and b', respectively.

The larger ΔE means the greater the degree of coloring. The results are shown in Table 2.

Table 2 ΔE= + a-a ) +
(b-b') 2 Harm UL was weighed to give each test sample a concentration shown in Table 3, and 25 g of a 2% aqueous solution of kojic acid was added. The pH was adjusted to 5.5 with a 3% aqueous sodium hydroxide solution or hydrochloric acid. Furthermore, 25 g of distilled water was added.

After placing this in a constant temperature bath at 40°C for 1 to 2 weeks,
The pH was measured. The results are shown in Table 3.

(Margins below) Seiichiori Mawari-1-Q Cream (oil phase) wt%・
Beeswax 6.0, Setanol 6.0, Reduced Lanolin 8.0 Squalane
30,0・Lipophilic glycerin monostearate 3.0・Polyoxyethylene sorbitan monolaurate 2.0 Paraoxyamne 7C1 butyl froate 0.2 (aqueous phase)・Propylene glycol 5.0・Kojic acid 1.0・Tartaric acid 1.0 ・Sodium hydroxide amount to make pH 5,6 ・Water
The residual oil phase is heated to 80° C., the aqueous phase is separately heated to 80° C., and the oil phase is gradually added to the aqueous phase with stirring. A cream was prepared by cooling to 30° C. while stirring.

Fruit” 1 Example 11 Ribe K (oil phase) wt%・Beeswax 7.0・Cetanol 5.0・Reduced lanolin 7.5・Squalane
28.0・Lipophilic glyceryl monostearate 3゜0・Polyoxyethylene sorbitan monolaurate 2.0・Paraoxyamdeme, butyl fragrant 0.2 (aqueous phase)・Propylene glycol 5.0・Kojic acid 1 .0・Hyaluronic acid 0. Tochondroitin sulfate 1.0・Sodium hydroxide Amount to adjust pH to 5.6・Water
A cream was prepared according to the remaining Example 10.

Harm - Example - Shi-12 Cream (oil phase) Liquid paraffin, solid paraffin, vaseline, polyoxyethylene (2) Di-2-octyldodecyl-N-lauroyl monoglutamic acid ester N-lauroyl-glutamic acid polyoxy Ethylene (5) Distearyl diester Isopropyl myristate/cetanol/polyoxyethylene (3) Stearyl ether polyoxyethylene (8) Stearyl ether polyoxyethylene (20) Cetyl ether (aqueous phase) wt% 3.2 1.5 1 .0 2.0 0.5 0.2 ・N-lauroyl=monosodium L-glutamate 0.2・Polyethylene glycol 400 0.2・Propylene glycol 2・Kojic acid
0.5. Disodium ethylenediaminetetraacetate 1.5. Monosodium L-aspartate 0.5. Sodium hydroxide
Amount to adjust pH to 6.0/Methyl paraoxybenzoate
0.5 Water A cream was prepared according to the remainder of Example 10.

Example 13 Milk lotion (oil phase) wt%
Liquid paraffin 32, solid paraffin 4, cetanol
4. Sorbitan monostearate 1.5. Polyoxyethylene (2
0) Sorbitan monooleate 2.8 Propyl paraoxybenzoate 0.2 (aqueous phase) Kojic acid 2° Malic acid 0.5 ■--
Glutamic acid 1.0 Hyaluronic acid 0.01, Sodium hydroxide Amount to adjust pH to 5, Fragrance
Appropriate amount/water
A milk lotion was prepared according to the remaining Example 10.

Seed - 5 mortar (Example - 1 - Seed YL - Liquid 1 (oil phase) wt%
Self-emulsifying glyceryl monostearate 1.5, polyoxyethylene cetyl ether 2°, stearic acid 2.0, cetanol
1.0・Isopropyl myristate 2゜・Butyl hydroxybenzoate 0.2 (aqueous phase) ・Kojic acid 3.0・L
-Glutamic acid 20・L-aspartic acid 2.0・Allantoin 0.1・Sodium hydroxide Amount to make pH 5.5・Water
A milky lotion was prepared according to the remaining Example 10.

Example 15 Lotion wt% ・Polyoxyethylene (25) glyceryl monopyroglutamate monoisostearate
1.0・Ethanol
15.0 Methyl paraoxybenzoate
0.1' kojic acid
0゜7・Tetrasodium ethylenediaminetetraacetate 1.0・L
-Disodium glutamate 1.5・Loofa water 2! ,0・Allantoin 0. Tocarboxymethyl chitin 0.05・Methyl paraoxybenzoate 0.1・Fragrance
Appropriate amount/hydrochloric acid pH
Amount of water to adjust the amount to 5.8 After heating and dissolving the remaining gold components, the pH was adjusted to 5.8 and cooled to prepare a lotion.

%i%16 Pack (A) ・Carboxyvinyl polymer 1.0・Kojic acid 25D Monosodium L-glutamate 0.5・Cynalium-ethylenediaminetetraacetic acid 1.0 Chitosan lactate
0.05・Fragrance
Appropriate amount/Methyl paraoxybenzoate
0.1・Water
Remainder (B) - Calcium carbonate 0.3 Titanium dioxide 0.02 (C) - Ethanol 3.0 After dissolving and swelling the above (A> component, add component (B), and finally add component (C). The mixture was added and kneaded to prepare a pack.

Comparative Examples 3 to 9 Cosmetics from Examples 10 to 16 and cosmetics obtained by removing organic acids (salts) and acidic amino acids (salts) from these cosmetics (however, the pH was adjusted according to the examples using sodium hydroxide or hydrochloric acid) ) were used as Comparative Examples 3 to 9, respectively, and 45°
C for 2 months, and the change in pH was examined. The results are shown in Table 4.

(Margin below) Table 4 Example 17 Cream (oil phase) wt%・M
C Stearin 10.0・Liquid paraffin 2.0・Isopropyl myristate 1.0・Tyrchol
20. Hydrogenated lanolin
1.0・Glycerin monostearate 1.5・Polyoxyethylene (20) cetyl ether 2.0・Propyl roseoxybenzoate 0.2・Fragrance
0.2 (aqueous phase) Kojic acid 1.0 Citric acid 1.5 Monoammonium glycyrrhizinate 0.1 Lactic acid
1.0・Sodium hydroxide Amount to adjust pH to 5.5・Water
A cream was prepared according to the remaining Example 10.

Harm U1 example - 1,53-gold oil phase) wt% liquid paraffin 8.0 beeswax 1.0 stearyl alcohol 1.4 63-stearin 1.2 polyoxyethylene (
10) Glyceryl tristearate
2.4 Polyoxyethylene (15) Cetyl ether 0.8 Butyl paraoxybenzoate 0.1 (aqueous phase) Kojic acid 0.7 Disodium ethylenediaminetetraacetate 0.5 Glycine
1.0・Hyaluronic acid
0.05・Methyl roseoxybenzoate 0.3・Sodium hydroxide
A milky lotion was prepared according to Example 10 in an amount to adjust the pH to 5 and 8.

Fire power father-in-law 19 Park (A) wt% Kojic acid 20 Tartaric acid
1.0. Monosodium L-glutamate 0.3. L-lysine hydrochloride 1.0. Glycyrrhetinic acid
0.02・L-proline
0.5 Brodieu 100
2.0 Begum
5.0 Squalane
20 Propylene Glycol 5.
0, methyl roseoxybenzoate 0.3.
Sodium hydroxide Amount to adjust pH to 6.0 (B
) - Zinc oxide 10.0 - Kaolin 10.0 (C) - Ethanol 5.0 A pack was prepared according to Example 16.

Comparative Examples 10-12 Example 17.18. Organic acid salts from each cosmetic product)
, neutral amino acids (salts), acidic amino acids (salts), and basic amino acids (salts) were prepared as Comparative Examples 10, 11, and 12, respectively, but the pH was adjusted to the corresponding level using sodium hydroxide. (adjusted to be the same as the example).

Each cosmetic of Examples 17 to 19 and Comparative Examples 1O to 12 was
After being left at ℃ for 2 months, changes in pH and color were measured. The measurement conditions were as in Examples 2 and 5, Comparative Examples 1.2 (Table 2), Examples 10 to 16, and Comparative Examples 3 to 9 (Table 71). The measurement results are shown in Table 5.

From the above results, specific organic acids (salts) and amino acids (salts)
It can be seen that by the combination of the following, a cosmetic containing kojic acid with suppressed changes in pH and color can be obtained.

According to the present invention, a stable cosmetic composition containing kojic acid can be obtained.

Claims (1)

[Scope of Claims] 1. A cosmetic containing at least one selected from organic monocarboxylic acids, neutral amino acids, basic amino acids, and salts thereof and kojic acid. 2. A cosmetic containing at least one selected from organic dicarboxylic acids, organic tetracarboxylic acids, high-molecular polycarboxylic acids, acidic amino acids, and salts thereof, and kojic acid. 3. A cosmetic containing the following components (A), (B), and (C) as essential components. (A) At least one selected from organic monocarboxylic acids, neutral amino acids, basic amino acids, and salts thereof (B) organic dicarboxylic acids, organic tricarboxylic acids, organic tetracarboxylic acids, high molecular polycarboxylic acids, acidic amino acids, and At least one selected from these salts (C) kojic acid