JPH1171223A - Skin preparation for external use for preventing obscurity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare the subject skin preparation for external use, capable of improving skin obscurity by mainly promoting the peeling of horny substance, and useful for a medicine and cosmetic as a preventive and therapeutic agent by mainly including alanine. SOLUTION: The objective skin preparation for external use is obtained by allowing the preparation to include 0.001-20.0 wt.%, preferably 0.01-10.0 wt.% alanine (L-alanine, DL-alanine and D-alanine) produced, for example, by hydrolyzing a silk fibroin by using a selective precipitant such as azobenzene- p-sulfonic acid, and optionally an ultraviolet absorbent, an ultraviolet blocking agent, a humectant, a skin-activating ingredient, various kinds of vitamins, and preparing the composition into wide dosage forms (an aqueous solution system, an aerosol system, a water-oil bilayer system, a water-oil-powder trilayer system or the like).

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD [0001] The present invention relates to an external preparation for the skin. More specifically, the invention relates to an external preparation for skin having a dullness-preventing effect, which is formulated by combining specific amino acids.

[0002]

2. Description of the Related Art Even though skin dullness is a major problem in women's skin and is a major cosmetic problem,
The phenomenon itself has many vague aspects. Skin dullness is a particular visual phenomenon that occurs throughout the face or in areas around the eyes or cheeks, reducing redness and increasing yellowness of the skin, and / or
Or, in the state where the brightness and the transparency of the skin decrease and the brightness decreases due to the shadow due to the unevenness of the skin surface, etc.,
Its boundaries are unclear.

[0003] The following are assumed as causes of dullness, and these factors are grasped as specific phenomena by being involved alone or in combination. Deterioration of redness of skin color due to poor circulation.Pigmentation with indistinct morphogenesis of plaques or fine spots.Shadow due to fine irregularities on the skin surface caused by a decrease in skin elasticity. Decrease in transparency (light transmission) due to irregularity Reduced gloss due to irregular reflection on the skin surface Yellowing of skin Changes in skin color due to estrous cycle Dullness due to dirt such as dust, sweat, sebum, etc. In recent years, attempts to improve this dullness of the skin have been made. It has been conducted from a variety of viewpoints, but at present, no satisfactory results have been achieved.

[0004]

An object of the present invention is to provide a means for effectively preventing dull skin.

[0005]

Means for Solving the Problems The present inventor has made intensive studies to solve this problem. As a result, they have found that when an alanine, which is a kind of amino acid, is incorporated into an external preparation for skin, the external preparation for skin has an excellent dullness-preventing effect, that is, a preventive and therapeutic effect, and completed the present invention. That is, the present invention provides a skin external preparation for preventing dullness, comprising alanine as an active ingredient.

[0006]

Embodiments of the present invention will be described below. The external preparation for skin of the present invention is a skin external preparation for preventing dullness, which is formed by blending alanine as an active ingredient, for the purpose of preventing and treating dullness exclusively.

[0007] The alanine compounded in the external preparation for skin of the present invention is
Any of L-alanine, DL-alanine and D-alanine may be used, but alanine derivatives such as amide derivatives are excluded.

In the present invention, alanine produced by a generally known method can be used. That is, for example, alanine produced by hydrolyzing silk fibroline using a selective precipitant such as azobenzene-p-sulfonic acid, alanine separated from a hydrolyzate of silk by Fischer's ester method, and further by fermentation. The manufactured L-alanine and the like can be used.

It is of course possible to use commercially available products,
For L-alanine, for example, alanine (Musashino Chemical Laboratory) (Takeda Pharmaceutical), DL-alanine (Showa Denko)
(Nippon Physical and Chemical) (Ajinomoto), DL-alanine Kyowa (Kyowa Hakko Kogyo) and the like can be used. For L-alanine, for example, L-alanine (Tanabe Seiyaku) (Nippon Chemical) (Ajinomoto) , L-alanine Kyowa (Kyowa Hakko Kogyo) or the like can be used.

In the external preparation for skin of the present invention, alanine is present in an amount of 0.001% to 20.0% by weight, preferably 0.1% to 10.0% by weight, based on the external preparation. .

[0011] The amount of this compound is 0.00
If the amount is less than 1% by weight, the effect of alanine to be exerted in the external preparation for skin, which is a dullness-preventing effect, cannot be sufficiently exhibited.
Even if the amount is more than 0% by weight, it is difficult to expect an increase in the effect corresponding to the increase in the amount.

[0012] In this way, by providing alanine as an active ingredient in a skin external preparation, the skin external preparation of the present invention which can improve dullness of the skin mainly by accelerating exfoliation of the stratum corneum is provided. Is done. In the skin external preparation of the present invention, other components are blended, and as long as the medicinal effect is added to the skin external preparation of the present invention, other components are blended within a range that does not impair the intended effect of the present invention. be able to.

For example, components which are already known to be effective for dullness can be incorporated into the external preparation for skin of the present invention, and these dull-preventing effects can be added to the external preparation for skin of the present invention. This component includes, for example, tranexamic acids, arbutin, trimethylglycine, vitamin Es,
Serine and the like can be mentioned.

Further, for example, when an ultraviolet ray shielding effect is further imparted to the skin external preparation of the present invention, an ultraviolet absorber or an ultraviolet ray blocking agent can be incorporated into the skin external preparation of the present invention. Examples of the ultraviolet absorber include para-aminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester, N,
N-dimethyl PABA ethyl ester, N, N-dimethyl PABA butyl ester, N, N-dimethyl PABA
Para-aminobenzoic acid-based UV absorbers such as tyl esters,
Anthranilic acid ultraviolet absorbers such as homomenthyl-N-acetylanthranilate, salicylic acid ultraviolet absorbers such as amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, and octyl Cinnamate, ethyl-4-isopropyl cinnamate, methyl-
2,5-diisopropylcinnamate, ethyl-2,4
Diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate,
Isoamyl-p-methoxycinnamate, octyl-p
-Methoxycinnamate (2-ethylhexyl-p-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl Cinnamic acid-based ultraviolet absorbers such as -α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate;

2,4-dihydroxybenzophenone,
2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4′-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4′-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4
-N-octoxybenzophenone, 4-hydroxy-3
A benzophenone-based ultraviolet absorber such as carboxybenzophenone, 3- (4′-methylbenzylidene) -d, l
-Camphor, 3-benzylidene-d, l-camphor, urocanic acid, urocanic acid ethyl ester, 2-
Phenyl-5-methylbenzoxazole, 2,2′-hydroxy-5-methylphenylbenzotriazole,
-(2'-hydroxy-5'-t-octylphenyl)
Benzotriazole, 2- (2'-hydroxy-5'-
Methylphenylbenzotriazole, dibenzalazine,
Examples thereof include dianisoylmethane, 4-methoxy-4′-t-butyldibenzoylmethane, and 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one.

When the moisturizing effect is positively imparted to the external preparation for skin of the present invention, a moisturizing agent can be incorporated in the external preparation for skin of the present invention. Examples of the humectant include polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate. , Sodium lactate, bile salts, dl-pyrrolidone carboxylate, short-chain soluble collagen, diglycerin (EO) PO
Examples include an adduct, a primrose extract, a Yarrow extract, and a melilot extract.

Further, in order to impart various medicinal effects to the external preparation for skin of the present invention, other medicinal ingredients other than the above-mentioned essential ingredients [eg, skin activating ingredients, additional vitamins (vitamin A, B ₁ , B ₂ , B ₆ , C, pantothenic acid and its derivatives, biotin, etc.) and amino acids (glycine, valine,
Neutral amino acids such as leucine, isoleucine, threonine, tryptophan, cystine, cysteine, methionine, proline, and hydroxyproline; aspartic acid,
Acidic amino acids such as glutamic acid, asparagine and glutamine; and basic amino acids such as arginine, histidine, lysine and hydroxylysine. In addition, as the amino acid derivative, for example, acyl sarcosine sodium (sodium lauroyl sarcosine), acyl glutamate, sodium acyl β-alanine, glutathione, pyrrolidone carboxylic acid, etc.) are included in the external preparation for skin of the present invention. Can be.

The external preparation for skin of the present invention includes pharmaceuticals, quasi-drugs (ointments, etc.) and cosmetics (basic cosmetics such as facial cleansers, emulsions, creams, gels, essences (cosmetics), packs and masks; foundations, lipsticks) And other makeup cosmetics; aromatic cosmetics, body cosmetics, etc.]. The form that the external preparation for skin of the present invention can take is not limited to these forms. A wide range of dosage forms are available, including aqueous, solubilized, emulsified, powder, oil-liquid, gel, ointment, aerosol, water-oil two-layer systems, water-oil-powder three-layer systems, and the like. Can take a type.

In the skin preparation for external use of the present invention, commonly known base components and the like are widely blended according to the desired form and dosage form as long as the desired effects of the present invention are not impaired by the blending. Can be used.

That is, powder component, liquid fat, solid fat, wax, ester oil, hydrocarbon oil, silicone, anionic surfactant, cationic surfactant, amphoteric surfactant, lipophilic nonionic surfactant , Hydrophilic nonionic surfactants, lower alcohols, sterols, water-soluble polymers, sequestering agents, neutralizing agents, pH adjusters, antioxidants, antibacterial agents, fragrances, dyes, etc. Can be added to the external preparation for skin of the present invention within a range that does not impair the effect of.

Examples of the powder component include talc, kaolin, mica, sericite (sericite), muscovite, phlogopite,
Synthetic mica, mica, biotite, lithia mica, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, zeolite , Barium sulfate, calcined calcium sulfate (baked gypsum), calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, metal soap (zinc myristate, calcium palmitate, aluminum stearate), inorganic powder such as boron nitride, polyamide resin powder ( Nylon powder), polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, benzoquanamine resin powder, polytetrafluoroethylene powder, cellulo Organic powders scan powder such as titanium dioxide, inorganic white pigments such as zinc oxide,

Inorganic red pigments such as iron oxide (iron oxide) and iron titanate; inorganic brown pigments such as γ-iron oxide; inorganic yellow pigments such as yellow iron oxide and loess; black iron oxide; carbon black; Inorganic black pigments such as titanium oxide, inorganic violet pigments such as mango violet and cobalt violet, inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; inorganic blue pigments such as ultramarine blue and navy blue; titanium oxide Coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, pearl pigments such as fish scale foil, aluminum powder, metal powder pigments such as copper powder, red No. 201, red No. 202 , Red 2
04, Red 205, Red 220, Red 226,
Red No. 228, Red No. 405, Orange No. 203, Orange No. 20
Organic pigments such as No. 4, Yellow 205, Yellow 401 and Blue 404, Red No. 3, Red No. 104, Red No. 106
No. Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 2
Organic pigments such as zirconium, barium or aluminum lakes such as No. 02, Yellow No. 203, Green No. 3 and Blue No. 1, and natural pigments such as chlorophyll and β-carotene. However, any powder can be used as long as it can be applied to general cosmetics, and is not limited to the above components.

Examples of liquid fats and oils include avocado oil,
Camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, linseed oil, safflower oil, cottonseed oil, eno oil, Soybean oil, peanut oil, teaseed oil, kaya oil, rice bran oil, sinagiri oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin,
Glycerin trioctanoate, glycerin triisopalmitate and the like can be mentioned.

Examples of solid fats and oils include cocoa butter, coconut oil, horse fat, hardened coconut oil, palm oil, tallow, sheep fat, hardened tallow, palm kernel oil, lard, beef tallow, mokuro kernel oil, hardened kernel oil Oil, beef tallow, mocro, hardened castor oil and the like.

Examples of the waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ibota wax, whale wax, montan wax, nuka wax, lanolin, kapok wax, lanolin acetate, liquid lanolin,
Sugar cane wax, isopropyl lanolin fatty acid, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether and the like. Can be

Examples of the hydrocarbon oil include liquid paraffin, ozokerite, squalene, pristane, paraffin, ceresin, vaseline, microcrystalline wax and the like.

The higher fatty acids include, for example, lauric acid, myristic acid, palmitic acid, stearic acid, behenic (behenic) acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tallic acid, isostearic acid, linoleic acid, linoleic acid Acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and the like.

Examples of the higher alcohol include straight-chain alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, and cetostearyl alcohol, monostearyl glycerin ether (bacyl alcohol), and 2-decyltetradecyl alcohol. And branched-chain alcohols such as knol, lanolin alcohol, cholesterol, phytosterol, hexyldecanol, isostearyl alcohol, octyldodecanol, and the like.

Examples of synthetic ester oils include isopropyl myristate, cetyl octoate, octyl dodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyl decyl dimethyl octanoate, Cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexylate, fatty acid ester of dipentaerythritol, N-alkyl glycol monoisostearate, neodicaprate Pentyl glycol, diisostearyl malate, glycerin di-2-heptylundecanoate, trimethylol tri-2-ethylhexylate Bread, trimethylolpropane triisostearate, pentaneerythritol tetra-2-ethylhexylate, glycerin tri-2-ethylhexylate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, trimyristate Glycerin, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleic acid oil, cetostearyl alcohol, acetoglyceride, palmitic acid 2-
Heptylundecyl, diisobutyl adipate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, ethyl acetate, butyl acetate, amyl acetate, triethyl citrate and the like.

Examples of the silicone include linear polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane and methylhydrogenpolysiloxane, and cyclic polysiloxanes such as decamethylpolysiloxane, dodecamethylpolysiloxane and tetramethyltetrahydrogenpolysiloxane. Examples include polysiloxane, silicone resin and silicone rubber forming a three-dimensional network structure.

Examples of the anionic surfactant include soap bases, fatty acid soaps such as sodium laurate and sodium palmitate, higher alkyl sulfates such as sodium lauryl sulfate and lauryl sulfate K,
POE lauryl sulfate triethanolamine, alkyl ether sulfates such as POE lauryl sodium sulfate, N-acyl sarcosine acids such as lauroyl sarcosine sodium, N-myristoyl-N-methyltaurine sodium, coconut oil fatty acid methyltauride sodium,
Higher fatty acid amide sulfonates such as sodium lauryl methyl tauride, POE oleyl ether sodium phosphate, phosphate ester salts such as POE stearyl ether phosphoric acid, sodium di-2-ethylhexyl sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene Sulfosuccinates such as sodium sulfosuccinate and sodium lauryl polypropylene glycol sulfosuccinate; alkylbenzene sulfonates such as sodium linear dodecylbenzenesulfonate, linear dodecylbenzenesulfonate triethanolamine and linear dodecylbenzenesulfonate; monosodium N-lauroylglutamate , N-stearoyl disodium glutamate, N-myristoyl-L-monosodium glutamate and the like. Acyl glutamate, higher fatty acid ester sulfate such as hydrogenated coconut oil fatty acid glycerin sodium sulfate, sulfated oil such as funnel oil, POE alkyl ether carboxylic acid, POE alkyl allyl ether carboxylate, α-olefin sulfonate, higher grade Fatty acid ester sulfonate, secondary alcohol sulfate, higher fatty acid alkylolamide sulfate,
Sodium lauroyl monoethanolamidosuccinate,
N-palmitoyl aspartate ditriethanolamine, sodium caseinate and the like.

Examples of the cationic surfactant include alkyltrimethylammonium salts such as stearyltrimethylammonium chloride and lauryltrimethylammonium chloride, distearyldimethylammoniumdialkyldimethylammonium chloride, and poly (N, N'-dimethyl-3,3,3,4,5,6,7,8). Alkylpyridinium salts such as 5-methylenepiperidinium) and cetylpyridinium chloride, alkyl quaternary ammonium salts, alkyldimethylbenzylammonium salts, alkylisoquinolinium salts, dialkylmorphonium salts, POE alkylamines, alkylamine salts, Examples thereof include polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride, benzethonium chloride and the like.

Examples of the amphoteric surfactant include 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium and 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyl. Imidazoline amphoteric surfactants such as roxy disodium salt, 2-heptadecyl-N-carboxymethyl-
N-hydroxyethyl imidazolinium betaine, lauryl dimethylamino acetate betaine, alkyl betaine,
Betaine-based surfactants such as amidobetaine and sulfobetaine are exemplified.

Examples of the lipophilic nonionic surfactant include sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, Sorbitan fatty acid esters such as penta-2-ethylhexyl diglycerol sorbitan, tetra-2-ethylhexyl diglycerol sorbitan, mono-cottonseed oil fatty acid glycerin, glycerin monoerucate, glycerin sesquioleate, glyceryl monostearate, α,
Glycerin polyglycerin fatty acids such as glycerin α'-oleate pyroglutamate and glyceryl monostearate; propylene glycol fatty acid esters such as propylene glycol monostearate; hydrogenated castor oil derivatives; glycerin alkyl ether;

Examples of the hydrophilic nonionic surfactant include POE sorbitan fatty acid esters such as POE sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate, and POE-sorbitan. Sorbit Monolaurate, POE-Sorbit Monooleate, POE
-POE sorbitol fatty acid esters such as sorbit pentaoleate and POE-sorbit monostearate, POE glycerin fatty acid esters such as POE-glycerin monostearate, POE-glycerin monoisostearate and POE-glycerin triisostearate; POE monooleate, POE distearate,
POE fatty acid esters such as POE monodioleate and ethylene glycol cysteate, POE lauryl ether, POE oleyl ether, POE stearyl ether, POE behenyl ether, POE alkyl ethers such as POE2-octyldodecyl ether, POE cholestanol ether, POE octyl POE alkyl phenyl ethers such as phenyl ether, POE nonyl phenyl ether, and POE dinonyl phenyl ether;

Bluronic types such as bruronic, P
OE • POP cetyl ether, POE • POP2-decyltetradecyl ether, POE • POP monobutyl ether, POE • POP hydrogenated lanolin, POE • POP
POE / POP alkyl ethers such as glycerin ether, tetra POE / tetra POP ethylenediamine condensates such as tetronic, POE castor oil, POE hardened castor oil, POE hardened castor oil monoisostearate,
POE-cured castor oil triisostearate, POE-cured castor oil monopyroglutamic acid monoisostearate diester, POE-casted oil-cured castor oil derivatives such as POE-cured castor oil maleic acid, POE beeswax lanolin derivatives such as POE sorbitol beeswax, coconut oil Fatty acid diethanolamide, lauric acid monoethanolamide,
Alkanolamides such as fatty acid isopropanolamide, POE propylene glycol fatty acid ester, PO
E alkylamine, POE fatty acid amide, sucrose fatty acid ester, POE nonylphenylformaldehyde condensate, alkylethoxydimethylamine oxide, trioleyl phosphoric acid and the like.

Examples of natural water-soluble polymers include, for example, gum arabic, tragacanth, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (quince), alge colloid (cassow extract), starch (rice, corn) , Potato, wheat), plant polymers such as glycyrrhizic acid, microbial polymers such as xanthan gum, dextran, succinoglucan, pullulan, collagen,
Animal-based polymers such as casein, albumin, and gelatin are exemplified.

The semi-synthetic water-soluble polymer includes, for example,
Starch-based polymers such as carboxymethyl starch and methylhydroxypropyl starch, methylcellulose, nitrocellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, cellulose sodium sulfate, hydroxypropylcellulose, sodium carboxymethylcellulose (CM
C), cellulosic polymers such as crystalline cellulose and cellulose powder, and alginic acid polymers such as sodium alginate and propylene glycol alginate.

As the synthetic water-soluble polymer, for example, vinyl polymers such as polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, carboxyvinyl polymer (Carbopol), polyethylene glycol 20,000, 4,000,000, Polyoxyethylene polymer such as 600,000, polyoxyethylene polyoxypropylene copolymer copolymer polymer, acrylic polymer such as sodium polyacrylate, polyethyl acrylate, polyacrylamide, polyethyleneimine, cationic polymer And the like.

Examples of the inorganic water-soluble polymer include bentonite, silicic acid A1Mg (veegum), laponite, hectorite, silicic anhydride and the like.

Examples of the thickener include gum arabic,
Carrageenin, karaya gum, tragacanth gum, carob gum, quince seed (quince), casein, dextrin, gelatin, sodium pectate, sodium alginate, methylcellulose, ethylcellulose,
CMC, hydroxyethylcellulose, hydroxypropylcellulose, PVA, PVM, PVP, sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, dialkyldimethylammonium cellulose sulfate, xanthan gum, aluminum magnesium silicate, bentonite,
Hectorite and the like.

As the sequestering agent, for example, 1-
Hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, tetrasodium edetate, sodium citrate, sodium polyphosphate, metaphosphoric acid Examples include sodium, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid and the like.

Examples of the lower alcohol include methanol, ethanol, propanol, isopropanol,
Isobutyl alcohol, t-butyl alcohol and the like.

Examples of the polyhydric alcohol include ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, and 2,3-butyl glycol.
Butylene glycol, pentamethylene glycol, 2-
Dihydric alcohols such as butene-1,4-diol, hexylene glycol and octylene glycol; trihydric alcohols such as glycerin, trimethylolpropane and 1,2,6-hexanetriol; and tetrahydric alcohols such as pentaerythritol Pentahydric alcohols such as xylitol, sorbitol, hexahydric alcohols such as mannitol,
Polyhydric alcohol polymers such as diethylene glycol, dipropylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol, diglycerin, polyethylene glycol, triglycerin, tetraglycerin, polyglycerin, ethylene glycol monomethyl ether, ethylene glycol monoethyl Ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono 2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, ethylene glycol isopropyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl Ether, d Dihydric alcohol alkyl ethers such as glycol dibutyl ether,

Diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene Dihydric alcohols such as glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether, and dipropylene glycol butyl ether Ethers,

Ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diazibate, ethylene glycol disuccinate, diethylene glycol monoethyl ether acetate, diethylene glycol monoethyl Dihydric alcohol ether esters such as butyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propylene glycol monophenyl ether acetate, xyl alcohol, seralkyl alcohol, and batyl alcohol Glycerin mono-alkyl ether,
Sorbitol, maltitol, maltotriose, mannitol, sucrose, erythritol, glucose, fructose, amylolytic sugar, maltose, xylitolose, sugar alcohols such as amylolytic sugar reducing alcohol,
Glysolid, tetrahydrofurfuryl alcohol,
POE tetrahydrofurfuryl alcohol, POP butyl ether, POP / POE butyl ether, tripolyoxypropylene glycerin ether, POP glycerin ether, POP glycerin ether phosphoric acid, PO
P. POE pentane erythritol ether and the like.

Examples of the monosaccharide include tricarbonates such as D-glyceryl aldehyde and dihydroxyacetone, tetracarbons such as D-erythrose, D-erythrulose, D-threose and erythritol, L-arabinose, D-xylose, and the like. Pentoses such as L-lyxose, D-arabinose, D-ribose, D-ribulose, D-xylulose, D-xylulose, D-glucose, D-talose, D-
Psicose, D-galactose, D-fructose, L
-Hexoses such as galactose, L-mannose, D-tagatose, heptose such as aldoheptose and heptulose;
Octanose such as octulose, 2-deoxy-D-ribose, 6-deoxy-L-galactose, 6-deoxy-
Deoxy sugars such as L-mannose, D-glucosamine, D
-Amino sugars such as galactosamine, sialic acid, aminouronic acid and muramic acid, and uronic acids such as D-glucuronic acid, D-mannuronic acid, L-guluronic acid, D-galacturonic acid and L-iduronic acid.

The oligosaccharides include, for example, sucrose, guntianose, umbelliferose, lactose, brantose, isoliqunoses, α, α-trehalose,
Raffinose, liqunoses, umbilicin, stachyose bell bath courses and the like.

Examples of polysaccharides include cellulose, quince seed, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, gum arabic, heparan sulfate, hyaluronic acid, tragacanth gum, keratan sulfate, chondroitin, xanthan gum, mucoitin sulfate, guar gum, dextran Keratosulfuric acid, locust bean gum, succinoglucan, caronic acid and the like.

Examples of the organic amine include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, and 2-amino-2-methyl-1. -Pronol and the like.

As the synthetic resin emulsion, for example,
An acrylic resin emulsion, a polyethyl acrylate emulsion, an acrylic resin liquid, a polyacryl alkyl ester emulsion, a polyvinyl acetate resin emulsion, and the like are included.

Examples of the pH adjusting agent include buffers such as lactic acid-sodium lactate and citric acid-sodium citrate.

Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, gallic esters and the like.

Examples of the antioxidant aid include phosphoric acid,
Examples include citric acid, maleic acid, malonic acid, succinic acid, fumaric acid, kephalin, hexametaphosphate, phytic acid, ethylenediaminetetraacetic acid and the like.

These base components can be combined in the skin external preparation of the present invention in an appropriate combination in accordance with the formulation according to the desired form. The specific prescription of the skin external preparation of the present invention will be described in Examples described later.

[0056]

EXAMPLES The present invention will be described more specifically with reference to examples and the like. However, it should not be construed that the technical scope of the present invention is limited by these examples.
In addition, in this example and the like, the blending amount represents the weight% in the object to which the component is blended, unless otherwise specified.

First, a cream having the following formulation was prepared. [Example 1] Cream Ingredients% by weight A (oil phase) Squalane 15.0 Vaseline 7.0 Cetanol 4.0 Isopropyl myristate 8.0 Stearic acid monoglycerin ester 2.0 POE (20) Sorbitan monostearate 2 1.0 Vitamin E acetate 1.0 Ethyl paraben 0.2 Fragrance 0.2 B (aqueous phase) Glycerin 4.0 Dipropylene glycol 4.0 DL-alanine 5.0 Sodium lactate 2.0 Trisodium edetate 0.01 Potassium hydroxide 0.2 Purified water Residue

<Production Method> A (oil phase) and B (aqueous phase) were completely dissolved by heating to 70 ° C., respectively. Then A becomes B
In addition, the emulsion produced by emulsifying with an emulsifier was cooled with a heat exchanger to obtain a desired cream.

Test for evaluating the effect of preventing dulling The cream according to the present invention of Example 1 was evaluated for its effect of preventing dulling by the following method (Example 1 below).
The control was a cream in which DL-alanine was removed from the cream formulation of Example 1). The subjects were women in their 30s and 50s,
Twenty people in each group applied the test article to the cheeks of the face twice a day (morning and evening) and performed a continuous test for two months.

After completion of the continuous test, the effect of improving dullness (evaluation items were “improvement of dullness”, “improvement of skin clarity”, “ "Improvement of whiteness") was evaluated. The evaluation was significant (3 points), effective (2 points), slightly effective (1 point),
It was divided into four stages of no effect (0 point), and represented by the average evaluation score between each subject and a beauty technician.

Results (1) Evaluation items evaluated by the subject himself / herself Example 1 Improvement of dullness of control product 1.95 0.95 Improvement of transparency of skin 1.40 1.20 Improvement of whiteness of skin 1.30 0. 90

(2) Evaluation Evaluation Items by Beauty Technician Example 1 Control Product Improvement of dullness 1.90 0.60 Improvement of skin transparency 2.05 1.35 Improvement of skin whiteness 1.40 1. 05

From these results, it can be seen that the incorporation of alanine as an active ingredient in an external preparation for skin not only can improve dullness but also improve skin clarity and skin whiteness. Was revealed.

Hereinafter, various prescription examples of the external preparation for skin of the present invention are shown below as examples. In addition, when the above-mentioned test for judging the dulling effect was performed on these external preparations for skin of the present invention, both by the test subjects themselves and by a beauty technician, all the evaluation items were significantly superior to the control product from which alanine was removed. I was

Example 2 Lotion Formulation Components Weight% Ethanol 5.0 Carboxyvinyl polymer 0.3 POE (15) Oleyl ether 0.8 Glycerin 5.0 1,3-butylene glycol 5.0 L-alanine 1 0.0 Citric acid 0.03 Sodium citrate 0.07 Methyl paraben 0.1 Purified water Residue

<Production method> L-alanine, citric acid and sodium citrate were dissolved in purified water to obtain an aqueous phase. On the other hand, other components were stirred and dissolved, and this was added to the aqueous phase to make it homogeneous, thereby obtaining a lotion.

Example 3 Cream Ingredients Weight% Stearic Acid 2.0 Stearyl Alcohol 7.0 Hydrogenated Lanolin 2.0 Squalane 5.0 2-Octyldodecyl Alcohol 6.0 POE (25) Cetyl Alcohol Ether 0 glycerin monostearate 2.0 1,3-butylene glycol 5.0 edetate trisodium 0.1 DL-alanine 5.0 sodium glycyrrhetinate 0.1 arbutin 5.0 vitamin E acetate 0.3 ethyl paraben 0.3 Purified water residue

<Production Method> To purified water was added 1,3-butylene glycol, trisodium edetate, DL-alanine, sodium glycyrrhetinate and arbutin to give 70%.
C. and this was the aqueous phase. On the other hand, other components were mixed, heated and melted and kept at 70 ° C., and this was used as an oil phase.
Preliminary emulsification was performed by adding the oil phase to the aqueous phase, and after uniformly emulsifying with a homomixer, the mixture was cooled to 30 ° C. and filled.
I got a cream.

Example 4 Packing Components Weight% (Phase A) Polyvinyl Alcohol 12.0 Glycerin 3.0 Polyethylene Glycol 1500 1.0 L-Alanine 10.0 Purified Water Residue (Phase B) Ethanol 10.0 Vitamin E acetate 0.2 POE (15) oleyl alcohol ether 2.0 Methyl paraben 0.2

<Production Method> Each component of phase A was heated to 70 ° C. and dissolved by stirring, and a mixed solution of phase B was uniformly mixed with stirring, cooled and filled to prepare a pack.

Example 5 Emulsion Ingredients Composition% by Weight Stearic Acid 2.5 Cetyl Alcohol 1.5 Vaseline 5.0 Liquid Paraffin 10.0 POE (10) Monooleate 2.0 Polyethylene Glycol 1500 3.0 Tri Ethanolamine 1.0 DL-alanine 3.0 sodium bisulfite 0.01 ethyl paraben 0.3 carboxyvinyl polymer 0.05 purified water residue

<Production method> A carboxyvinyl polymer was dissolved in a small amount of purified water (phase A). Polyethylene glycol 1500, triethanolamine and DL-alanine were added to the remaining purified water, and heated to 70 ° C. to dissolve (aqueous phase). The other components were mixed and melted and kept at 70 ° C. (oil phase). The oil phase was added to the water phase to perform preliminary emulsification, the phase A was added, and the mixture was uniformly emulsified with a homomixer, cooled to 30 ° C. and filled to obtain an emulsion.

[0073]

According to the present invention, there is provided a skin external preparation for preventing dullness having an excellent dulling-preventing effect.

Claims (3)

[Claims] 1. An alanine compounded as an active ingredient.
An external preparation for preventing dull skin. 2. The skin external preparation for preventing dullness according to claim 1, wherein the amount of alanine is 0.001% by weight or more and 20.0% by weight or less based on the external preparation for skin. 3. The dull-preventing skin external preparation according to claim 1, wherein the blending amount of alanine is 0.01% by weight or more and 10.0% by weight or less with respect to the skin external preparation.