JP3471601B2 - External preparation for skin - Google Patents

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an external preparation for skin. More specifically, it relates to a skin external preparation which is excellent in the effect of promoting lipid decomposition and the effect of improving rough skin.

[0002]

2. Description of the Related Art Conventionally, in order to reduce excess fat and maintain a lean body, in addition to various exercises and dietary restrictions, use of skin cosmetics such as gels and creams that promote metabolism in the body. It has been known.

[0003] Such cosmetics contain an extract of seaweed for the purpose of slimming effect in order to promote the lipolysis of adipocytes constituting fat.

[0004] It is known that the seaweed extract contained in the skin cosmetic also has a rough skin improving effect.

[0005]

However, in the conventional skin cosmetics for slimming effect, the effect of promoting lipolysis of adipocytes is not always sufficient.

[0006] In view of the above-mentioned viewpoints, the inventors of the present invention have earnestly studied the lipid decomposing effect and the skin roughening improving effect of the seaweed extract, and as a result, as a skin external preparation, a particular seaweed extract and a certain specific compound. Surprisingly, it was found that the effect of accelerating lipolysis of adipocytes and the effect of improving rough skin are synergistically increased by the addition of and, and the present invention has been completed.

An object of the present invention is to provide a skin external preparation which is extremely excellent in promoting lipolysis of adipocytes and improving rough skin.

[0008]

Means for Solving the Problems That is, the present invention comprises an extract of all five types of seaweed shown in (1) below and at least one of the specific compounds shown in (2) below. The present invention provides a characteristic external preparation for skin. (1) Mitsuishikonbu, seaweed, giraffe, hijirimen, usubaonori. (2) Serine, alanine, trimethylglycine.

In the present invention, the content of the seaweed extract is 0.001 to 30.0 relative to the total amount of the skin external preparation.
The above-mentioned external preparation for skin is provided in the amount of% by weight.

Furthermore, the present invention is characterized in that the extraction solvent for the seaweed extract is one or more extraction solvents selected from the group consisting of water, ethanol and 1,3-butylene glycol. The above-mentioned external preparation for skin is provided.

[0011]

BEST MODE FOR CARRYING OUT THE INVENTION The constitution of the present invention will be described in detail below.

The seaweed extract used in the present invention is an extract from whole algae of Mitsuishikonbu, seaweed, ginkgo cypress, hydrangea and Usbaaonori.

The method for extracting the extract is not particularly limited, and for example, a shredded product of seaweed may be heated under reflux in the extraction solvent for a certain period of time, filtered, and then concentrated or diluted to obtain an extract. The above five kinds of seaweed can be extracted at the same time, but the extracts extracted separately may be used together.

The extraction solvent is not particularly limited, and water, an organic solvent or the like is used, but in the present invention, an extract extracted with water, a lower alcohol such as ethanol, 1,3-butylene glycol or the like is preferable.

The amount of the above extract blended in the external preparation for skin is
0.001 to 3 based on the total amount of external preparation for dry skin
0.0% by weight, preferably 0.01-10.0% by weight
Is. If the compounding amount of the extract is less than 0.001% by weight, a sufficient effect cannot be obtained, and if it exceeds 30.0% by weight, the effect is not increased.

The specific compound used in the present invention is a compound shown in the following (2) and can be used alone or in combination of two or more kinds. (2) Serine, alanine, trimethylglycine.

The amount of the above specified compound incorporated into the external preparation for skin is 0.001% by weight or more, preferably 0.001% by weight or more.
It is 5 to 10% by weight.

In addition to the above-mentioned essential constituents, the external preparation for skin of the present invention contains other components usually used in external preparations for skin such as cosmetics and pharmaceuticals, for example, powder components, liquid oils and fats, solid oils and fats, waxes and hydrocarbons. , Higher fatty acids, higher alcohols, esters, silicones, anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, humectants, water-soluble polymer compounds, thickeners, film agents, ultraviolet rays Absorbents, sequestering agents, lower alcohols, polyhydric alcohols, sugars, amino acids, organic amines, synthetic resin emulsions, pH adjusting agents, skin nutrients, vitamins, antioxidants, antioxidant aids, fragrances, Water and the like can be appropriately added as needed, and the compound can be produced by a conventional method depending on the intended dosage form. The specific ingredients that can be mixed are listed below.
The external preparation for skin of the present invention can be prepared by blending the above essential ingredients and one or more of the following ingredients.

The powder components include talc, kaolin, mica, sericite, muscovite, phlogopite, synthetic mica, phlogopite, biotite, lithia mica, permiculite,
Magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, tungstate metal salt, magnesium, silica, zeolite, barium sulfate, calcined calcium sulfate, (calculated gypsum), calcium phosphate , Fluorapatite, Hydroxyapatite, Ceramic powder, Metal soap (Zinc myristate, Calcium palmitate, Aluminum stearate), Inorganic powder such as boron nitride, Polyamide resin powder (Nylon powder), Polyethylene powder, Polymethylmethacrylate powder, Polystyrene powder, styrene-acrylic acid copolymer resin powder, benzoguanamine resin powder, polytetrafluoroethylene powder, organic powder such as cellulose powder, titanium dioxide, inorganic white such as zinc oxide Pigments, iron oxide (red iron oxide),
Inorganic red pigments such as iron titanate, inorganic brown pigments such as γ-iron oxide, yellow iron oxide, inorganic yellow pigments such as ocher black iron oxide, carbon black, inorganic black pigments such as low order titanium oxide, Inorganic purple pigments such as mango violet and cobalt violet, inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate, inorganic blue pigments such as ultramarine blue and navy blue, titanium oxide coated mica, titanium oxide coated bismuth oxychloride. , Titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, pearl pigments such as fish scale foil, aluminum powder,
Metal powder pigments such as copper powder, Red No. 201, Red No. 202, Red No. 204, Red No. 205, Red 220
No., Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401
And organic pigments such as Blue No. 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230
No., Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3
And organic pigments such as barium or aluminum lakes such as No. 1 and Blue No. 1 and natural pigments such as chlorophyll and β-carotene. However, the powder is not limited to the above components as long as it is a powder applicable to general cosmetics.

The liquid oils and fats include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, southern oil, castor oil, linseed oil. Oil, safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, teaseed oil, kaya oil, rice bran oil, cinnamon oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin,
Examples thereof include glycerin trioctanoate and glycerin triisopalmitate.

Examples of solid fats and oils include cacao butter, coconut oil, horse fat, hardened coconut oil, palm oil, beef tallow, sheep fat, hardened beef tallow, palm kernel oil, pork fat, beef bone fat, sorghum kernel oil, hardened oil, Examples include beef tallow, mokuro, hydrogenated castor oil, and the like.

Examples of the waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ivota wax, whale wax, montan wax, nukarou, lanolin, capock wax, lanolin acetate, liquid lanolin, sugarcane wax, lanolin fatty acid isopropyl, hexyl laurate, and reduction. Lanolin, jojoba wax, hard lanolin, shellac wax, POE-lanolin alcohol ether, POE-lanolin alcohol acetate, POE-cholesterol ether, lanolin fatty acid polyethylene glycol, POE-hydrogenated lanolin alcohol ether and the like can be mentioned.

Examples of the hydrocarbon oil include liquid paraffin, ozokerite, squalene, pristane, paraffin, ceresin, squalene, petrolatum and microcrystalline wax.

Examples of the higher fatty acid include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall acid, isostearic acid, linoleic acid and linolein. Acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and the like.

The higher alcohols include, for example, straight chain alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol and cetostearyl alcohol, monostearyl glycerin ether (batyl alcohol), 2-decyltetradecyl alcohol. Examples thereof include branched chain alcohols such as knoll, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, and octyldodecanol.

The synthetic ester oils include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate,
Decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, 1
Cholesteryl 2-hydroxystearate, ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, diisostearyl malate, glycerin di-2-heptylundecanoate Trimethylolpropane tri-2-ethylhexylate, trimethylolpropane triisostearate, pentaneerythritol tetra-2-ethylhexylate, glycerin tri-2-ethylhexylate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glycerin trimyristate, glyceride tri-2-heptylundecanoate, castor oil fatty acid methyl ester, oleic acid oil, cetostearyl alcohol , Acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2 sebacate -Ethylhexyl, 2-hexyldecyl myristate, palmitic acid
Examples thereof include 2-hexyldecyl, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, ethyl acetate, butyl acetate, amyl acetate, triethyl citrate and the like.

Examples of the silicone include chain polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane, cyclic chains such as decamethylpolysiloxane, dodecamethylpolysiloxane, and tetramethyltetrahydrogenpolysiloxane. Examples thereof include polysiloxane, a silicone resin having a three-dimensional network structure, silicone rubber, and a trimethylsiloxysilicic acid-octamethylcyclotetrasiloxane solution (50%).

Examples of the anionic surfactant include a soap base, a fatty acid soap such as sodium laurate and sodium palmitate, a higher alkyl sulfate ester salt such as sodium lauryl sulfate and potassium lauryl sulfate, and POE-triethanolamine lauryl sulfate. , POE-alkyl ether sulfate salts such as sodium lauryl sulfate, N-acyl sarcosinic acid such as sodium lauroyl sarcosine, N-myristoyl-N-methyl taurine sodium, coconut oil fatty acid methyl tauride sodium, sodium lauryl methyl tauride etc. Higher fatty acid amide sulfonate, POE-sodium oleyl ether phosphate, POE-phosphate ester salts such as stearyl ether phosphate, sodium di-2-ethylhexyl sulfosuccinate,
Monolauroyl monoethanolamide sodium polyoxyethylene sulfosuccinate, sulfosuccinates such as sodium lauryl polypropylene glycol sulfosuccinate, sodium linear dodecylbenzene sulfonate,
Alkylbenzene sulfonates such as linear dodecylbenzene sulfonic acid triethanolamine, linear dodecyl benzene sulfonic acid, monosodium N-lauroyl glutamate, disodium N-stearoyl glutamate,
N-myristoyl-L-monosodium glutamate and other N-
Acyl glutamate, higher fatty acid ester sulfate ester salt such as hydrogenated coconut oil fatty acid glycerin sodium sulfate,
Sulfated oil such as funnel oil, POE-alkyl ether carboxylic acid, POE-alkyl allyl ether carboxylate, α-olefin sulfonate, higher fatty acid ester sulfonate, secondary alcohol sulfate ester salt, higher fatty acid alkylolamide Examples thereof include sulfate ester salts, sodium lauroyl monoethanolamide succinate, ditriethanolamine N-palmitoyl aspartate, and sodium caseinate.

Examples of the cationic surfactant include alkyltrimethylammonium salts such as stearyltrimethylammonium chloride and lauryltrimethylammonium chloride, distearyldimethylammonium dialkyldimethylammonium chloride and poly (N, N'-dimethyl chloride).
-3,5-methylenepiperidinium), an alkylpyridinium salt such as cetylpyridinium chloride, an alkyl quaternary ammonium salt, an alkyldimethylbenzylammonium salt, an alkylisoquinolinium salt, a dialkylmorphonium salt, a POE-alkylamine, Examples thereof include alkylamine salts, polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride and benzethonium chloride.

Examples of the amphoteric surfactant include 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-
Imidazoline amphoteric surfactants such as sodium imidazoline, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, 2-heptadecyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine And betaine-based surfactants such as lauryl dimethylamino acetic acid betaine, alkyl betaine, amidobetaine and sulfobetaine.

Examples of lipophilic nonionic surfactants include sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, Penta-2-ethylhexyl diglycerol sorbitan,
Tetra-2-ethylhexylate diglycerol sorbitan and other sorbitan fatty acid esters, monocotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, glyceryl monostearate, α, α'-glyceryl pyroglutamate oleate, glyceryl monostearate Examples thereof include glycerin polyglycerin fatty acid such as malic acid, propylene glycol fatty acid ester such as propylene glycol monostearate, hydrogenated castor oil derivative, and glycerin alkyl ether.

As the hydrophilic nonionic surfactant, for example, POE-sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate and other POE-sorbitan fatty acid esters, POE-sorbit monolaurate, POE-sorbit monooleate, POE-sorbit pentaoleate, POE-sorbit monostearate and other POE-sorbit fatty acid esters, POE-glycerin monostearate, POE-glycerin monoisostearate , POE-glycerin triisostearate and other POE-glycerin fatty acid esters, POE-monooleate, POE-distearate,
POE-monodioleate, POE-fatty acid esters such as ethylene glycol distearate, POE-lauryl ether, POE-oleyl ether, POE-stearyl ether,
POE-behenyl ether, POE-2-octyldodecyl ether, POE-cholestanol ether and other POE-alkyl ethers, POE-octylphenyl ether, POE-nonylphenyl ether, POE-dinonylphenyl ether and other PO
E-alkyl phenyl ethers, Pluronic types such as Bourronic, POE / POP cetyl ether, POE / POP-2
-POE / POP-alkyl ethers such as decyl tetradecyl ether, POE / POP-monobutyl ether, POE / POP-hydrogenated lanolin, POE / POP-glycerin ether, and tetra-POE / tetra-POP-ethylenediamine condensates such as Tetronic , POE-castor oil, POE-hardened castor oil, POE-hardened castor oil monoisostearate, POE-hardened castor oil triisostearate, POE-hardened castor oil monopyroglutamic acid monoisostearate diester, POE-hardened castor Oil POE-castor oil hardened castor oil derivative such as maleic acid, POE-Solubit beeswax and other POE- beeswax lanolin derivatives,
Palm oil fatty acid diethanolamide, lauric acid monoethanolamide, alkanolamides such as fatty acid isopropanolamide, POE-propylene glycol fatty acid ester, POE-alkylamine, POE-fatty acid amide, sucrose fatty acid ester, POE-nonylphenylformaldehyde condensate, Alkyl ethoxy dimethyl amine oxide, trioleyl phosphoric acid, etc. are mentioned.

Examples of moisturizers include polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-. Examples thereof include hydroxy stearate, sodium lactate, bile salts, dl-pyrrolidone carboxylate, short-chain soluble collagen, diglycerin (EO) PO adduct, Isaioba rose extract, Yarrow millet extract and Merrilot extract.

Examples of natural water-soluble polymers include, for example, araavia gum, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (quince), arge colloid (cassius extract), starch (rice, corn, Potato, wheat), plant-based polymers such as glycyrrhizinate, microbial-based polymers such as xanthan gum, dextran, succinoglucan, and vullan, collagen,
Animal-based polymers such as casein, albumin and gelatin can be mentioned.

As the semi-synthetic water-soluble polymer, for example,
Starch-based polymers such as carboxymethyl starch and methyl hydroxypropyl starch, methyl cellulose, nitrocellulose, ethyl cellulose, methyl hydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, hydroxypropyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, crystalline cellulose, cellulose powder And the like, and alginic acid-based polymers such as sodium alginate and propylene glycol alginate.

Examples of the synthetic water-soluble polymer include polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, vinyl polymers such as carboxyvinyl polymer (Carbopol), and polyethylene glycol.
Polyoxyethylene-based polymers such as 20,000, 40,000 and 60,000, polyoxyethylene-polyoxypropylene copolymer copolymer-based polymers, sodium-acrylate, polyethyl acrylate, acrylic polymers such as polyacrylamide, polyethyleneimine, Examples include cationic polymers.

Examples of the inorganic water-soluble polymer include bentonite, silicic acid A1Mg (veegum), laponite, hectorite, silicic acid anhydride and the like.

Examples of the thickener include gum arabic,
Carrageenan, karaya gum, tragacanth gum, carob gum, quince seed (quince), casein, dextrin, gelatin, sodium pectate, sodium alginate, methyl cellulose, ethyl cellulose,
CMC, hydroxyethyl cellulose, hydroxypropyl cellulose, PVA, PVM, PVP, sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, dialkyldimethylammonium sulfate cellulose, xanthan gum, magnesium aluminum silicate, bentonite,
Hectorite and the like can be mentioned.

Examples of the ultraviolet absorber include para-aminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N,
N-diethoxy PABA ethyl ester, N, N-dimethyl PABA ethyl ester, N, N-dimethyl PABA butyl ester, N, N-
Benzoic acid-based UV absorbers such as dimethyl PABA ethyl ester, anthranilate-based UV absorbers such as homomenthyl-N-acetylanthranilate, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p -Salicylic acid type UV absorbers such as isopropanol phenyl salicylate, octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-
Diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl- p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2- Ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-
Cinnamic acid-based ultraviolet absorbers such as diparamethoxycinnamate, 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-
4,4'-dimethoxybenzophenone, 2,2 ', 4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4 -Methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxy Benzophenone-based UV absorbers such as benzophenone, 3- (4'-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor, urocanic acid, urocanic acid ethyl ester, 2-phenyl-5-methyl Benzoxazole, 2,2'-hydroxy-5
-Methylphenylbenzotriazole, 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole, 2-
(2'-hydroxy-5'-methylphenylbenzotriazole, dibenzalazine, dianisoylmethane, 4-methoxy
-4'-t-butyldibenzoylmethane, 5- (3,3-dimethyl-2-
Norbornylidene) -3-pentan-2-one and the like.

Examples of the sequestering agent include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, edetate disodium, edetate trisodium, and edet. Tetrasodium acid, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid,
Examples thereof include ascorbic acid, succinic acid, edetic acid, trisodium ethylenediamine hydroxyethyl triacetate and the like.

As the lower alcohol, for example, methanol, ethanol, propanol, isopropanol,
Examples thereof include isobutyl alcohol and t-butyl alcohol.

Examples of polyhydric alcohols are ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, 2,3-butylene glycol, pentamethylene. Glycol, 2-butene-1,4-diol, dihydric alcohol such as hexylene glycol and octylene glycol, trihydric alcohol such as glycerin, trimethylolpropane and 1,2,6-hexanetriol, pentaerythritol. Etc., tetravalent alcohols such as xylitol, hexavalent alcohols such as sorbitol, mannitol, diethylene glycol, dipropylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol, diglycerin, polyethylene glycol. Polyol, triglycerin, tetraglycerin, polyglycerin and other polyhydric alcohol polymers, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether,
Dihydric alcohol alkyl ethers such as ethylene glycol mono 2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, ethylene glycol isopropyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, diethylene glycol monomethyl ether , Diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, Dihydric alcohol alkyl ethers such as ropylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether and dipropylene glycol butyl ether, ethylene glycol monomethyl ether Acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diadibate, ethylene glycol disuccinate, diethylene glycol monoethyl ether state, diethylene glycol monobutyl ether acetate , Dihydric alcohol ether esters such as propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propylene glycol monophenyl ether acetate, etc., glycerin monoalkyl such as xyl alcohol, ceracyl alcohol, batyl alcohol, etc. Ether, sorbitol, maltitol, maltotriose, mannitol, sucrose, erythritol,
Glucose, fructose, starch-degrading sugar, maltose, xylitose, starch-degrading sugar Sugar alcohol such as reducing alcohol, glycolid, tetrahydrofurfuryl alcohol, POE tetrahydrofurfuryl alcohol, POP-butyl ether, POP / POE-butyl ether, tripolyoxy Propylene glycerin ether, POP-glycerin ether, POP-glycerin ether phosphoric acid, POP
Examples thereof include POE-pentane erythritol ether.

Examples of monosaccharides include tricarbon sugars such as D-glyceryl aldehyde and dihydroxyacetone, tetracarbon sugars such as D-erythrose, D-erythrulose, D-threose and erythritol, L-arabinose and D-xylose. L-lyxose, D-arabinose, D-ribose, D-ribulose,
Pentose sugars such as D-xylulose and L-xylulose, D-glucose, D-talose, D-busicose, D-galactose, D-
Fructose, L-galactose, L-mannose, D-tagatose and other hexoses, aldoheptose, heptulose and other heptasaccharides, octulose and other octose sugars, 2-deoxy-D-ribose, 6-deoxy-L-galactose , Deoxy sugars such as 6-deoxy-L-mannose, D-glucosamine, D-galactosamine, sialic acid, aminouronic acid, amino sugars such as muramic acid, D-glucuronic acid, D-mannuronic acid, L-guluronic acid, D -Examples include uronic acids such as galacturonic acid and L-iduronic acid.

Examples of oligosaccharides include sucrose, guanthianose, umbelliferose, lactose, planteose, isoliknoses, α, α-trehalose,
Raffinose, lychnose, umbilicin, stachyose bell bass course, etc. may be mentioned.

Examples of the polysaccharides include cellulose, quince seed, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, gum arabic, heparan sulfate, hyaluronic acid, tragacanth gum, keratan sulfate, chondroitin, xanthan gum, mucoitin sulfate, guar gum and dextran. , Keratosulfate, locust bingham, succinoglucan, caronic acid and the like.

Examples of amino acids include glycine, valine, leucine, isoleucine, threonine, tryptophan, cystine, cysteine, methionine, proline,
Examples thereof include neutral amino acids such as hydroxyproline, acidic amino acids such as aspartic acid, glutamic acid, asparagine and glutamine, and basic amino acids such as arginine, histidine, lysine and hydroxylysine. Examples of amino acid derivatives include sodium acylsarcosine (sodium lauroylsarcosine), acylglutamate, sodium β-alanine acyl, glutathione, and pyrrolidonecarboxylic acid.

Examples of the organic amine include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-1. -Propanol and the like can be mentioned.

As the synthetic resin emulsion, for example,
Examples thereof include acrylic resin emulsion, polyethyl acrylate emulsion, acrylic resin solution, polyacrylic alkyl ester emulsion, and polyvinyl acetate resin emulsion.

Examples of the pH adjusting agent include buffers such as lactic acid-sodium lactate and citric acid-sodium citrate.

Examples of vitamins include vitamins A, B1, B2, B6, E and derivatives thereof, pantothenic acid and derivatives thereof, biotin and the like.

Examples of the antioxidant include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, gallic acid esters and the like.

As the antioxidant aid, for example, phosphoric acid,
Examples thereof include citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, kephalin, hexametaphosphate, phytic acid and ethylenediaminetetraacetic acid.

Other components that can be blended include preservatives such as ethylparaben and butylparaben, glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, and the like.
Anti-inflammatory agents such as hinokitiol, zinc oxide, allantoin,
Whitening agents such as placenta extract, Yukinoshita extract, psyllium,
Of Coptis, Sikon, Peony, Assemblage, Birch, Sage, Loquat, Carrot, Aloe, Mallow, Iris, Grapes, Yokuinin, Loofah, Lily, Saffron, Senkyu, Ginger, Hypericum, Ononis, Garlic, Capsicum, Chili, Touki etc. Extract, royal jelly, photosensitizer, cholesterol derivative, activator of juvenile blood extract, nonyl acid warenylamide, nicotinic acid benzyl ester, nicotinic acid β-butoxyethyl ester, capsaicin, zingerone, cantharisin tincture, ictamol, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, cyclanderate, cinnarizine, tolazoline,
Examples include blood circulation promoters such as acetylcholine, verapamil, cepharanthin and γ-oryzanol, antiseborrheic agents such as sulfur and thiantol, tranexamic acid, thiotaurine, and hypotaurine.

The dosage form of the external preparation for skin of the present invention is arbitrary,
For example, a solubilizing system such as lotion, an emulsifying system such as emulsion or cream, or an arbitrary dosage form such as ointment or dispersion can be employed.

[0055]

EXAMPLES Next, the present invention will be described in more detail with reference to examples. The present invention is not limited to this. The blending amount is% by weight. Prior to the examples, the effect test method and evaluation method of the present invention will be described.

(1) Lipid-degrading effect test and evaluation method Adipocytes were isolated from adipose tissue by the method of Rodbell (M.
Rodbell, J. B. C. , 239 (2), 1964). Human adipose tissue obtained by liposuction into 2-3 mm strips,
Incubation (37 ° C, 45-60) in 0.05% collagenase solution (Banks buffer, containing 4% glucose).
Minutes) Then, it was filtered to remove undigested adipose tissue and centrifuged (1000 rpm, 1 minute). Since the specific gravity of adipocytes is less than 1, they float above. The lower layer solution was removed, a culture solution (199 medium, containing 10% newborn calf serum) was added, and redispersed. The centrifugation and medium addition were repeated twice to remove collagenase. Finally, 30 ml of the medium described in "Table 1" was added to disperse the cells, and the cells were cultivated for 1 day in rotation. In each sample, the seaweed extract was 0.2% by weight, and the specific compound was 0.5% by weight. The lipid content of adipocytes before and after the culture was quantified using Triglyceride-Test Wako (Wako Pure Chemical Industries, Ltd.) (color reagent for lipid quantification) to measure the amount of degraded lipid (mg / tube). The measurement results are shown in "Table 1". In addition, the above seaweed extract is the finely chopped 20 types of seaweed of the five types shown in (1) above.
500 ml of water was added to 100 g of each g, extracted at 50 ° C. for 60 minutes, cooled, naturally filtered with filter paper, and water was added to bring the total amount to 500 ml, and the seaweed extract was used.

[0057]

[Table 1] -------------------------------------------------- ---------------------           Sample Degraded lipid amount (mg / tube) -------------------------------------------------- ---------------------           Not added 1.20 ± 0.18 -------------------------------------------------- ---------------------        Seaweed extract 3.50 ± 0.56 -------------------------------------------------- ---------------------        Seaweed extract + trimethylglycine 5.55 ± 0.30 -------------------------------------------------- ---------------------        Seaweed extract + L-alanine 5.65 ± 0.45 -------------------------------------------------- ---------------------        Seaweed extract + L-serine 6.45 ± 0.89 -------------------------------------------------- ---------------------

It is understood from "Table 1" that the lipolytic effect is promoted when the extract of all five types of seaweed and any one of serine, L-alanine and L-trimethylglycine are blended.

(2) Lipid metabolism accelerating effect test, skin roughening improving effect test and evaluation method The cream of Example 1 described below was applied to 100 women in their 20s to 30s on their whole body in the morning and evening, and they were continuously used for 3 months. The body fat percentage (ratio of fat to the whole body) before and after continuous use was measured by a measuring device (body fat meter BFT-2000, manufactured by Kett Science Co., Ltd.) based on the principle of light reflection of an external infrared wavelength. 40 out of 100 were used as a control group from which trimethylglycine was removed, and the average value of each body fat percentage was calculated. The results are shown in "Table 3". In addition, the degree of rough skin of the legs was evaluated in four levels according to the evaluation criteria of "Table 2", and the results are shown in "Table 4".

[0060]

[Table 2] "Roughness of the skin" -------------------------------------------------- --------------     Score observation state -------------------------------------------------- --------------       0 No rough skin on the legs       1 The skin is slightly rough on one leg       2 There is rough skin on the legs       3 The skin is rough as if all the legs were dusted -------------------------------------------------- --------------

[0061]

[Table 3] "Changes in body fat percentage" -------------------------------------------------- --------------                             Before continuous use After continuous use -------------------------------------------------- --------------   Control 35.5 ± 8.3% 34.2 ± 5.0%   Example 1 37.5 ± 5.3% 30.6 ± 7.9% -------------------------------------------------- --------------

[0062]

[Table 4] "Rough skin improvement effect" -------------------------------------------------- --------------                             Before continuous use After continuous use -------------------------------------------------- --------------   Control 3.1 ± 1.2 3.5 ± 1.5   Example 1 3.3 ± 1.8 4.2 ± 1.2 -------------------------------------------------- --------------

As is clear from the results of "Table 3" and "Table 4," the examples of the present invention have a lower body fat percentage and a remarkable effect of improving rough skin in comparison with the control.

Examples of the external preparation for skin of the present invention will be shown below.

Example 1 Cream (1) 3.5% by weight cetostearyl alcohol (2) Squalane 40.0 (3) Beeswax 3.0 (4) Reduced lanolin 5.0 (5) Ethylparaben 0.3 (6) ) Polyoxyethylene (20) sorbitan monopalmitate 2.0 (7) stearic acid monoglyceride 2.0 (8) sodium N-stearoylglutamate 0.5 (9) 2-hydroxy-4-methoxybenzophenone 1.0 ( 10) Fragrance 0.05 (11) Seaweed extract 1.0 (12) Trimethylglycine 0.2 (13) 1,3-Butylene glycol 0.1 (14) Purified water Residue (production method) (1) ~ (10) was dissolved by heating and heated to 70 ℃ (1
Add to 1) to (14) while stirring. The mixture was treated with a homomixer to make the emulsified particles finer, and then rapidly cooled with stirring to obtain a cream. The above seaweed extract was added with 500 ml of 30V / V% ethanol solution to a total of 100 g of each 5 g of seaweed shredded and extracted at 50 ° C. for 60 minutes,
After cooling, naturally filter with filter paper and add water to a total volume of 500 m.
The seaweed extract designated as 1 was used.

Example 2 Lotion (1) Seaweed extract 0.5% by weight (2) Trimethylglycine 0.5 (3) Caffeine 0.1 (4) Glycerin 4.0 (5) 1,3-Butylene Glycol 4.0 (6) Tocopherol acetate 0.05 (7) Ethanol 7.0 (8) Polyoxyethylene (18) Oleyl alcohol ether 0.5 (9) Methylparaben 0.2 (10) Citric acid 0. 05 (11) Sodium citrate 0.1 (12) Ethylenediaminetetraacetic acid trisodium 0.02 (13) Perfume 0.05 (14) Purified water Residue (manufacturing method) Purified water (1) to (5), ( Dissolve 10) to (12) (aqueous phase). Separately from (7) to (6), (8),
(9) and (13) were dissolved, and this was added to the aforementioned aqueous phase to solubilize it, and filtered to obtain a lotion. In addition, the above seaweed extract was added with 100 ml of an ethanol solution to a total of 50 g each of 5 g of seaweed finely chopped 10 g, and extracted at room temperature overnight.
After natural filtration with filter paper, add air tonol for a total volume of 200
The seaweed extract made into ml was used.

Example 3 Emulsion (1) Stearic Acid 1.5% by Weight (2) Cetyl Alcohol 0.5 (3) Beeswax 2.0 (4) Polyoxyethylene (10) Monooleate 1.0 (5) ) Octyl methoxycinnamate 2.0 (6) Seaweed extract 0.2 (7) L-serine 0.5 (8) Sodium hyaluronate 0.01 (9) Triethanolamine 0.75 (10) Glycerin 7.0 (11) ) Inosit 0.5 (12) 1,3-butylene glycol 0.5 (13) DL-alanine 0.2 (14) Ethylenediaminehydroxyethyl triacetate trisodium 0.01 (15) Ethylparaben 0.3 (16) Perfume 0 .03 (17) Purified water Add (6) to (14) to the residue (manufacturing method) (17) and keep at 70 ° C (aqueous phase). Other ingredients are mixed, dissolved by heating and kept at 70 ° C (oil phase). The oil phase is added to the aqueous phase for preliminary emulsification, and the mixture is uniformly emulsified with a homomixer. Then, it was rapidly cooled with stirring to obtain an emulsion. In addition, the above seaweed extract is 100m of ethanol solution in a total of 50g of 5g seaweed 10g each.
l, extracted at room temperature for 24 hours, filtered naturally with filter paper,
A seaweed extract solution was prepared by adding aeranol to a total volume of 200 ml.

Example 4 Foam pack (1) L-arginine 0.1% by weight (2) Seaweed extract 1.0 (3) DL-serine 0.2 (4) Sodium metaphosphate 0.02 (5) Trehalose 2.0 (6) Glycerin 7.0 (7) Methylparaben 0.1 (8) Potassium hydroxide 0.15 (9) Stearic acid 0.5 (10) Myristic acid 1.0 (11) Batyl alcohol 1.5 (12) Polyoxyethylene (60) Hydrogenated castor oil 3.0 (13) Perfume 0.05 (14) Liquefied petroleum gas 6.0 (15) Dimethyl ether 3.0 (16) Purified water Residue (production method) (16) (1) to (8) are added to () and dissolved by heating at 70 ° C, and (9) to (13) heated and stirred at 75 ° C are added thereto, and the mixture is sufficiently stirred and then cooled. This was filled in a container, and finally (14) and (15) were filled as a propellant to obtain a foam pack. The above seaweed extract was added with 100 ml of 1,3-butylene glycol solution in a total of 50 g of 10 g of each of the 5 types of seaweed shreds, extracted at 50 ° C. for 60 minutes, cooled, and naturally filtered with filter paper, A seaweed extract solution was prepared by adding 1,3-butylene glycol to a total volume of 200 ml.

Example 5 Ointment (1) Seaweed extract 10.0% by weight (2) Rosemary extract 1.0 (3) Trehalose 0.2 (4) Trimethylglycine 0.2 (5) Ethylenediamine hydroxyethyl ternary Acetic acid trisodium 0.01 (6) Retinol palmitate 0.5 (7) Stearyl alcohol 18.0 (8) Moku 20.0 (9) Polyoxyethylene (20) monooleate 0.25 (10) Glycerin Monostearic acid ester 0.3 (11) Vaseline 40.0 (12) Purified water Add (1) to (5) to the residue (production method) (12), dissolve and maintain at 70 ° C (aqueous phase). The remaining components (6) to (11) are mixed and dissolved at 70 ° C (oil phase). The oil phase was added to the aqueous phase, and the mixture was uniformly emulsified with a homomixer and then cooled to obtain an ointment. The above seaweed extract is a total of 5 pieces of seaweed 10 g
100 ml of ethanol was added to 0 g, and the mixture was extracted at room temperature for one day and then filtered naturally with filter paper.
A 0 ml seaweed extract was used.

Example 6 Emulsion for massage (1) Stearic acid 1.5% by weight (2) Cetyl alcohol 0.5 (3) Polyoxyethylene (10) monooleate 1.0 (4) Vaseline 3.0 (5) Squalane 10.0 (6) Liquid paraffin 5.0 (7) Glycerin 7.0 (8) Glutathione 0.2 (9) Triethanolamine 0.75 (10) L-serine 0.05 (11) Seaweed extract 1.0 (12) Green tea extract 3.0 (13) Trehalose 2.0 (14) Sodium metaphosphate 0.02 (15) Ethylenediaminehydroxyethyl trisodium triacetate 0.01 (16) Ethylparaben 0 25 (17) Perfume 0.02 (18) Purified water Add (7) to (15) to the residue (production method) (18) and keep at 70 ° C (water phase). Other ingredients are mixed, dissolved by heating and kept at 70 ° C (oil phase). The oil phase is added to the aqueous phase for preliminary emulsification, and the mixture is uniformly emulsified with a homomixer. Then, it was rapidly cooled with stirring to obtain a milky lotion for massage. The above seaweed extract is 5
1 g of seaweed of each kind, 1 g of ethanol for 50 g in total
The seaweed extract was added with 00 ml, extracted at room temperature for one day, filtered naturally with filter paper, and added with ethanol to a total volume of 200 ml.

Example 7 Massage Gel (1) Erythritol 2.0% by Weight (2) Seaweed Extract 5.0 (3) Oat Extract 3.0 (4) Glycerin 50.0 (5) Trimethylglycine 0.1. 2 (6) Carboxyvinyl polymer 0.40 (7) Polyethylene glycol 400 30.0 (8) Ethylenediamine hydroxyethyl trisodium trisodium 0.1 (9) Polyoxyethylene (10) methylpolysiloxane copolymer 2. 0 (10) Squalane 1.0 (11) Perfume 0.12 (12) Potassium hydroxide 0.15 (13) Purified water Dissolve (1) to (8) in the residue (production method) (13). Apart (9)
After adding a mixture of ~ (11), (12) was added to obtain a massage gel. In addition, the above seaweed extract is 1,3 in a total of 50g of 5g seaweed 10g each
-Add 100 ml of butylene glycol solution, extract at 30 ° C for 20 minutes, cool, and then naturally filter with filter paper to give 1,3-
A seaweed extract solution was prepared by adding butylene glycol to a total volume of 200 ml.

Example 8 Beauty essence (1) Seaweed extract 20.0% by weight (2) Tranexamic acid 1.0 (3) Rosemary extract 0.1 (4) L-serine 0.1 (5) Hyaluronic acid Sodium acid salt 0.01 (6) Glycerin 10.0 (7) Erythrilol 5.0 (8) Carboxyvinyl polymer 0.3 (9) Ethylenediaminehydroxyethyl triacetate trisodium 0.01 (10) Ethanol 7.0 ( 11) Polyoxyethylene (18) oleyl alcohol ether 0.8 (12) Macadamia nut oil 0.1 (13) Evening primrose oil 0.01 (14) Tocopherol acetate 0.01 (15) Methylparaben 0.15 (16) Perfume 0 1 (17) Potassium hydroxide 0.08 (18) Purified water Dissolve (1) to (9) in the residue (production method) (18), and separately dissolve (11) to (16) in (10) Add what was done. Then (1
7) was added to obtain a serum. In addition, the above seaweed extract was added with 100 ml of an ethanol solution to a total of 50 g each of 10 g of finely chopped seaweed, and extracted at room temperature all day and night, naturally filtered with a filter paper, and added with air ethanol to obtain a total amount of 200 m.
The seaweed extract designated as 1 was used.

[0073]

EFFECTS OF THE INVENTION According to the present invention, an external preparation for skin having an extremely excellent lipid decomposition promoting effect and skin roughening improving effect can be provided.

─────────────────────────────────────────────────── ─── Continuation of front page (56) References JP-A-9-301821 (JP, A) JP-A-9-255552 (JP, A) (58) Fields investigated (Int.Cl. ⁷ , DB name) A61K 7/00 ADN

Claims (4)

(57) [Claims] 1. An external preparation for skin comprising the extract of all five kinds of seaweed shown in (1) below and at least one of the specific compounds shown in (2) below. (1) Mitsuishikonbu, seaweed, giraffe, hijirimen, usubaonori. (2) serine, alanine, Torimechirugurishi down. 2. The skin external preparation according to claim 1, wherein the content of the seaweed extract is 0.001 to 30.0% by weight based on the total amount of the skin external preparation. 3. The extraction solvent of the seaweed extract is one or more kinds of extraction solvent selected from the group consisting of water, ethanol and 1,3-butylene glycol. Or the external skin preparation described in 2. 4. The skin external preparation is a skin for promoting lipid decomposition.
4. An external preparation, which is characterized in that it is an external preparation.
External skin preparations listed.