WO2023002847A1 - Oil dispersion composition - Google Patents

Oil dispersion composition Download PDF

Info

Publication number
WO2023002847A1
WO2023002847A1 PCT/JP2022/026783 JP2022026783W WO2023002847A1 WO 2023002847 A1 WO2023002847 A1 WO 2023002847A1 JP 2022026783 W JP2022026783 W JP 2022026783W WO 2023002847 A1 WO2023002847 A1 WO 2023002847A1
Authority
WO
WIPO (PCT)
Prior art keywords
oil
mass
acid
particles
agar gel
Prior art date
Application number
PCT/JP2022/026783
Other languages
French (fr)
Japanese (ja)
Inventor
孝太 鴛渕
Original Assignee
株式会社 資生堂
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社 資生堂 filed Critical 株式会社 資生堂
Priority to CN202280043841.3A priority Critical patent/CN117545460A/en
Priority to JP2023536681A priority patent/JPWO2023002847A1/ja
Publication of WO2023002847A1 publication Critical patent/WO2023002847A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/256—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from seaweeds, e.g. alginates, agar or carrageenan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/52—Natural or synthetic resins or their salts

Definitions

  • the present disclosure relates to compositions in which an oil phase is dispersed.
  • emulsification (dispersion) of the oil is usually performed using a surfactant.
  • a technique for dispersing oil by the action of is also known (see, for example, Patent Document 1).
  • Patent Document 1 discloses an aqueous phase, an oil phase having an average particle size of 4 ⁇ m to 130 ⁇ m, and agar sol fine particles having an average particle size of 65 nm to 140 nm. (20° C.) of 31.5 cp (mPa ⁇ s) to 176.8 cp are described.
  • the oil phase is dispersed (emulsified) in an agar sol fine particle aqueous solution using a homogenizer.
  • a first aspect of the present disclosure provides an oil-dispersed composition containing water, agar, and oil particles. At least a portion of the water and the agar form agar gel particles.
  • the average particle size of the agar gel particles is 10 ⁇ m to 150 ⁇ m.
  • the average particle size of the oil particles is 200 ⁇ m to 2,000 ⁇ m.
  • a plurality of agar gel particles surround one oil particle.
  • Agar is 8 ⁇ 10 ⁇ 3 parts by mass or more per 1 part by mass of water.
  • oil particles can be stably dispersed with agar gel particles.
  • part of the water exists outside the agar gel particles.
  • the agar gel particles have at least one needle-like portion protruding from the surface.
  • the total amount of agar gel particles is 2 parts by mass or more with respect to 1 part by mass of the total amount of oil particles.
  • the composition has a viscosity of 2,000 mPa ⁇ s to 100,000 mPa ⁇ s at 30°C.
  • the plurality of agar gel particles before surrounding the oil particles have a viscosity of 3,000 mPa ⁇ s to 100,000 mPa ⁇ s at 30°C.
  • the oil particles are liquid at 25°C under atmospheric pressure.
  • the content of oil particles is 5% by mass to 35% by mass with respect to the mass of the composition.
  • the surfactant content is 1% by mass or less with respect to the mass of the composition.
  • the content of the thickener is 1% by mass or less with respect to the mass of the composition.
  • the agar gel particles do not enclose an oily component in the particles.
  • the oil particles contain at least one selected from the group consisting of hydrocarbons, ester oils, silicone oils, fluorine oils, higher alcohols, higher fatty acids, and fats and oils.
  • the composition is applied as an external preparation for skin.
  • the oil particles contain ⁇ -linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid, linoleic acid, ⁇ -linolenic acid, oleic acid, myristoleic acid, eicosenoic acid, and lauric acid.
  • ricinoleic acid stearic acid, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, olive oil, rapeseed oil, avocado, cod liver oil, sardine oil, corn oil, soybean oil, salad oil, perilla oil, linseed oil, vitamins, polyphenols, and At least one selected from the group consisting of carotenoids.
  • the composition is applied to food and drink.
  • POE is an abbreviation for polyoxyethylene
  • POP is an abbreviation for polyoxypropylene
  • the number in parentheses after POE or POP represents the average number of added moles of POE or POP groups in the compound.
  • the term “substantial amount” refers to the amount in which the addition of the compound can produce an effect.
  • liquid refers to a substance that is liquid at 25°C and has fluidity.
  • the oil dispersion composition of the present disclosure contains water, agar, and oil particles. At least a portion of the water and the agar form agar gel particles. A plurality of agar gel particles surround one oil particle. Thereby, a plurality of oil particles are dispersed in the composition.
  • Compositions of the present disclosure can be considered to have a morphology similar to oil-in-water compositions. However, in compositions of the present disclosure, an aqueous phase may not be present.
  • composition of the present disclosure may be equated with an oil-in-water composition
  • the oil particles may be referred to as the internal phase
  • the phase containing the agar gel surrounding the oil particles may be referred to as the external phase.
  • Agar gel particles can have irregular shapes.
  • One agar gel particle may have at least one spicule protruding from the surface. The shape of the agar gel particles can be observed with a microscope.
  • the agar gel particles surrounding the oil particles preferably have an average particle size of 10 ⁇ m or more.
  • the average particle size of the agar gel particles surrounding the oil particles can be, for example, 20 ⁇ m or more, or 50 ⁇ m or more. If the average particle size of the agar gel particles is less than 10 ⁇ m, it becomes difficult to stably disperse the oil particles.
  • the agar gel particles surrounding the oil particles preferably have an average particle size of 150 ⁇ m or less.
  • the average particle size of the agar gel particles surrounding the oil particles can be, for example, 130 ⁇ m or less, or 110 ⁇ m or less.
  • the average particle size of the agar gel particles surrounding the oil particles can be the average value of the particle sizes of arbitrary 100 oil particles measured by microscopic observation.
  • the average particle size of the agar gel particles can be calculated by measuring the longest particle size including the acicular portion of any 100 agar gel particles.
  • agar is 8 ⁇ 10 -3 parts by weight or more, preferably 1 ⁇ 10 -2 parts by weight or more, more preferably 1.5 ⁇ 10 -2 parts by weight, relative to 1 part by weight of water That's it.
  • Agar is, for example, 2 ⁇ 10 -2 parts by weight or more, 2.5 ⁇ 10 -2 parts by weight or more, 3 ⁇ 10 -2 parts by weight or more, 3.5 ⁇ 10 -2 parts by weight with respect to 1 part by weight of water parts or more, or 4 ⁇ 10 ⁇ 2 parts by mass or more.
  • Agar is, for example, 0.1 parts by mass or less, 0.08 parts by mass or less, 0.05 parts by mass or less, 0.03 parts by mass or less, or 0.02 parts by mass or less with respect to 1 part by mass of water. be able to.
  • Agar gel particles useful for the oil-dispersed composition of the present disclosure should be allowed to be specified by their production method when it is impossible to directly specify them by their composition, structure, etc.
  • the total amount of agar gel particles is preferably 2 parts by mass or more with respect to 1 part by mass of the total amount of oil particles.
  • the total amount of agar gel particles is, for example, 2.5 parts by mass or more, 3 parts by mass or more, 4 parts by mass or more, 5 parts by mass or more, or 6 parts by mass or more with respect to 1 part by mass of the total amount of oil particles. can be done. If the total amount of the agar gel particles is less than 2 parts by mass, the ability to disperse the oil particles may be reduced.
  • the total amount of agar gel particles can be, for example, 12 parts by mass or less, 10 parts by mass or less, 8 parts by mass or less, 6 parts by mass or less, or 5 parts by mass or less with respect to 1 part by mass of the total amount of oil particles. .
  • Agar is preferably 0.5% by mass or more with respect to the mass of the external phase.
  • Agar is, for example, 0.8% by mass or more, 1% by mass or more, 1.5% by mass or more, 2% by mass or more, 2.5% by mass or more, 3% by mass or more, or 3% by mass or more with respect to the mass of the external phase .5% by mass or more. If the agar content is less than 0.5% by mass, the water content of the agar gel will be low and the viscosity will be low, and the oil particles will not be stably supported.
  • the content of agar is preferably 10% by mass or less with respect to the mass of the external phase.
  • Agar can be, for example, 8% or less, 6% or less, 5% or less, 4% or less, 3% or less, or 2% or less by weight relative to the weight of the external phase. If the agar content exceeds 10% by mass, it becomes hard and difficult to apply.
  • the water content of the agar gel is preferably 85% by mass or more.
  • the water content of the agar gel can be 90% by mass or more, 95% by mass or more, or 100% by mass.
  • the water content as used herein is the ratio of the mass of the aqueous solvent (bound water) contained in the agar gel to the mass of the aqueous solvent blended during the preparation of the agar gel.
  • the water content of agar gel can be calculated from the following formula.
  • Moisture content (%) ⁇ (mass of blended aqueous solvent-mass of aqueous solvent dropped from sieve by sieving prepared agar gel)/mass of blended aqueous solvent ⁇ x 100
  • Agar gel particles (aggregates) that do not surround oil particles preferably have a viscosity of 3,000 mPa ⁇ s or more at 30°C.
  • the viscosities of agar gel particles (aggregates) that do not surround oil particles are 5,000 mPa s or more, 8,000 mPa s or more, 10,000 mPa s or more, 20,000 mPa s or more, 40 ,000 mPa ⁇ s or more, or 60,000 mPa ⁇ s or more. If the viscosity of the external phase is less than 3,000 mPa ⁇ s, the ability to disperse oil particles will be reduced.
  • the agar gel particles (aggregates) that do not surround the oil particles preferably have a viscosity of 100,000 mPa ⁇ s or less at 30°C.
  • the viscosity of agar gel particles (aggregates) that do not surround oil particles is 80,000 mPa s or less, 60,000 mPa s or less, 40,000 mPa s or less, 20,000 mPa s or less, 10 ,000 mPa ⁇ s or less, or 8,000 mPa ⁇ s or less. If the viscosity of the external phase exceeds 100,000 mPa ⁇ s, the viscosity of the composition increases, making it difficult to apply.
  • the viscosity of the agar gel particles may be the viscosity at 30° C. 60 seconds after the start of measurement with a Brookfield viscometer (rotor number 22, rotation speed 12 rpm) 24 hours after the agar gel particles are produced. can.
  • the agar gel does not contain oily components.
  • the agar gel can contain the water-soluble components listed below.
  • the external phase can contain an aqueous component on the outside of the agar gel particles.
  • aqueous components include water, lower alcohols, polyhydric alcohols, preservatives, drugs, chelating agents, pH buffers, sugars, and the like.
  • water used for cosmetics, quasi-drugs, etc. can be used, for example, purified water, ion-exchanged water, tap water, etc. can be used.
  • lower alcohols examples include ethanol, propanol, isopropanol, isobutyl alcohol, t-butyl alcohol and the like.
  • liquid polyhydric alcohols examples include glycerin, 1,3-butylene glycol, polyethylene glycol, diglycerin, and dipropylene glycol.
  • the aqueous component can be, for example, 1% by mass or more, 5% by mass or more, 10% by mass or more, 15% by mass or more, 20% by mass or more, or 25% by mass or more with respect to the mass of the composition.
  • the aqueous component is, for example, 35% by mass or less, 30% by mass or less, 25% by mass or less, 20% by mass or less, 15% by mass or less, 10% by mass or less, or 5% by mass or less with respect to the mass of the composition. can do.
  • the content of the aqueous component can be appropriately set according to the use of the composition.
  • the content of the external phase can be set according to the content of the internal phase.
  • the external phase can be, for example, 65% or more, 70% or more, 75% or more, 80% or more, 85% or more, or 90% or more by weight of the composition.
  • the external phase is, for example, 95% by mass or less, 90% by mass or less, 85% by mass or less, 80% by mass or less, 75% by mass or less, 70% by mass or less, or 65% by mass or less with respect to the mass of the composition. be able to.
  • the oil particles which are the internal phase, are preferably liquid at atmospheric pressure and 25°C.
  • the liquid oily component is preferably at least one selected from the group consisting of fluorine oils, silicone oils, hydrocarbon oils, ester oils, higher alcohols, higher fatty acids and fats and oils.
  • liquid oily components include, for example, dimethicone, hydrogenated polydecene, triethylhexanoin, ethylhexyl methoxycinnamate, squalane, mineral oil, and cetyl ethylhexanoate. , petroleum jelly and the like.
  • liquid oily components include, for example, ⁇ -linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid, linoleic acid, ⁇ -linolenic acid, oleic acid, mili Strain acid, eicosenoic acid, lauric acid, ricinoleic acid, stearic acid, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, olive oil, rapeseed oil, avocado, cod liver oil, sardine oil, corn oil, soybean oil, salad oil, perilla oil, linseed oil , vitamins, polyphenols, and carotenoids.
  • the internal phase can contain solid oil.
  • a solid oil can be dispersed by dissolving it in a liquid oil, or by making it into a molten state at the time of dispersion.
  • oil dispersion composition of the present disclosure can also contain oily components other than the above oily components.
  • oily components that can be used include oil-soluble ultraviolet absorbers, waxes, liquid fats and oils, solid fats and oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, synthetic ester oils, and silicone oils.
  • oil-soluble UV absorbers examples include benzoic acid-based UV absorbers (e.g., para-aminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N,N-dipropoxy PABA ethyl ester, N,N-diethoxy PABA ethyl ester, N,N-dimethyl PABA ethyl ester, N,N-dimethyl PABA butyl ester, N,N-dimethyl PABA ethyl ester, diethylaminohydroxybenzoyl hexyl benzoate, etc.); N-acetylanthranilate, etc.); salicylic acid-based UV absorbers (e.g., ethylhexyl salicylate, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate,
  • Waxes include, for example, beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, wart wax, whale wax, montan wax, bran wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugar cane wax, isopropyl lanolin fatty acid, hexyl laurate, reduced lanolin, Jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, such as liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene , vaseline, microcrystalline wax, Fischer-Tropsch wax, and the like.
  • liquid oils examples include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, and linseed oil. , safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, sinagiri oil, Japanese paulownia oil, jojoba oil, germ oil, triglycerin, and the like.
  • solid fats and oils examples include cacao butter, coconut oil, horse fat, hydrogenated coconut oil, palm oil, beef tallow, mutton tallow, hydrogenated beef tallow, palm kernel oil, lard, beef bone fat, Japanese wax kernel oil, hydrogenated oil, beef leg fat, Japanese wax, hydrogenated castor oil and the like.
  • waxes examples include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, wart wax, whale wax, montan wax, bran wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugarcane wax, isopropyl lanolin fatty acid, hexyl laurate, and reduced lanolin.
  • jojoba wax hard lanolin, shellac wax
  • POE lanolin alcohol ether POE lanolin alcohol acetate
  • POE cholesterol ether lanolin fatty acid polyethylene glycol
  • POE hydrogenated lanolin alcohol ether examples include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, wart wax, whale wax, montan wax, bran wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugarcane wax, isopropyl lanolin fatty acid, hexyl laurate, and
  • hydrocarbon oils examples include liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, and microcrystalline wax.
  • the carbon number of the higher fatty acid can be, for example, 6 or more, 8 or more, or 10 or more.
  • the carbon number of the higher fatty acid can be, for example, 28 or less, 26 or less, or 24 or less.
  • higher fatty acids examples include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, toric acid, isostearic acid, linoleic acid, linoleic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid ( DHA) and the like.
  • the carbon number of the higher alcohol can be, for example, 6 or more, 8 or more, or 10 or more.
  • the carbon number of the higher alcohol can be, for example, 28 or less, 26 or less, or 24 or less.
  • Higher alcohols include, for example, straight-chain alcohols (e.g., lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, etc.); branched-chain alcohols (e.g., monostearyl glycerin ether (bacyl alcohol ), 2-decyltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, octyldodecanol, etc.) can be used.
  • straight-chain alcohols e.g., lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, etc.
  • branched-chain alcohols e.g., monostearyl glycerin ether (bacyl alcohol ), 2-decyltetrade
  • Synthetic ester oils include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, and myristyl lactate.
  • silicone oils include dimethylpolysiloxane, methylhydrogenpolysiloxane, methylphenylpolysiloxane, stearoxymethylpolysiloxane, polyether-modified organopolysiloxane, fluoroalkyl/polyoxyalkylene co-modified organopolysiloxane, and alkyl-modified organopolysiloxane.
  • terminal-modified organopolysiloxane terminal-modified organopolysiloxane, fluorine-modified organopolysiloxane, amino-modified organopolysiloxane, silicone gel, acrylic silicone, trimethylsiloxysilicate, silicone RTV rubber, and silicone compounds such as cyclopentasiloxane.
  • the oil particles (internal phase) surrounded by the agar gel particles preferably have an average particle size of 200 ⁇ m or more.
  • the average particle size of the oil particles can be, for example, 300 ⁇ m or more, 400 ⁇ m or more, 500 ⁇ m or more, 600 ⁇ m or more, 700 ⁇ m or more, or 800 ⁇ m or more.
  • the oil particles (internal phase) surrounded by the agar gel particles preferably have an average particle size of 2,000 ⁇ m or less.
  • the average particle size of the oil particles can be, for example, 1,800 ⁇ m or less, 1,600 ⁇ m or less, 1,400 ⁇ m or less, 1,200 ⁇ m or less, 1,000 ⁇ m or less, 800 ⁇ m or less, 600 ⁇ m or less, or 400 ⁇ m or less.
  • the average particle size of the oil particles surrounded by the agar gel particles can be the average value of the particle sizes of arbitrary 100 oil particles measured by microscopic observation.
  • the content of the internal phase is preferably 5% by mass or more relative to the mass of the composition.
  • the internal phase can be, for example, 10% or more, 15% or more, 20% or more, 25% or more, 30% or more, or 35% or more by weight of the composition. If the content of the internal phase is less than 5% by mass, the effect of the internal phase cannot be obtained.
  • the content of the internal phase is preferably 35% by mass or less relative to the mass of the composition.
  • the internal phase can be, for example, 30% or less, 25% or less, 20% or less, 15% or less, or 10% or less by weight of the composition. When the content of the internal phase exceeds 35% by mass, the dispersion stability of the internal phase is lowered.
  • the surfactant is 0.5% by mass or less, preferably 0.3% by mass or less, more preferably 0.1% by mass or less, based on the mass of the oil dispersion composition. More preferably, it should not be contained. By setting the surfactant to 0.5% by mass or less, irritation to the skin can be reduced. In addition, it becomes possible to apply the oil dispersion composition to food and drink.
  • anionic surfactants include fatty acid soaps (e.g., sodium laurate, sodium palmitate, etc.); higher alkyl sulfate salts (e.g., sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfates (e.g., , POE-triethanolamine lauryl sulfate, POE-sodium lauryl sulfate, etc.); N-acylsarcosic acid (e.g., sodium lauroyl sarcosinate, etc.); sodium N-myristoyl-N-methyltaurate, sodium coconut oil fatty acid methyltaurate, sodium lauryl methyl tauride, etc.); phosphate ester salts (POE-sodium oleyl ether phosphate, POE-stearyl ether phosphate, etc.); sulfosuccinate (For example, sodium di-2-ethylhexyl
  • POE-alkyl ether carboxylic acid POE-alkyl allyl ether carboxylate; ⁇ -olefin sulfonate higher fatty acid ester sulfonate; secondary alcohol sulfate; higher fatty acid alkylolamide sulfate; sodium lauroyl monoethanolamide succinate; N-palmitoyl aspartic acid ditriethanolamine; .
  • Cationic surfactants include, for example, alkyltrimethylammonium salts (e.g., stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.); alkylpyridinium salts (e.g., cetylpyridinium chloride, etc.); dialkyldimethylammonium salts (e.g., distearyl chloride dimethylammonium); poly(N,N'-dimethyl-3,5-methylenepiperidinium) chloride; alkyl quaternary ammonium salts; alkyldimethylbenzylammonium salts; alkylisoquinolinium salts; - alkylamine; alkylamine salt; polyamine fatty acid derivative; amyl alcohol fatty acid derivative; benzalkonium chloride;
  • alkyltrimethylammonium salts e.g., stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.
  • Amphoteric surfactants include, for example, imidazoline-based amphoteric surfactants (e.g., 2-undecyl-N,N,N-(hydroxyethylcarboxymethyl)-2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide side-1-carboxyethyloxy disodium salt, etc.); betaine surfactants (e.g., 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkylbetaine, amidobetaine , sulfobetaine, etc.) and the like.
  • imidazoline-based amphoteric surfactants e.g., 2-undecyl-N,N,N-(hydroxyethylcarboxymethyl)-2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide side-1-carbox
  • Hydrophilic nonionic surfactants include, for example, POE-sorbitan fatty acid esters (eg, POE-sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate, etc.); POE-sorbitol fatty acid esters (eg, POE-sorbitol monolaurate, POE-sorbitol monooleate, POE-sorbitol pentaoleate, POE-sorbitol monostearate, etc.); POE-glycerin fatty acid esters (eg, POE-glycerol mono stearate, POE-monooleate such as POE-glycerin monoisostearate, POE-glycerin triisostearate, etc.); POE-fatty acid esters (e.g., POE-distearate, POE-monodioleate, ethylene glycol diste
  • Lipophilic nonionic surfactants include, for example, sorbitan fatty acid esters (e.g., sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate, etc.); , ⁇ , ⁇ '-glycerol pyroglutamate, glyceryl monostearate, malic acid, etc.); propylene glycol fatty acid esters (eg, propylene glycol monostearate, etc.); hydrogenated castor oil derivatives;
  • sorbitan fatty acid esters e.g., sorbitan monooleate, sorbitan monoisostearate, sorbitan monol
  • the thickening agent does not include agar.
  • the thickener is, for example, 1% by mass or less, 0.5% by mass or less, 0.3% by mass or less, 0.1% by mass or less, or 0% by mass (not containing ).
  • Thickeners include, for example, gum arabic, carrageenan, karaya gum, tragacanth gum, carob gum, quince seed (quince), casein, dextrin, gelatin, sodium pectate, sodium alginate, methylcellulose, ethylcellulose, carboxymethylcellulose (CMC), and hydroxyethylcellulose.
  • hydroxypropylcellulose polyvinyl alcohol (PVA), polyvinyl methyl ether (PVM), PVP (polyvinylpyrrolidone), sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, dialkyldimethylammonium cellulose sulfate, xanthan gum, silica
  • PVA polyvinyl alcohol
  • PVM polyvinyl methyl ether
  • PVP polyvinylpyrrolidone
  • sodium polyacrylate sodium polyacrylate
  • carboxyvinyl polymer locust bean gum, guar gum, tamarind gum, dialkyldimethylammonium cellulose sulfate, xanthan gum
  • silica examples include magnesium aluminum oxide, bentonite, hectorite, magnesium aluminum silicate (Vegum), laponite, silicic anhydride, taurate-based synthetic polymer, and acrylate-based synthetic polymer.
  • the oil dispersion composition of the present disclosure contains other ingredients such as powders, water-soluble alcohols, humectants, film-forming agents, water-soluble ultraviolet absorbers, sequestering agents, amino acids, as long as the effects of the present disclosure are not impaired.
  • Organic amines, polymer emulsions, pH adjusters, skin nutrients, vitamins, antioxidants, antioxidant aids, fragrances and the like can be appropriately contained as necessary.
  • Powders include, for example, inorganic powders (e.g., talc, kaolin, mica, sericite (sericite), muscovite, phlogopite, synthetic mica, red mica, biotite, slithiamite, calcined mica, calcined talc, vermiculite, Magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, fumed silica, zeolite, glass, barium sulfate, calcined calcium sulfate ( Calcined gypsum), calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, metal soap (e.g.
  • inorganic powders e.g., talc, kaolin, mica, sericite (sericite), muscovite, phlogopite, synthetic mica, red
  • organic powder e.g. polyamide resin powder (nylon powder) , polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, silicone resin powder, silk powder, wool powder, urethane powder etc.
  • inorganic white pigments e.g., titanium dioxide, zinc oxide, etc.
  • inorganic red pigments e.g., iron oxide (red iron oxide), iron titanate, etc.
  • inorganic brown pigments ⁇ -iron oxide, etc.
  • inorganic yellow system pigments yellow iron oxide, ocher, etc.
  • inorganic black pigments black iron oxide, carbon black, low order titanium oxide, etc.
  • inorganic purple pigments e.g., manganese violet, cobalt violet, etc.
  • inorganic purple pigments e.g., manganese violet, cobalt violet, etc
  • Red No. 202 Organic pigments such as Red No. 204, Red No. 205, Red No. 220, Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401, and Blue No. 404, red Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3 and Blue No.
  • natural pigments e.g., chlorophyll, ⁇ -carotene, etc.
  • wax powders e.g., carnauba wax powder, etc.
  • starch powders e.g., corn starch powder, rice starch powder
  • water-soluble alcohols include lower alcohols, polyhydric alcohols, polyhydric alcohol polymers, dihydric alcohol alkyl ethers, dihydric alcohol alkyl ethers, dihydric alcohol ether esters, glycerin monoalkyl ethers, sugar alcohols, At least one selected from monosaccharides, oligosaccharides, polysaccharides, derivatives thereof, and the like can be mentioned.
  • Polyhydric alcohols include, for example, dihydric alcohols (e.g., ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, 2,3-butylene glycol, pentamethylene glycol, 2-butene-1,4-diol, hexylene glycol, octylene glycol, etc.); trihydric alcohols (e.g., glycerin, trimethylolpropane, etc.); tetrahydric alcohols (e.g., 1,2,6 -pentaerythritol such as hexanetriol); pentahydric alcohols (e.g., xylitol, etc.); hexahydric alcohols (e.g., sorbitol, mannitol, etc.); polyhydric alcohol polymers (e.g., diethylene glycol, dipropylene glycol, tri
  • dihydric alcohol alkyl ethers e.g., diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl Ether, Propylene Glycol Monomethyl Ether, Propylene Glycol Monoethyl Ether, Propylene Glycol Monobutyl Ether, Propylene Glycol Isopropyl Ether, Dipropylene Glycol Methyl Ether, Dipropylene Glycol Ethyl Ether, Dipropylene Glycol coal butyl ether, etc.); dihydric alcohol ether ester (e.g., ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene
  • monosaccharides include three-carbon sugars (eg, D-glycerylaldehyde, dihydroxyacetone, etc.), four-carbon sugars (eg, D-erythrose, D-erythrulose, D-threose, erythritol, etc.), Five carbon sugars (e.g., L-arabinose, D-xylose, L-lyxose, D-arabinose, D-ribose, D-ribulose, D-xylulose, L- xylulose, etc.), hexoses (e.g., D-glucose, D-talose, D-psicose, D-galactose, D-fructose, L-galactose, L- mannose, D-tagatose, etc.), heptose (e.g., aldoheptose, heptulose, etc.), heptose
  • oligosaccharides include at least one selected from sucrose, guntianose, umbelliferose, lactose, planteose, isoliquinoses, ⁇ , ⁇ -trehalose, raffinose, lignoses, umbilicine, stachyose, verbascoses, and the like. can be mentioned.
  • polysaccharides include cellulose, quince seed, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, gum arabic, heparan sulfate, hyaluronic acid, tragacanth gum, keratan sulfate, chondroitin, xanthan gum, mucoitin sulfate, guar gum, dextran, and keratosulfate. , locust bean gum, succinoglucan, caroninic acid and the like.
  • Examples of other polyols include at least one selected from polyoxyethylene methyl glucoside (glucum E-10), polyoxypropylene methyl glucoside (glucum P-10), and the like.
  • natural water-soluble polymers include plant-based polymers (e.g., gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (quince), algecolloid (cassou extract), starch ( rice, corn, potato, wheat), glycyrrhizic acid); microbial macromolecules (e.g., xanthan gum, dextran, succinoglucan, pullulan, etc.); mentioned.
  • plant-based polymers e.g., gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (quince), algecolloid (cassou extract), starch ( rice, corn, potato, wheat), glycyrrhizic acid
  • microbial macromolecules e.g., xanthan gum,
  • semi-synthetic water-soluble polymers include starch-based polymers (e.g., carboxymethyl starch, methylhydroxypropyl starch, etc.); cellulose-based polymers (methylcellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, hydroxypropylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder, etc.); alginate-based polymers (eg, sodium alginate, propylene glycol alginate, etc.);
  • Water-soluble polymer In the oil dispersion composition of the present disclosure, it is not necessary to use the action of a water-soluble polymer to disperse the oily component.
  • water-soluble polymers do not include agar.
  • the water-soluble polymer is, for example, 1% by mass or less, 0.5% by mass or less, 0.3% by mass or less, 0.1% by mass or less, or 0% by mass (not containing ).
  • moisturizing agents include polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caroninic acid, atelocollagen, and cholesteryl-12-hydroxystearate. , sodium lactate, bile salts, dl-pyrrolidone carboxylate, alkylene oxide derivatives, short-chain soluble collagen, diglycerin (EO) PO adducts, rose barra extract, yarrow extract, melilot extract and the like.
  • EO diglycerin
  • film-forming agents examples include anionic film-forming agents (e.g., (meth)acrylic acid/(meth)acrylic acid ester copolymer, methyl vinyl ether/maleic anhydride high polymer, etc.), cationic film-forming agents (e.g., cationic cellulose, dimethyldiallylammonium chloride polymer, dimethyldiallylammonium chloride/acrylamide copolymer, etc.), nonionic film agents (e.g., polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl acetate, polyacrylate copolymer, (meth) acrylamide, polymer silicone, silicone resin, trimethylsiloxysilicate, etc.).
  • anionic film-forming agents e.g., (meth)acrylic acid/(meth)acrylic acid ester copolymer, methyl vinyl ether/maleic anhydride high polymer, etc.
  • cationic film-forming agents e.g., cationic cellulose
  • water-soluble UV absorbers examples include benzophenone UV absorbers (eg, 2-hydroxy-4-methoxybenzophenone-5-sulfonate), benzylidene camphor UV absorbers (benzylidene camphor sulfonic acid, terephthalyl camphor sulfonic acid, etc.), phenylbenzimidazole-based UV absorbers (phenylbenzimidazole sulfonic acid, etc.), and the like.
  • benzophenone UV absorbers eg, 2-hydroxy-4-methoxybenzophenone-5-sulfonate
  • benzylidene camphor UV absorbers benzylidene camphor sulfonic acid, terephthalyl camphor sulfonic acid, etc.
  • phenylbenzimidazole-based UV absorbers phenylbenzimidazole sulfonic acid, etc.
  • sequestering agents include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, and tetrasodium edetate. , sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, trisodium ethylenediaminehydroxyethyl triacetate, and the like.
  • Amino acids include, for example, neutral amino acids (eg, threonine, cysteine, etc.); basic amino acids (eg, hydroxylysine, etc.).
  • amino acid derivatives include sodium acyl sarcosinate (sodium lauroyl sarcosinate), acyl glutamate, sodium acyl ⁇ -alanine, glutathione, pyrrolidone carboxylic acid and the like.
  • organic amines examples include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-1-propanol, and the like. is mentioned.
  • polymer emulsions examples include acrylic resin emulsions, polyethyl acrylate emulsions, acrylic resin liquids, polyacryl alkyl ester emulsions, polyvinyl acetate resin emulsions, and natural rubber latex.
  • pH adjusters examples include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinic acid-sodium succinate.
  • vitamins examples include vitamins A, B1, B2, B6, C, E and their derivatives, pantothenic acid and its derivatives, biotin, and the like.
  • antioxidants examples include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, and gallic acid esters.
  • antioxidant aids include phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, cephalin, hexametaphosphate, phytic acid, and ethylenediaminetetraacetic acid.
  • ingredients that can be blended include, for example, preservatives (ethylparaben, butylparaben, chlorphenesin, phenoxyethanol, etc.); ); whitening agent (e.g., placenta extract, saxifrage extract, arbutin, etc.); , coix seed, loofah, lily, saffron, cnidium, ginger, hypericum, ononis, garlic, red pepper, chimp, angelica, seaweed, etc.), activator (e.g., royal jelly, photosensitizer, cholesterol derivative, etc.); blood circulation promoter (e.g., , Nonylic Acid Vanillylamide, Nicotinic Acid Benzyl Ester, Nicotinic Acid ⁇ -Butoxyethyl Ester, Capsaicin, Zingerone, Cantharis Tincture, Ictamol, Tannic Acid, ⁇ -Borneol, Tocopherol Nicotinate, Inositol
  • composition of the present disclosure contains caffeine, tannin, verapamil, tranexamic acid and its derivatives, various crude drug extracts such as licorice, Chinese quince, and Ichiyakuso, tocopheryl acetate, glycyrrhizic acid, glycyrrhizic acid and its derivatives or salts thereof, and the like.
  • Pharmaceutical agents, whitening agents such as vitamin C, magnesium ascorbyl phosphate, ascorbyl glucoside, arbutin and kojic acid, amino acids such as arginine and lysine and their derivatives may also be contained as appropriate.
  • the oil dispersion composition of the present disclosure preferably has a viscosity of 2,000 mPa ⁇ s or more at 30°C.
  • the viscosity of the oil dispersion composition of the present disclosure is, for example, 3,000 mPa s or more, 5,000 mPa s or more, 8,000 mPa s or more, 10,000 mPa s or more, 20,000 mPa s at 30°C. or more, or 30,000 mPa ⁇ s or more. If the viscosity is less than 2,000 mPa ⁇ s, usability will be reduced when used as an external preparation for skin.
  • the oil dispersion composition of the present disclosure preferably has a viscosity of 100,000 mPa ⁇ s or less, more preferably 80,000 mPa ⁇ s or less, at 30°C.
  • the viscosity of the oil dispersion composition of the present disclosure can be, for example, 70,000 mPa s or less, 60,000 mPa s or less, 40,000 mPa s or less, or 20,000 mPa s or less at 30°C. . If the viscosity exceeds 100,000 mPa ⁇ s, the ease of application to the skin is reduced.
  • the viscosity can be measured 60 seconds after the start of measurement with a Brookfield viscometer (rotor number 22, rotation speed 12 rpm) at 30°C.
  • oil dispersion composition of the present disclosure it may be difficult or almost impractical to directly specify the phase structure, dispersion state, etc. by composition. In such cases, the oil dispersion composition of the present disclosure should be allowed to be identified by its manufacturing method described below.
  • oil particles are uniformly and stably dispersed in the agar gel.
  • large oil particles with an average particle size of 200 ⁇ m or more can be dispersed using large agar gel particles with an average particle size of 10 ⁇ m or more.
  • the oil can be uniformly and stably dispersed without using a surfactant.
  • the oil can be uniformly and stably dispersed without thickening with a thickener.
  • the oil dispersion composition of the present disclosure When the oil dispersion composition of the present disclosure is used for an external skin preparation, the user can feel good freshness when applying the composition to the skin. After applying the oil dispersion composition of the present disclosure to the skin, the user can obtain richness, freshness and moisture.
  • the full-bodied feeling referred to in the present disclosure is a feeling of use that gives a moist and rich impression to the skin.
  • freshness refers to non-stickiness, good spreadability, and refreshing feeling.
  • the moist feeling means that the skin has a moist feeling without drying.
  • oily components are dispersed without the action of surfactants.
  • a surfactant By not using a surfactant, irritation to the skin can be reduced, and stickiness when applied to the skin can be suppressed.
  • it can be used as an external preparation for skin that does not require wiping.
  • the oil-dispersed composition of the present disclosure When the oil-dispersed composition of the present disclosure is used for food and drink, the user can obtain the texture of the inner and outer phases with large particle sizes. Moreover, when using an oil that is easily oxidized, oxidation of the oil can be suppressed.
  • a method for producing the oil dispersion composition of the present disclosure will be described. First, agar gel particles to be the outer phase are produced.
  • a method for producing an oil-dispersed composition can include a dissolving step of dissolving agar in heated water and a cooling step of stirring while cooling the aqueous agar solution.
  • the water can be heated to, for example, 85°C to 90°C.
  • the amount of dissolved agar is 8 ⁇ 10 ⁇ 3 parts by mass or more per 1 part by mass of water, as described above.
  • the cooling step it is preferable to stir when the aqueous agar solution reaches 40° C. or lower.
  • any method for stirring the aqueous agar solution any method can be employed as long as the agar gel particles have a desired particle size.
  • a stirring method for example, a paddle, a disper, or the like can be used. Stirring is preferably performed until the temperature of the agar gel reaches room temperature. By agitating (pulverizing) the agar in the process of solidifying the agar, it is possible to obtain agar gel particles in which the oil is easily dispersed.
  • the agar gel may be granulated after the agar gel has solidified.
  • the agar solution can be allowed to stand and sufficiently cooled to room temperature to solidify the agar gel.
  • the solidified agar gel may be pulverized using a disper, homogenizer, or the like to produce agar gel particles.
  • the method for producing the oil-dispersed composition can then include a dispersing step of dispersing the oil in the agar gel particles (aggregate of particles) serving as the outer phase.
  • the dispersion process can use so-called in-line mixing. In-line mixing may be driven stirring with power, or static mixing using a static mixer or the like.
  • the in-line mixing device may be a pump that also serves as a liquid feeder.
  • the dispersion step includes a supply step of supplying the external phase component and the internal phase component to the in-line mixing device at a target mass ratio of the external phase and the internal phase of ⁇ 10%, and an in-line mixing device so that the internal phase has a desired average particle size.
  • the feeding step, the dispersing step and the discharging step at the same time.
  • the amount of internal phase and the amount of external phase can be determined based on the above-mentioned content.
  • the method for producing an oil dispersion composition can further include an addition step of adding a liquid aqueous component to the external phase before and/or after the dispersion step.
  • the liquid aqueous component can contain any desired ingredients. By adding a liquid aqueous component, it is possible to adjust the ingredients, viscosity, feeling of use, and the like.
  • the oil can be dispersed uniformly and stably with the agar gel particles.
  • oil can be dispersed with large agar gel particles with an average particle size greater than 10 ⁇ m.
  • even large oil particles with an average particle size exceeding 200 ⁇ m can be dispersed.
  • the oil dispersion composition of the present disclosure will be described below with examples. However, the oil dispersion composition of the present disclosure is not limited to the following examples.
  • the unit of the content of each component shown in each table is % by mass.
  • Test Examples 1 and 2 [Preparation of foreign phase] An outer phase (agar gel particles) was prepared to disperse the inner phase. Test Example 1 and Test Example 2 differ in the method of producing the agar gel particles. The particle size range of the agar gel, the water content of the agar gel, and the viscosity of the agar gel thus prepared were measured.
  • Test Example 1 agar powder was dissolved in water at 85°C to 90°C, and after the agar was dissolved in water, the agar solution was cooled to room temperature (25°C) to 30°C. While cooling, agar gel particles were formed by stirring with a paddle type stirrer (Three One Motor (registered trademark) (manufactured by Shinto Kagaku Co., Ltd.)). Table 1 shows the composition and measurement results.
  • Test Example 2 agar powder was dissolved in water at 85 ° C. to 90 ° C., and after the agar was dissolved in water, it was allowed to stand still and cooled to room temperature (25 ° C.). solidified. After solidification, the agar gel was pulverized using a disper to form agar gel particles. Table 2 shows the composition and measurement results.
  • the average particle size of the agar gel particles surrounding the oil particles was obtained by measuring the particle size of arbitrary 100 agar gel particles in the oil-dispersed composition by microscopic observation and calculating the average value.
  • the particle size of the agar gel was defined as the longest portion including the needle-like portion.
  • the particle size range of the agar gel surrounding the oil particles was obtained by measuring the particle size of any 100 agar gel particles in the oil dispersion composition by microscopic observation, and using the minimum and maximum values as the particle size range.
  • the particle size of the agar gel was defined as the longest portion including the needle-like portion.
  • the water content shown in Tables 1 and 2 indicates the ratio of the water content contained in the agar gel to the blended water content.
  • the prepared agar gel was sieved through a 350-mesh (40 ⁇ m mesh) sieve, and the mass of the aqueous solvent dropped from the sieve was measured.
  • the water content was calculated from the following formula.
  • Moisture content (%) ⁇ (mass of blended aqueous solvent - mass of aqueous solvent dropped from sieve) / mass of blended aqueous solvent ⁇ x 100
  • the viscosity of the agar gel was measured 24 hours after the preparation of the agar gel particles, using a Brookfield viscometer (TVB-15 (manufactured by Toki Sangyo)) at 30 ° C. with a rotor number of 22 and a rotation speed of 12 rpm 60 seconds after the start of measurement. was measured.
  • Brookfield viscometer (TVB-15 (manufactured by Toki Sangyo)
  • Test Examples 3-4 Using the outer phase (agar gel particles) prepared in Test Examples 1 and 2, compositions in which an oily component was dispersed were prepared. For each composition, the average particle size and particle size range of the agar gel particles surrounding the oil particles and the average particle size and particle size range of the oil particles surrounded by the agar gel particles were measured. In addition, the dispersion stability of each composition and usability when applied to the skin were evaluated. Measurement methods and evaluation criteria are shown below. Tables 3 and 4 show the composition, measurement results and evaluation.
  • the average particle size of the oil particles surrounded by the agar gel particles was obtained by measuring the particle size of arbitrary 100 oil particles by microscopic observation and calculating the average value.
  • the particle size of the oil particles was defined as the particle size of the longest portion.
  • the average particle size of oil particles surrounded by agar gel particles was obtained by measuring the particle size of arbitrary 100 oil particles by microscopic observation, and using the minimum and maximum values as the particle size range.
  • the particle size of the oil particles was defined as the particle size of the longest portion.
  • the viscosity of the oil dispersion composition was measured 60 seconds after the start of measurement with a Brookfield viscometer at 30°C with a spindle number of 22 and a rotation speed of 12 rpm.
  • the in-line emulsification method was used to disperse the oily component in the external phase containing the agar gel particles.
  • the external phase containing the agar gel particles prepared in Test Example 1 or Test Example 2 and the oily component are supplied to a dynamic mixer, the agar gel and the oily component are mixed, and the oil is dispersed in the agar gel.
  • the average particle size of the agar gel particles in the compositions of Test Examples 3 and 4 after in-line emulsification is the same as the average particle size of the agar gel particles shown in Tables 1 and 2.
  • the agar gel particles produced in Test Examples 1-1 to 1-3 and Test Examples 2-1 to 2-3 could not stably emulsify (disperse) the oil component.
  • the oil component could be stably emulsified (dispersed).
  • the amount of agar is preferably 8 ⁇ 10 -3 parts by weight or more, and 1 ⁇ 10 -2 parts by weight with respect to 1 part by weight of water It turned out that it is more preferable when it is above.
  • compositions according to Test Examples 1-4 to 1-7 and Test Examples 2-4 to 2-7 are highly evaluated for freshness, richness and moistness when applied to external preparations for skin. I was able to From this, it is considered that when the average particle size of the agar gel is 200 ⁇ m or more, the feeling of use can be enhanced.
  • the viscosity of the composition is preferably 100,000 mPa ⁇ s or less in order to improve the ease of application.
  • Test Example 5 In Test Example 5, the oily component was dispersed in the external phase prepared in the above Test Example by electric stirring in a batch system. The average particle size of the agar gel particles became smaller than the average particle sizes of Test Examples 1 and 2 due to the electric stirring by the batch method. Table 5 shows the compositions and results.
  • Test Examples 5-4 and 5-5 in which the average particle size of the agar gel was less than 1 ⁇ m, the agar gel and the oily component were separated, and the oily component could not be dispersed. In addition, the evaluation of the usability was also low. In Test Example 5-3, even if the particle size of the agar gel particles was increased, if the oil particles were as small as 20 ⁇ m, the agar gel and the oily component were separated. On the other hand, in Test Examples 5-1 and 5-2 in which the agar gel particle size and the average particle size of the oil particles were larger than those in Test Examples 5-3 and 5-5, the dispersion stability of the oil particles was improved. was made.
  • the average particle size of the agar gel is 10 ⁇ m or more. It is believed that the average particle size of the agar gel can be 150 ⁇ m or less. It is considered preferable that the average particle size of the oil particles is 200 ⁇ m or more. It is considered that the average particle size of the oil particles can be 2000 ⁇ m or less.
  • Test Example 6 In Test Example 6, dispersion compositions were prepared by changing the type and amount of the liquid oil. Tables 6 and 7 show the compositions and results.
  • liquid oil was a hydrocarbon oil, an ester oil, or a silicone oil
  • the type of liquid oil dispersed in the agar gel particles is not limited.
  • agar gel can disperse 5% by mass or more of oily components. It is believed that agar gel can disperse up to 40% by weight of oily components.
  • agar gel can be used for 1 part by mass of the oily component. It was also found that the amount of agar gel can be 20 parts by mass or less per 1 part by mass of the oily component.
  • the oil-dispersed composition of the present disclosure can be applied, for example, to skin external preparations, cosmetics, cleansers, food and drink, and the like.
  • the oil dispersion composition of the present disclosure can be applied to base cosmetics, top cosmetics, makeup cosmetics, antiperspirants, deodorants, sunscreen cosmetics, skin care agents, cleansers, and the like.
  • the oil dispersion composition of the present disclosure can be applied to food and drink.

Abstract

This oil dispersion composition contains water, agar and oil particles. At least a portion of water and the agar form agar gel particles. The average particle diameter of the agar gel particles is 10-150 μm. The average particle diameter of the oil particles is 200-2,000 μm. A plurality of the agar gel particles surround one oil particle. The amount of the agar is 8×10-3 parts by mass or more per part by mass of water.

Description

油分散組成物Oil dispersion composition 関連出願Related application
　本発明は、日本国特許出願：特願２０２１－１２００２０号（２０２１年０７月２０日出願）の優先権主張に基づくものであり、同出願の全記載内容は引用をもって本書に組み込み記載されているものとする。 The present invention is based on the priority claim of Japanese Patent Application: Japanese Patent Application No. 2021-120020 (filed on July 20, 2021), and the entire content of the application is incorporated herein by reference. shall be
　本開示は、油相が分散された組成物に関する。 The present disclosure relates to compositions in which an oil phase is dispersed.
　水中油型乳化組成物において、油の乳化（分散）は、通常、界面活性剤を用いて行われているが、界面活性剤を用いない代わりに、寒天を含む糖ポリマー微粒子でもって、乳化類似の作用で油を分散させた技術も知られている（例えば、特許文献１参照）。 In the oil-in-water emulsion composition, emulsification (dispersion) of the oil is usually performed using a surfactant. A technique for dispersing oil by the action of is also known (see, for example, Patent Document 1).
　特許文献１には、水相と、平均粒子径４μｍ～１３０μｍの油相と、平均粒子径６５ｎｍ～１４０ｎｍである寒天ゾル微粒子とを含み、寒天ゾル微粒子で油相が乳化（分散）され、粘度（２０℃）が３１．５ｃｐ（ｍＰａ・ｓ）～１７６．８ｃｐであるドレッシングが記載されている。特許文献１において、油相は、寒天ゾル微粒子水溶液中にホモジナイザ―を用いて分散（乳化）させている。 Patent Document 1 discloses an aqueous phase, an oil phase having an average particle size of 4 μm to 130 μm, and agar sol fine particles having an average particle size of 65 nm to 140 nm. (20° C.) of 31.5 cp (mPa·s) to 176.8 cp are described. In Patent Document 1, the oil phase is dispersed (emulsified) in an agar sol fine particle aqueous solution using a homogenizer.
特開２０１４－３９７４号公報JP 2014-3974 A
　以下の分析は、本開示の観点から与えられる。 The following analysis is given in light of this disclosure.
　水中油型組成物のような油相を分散させた組成物を皮膚外用剤に適用する場合には、油相の分散について高度の安定性が要求される。特許文献１に記載のドレッシングにおいては油分を寒天ゾル微粒子で分散（乳化）させているが、皮膚外用剤においては、このようなドレッシングよりも、より高度の油分散安定性が要求される。 When applying a composition in which an oil phase is dispersed, such as an oil-in-water composition, to an external preparation for skin, a high degree of stability is required for the dispersion of the oil phase. In the dressing described in Patent Document 1, the oil is dispersed (emulsified) with agar sol fine particles, but external skin preparations require higher oil dispersion stability than such dressings.
　そこで、寒天ゲル粒子によってより安定に油を分散させた油分散組成物が求められている。 Therefore, there is a demand for an oil-dispersed composition in which oil is more stably dispersed by agar gel particles.
　本開示の第１視点によれば、水と、寒天と、油分粒子と、を含む油分散組成物が提供される。水の少なくとも一部及び寒天は寒天ゲル粒子を形成する。寒天ゲル粒子の平均粒径が１０μｍ～１５０μｍである。油分粒子の平均粒径が２００μｍ～２，０００μｍである。複数の寒天ゲル粒子が１つの油分粒子を取り囲んでいる。寒天が水１質量部に対して８×１０－３質量部以上である。 A first aspect of the present disclosure provides an oil-dispersed composition containing water, agar, and oil particles. At least a portion of the water and the agar form agar gel particles. The average particle size of the agar gel particles is 10 μm to 150 μm. The average particle size of the oil particles is 200 μm to 2,000 μm. A plurality of agar gel particles surround one oil particle. Agar is 8×10 −3 parts by mass or more per 1 part by mass of water.
　本開示の組成物によれば、油分粒子を寒天ゲル粒子でもって安定に分散させることができる。 According to the composition of the present disclosure, oil particles can be stably dispersed with agar gel particles.
　上記各視点の好ましい形態を以下に記載する。 The preferred form of each of the above viewpoints is described below.
　上記第１視点の好ましい形態によれば、水の一部は前記寒天ゲル粒子の外部に存在する。 According to the preferred form of the first aspect, part of the water exists outside the agar gel particles.
　上記第１視点の好ましい形態によれば、寒天ゲル粒子は、表面から突出する少なくとも１つの針状部を有する。 According to the preferred embodiment of the first aspect, the agar gel particles have at least one needle-like portion protruding from the surface.
　上記第１視点の好ましい形態によれば、寒天ゲル粒子の総量は、油分粒子の総量１質量部に対して２質量部以上である。 According to the preferred embodiment of the first aspect, the total amount of agar gel particles is 2 parts by mass or more with respect to 1 part by mass of the total amount of oil particles.
　上記第１視点の好ましい形態によれば、組成物は、３０℃において、２，０００ｍＰａ・ｓ～１００，０００ｍＰａ・ｓの粘度を有する。 According to the preferred embodiment of the first aspect, the composition has a viscosity of 2,000 mPa·s to 100,000 mPa·s at 30°C.
　上記第１視点の好ましい形態によれば、油分粒子を取り囲む前の複数の寒天ゲル粒子は、３０℃において、３，０００ｍＰａ・ｓ～１００，０００ｍＰａ・ｓの粘度を有する。 According to the preferred embodiment of the first aspect, the plurality of agar gel particles before surrounding the oil particles have a viscosity of 3,000 mPa·s to 100,000 mPa·s at 30°C.
　上記第１視点の好ましい形態によれば、油分粒子は、大気圧下、２５℃において液状である。 According to the preferred embodiment of the first aspect, the oil particles are liquid at 25°C under atmospheric pressure.
　上記第１視点の好ましい形態によれば、油分粒子の含有率は、組成物の質量に対して５質量％～３５質量％である。 According to the preferred embodiment of the first aspect, the content of oil particles is 5% by mass to 35% by mass with respect to the mass of the composition.
　上記第１視点の好ましい形態によれば、界面活性剤の含有率が組成物の質量に対して１質量％以下である。 According to the preferred embodiment of the first aspect, the surfactant content is 1% by mass or less with respect to the mass of the composition.
　上記第１視点の好ましい形態によれば、増粘剤の含有率が組成物の質量に対して１質量％以下である。 According to the preferred embodiment of the first aspect, the content of the thickener is 1% by mass or less with respect to the mass of the composition.
　上記第１視点の好ましい形態によれば、寒天ゲル粒子は粒子中に油性成分を内包していない。 According to the preferred form of the first aspect, the agar gel particles do not enclose an oily component in the particles.
　上記第１視点の好ましい形態によれば、油分粒子は、炭化水素、エステル油、シリコーン油、フッ素油、高級アルコール、高級脂肪酸及び油脂からなる群から選択される少なくとも１つを含む。 According to the preferred embodiment of the first aspect, the oil particles contain at least one selected from the group consisting of hydrocarbons, ester oils, silicone oils, fluorine oils, higher alcohols, higher fatty acids, and fats and oils.
　上記第１視点の好ましい形態によれば、組成物は皮膚外用剤に適用される。 According to the preferred embodiment of the first aspect, the composition is applied as an external preparation for skin.
　上記第１視点の好ましい形態によれば、油分粒子は、α-リノレン酸、エイコサペンタエン酸、ドコサヘキサエン酸、アラキドン酸、リノール酸、γ－リノレン酸、オレイン酸、ミリストレイン酸、エイコセン酸、ラウリン酸、リシノール酸、ステアリン酸、アラキドン酸、エイコサペンタエン酸、ドコサヘキサエン酸、オリーブオイル菜種油、アボカド、タラ肝油、イワシ油、トウモロコシ油、大豆油、サラダ油、えごま油、亜麻仁油、ビタミン類、ポリフェノール類、及びカロテノイド類からなる群から選択される少なくとも１つを含む。 According to the preferred embodiment of the first aspect, the oil particles contain α-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid, linoleic acid, γ-linolenic acid, oleic acid, myristoleic acid, eicosenoic acid, and lauric acid. , ricinoleic acid, stearic acid, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, olive oil, rapeseed oil, avocado, cod liver oil, sardine oil, corn oil, soybean oil, salad oil, perilla oil, linseed oil, vitamins, polyphenols, and At least one selected from the group consisting of carotenoids.
　上記第１視点の好ましい形態によれば、組成物は飲食料に適用される。 According to the preferred embodiment of the first aspect, the composition is applied to food and drink.
　以下の説明において、ＰＯＥはポリオキシエチレン、ＰＯＰはポリオキシプロピレンの略記で、ＰＯＥ又はＰＯＰの後ろのカッコ内の数字は当該化合物中におけるＰＯＥ基又はＰＯＰ基の平均付加モル数を表す。 In the following explanation, POE is an abbreviation for polyoxyethylene, POP is an abbreviation for polyoxypropylene, and the number in parentheses after POE or POP represents the average number of added moles of POE or POP groups in the compound.
　本開示において「実質量」とは、その化合物の添加による作用効果が生じ得る量をいう。 In the present disclosure, the term "substantial amount" refers to the amount in which the addition of the compound can produce an effect.
　本開示の油分散組成物について説明する。 The oil dispersion composition of the present disclosure will be explained.
　本開示において「液状」とは、２５℃で液体のもの、流動性を有するものをいう。 In the present disclosure, "liquid" refers to a substance that is liquid at 25°C and has fluidity.
　本開示の油分散組成物は、水と、寒天と、油分粒子と、を含む。水の少なくとも一部と寒天とは寒天ゲル粒子を形成する。複数の寒天ゲル粒子が１つの油分粒子を取り囲んでいる。これにより、複数の油分粒子が組成物中に分散している。本開示の組成物は、水中油型組成物と同様の形態を有するとみなすことができる。ただし、本開示の組成物において、水相は存在しなくてもよい。 The oil dispersion composition of the present disclosure contains water, agar, and oil particles. At least a portion of the water and the agar form agar gel particles. A plurality of agar gel particles surround one oil particle. Thereby, a plurality of oil particles are dispersed in the composition. Compositions of the present disclosure can be considered to have a morphology similar to oil-in-water compositions. However, in compositions of the present disclosure, an aqueous phase may not be present.
　本開示においては、本開示の組成物を水中油型組成物と同視して、油分粒子を内相と称し、油分粒子を取り囲む、寒天ゲルを含む相を外相と称することがある。 In the present disclosure, the composition of the present disclosure may be equated with an oil-in-water composition, the oil particles may be referred to as the internal phase, and the phase containing the agar gel surrounding the oil particles may be referred to as the external phase.
［外相］
　寒天ゲル粒子は不定形状を有することができる。１つの寒天ゲル粒子は、表面から突出する少なくとも１つの針状部を有することがある。寒天ゲル粒子の外形は、顕微鏡によって観察することができる。 [Foreign Minister]
Agar gel particles can have irregular shapes. One agar gel particle may have at least one spicule protruding from the surface. The shape of the agar gel particles can be observed with a microscope.
　油分粒子を取り囲む寒天ゲル粒子は、１０μｍ以上の平均粒径を有すると好ましい。油分粒子を取り囲む寒天ゲル粒子の平均粒径は、例えば、２０μｍ以上、又は５０μｍ以上とすることができる。寒天ゲル粒子の平均粒径が１０μｍ未満であると、油分粒子を安定して分散させることが困難となる。油分粒子を取り囲む寒天ゲル粒子は、１５０μｍ以下の平均粒径を有すると好ましい。油分粒子を取り囲む寒天ゲル粒子の平均粒径は、例えば、１３０μｍ以下、又は１１０μｍ以下とすることができる。寒天ゲル粒子の平均粒径が１５０μｍを超えると、油分粒子を安定かつ均一に外相中に分散させることが困難となる。油分粒子を取り囲む寒天ゲル粒子の平均粒径は、顕微鏡観察によって測定された任意の１００個の油分粒子の粒径の平均値とすることができる。例えば、寒天ゲル粒子の平均粒径は、任意の１００個の寒天ゲル粒子の、針状部を含む最も長い粒径を測定して算出することができる。 The agar gel particles surrounding the oil particles preferably have an average particle size of 10 μm or more. The average particle size of the agar gel particles surrounding the oil particles can be, for example, 20 μm or more, or 50 μm or more. If the average particle size of the agar gel particles is less than 10 μm, it becomes difficult to stably disperse the oil particles. The agar gel particles surrounding the oil particles preferably have an average particle size of 150 μm or less. The average particle size of the agar gel particles surrounding the oil particles can be, for example, 130 μm or less, or 110 μm or less. When the average particle size of the agar gel particles exceeds 150 μm, it becomes difficult to disperse the oil particles stably and uniformly in the external phase. The average particle size of the agar gel particles surrounding the oil particles can be the average value of the particle sizes of arbitrary 100 oil particles measured by microscopic observation. For example, the average particle size of the agar gel particles can be calculated by measuring the longest particle size including the acicular portion of any 100 agar gel particles.
　本開示の組成物において、寒天は、水１質量部に対して、８×１０－３質量部以上、好ましくは１×１０－２質量部以上、より好ましくは１．５×１０－２質量部以上である。寒天は、水１質量部に対して、例えば、２×１０－２質量部以上、２．５×１０－２質量部以上、３×１０－２質量部以上、３．５×１０－２質量部以上、又は４×１０－２質量部以上とすることができる。寒天が水１質量部に対して８×１０－３質量部未満であると、油分粒子を外相中に安定に分散（乳化）させることが困難となる。寒天は、例えば、水１質量部に対して、０．１質量部以下、０．０８質量部以下、０．０５質量部以下、０．０３質量部以下、又は０．０２質量部以下とすることができる。 In the composition of the present disclosure, agar is 8 × 10 -3 parts by weight or more, preferably 1 × 10 -2 parts by weight or more, more preferably 1.5 × 10 -2 parts by weight, relative to 1 part by weight of water That's it. Agar is, for example, 2 × 10 -2 parts by weight or more, 2.5 × 10 -2 parts by weight or more, 3 × 10 -2 parts by weight or more, 3.5 × 10 -2 parts by weight with respect to 1 part by weight of water parts or more, or 4×10 −2 parts by mass or more. If the amount of agar is less than 8×10 −3 parts by mass with respect to 1 part by mass of water, it becomes difficult to stably disperse (emulsify) the oil particles in the external phase. Agar is, for example, 0.1 parts by mass or less, 0.08 parts by mass or less, 0.05 parts by mass or less, 0.03 parts by mass or less, or 0.02 parts by mass or less with respect to 1 part by mass of water. be able to.
　本開示の油分散組成物に有用な寒天ゲル粒子は、その組成、構造等によって直接特定することが不可能である場合には、その製造方法によって特定することが許容されるべきものである。 Agar gel particles useful for the oil-dispersed composition of the present disclosure should be allowed to be specified by their production method when it is impossible to directly specify them by their composition, structure, etc.
　寒天ゲル粒子の総量は、油分粒子の総量１質量部に対して２質量部以上であると好ましい。寒天ゲル粒子の総量は、例えば、油分粒子の総量１質量部に対して、２．５質量部以上、３質量部以上、４質量部以上、５質量部以上、又は６質量部以上とすることができる。寒天ゲル粒子の総量が２質量部未満であると、油分粒子の分散能力が低下するおそれがある。寒天ゲル粒子の総量は、例えば、油分粒子の総量１質量部に対して、１２質量部以下、１０質量部以下、８質量部以下、６質量部以下、又は５質量部以下とすることができる。 The total amount of agar gel particles is preferably 2 parts by mass or more with respect to 1 part by mass of the total amount of oil particles. The total amount of agar gel particles is, for example, 2.5 parts by mass or more, 3 parts by mass or more, 4 parts by mass or more, 5 parts by mass or more, or 6 parts by mass or more with respect to 1 part by mass of the total amount of oil particles. can be done. If the total amount of the agar gel particles is less than 2 parts by mass, the ability to disperse the oil particles may be reduced. The total amount of agar gel particles can be, for example, 12 parts by mass or less, 10 parts by mass or less, 8 parts by mass or less, 6 parts by mass or less, or 5 parts by mass or less with respect to 1 part by mass of the total amount of oil particles. .
　寒天は、外相の質量に対して、０．５質量％以上であると好ましい。寒天は、例えば、外相の質量に対して、０．８質量％以上、１質量％以上、１．５質量％以上、２質量％以上、２．５質量％以上、３質量％以上、又は３．５質量％以上とすることができる。寒天が０．５質量％未満であると、寒天ゲルの含水率が低くなって粘度が低くなってしまい、油分粒子を安定に支えられなくなってしまう。寒天は、外相の質量に対して、１０質量％以下であると好ましい。寒天は、例えば、外相の質量に対して、８質量％以下、６質量％以下、５質量％以下、４質量％以下、３質量％以下、又は２質量％以下とすることができる。寒天が１０質量％を超えると硬くなり、塗布しづらくなってしまう。 Agar is preferably 0.5% by mass or more with respect to the mass of the external phase. Agar is, for example, 0.8% by mass or more, 1% by mass or more, 1.5% by mass or more, 2% by mass or more, 2.5% by mass or more, 3% by mass or more, or 3% by mass or more with respect to the mass of the external phase .5% by mass or more. If the agar content is less than 0.5% by mass, the water content of the agar gel will be low and the viscosity will be low, and the oil particles will not be stably supported. The content of agar is preferably 10% by mass or less with respect to the mass of the external phase. Agar can be, for example, 8% or less, 6% or less, 5% or less, 4% or less, 3% or less, or 2% or less by weight relative to the weight of the external phase. If the agar content exceeds 10% by mass, it becomes hard and difficult to apply.
　寒天ゲルの含水率は、８５％質量％以上であると好ましい。寒天ゲルの含水率は、９０質量％以上、９５質量％以上、又は１００質量％とすることができる。寒天ゲルの含水率が８５質量％以上であると、油分粒子の分散をより安定にすることができる。ここでいう含水率とは、寒天ゲル作製時に配合した水性溶媒の質量に対する寒天ゲルが包含する水性溶媒（束縛水）の質量の割合である。寒天ゲルの含水率は以下の式より算出することができる。
含水率（％）＝｛（配合した水性溶媒の質量－作製した寒天ゲルを篩にかけて篩から落ちた水性溶媒の質量）／配合した水性溶媒の質量｝×１００ The water content of the agar gel is preferably 85% by mass or more. The water content of the agar gel can be 90% by mass or more, 95% by mass or more, or 100% by mass. When the water content of the agar gel is 85% by mass or more, the oil particles can be more stably dispersed. The water content as used herein is the ratio of the mass of the aqueous solvent (bound water) contained in the agar gel to the mass of the aqueous solvent blended during the preparation of the agar gel. The water content of agar gel can be calculated from the following formula.
Moisture content (%) = {(mass of blended aqueous solvent-mass of aqueous solvent dropped from sieve by sieving prepared agar gel)/mass of blended aqueous solvent} x 100
　油分粒子を取り囲んでいない寒天ゲル粒子（集合体）（すなわち、内相が存在していない状態の寒天ゲル粒子；外相）は、３０℃において、３，０００ｍＰａ・ｓ以上の粘度を有すると好ましい。油分粒子を取り囲んでいない寒天ゲル粒子（集合体）の粘度は、３０℃において、５，０００ｍＰａ・ｓ以上、８，０００ｍＰａ・ｓ以上、１０，０００ｍＰａ・ｓ以上、２０，０００ｍＰａ・ｓ以上、４０，０００ｍＰａ・ｓ以上、又は６０，０００ｍＰａ・ｓ以上とすることができる。外相の粘度が３，０００ｍＰａ・ｓ未満であると、油分粒子に対する分散能力が低下してしまう。油分粒子を取り囲んでいない寒天ゲル粒子（集合体）は、３０℃において、１００，０００ｍＰａ・ｓ以下の粘度を有すると好ましい。油分粒子を取り囲んでいない寒天ゲル粒子（集合体）の粘度は、３０℃において、８０，０００ｍＰａ・ｓ以下、６０，０００ｍＰａ・ｓ以下、４０，０００ｍＰａ・ｓ以下、２０，０００ｍＰａ・ｓ以下、１０，０００ｍＰａ・ｓ以下、又は８，０００ｍＰａ・ｓ以下とすることができる。外相の粘度が１００，０００ｍＰａ・ｓを超えると組成物の粘度が高くなり、塗布しづらくなってしまう。 Agar gel particles (aggregates) that do not surround oil particles (that is, agar gel particles without an internal phase; external phase) preferably have a viscosity of 3,000 mPa·s or more at 30°C. The viscosities of agar gel particles (aggregates) that do not surround oil particles are 5,000 mPa s or more, 8,000 mPa s or more, 10,000 mPa s or more, 20,000 mPa s or more, 40 ,000 mPa·s or more, or 60,000 mPa·s or more. If the viscosity of the external phase is less than 3,000 mPa·s, the ability to disperse oil particles will be reduced. The agar gel particles (aggregates) that do not surround the oil particles preferably have a viscosity of 100,000 mPa·s or less at 30°C. The viscosity of agar gel particles (aggregates) that do not surround oil particles is 80,000 mPa s or less, 60,000 mPa s or less, 40,000 mPa s or less, 20,000 mPa s or less, 10 ,000 mPa·s or less, or 8,000 mPa·s or less. If the viscosity of the external phase exceeds 100,000 mPa·s, the viscosity of the composition increases, making it difficult to apply.
　寒天ゲル粒子の粘度は、寒天ゲル粒子を作製した２４時間後において、ブルックフィールド型粘度計（ローター番号２２、回転数１２ｒｐｍ）で測定開始してから６０秒後の３０℃における粘度とすることができる。 The viscosity of the agar gel particles may be the viscosity at 30° C. 60 seconds after the start of measurement with a Brookfield viscometer (rotor number 22, rotation speed 12 rpm) 24 hours after the agar gel particles are produced. can.
　寒天ゲルは油性成分を内包していないことが好ましい。寒天ゲルは、以下に挙げる水溶性成分を含むことができる。 It is preferable that the agar gel does not contain oily components. The agar gel can contain the water-soluble components listed below.
　外相は、寒天ゲル粒子の外側に水性成分を含むことができる。水性成分としては、水、低級アルコール、多価アルコール、防腐剤、薬剤、キレート剤、ｐＨ緩衝剤、糖等を挙げることができる。 The external phase can contain an aqueous component on the outside of the agar gel particles. Examples of aqueous components include water, lower alcohols, polyhydric alcohols, preservatives, drugs, chelating agents, pH buffers, sugars, and the like.
　水としては、化粧料、医薬部外品等に使用される水を使用することができ、例えば、精製水、イオン交換水、水道水等を使用することができる。 As water, water used for cosmetics, quasi-drugs, etc. can be used, for example, purified water, ion-exchanged water, tap water, etc. can be used.
　低級アルコールとしては、例えば、エタノール、プロパノール、イソプロパノール、イソブチルアルコール、ｔ－ブチルアルコール等が挙げられる。 Examples of lower alcohols include ethanol, propanol, isopropanol, isobutyl alcohol, t-butyl alcohol and the like.
　液状多価アルコールとしては、例えば、グリセリン、１，３－ブチレングリコール、ポリエチレングリコール、ジグリセリン、ジプロピレングリコール等を挙げることができる。 Examples of liquid polyhydric alcohols include glycerin, 1,3-butylene glycol, polyethylene glycol, diglycerin, and dipropylene glycol.
　水性成分は、例えば、組成物の質量に対して、１質量％以上、５質量％以上、１０質量％以上、１５質量％以上、２０質量％以上、又は２５質量％以上とすることができる。水性成分は、例えば、組成物の質量に対して、３５質量％以下、３０質量％以下、２５質量％以下、２０質量％以下、１５質量％以下、１０質量％以下、又は５質量％以下とすることができる。水性成分の含有率は、組成物の用途に応じて適宜設定することができる。 The aqueous component can be, for example, 1% by mass or more, 5% by mass or more, 10% by mass or more, 15% by mass or more, 20% by mass or more, or 25% by mass or more with respect to the mass of the composition. The aqueous component is, for example, 35% by mass or less, 30% by mass or less, 25% by mass or less, 20% by mass or less, 15% by mass or less, 10% by mass or less, or 5% by mass or less with respect to the mass of the composition. can do. The content of the aqueous component can be appropriately set according to the use of the composition.
　外相の含有率は、内相の含有率に応じて設定することができる。外相は、例えば、組成物の質量に対して、６５質量％以上、７０質量％以上、７５質量％以上、８０質量％以上、８５質量％以上、又は９０質量％以上とすることができる。外相は、例えば、組成物の質量に対して、９５質量％以下、９０質量％以下、８５質量％以下、８０質量％以下、７５質量％以下、７０質量％以下、又は６５質量％以下とすることができる。 The content of the external phase can be set according to the content of the internal phase. The external phase can be, for example, 65% or more, 70% or more, 75% or more, 80% or more, 85% or more, or 90% or more by weight of the composition. The external phase is, for example, 95% by mass or less, 90% by mass or less, 85% by mass or less, 80% by mass or less, 75% by mass or less, 70% by mass or less, or 65% by mass or less with respect to the mass of the composition. be able to.
［内相］
　内相である油分粒子は、大気圧、２５℃において液状であると好ましい。液状油性成分は、フッ素油、シリコーン油、炭化水素油、エステル油、高級アルコール、高級脂肪酸及び油脂からなる群から選択される少なくとも１つであると好ましい。 [Internal Affairs]
The oil particles, which are the internal phase, are preferably liquid at atmospheric pressure and 25°C. The liquid oily component is preferably at least one selected from the group consisting of fluorine oils, silicone oils, hydrocarbon oils, ester oils, higher alcohols, higher fatty acids and fats and oils.
　例えば、本開示の油分散組成物を皮膚外用剤に適用する場合、液状油性成分としては、例えば、ジメチコン、水添ポリデセン、トリエチルヘキサノイン、メトキシケイヒ酸エチルヘキシル、スクワラン、ミネラルオイル、エチルヘキサン酸セチル、ワセリン等を挙げることができる。 For example, when the oil-dispersed composition of the present disclosure is applied to an external skin preparation, liquid oily components include, for example, dimethicone, hydrogenated polydecene, triethylhexanoin, ethylhexyl methoxycinnamate, squalane, mineral oil, and cetyl ethylhexanoate. , petroleum jelly and the like.
　本開示の油分散組成物を飲食料に適用する場合、液状油性成分としては、例えば、α-リノレン酸、エイコサペンタエン酸、ドコサヘキサエン酸、アラキドン酸、リノール酸、γ－リノレン酸、オレイン酸、ミリストレイン酸、エイコセン酸、ラウリン酸、リシノール酸、ステアリン酸、アラキドン酸、エイコサペンタエン酸、ドコサヘキサエン酸、オリーブオイル菜種油、アボカド、タラ肝油、イワシ油、トウモロコシ油、大豆油、サラダ油、えごま油、亜麻仁油、ビタミン類、ポリフェノール類、及びカロテノイド類等を挙げることができる。 When the oil dispersion composition of the present disclosure is applied to food and drink, liquid oily components include, for example, α-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid, linoleic acid, γ-linolenic acid, oleic acid, mili Strain acid, eicosenoic acid, lauric acid, ricinoleic acid, stearic acid, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, olive oil, rapeseed oil, avocado, cod liver oil, sardine oil, corn oil, soybean oil, salad oil, perilla oil, linseed oil , vitamins, polyphenols, and carotenoids.
　内相は、固形油分を含むことができる。固形油分は、液状油分に溶解させたり、分散時に溶融状態にしたりすることによって分散させることができる。 The internal phase can contain solid oil. A solid oil can be dispersed by dissolving it in a liquid oil, or by making it into a molten state at the time of dispersion.
　本開示の油分散組成物は、上記油性成分以外の油性成分も含むことができる。油性成分としては、例えば、油溶性紫外線吸収剤、ワックス、液体油脂、固体油脂、ロウ、炭化水素、高級脂肪酸、高級アルコール、合成エステル油、シリコーン油等を使用することができる。 The oil dispersion composition of the present disclosure can also contain oily components other than the above oily components. Examples of oily components that can be used include oil-soluble ultraviolet absorbers, waxes, liquid fats and oils, solid fats and oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, synthetic ester oils, and silicone oils.
　油溶性紫外線吸収剤としては、例えば、安息香酸系紫外線吸収剤（例えば、パラアミノ安息香酸(以下、ＰＡＢＡと略す)、ＰＡＢＡモノグリセリンエステル、Ｎ，Ｎ－ジプロポキシＰＡＢＡエチルエステル、Ｎ，Ｎ－ジエトキシＰＡＢＡエチルエステル、Ｎ，Ｎ－ジメチルＰＡＢＡエチルエステル、Ｎ，Ｎ－ジメチルＰＡＢＡブチルエステル、Ｎ，Ｎ－ジメチルＰＡＢＡエチルエステル、ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル等）；アントラニル酸系紫外線吸収剤（例えば、ホモメンチル-N-アセチルアントラニレート等）；サリチル酸系紫外線吸収剤（例えば、サリチル酸エチルヘキシル、アミルサリシレート、メンチルサリシレート、ホモメンチルサリシレート、オクチルサリシレート、フェニルサリシレート、ベンジルサリシレート、ｐ－イソプロパノールフェニルサリシレート、ホモサレート等）；桂皮酸系紫外線吸収剤（例えば、オクチルメトキシシンナメート、エチル－４－イソプロピルシンナメート、メチル－２，５－ジイソプロピルシンナメート、エチル－２，４－ジイソプロピルシンナメート、メチル－２，４－ジイソプロピルシンナメート、プロピル－ｐ－メトキシシンナメート、イソプロピル－ｐ－メトキシシンナメート、イソアミル－ｐ－メトキシシンナメート、オクチル－ｐ－メトキシシンナメート(２－エチルヘキシル－ｐ－メトキシシンナメート、メトキシケイ皮酸エチルヘキシル)、２－エトキシエチル－ｐ－メトキシシンナメート、シクロヘキシル－ｐ－メトキシシンナメート、エチル－α－シアノ－β－フェニルシンナメート、２－エチルヘキシル－α－シアノ－β－フェニルシンナメート、グリセリルモノ－２－エチルヘキサノイル-ジパラメトキシシンナメート等）；３－（４’－メチルベンジリデン）－ｄ，ｌ－カンファー、３－ベンジリデン－ｄ，ｌ－カンファー；２－フェニル－５－メチルベンゾキサゾール；２，２’－ヒドロキシ－５－メチルフェニルベンゾトリアゾール；２－（２’－ヒドロキシ－５’－ｔ－オクチルフェニル） ベンゾトリアゾール；２－（２’－ヒドロキシ－５’－メチルフェニルベンゾトリアゾール；ジベンザラジン；ジアニソイルメタン；４－メトキシ－４’－ｔ－ブチルジベンゾイルメタン；５－（３，３－ジメチル－２－ノルボルニリデン）－３－ペンタン－２－オン、ジモルホリノピリダジノン；２－エチルヘキシル－２－シアノ－３，３－ジフェニルアクリレート（オクトクレリン）；２，４－ビス－｛［４－（２－エチルヘキシルオキシ）－２－ヒドロキシ］－フェニル｝－６－（４－メトキシフェニル）－（１，３，５）－トリアジン、ベンゾフェノン系紫外線吸収剤（例えば、２，４－ジヒドロキシベンゾフェノン、２，２’－ジヒドロキシ－４－メトキシベンゾフェノン、２，２’－ジヒドロキシ－４，４’－ジメトキシベンゾフェノン、２，２’，４，４’－テトラヒドロキシベンゾフェノン、２－ヒドロキシ－４－メトキシベンゾフェノン、２－ヒドロキシ－４－メトキシ－４’－メチルベンゾフェノン、２－ヒドロキシ－４－メトキシベンゾフェノン－５－スルホン酸塩、４－フェニルベンゾフェノン、２－エチルヘキシル－４’－フェニル－ベンゾフェノン－２－カルボキシレート、２－ヒドロキシ－４－ｎ－オクトキシベンゾフェノン、４－ヒドロキシ－３－カルボキシベンゾフェノン等）等が挙げられる。 Examples of oil-soluble UV absorbers include benzoic acid-based UV absorbers (e.g., para-aminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N,N-dipropoxy PABA ethyl ester, N,N-diethoxy PABA ethyl ester, N,N-dimethyl PABA ethyl ester, N,N-dimethyl PABA butyl ester, N,N-dimethyl PABA ethyl ester, diethylaminohydroxybenzoyl hexyl benzoate, etc.); N-acetylanthranilate, etc.); salicylic acid-based UV absorbers (e.g., ethylhexyl salicylate, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, homosalate, etc.); Acid-based UV absorbers (e.g., octyl methoxycinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate , propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate, ethylhexyl methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2- ethylhexanoyl-diparamethoxycinnamate, etc.); 3-(4′-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2 , 2'-hydroxy-5-methylphenylbenzotriazole; 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole; 2-(2'-hydroxy-5'-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 4-methoxy-4′-t-butyldibenzoylmethane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one, dimorpholinopyridazinone; Xyl-2-cyano-3,3-diphenyl acrylate (octocrelin); 2,4-bis-{[4-(2-ethylhexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)- (1,3,5)-triazine, benzophenone UV absorbers (e.g., 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxy Benzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5- sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4′-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc.) and the like. be done.
　ワックスとしては、例えば、ミツロウ、カンデリラロウ、綿ロウ、カルナウバロウ、ベイベリーロウ、イボタロウ、鯨ロウ、モンタンロウ、ヌカロウ、ラノリン、カポックロウ、酢酸ラノリン、液状ラノリン、サトウキビロウ、ラノリン脂肪酸イソプロピル、ラウリン酸ヘキシル、還元ラノリン、ジョジョバロウ、硬質ラノリン、セラックロウ、ＰＯＥラノリンアルコールエーテル、ＰＯＥラノリンアルコールアセテート、ＰＯＥコレステロールエーテル、ラノリン脂肪酸ポリエチレングリコール、ＰＯＥ水素添加ラノリンアルコールエーテル、例えば、流動パラフィン、オゾケライト、スクワラン、プリスタン、パラフィン、セレシン、スクワレン、ワセリン、マイクロクリスタリンワックス、フィッシャートロプシュワックス等が挙げられる。 Waxes include, for example, beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, wart wax, whale wax, montan wax, bran wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugar cane wax, isopropyl lanolin fatty acid, hexyl laurate, reduced lanolin, Jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, such as liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene , vaseline, microcrystalline wax, Fischer-Tropsch wax, and the like.
　液体油脂としては、例えば、アボガド油、ツバキ油、タートル油、マカデミアナッツ油、トウモロコシ油、ミンク油、オリーブ油、ナタネ油、卵黄油、ゴマ油、パーシック油、小麦胚芽油、サザンカ油、ヒマシ油、アマニ油、サフラワー油、綿実油、エノ油、大豆油、落花生油、茶実油、カヤ油、コメヌカ油、シナギリ油、日本キリ油、ホホバ油、胚芽油、トリグリセリン等が挙げられる。 Examples of liquid oils include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, and linseed oil. , safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, sinagiri oil, Japanese paulownia oil, jojoba oil, germ oil, triglycerin, and the like.
　固体油脂としては、例えば、カカオ脂、ヤシ油、馬脂、硬化ヤシ油、パーム油、牛脂、羊脂、硬化牛脂、パーム核油、豚脂、牛骨脂、モクロウ核油、硬化油、牛脚脂、モクロウ、硬化ヒマシ油等が挙げられる。 Examples of solid fats and oils include cacao butter, coconut oil, horse fat, hydrogenated coconut oil, palm oil, beef tallow, mutton tallow, hydrogenated beef tallow, palm kernel oil, lard, beef bone fat, Japanese wax kernel oil, hydrogenated oil, beef leg fat, Japanese wax, hydrogenated castor oil and the like.
　ロウ類としては、例えば、ミツロウ、カンデリラロウ、綿ロウ、カルナウバロウ、ベイベリーロウ、イボタロウ、鯨ロウ、モンタンロウ、ヌカロウ、ラノリン、カポックロウ、酢酸ラノリン、液状ラノリン、サトウキビロウ、ラノリン脂肪酸イソプロピル、ラウリン酸ヘキシル、還元ラノリン、ジョジョバロウ、硬質ラノリン、セラックロウ、ＰＯＥラノリンアルコールエーテル、ＰＯＥラノリンアルコールアセテート、ＰＯＥコレステロールエーテル、ラノリン脂肪酸ポリエチレングリコール、ＰＯＥ水素添加ラノリンアルコールエーテル等が挙げられる。 Examples of waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, wart wax, whale wax, montan wax, bran wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugarcane wax, isopropyl lanolin fatty acid, hexyl laurate, and reduced lanolin. , jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, and the like.
　炭化水素油としては、例えば、流動パラフィン、オゾケライト、スクワラン、プリスタン、パラフィン、セレシン、スクワレン、ワセリン、マイクロクリスタリンワックス等が挙げられる。 Examples of hydrocarbon oils include liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, and microcrystalline wax.
　高級脂肪酸の炭素数は、例えば、６以上、８以上、又は１０以上とすることができる。高級脂肪酸の炭素数は、例えば、２８以下、２６以下、又は２４以下とすることができる。 The carbon number of the higher fatty acid can be, for example, 6 or more, 8 or more, or 10 or more. The carbon number of the higher fatty acid can be, for example, 28 or less, 26 or less, or 24 or less.
　高級脂肪酸としては、例えば、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、ベヘン酸、オレイン酸、ウンデシレン酸、トール酸、イソステアリン酸、リノール酸、リノレイン酸、エイコサペンタエン酸（ＥＰＡ）、ドコサヘキサエン酸（ＤＨＡ）等が挙げられる。 Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, toric acid, isostearic acid, linoleic acid, linoleic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid ( DHA) and the like.
　高級アルコールの炭素数は、例えば、６以上、８以上、又は１０以上とすることができる。高級アルコールの炭素数は、例えば、２８以下、２６以下、又は２４以下とすることができる。 The carbon number of the higher alcohol can be, for example, 6 or more, 8 or more, or 10 or more. The carbon number of the higher alcohol can be, for example, 28 or less, 26 or less, or 24 or less.
　高級アルコールとしては、例えば、直鎖アルコール（例えば、ラウリルアルコール、セチルアルコール、ステアリルアルコール、ベヘニルアルコール、ミリスチルアルコール、オレイルアルコール、セトステアリルアルコール等）；分枝鎖アルコール（例えば、モノステアリルグリセリンエーテル(バチルアルコール)、２－デシルテトラデシノール、ラノリンアルコール、コレステロール、フィトステロール、ヘキシルドデカノール、イソステアリルアルコール、オクチルドデカノール等）等を使用することができる。 Higher alcohols include, for example, straight-chain alcohols (e.g., lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, etc.); branched-chain alcohols (e.g., monostearyl glycerin ether (bacyl alcohol ), 2-decyltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, octyldodecanol, etc.) can be used.
　合成エステル油としては、ミリスチン酸イソプロピル、オクタン酸セチル、ミリスチン酸オクチルドデシル、パルミチン酸イソプロピル、ステアリン酸ブチル、ラウリン酸ヘキシル、ミリスチン酸ミリスチル、オレイン酸デシル、ジメチルオクタン酸ヘキシルデシル、乳酸セチル、乳酸ミリスチル、酢酸ラノリン、ステアリン酸イソセチル、イソステアリン酸イソセチル、１２－ヒドロキシステアリン酸コレステリル、ジ－２－エチルヘキサン酸エチレングリコール、ジペンタエリスリトール脂肪酸エステル、モノイソステアリン酸Ｎ－アルキルグリコール、ジカプリン酸ネオペンチルグリコール、リンゴ酸ジイソステアリル、ジ－２－ヘプチルウンデカン酸グリセリン、トリ－２－エチルヘキサン酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、テトラ－２－エチルヘキサン酸ペンタエリスリトール、トリ－２－エチルヘキサン酸グリセリン、トリオクタン酸グリセリン、トリイソパルミチン酸グリセリン、トリイソステアリン酸トリメチロールプロパン、セチル２－エチルヘキサノエート、２－エチルヘキシルパルミテート、トリミリスチン酸グリセリン、トリ－２－ヘプチルウンデカン酸グリセライド、ヒマシ油脂肪酸メチルエステル、オレイン酸オレイル、アセトグリセライド、パルミチン酸２－ヘプチルウンデシル、アジピン酸ジイソブチル、Ｎ－ラウロイル－Ｌ－グルタミン酸－２－オクチルドデシルエステル、アジピン酸ジ－２－ヘプチルウンデシル、エチルラウレート、セバシン酸ジ－２－エチルヘキシル、ミリスチン酸２－ヘキシルデシル、パルミチン酸２－ヘキシルデシル、アジピン酸２－ヘキシルデシル、セバシン酸ジイソプロピル、コハク酸２－エチルヘキシル、クエン酸トリエチル等が挙げられる。 Synthetic ester oils include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, and myristyl lactate. , lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, apple diisostearyl acid, glyceryl di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, pentaerythritol tetra-2-ethylhexanoate, glyceryl tri-2-ethylhexanoate , glyceryl trioctanoate, glyceryl triisopalmitate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimyristate, tri-2-heptyl undecanoic acid glyceride, castor oil fatty acid methyl ester, oleyl oleate, acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, N-lauroyl-L-glutamic acid 2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, sebacin di-2-ethylhexyl acid, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, triethyl citrate and the like.
　シリコーン油としては、ジメチルポリシロキサン、メチルハイドロジェンポリシロキサン、メチルフェニルポリシロキサン、ステアロキシメチルポリシロキサン、ポリエーテル変性オルガノポリシロキサン、フルオロアルキル・ポリオキシアルキレン共変性オルガノポリシロキサン、アルキル変性オルガノポリシロキサン、末端変性オルガノポリシロキサン、フッ素変性オルガノポリシロキサン、アミノ変性オルガノポリシロキサン、シリコーンゲル、アクリルシリコーン、トリメチルシロキシケイ酸、シリコーンＲＴＶゴム、シクロペンタシロキサン等のシリコーン化合物等が挙げられる。 Examples of silicone oils include dimethylpolysiloxane, methylhydrogenpolysiloxane, methylphenylpolysiloxane, stearoxymethylpolysiloxane, polyether-modified organopolysiloxane, fluoroalkyl/polyoxyalkylene co-modified organopolysiloxane, and alkyl-modified organopolysiloxane. , terminal-modified organopolysiloxane, fluorine-modified organopolysiloxane, amino-modified organopolysiloxane, silicone gel, acrylic silicone, trimethylsiloxysilicate, silicone RTV rubber, and silicone compounds such as cyclopentasiloxane.
　寒天ゲル粒子によって取り囲まれる油分粒子（内相）は、２００μｍ以上の平均粒径を有すると好ましい。油分粒子の平均粒径は、例えば、３００μｍ以上、４００μｍ以上、５００μｍ以上、６００μｍ以上、７００μｍ以上、又は８００μｍ以上とすることができる。油分粒子の平均粒径が２００μｍ未満であると、組成物を皮膚外用剤に適用した場合に、肌に塗布したときに良好な使用感を得ることが難しくなる。寒天ゲル粒子によって取り囲まれる油分粒子（内相）は、２，０００μｍ以下の平均粒径を有すると好ましい。油分粒子の平均粒径は、例えば、１，８００μｍ以下、１，６００μｍ以下、１，４００μｍ以下、１，２００μｍ以下、１，０００μｍ以下、８００μｍ以下、６００μｍ以下、又は４００μｍ以下、とすることができる。油分粒子の平均粒径が２，０００μｍを超えると、油分粒子を安定に外相中に分散させることが困難となる。寒天ゲル粒子によって取り囲まれる油分粒子の平均粒径は、顕微鏡観察によって測定された任意の１００個の油分粒子の粒径の平均値とすることができる。 The oil particles (internal phase) surrounded by the agar gel particles preferably have an average particle size of 200 μm or more. The average particle size of the oil particles can be, for example, 300 μm or more, 400 μm or more, 500 μm or more, 600 μm or more, 700 μm or more, or 800 μm or more. When the average particle size of the oil particles is less than 200 μm, it becomes difficult to obtain a good feel when applied to the skin when the composition is applied to the skin. The oil particles (internal phase) surrounded by the agar gel particles preferably have an average particle size of 2,000 μm or less. The average particle size of the oil particles can be, for example, 1,800 μm or less, 1,600 μm or less, 1,400 μm or less, 1,200 μm or less, 1,000 μm or less, 800 μm or less, 600 μm or less, or 400 μm or less. . When the average particle size of the oil particles exceeds 2,000 μm, it becomes difficult to stably disperse the oil particles in the external phase. The average particle size of the oil particles surrounded by the agar gel particles can be the average value of the particle sizes of arbitrary 100 oil particles measured by microscopic observation.
　内相は、組成物の質量に対して、５質量％以上であると好ましい。内相は、例えば、組成物の質量に対して、１０質量％以上、１５質量％以上、２０質量％以上、２５質量％以上、３０質量％以上、又は３５質量％以上とすることができる。内相が５質量％未満であると、内相の作用を得ることができない。内相は、組成物の質量に対して、３５質量％以下であると好ましい。内相は、例えば、組成物の質量に対して、３０質量％以下、２５質量％以下、２０質量％以下、１５質量％以下、又は１０質量％以下とすることができる。内相が３５質量％を超えると、内相の分散安定性が低下してしまう。 The content of the internal phase is preferably 5% by mass or more relative to the mass of the composition. The internal phase can be, for example, 10% or more, 15% or more, 20% or more, 25% or more, 30% or more, or 35% or more by weight of the composition. If the content of the internal phase is less than 5% by mass, the effect of the internal phase cannot be obtained. The content of the internal phase is preferably 35% by mass or less relative to the mass of the composition. The internal phase can be, for example, 30% or less, 25% or less, 20% or less, 15% or less, or 10% or less by weight of the composition. When the content of the internal phase exceeds 35% by mass, the dispersion stability of the internal phase is lowered.
［界面活性剤］
　本開示の油分散組成物において、界面活性剤は、油分散組成物の質量に対して、０．５質量％以下、好ましくは０．３質量％以下、より好ましくは０．１質量％以下、さらに好ましくは含有しないと好ましい。界面活性剤を０．５質量％以下とすることにより、肌への刺激を低減することができる。また、油分散組成物を飲食料への適用が可能となる。 [Surfactant]
In the oil dispersion composition of the present disclosure, the surfactant is 0.5% by mass or less, preferably 0.3% by mass or less, more preferably 0.1% by mass or less, based on the mass of the oil dispersion composition. More preferably, it should not be contained. By setting the surfactant to 0.5% by mass or less, irritation to the skin can be reduced. In addition, it becomes possible to apply the oil dispersion composition to food and drink.
　アニオン性界面活性剤としては、例えば、脂肪酸セッケン（例えば、ラウリン酸ナトリウム、パルミチン酸ナトリウム等）；高級アルキル硫酸エステル塩（例えば、ラウリル硫酸ナトリウム、ラウリル硫酸カリウム等）；アルキルエーテル硫酸エステル塩（例えば、ＰＯＥ－ラウリル硫酸トリエタノールアミン、ＰＯＥ－ラウリル硫酸ナトリウム等）；Ｎ－アシルサルコシン酸（例えば、ラウロイルサルコシンナトリウム等）；高級脂肪酸アミドスルホン酸塩（例えば、Ｎ‐ステアロイル‐Ｎ‐メチルタウリンナトリウム、Ｎ－ミリストイル－Ｎ－メチルタウリンナトリウム、ヤシ油脂肪酸メチルタウリンナトリウム、ラウリルメチルタウリッドナトリウム等）；リン酸エステル塩（ＰＯＥ－オレイルエーテルリン酸ナトリウム、ＰＯＥ－ステアリルエーテルリン酸等）；スルホコハク酸塩（例えば、ジ－２－エチルヘキシルスルホコハク酸ナトリウム、モノラウロイルモノエタノールアミドポリオキシエチレンスルホコハク酸ナトリウム、ラウリルポリプロピレングリコールスルホコハク酸ナトリウム等）；アルキルベンゼンスルホン酸塩（例えば、リニアドデシルベンゼンスルホン酸ナトリウム、リニアドデシルベンゼンスルホン酸トリエタノールアミン、リニアドデシルベンゼンスルホン酸等）；高級脂肪酸エステル硫酸エステル塩（例えば、硬化ヤシ油脂肪酸グリセリン硫酸ナトリウム等）；Ｎ－アシルグルタミン酸塩（例えば、Ｎ－ラウロイルグルタミン酸モノナトリウム、Ｎ－ステアロイルグルタミン酸ジナトリウム、Ｎ－ミリストイル－Ｌ－グルタミン酸モノナトリウム等）；硫酸化油（例えば、ロート油等）；ＰＯＥ－アルキルエーテルカルボン酸；ＰＯＥ－アルキルアリルエーテルカルボン酸塩；α-オレフィンスルホン酸塩；高級脂肪酸エステルスルホン酸塩；二級アルコール硫酸エステル塩；高級脂肪酸アルキロールアミド硫酸エステル塩；ラウロイルモノエタノールアミドコハク酸ナトリウム；Ｎ－パルミトイルアスパラギン酸ジトリエタノールアミン；カゼインナトリウム等を使用することができる。 Examples of anionic surfactants include fatty acid soaps (e.g., sodium laurate, sodium palmitate, etc.); higher alkyl sulfate salts (e.g., sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfates (e.g., , POE-triethanolamine lauryl sulfate, POE-sodium lauryl sulfate, etc.); N-acylsarcosic acid (e.g., sodium lauroyl sarcosinate, etc.); sodium N-myristoyl-N-methyltaurate, sodium coconut oil fatty acid methyltaurate, sodium lauryl methyl tauride, etc.); phosphate ester salts (POE-sodium oleyl ether phosphate, POE-stearyl ether phosphate, etc.); sulfosuccinate (For example, sodium di-2-ethylhexyl sulfosuccinate, monolauroyl monoethanolamide sodium polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc.); sulfonic acid triethanolamine, linadodecylbenzene sulfonic acid, etc.); higher fatty acid ester sulfate salts (eg, hydrogenated coconut oil fatty acid sodium glycerol sulfate, etc.); disodium stearoyl glutamate, monosodium N-myristoyl-L-glutamate, etc.); sulfated oil (e.g. funnel oil, etc.); POE-alkyl ether carboxylic acid; POE-alkyl allyl ether carboxylate; α-olefin sulfonate higher fatty acid ester sulfonate; secondary alcohol sulfate; higher fatty acid alkylolamide sulfate; sodium lauroyl monoethanolamide succinate; N-palmitoyl aspartic acid ditriethanolamine; .
　カチオン界面活性剤としては、例えば、アルキルトリメチルアンモニウム塩（例えば、塩化ステアリルトリメチルアンモニウム、塩化ラウリルトリメチルアンモニウム等）；アルキルピリジニウム塩（例えば、塩化セチルピリジニウム等）；ジアルキルジメチルアンモニウム塩（例えば、塩化ジステアリルジメチルアンモニウム）；塩化ポリ（Ｎ，Ｎ’－ジメチル－３，５－メチレンピペリジニウム)；アルキル四級アンモニウム塩；アルキルジメチルベンジルアンモニウム塩；アルキルイソキノリニウム塩；ジアルキルモリホニウム塩；ＰＯＥ－アルキルアミン；アルキルアミン塩；ポリアミン脂肪酸誘導体；アミルアルコール脂肪酸誘導体；塩化ベンザルコニウム；塩化ベンゼトニウム等が挙げられる。 Cationic surfactants include, for example, alkyltrimethylammonium salts (e.g., stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.); alkylpyridinium salts (e.g., cetylpyridinium chloride, etc.); dialkyldimethylammonium salts (e.g., distearyl chloride dimethylammonium); poly(N,N'-dimethyl-3,5-methylenepiperidinium) chloride; alkyl quaternary ammonium salts; alkyldimethylbenzylammonium salts; alkylisoquinolinium salts; - alkylamine; alkylamine salt; polyamine fatty acid derivative; amyl alcohol fatty acid derivative; benzalkonium chloride;
　両性界面活性剤としては、例えば、イミダゾリン系両性界面活性剤（例えば、２－ウンデシル－Ｎ，Ｎ，Ｎ－（ヒドロキシエチルカルボキシメチル）－２－イミダゾリンナトリウム、２－ココイル－２－イミダゾリニウムヒドロキサイド－１－カルボキシエチロキシ２ナトリウム塩等）；ベタイン系界面活性剤（例えば、２－ヘプタデシル－Ｎ－カルボキシメチル－Ｎ－ヒドロキシエチルイミダゾリニウムベタイン、ラウリルジメチルアミノ酢酸ベタイン、アルキルベタイン、アミドベタイン、スルホベタイン等）等が挙げられる。 Amphoteric surfactants include, for example, imidazoline-based amphoteric surfactants (e.g., 2-undecyl-N,N,N-(hydroxyethylcarboxymethyl)-2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide side-1-carboxyethyloxy disodium salt, etc.); betaine surfactants (e.g., 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkylbetaine, amidobetaine , sulfobetaine, etc.) and the like.
　親水性非イオン界面活性剤としては、例えば、ＰＯＥ－ソルビタン脂肪酸エステル（例えば、ＰＯＥ－ソルビタンモノオレエート、ＰＯＥ－ソルビタンモノステアレート、ＰＯＥ－ソルビタンモノオレエート、ＰＯＥ－ソルビタンテトラオレエート等）；ＰＯＥ－ソルビット脂肪酸エステル（例えば、ＰＯＥ－ソルビットモノラウレート、ＰＯＥ－ソルビットモノオレエート、ＰＯＥ－ソルビットペンタオレエート、ＰＯＥ－ソルビットモノステアレート等）；ＰＯＥ－グリセリン脂肪酸エステル（例えば、ＰＯＥ－グリセリンモノステアレート、ＰＯＥ－グリセリンモノイソステアレート、ＰＯＥ－グリセリントリイソステアレート等のＰＯＥ－モノオレエート等）；ＰＯＥ－脂肪酸エステル（例えば、ＰＯＥ－ジステアレート、ＰＯＥ－モノジオレエート、ジステアリン酸エチレングリコール等）；ＰＯＥ－アルキルエーテル（例えば、ＰＯＥ－ラウリルエーテル、ＰＯＥ－オレイルエーテル、ＰＯＥ－ステアリルエーテル、ＰＯＥ－ベヘニルエーテル、ＰＯＥ－２－オクチルドデシルエーテル、ＰＯＥ－コレスタノールエーテル等）；プルロニック型（例えば、プルロニック等）；ＰＯＥ・ＰＯＰ－アルキルエーテル（例えば、ＰＯＥ・ＰＯＰ－セチルエーテル、ＰＯＥ・ＰＯＰ－２－デシルテトラデシルエーテル、ＰＯＥ・ＰＯＰ－モノブチルエーテル、ＰＯＥ・ＰＯＰ－水添ラノリン、ＰＯＥ・ＰＯＰ－グリセリンエーテル等）；テトラＰＯＥ・テトラＰＯＰ－エチレンジアミン縮合物（例えば、テトロニック等）；ＰＯＥ－ヒマシ油硬化ヒマシ油誘導体（例えば、ＰＯＥ－ヒマシ油、ＰＯＥ－硬化ヒマシ油、ＰＯＥ－硬化ヒマシ油モノイソステアレート、ＰＯＥ－硬化ヒマシ油トリイソステアレート、ＰＯＥ－硬化ヒマシ油モノピログルタミン酸モノイソステアリン酸ジエステル、ＰＯＥ－硬化ヒマシ油マレイン酸等）；ＰＯＥ－ミツロウ・ラノリン誘導体（例えば、ＰＯＥ－ソルビットミツロウ等）；アルカノールアミド（例えば、ヤシ油脂肪酸ジエタノールアミド、ラウリン酸モノエタノールアミド、脂肪酸イソプロパノールアミド等）；ＰＯＥ－プロピレングリコール脂肪酸エステル；ＰＯＥ－アルキルアミン；ＰＯＥ－脂肪酸アミド；ショ糖脂肪酸エステル；アルキルエトキシジメチルアミンオキシド；トリオレイルリン酸等が挙げられる。 Hydrophilic nonionic surfactants include, for example, POE-sorbitan fatty acid esters (eg, POE-sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate, etc.); POE-sorbitol fatty acid esters (eg, POE-sorbitol monolaurate, POE-sorbitol monooleate, POE-sorbitol pentaoleate, POE-sorbitol monostearate, etc.); POE-glycerin fatty acid esters (eg, POE-glycerol mono stearate, POE-monooleate such as POE-glycerin monoisostearate, POE-glycerin triisostearate, etc.); POE-fatty acid esters (e.g., POE-distearate, POE-monodioleate, ethylene glycol distearate, etc.); Alkyl ethers (eg, POE-lauryl ether, POE-oleyl ether, POE-stearyl ether, POE-behenyl ether, POE-2-octyldodecyl ether, POE-cholestanol ether, etc.); Pluronic types (eg, Pluronic, etc.); POE/POP-alkyl ether (e.g., POE/POP-cetyl ether, POE/POP-2-decyltetradecyl ether, POE/POP-monobutyl ether, POE/POP-hydrogenated lanolin, POE/POP-glycerin ether, etc.) tetra-POE/tetra-POP-ethylenediamine condensates (e.g., Tetronic, etc.); POE-castor oil hydrogenated castor oil derivatives (e.g., POE-castor oil, POE-hydrogenated castor oil, POE-hydrogenated castor oil monoisostearate, POE-hydrogenated castor oil triisostearate, POE-hydrogenated castor oil monopyroglutamic acid monoisostearate diester, POE-hydrogenated castor oil maleic acid, etc.); amides (eg, coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.); POE-propylene glycol fatty acid esters; POE-alkylamines; POE-fatty acid amides; sucrose fatty acid esters; trioleyl phosphate and the like.
　親油性非イオン界面活性剤としては、例えば、ソルビタン脂肪酸エステル（例えば、ソルビタンモノオレエート、ソルビタンモノイソステアレート、ソルビタンモノラウレート、ソルビタンモノパルミテート、ソルビタンモノステアレート、ソルビタンセスキオレエート、ソルビタントリオレエート、ペンタ－２－エチルヘキシル酸ジグリセロールソルビタン、テトラ－２－エチルヘキシル酸ジグリセロールソルビタン等）；グリセリンポリグリセリン脂肪酸（例えば、モノ綿実油脂肪酸グリセリン、モノエルカ酸グリセリン、セスキオレイン酸グリセリン、モノステアリン酸グリセリン、α,α'－オレイン酸ピログルタミン酸グリセリン、モノステアリン酸グリセリンリンゴ酸等）；プロピレングリコール脂肪酸エステル（例えば、モノステアリン酸プロピレングリコール等）；硬化ヒマシ油誘導体；グリセリンアルキルエーテル等が挙げられる。 Lipophilic nonionic surfactants include, for example, sorbitan fatty acid esters (e.g., sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate, etc.); , α,α'-glycerol pyroglutamate, glyceryl monostearate, malic acid, etc.); propylene glycol fatty acid esters (eg, propylene glycol monostearate, etc.); hydrogenated castor oil derivatives;
［増粘剤］
　本開示の油分散組成物において、油性成分の分散に増粘剤の作用を利用する必要はない。なお、本開示において、増粘剤に寒天は含まれない。増粘剤は、油分散組成物の質量に対して、例えば、１質量％以下、０．５質量％以下、０．３質量％以下、０．１質量％以下、又は０質量％（無含有）とすることができる。 [Thickener]
In the oil dispersion composition of the present disclosure, it is not necessary to use the action of a thickener to disperse the oily component. In the present disclosure, the thickening agent does not include agar. The thickener is, for example, 1% by mass or less, 0.5% by mass or less, 0.3% by mass or less, 0.1% by mass or less, or 0% by mass (not containing ).
　増粘剤としては、例えば、アラビアガム、カラギーナン、カラヤガム、トラガカントガム、キャロブガム、クインスシード（マルメロ）、カゼイン、デキストリン、ゼラチン、ペクチン酸ナトリウム、アルギン酸ナトリウム、メチルセルロース、エチルセルロース、カルボキシメチルセルロース（ＣＭＣ）、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、ポリビニルアルコール（ＰＶＡ）、ポリビニルメチルエーテル（ＰＶＭ）、ＰＶＰ（ポリビニルピロリドン）、ポリアクリル酸ナトリウム、カルボキシビニルポリマー、ローカストビーンガム、グアガム、タマリントガム、ジアルキルジメチルアンモニウム硫酸セルロース、キサンタンガム、ケイ酸アルミニウムマグネシウム、ベントナイト、ヘクトライト、ケイ酸アルミニウムマグネシウム（ビーガム）、ラポナイト、無水ケイ酸、タウレート系合成高分子、アクリレート系合成高分子等が挙げられる。 Thickeners include, for example, gum arabic, carrageenan, karaya gum, tragacanth gum, carob gum, quince seed (quince), casein, dextrin, gelatin, sodium pectate, sodium alginate, methylcellulose, ethylcellulose, carboxymethylcellulose (CMC), and hydroxyethylcellulose. , hydroxypropylcellulose, polyvinyl alcohol (PVA), polyvinyl methyl ether (PVM), PVP (polyvinylpyrrolidone), sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, dialkyldimethylammonium cellulose sulfate, xanthan gum, silica Examples include magnesium aluminum oxide, bentonite, hectorite, magnesium aluminum silicate (Vegum), laponite, silicic anhydride, taurate-based synthetic polymer, and acrylate-based synthetic polymer.
［その他］
　本開示の油分散組成物は、本開示の効果を阻害しない範囲において、他の成分、例えば、粉末、水溶性アルコール、保湿剤、皮膜剤、水溶性紫外線吸収剤、金属イオン封鎖剤、アミノ酸、有機アミン、高分子エマルジョン、ｐＨ調整剤、皮膚栄養剤、ビタミン、酸化防止剤、酸化防止助剤、香料等を必要に応じて適宜含有することができる。 [others]
The oil dispersion composition of the present disclosure contains other ingredients such as powders, water-soluble alcohols, humectants, film-forming agents, water-soluble ultraviolet absorbers, sequestering agents, amino acids, as long as the effects of the present disclosure are not impaired. Organic amines, polymer emulsions, pH adjusters, skin nutrients, vitamins, antioxidants, antioxidant aids, fragrances and the like can be appropriately contained as necessary.
　粉末としては、例えば、無機粉末（例えば、タルク、カオリン、雲母、絹雲母(セリサイト)、白雲母、金雲母、合成雲母、紅雲母、黒雲母、リチア雲母、焼成雲母、焼成タルク、バーミキュライト、炭酸マグネシウム、炭酸カルシウム、ケイ酸アルミニウム、ケイ酸バリウム、ケイ酸カルシウム、ケイ酸マグネシウム、ケイ酸ストロンチウム、タングステン酸金属塩、マグネシウム、シリカ、煙霧状シリカ、ゼオライト、ガラス、硫酸バリウム、焼成硫酸カルシウム(焼セッコウ)、リン酸カルシウム、フッ素アパタイト、ヒドロキシアパタイト、セラミックパウダー、金属石鹸(例えば、ミリスチン酸亜鉛、パルミチン酸カルシウム、ステアリン酸アルミニウム)、窒化ホウ素等）；有機粉末（例えば、ポリアミド樹脂粉末(ナイロン粉末)、ポリエチレン粉末、ポリメタクリル酸メチル粉末、ポリスチレン粉末、スチレンとアクリル酸の共重合体樹脂粉末、ベンゾグアナミン樹脂粉末、ポリ四フッ化エチレン粉末、セルロース粉末、シリコーン樹脂粉末、シルクパウダー、ウールパウダー、ウレタンパウダー等）；無機白色顔料（例えば、二酸化チタン、酸化亜鉛等）；無機赤色系顔料（例えば、酸化鉄（ベンガラ）、チタン酸鉄等）；無機褐色系顔料（γ－酸化鉄等）、無機黄色系顔料（黄酸化鉄、黄土等）、無機黒色系顔料（黒酸化鉄、カーボンブラック、低次酸化チタン等）、無機紫色系顔料（例えば、マンガンバイオレット、コバルトバイオレット等）；無機緑色系顔料（例えば、酸化クロム、水酸化クロム、チタン酸コバルト等）；無機青色系顔料（例えば、群青、紺青等）；パール顔料（例えば、酸化チタンコーテッドマイカ、酸化チタンコーテッドオキシ塩化ビスマス、酸化チタンコーテッドタルク、着色酸化チタンコーテッドマイカ、オキシ塩化ビスマス、魚鱗箔等）；金属粉末顔料（例えば、アルミニウムパウダー、カッパーパウダー等）；ジルコニウム、バリウム又はアルミニウムレーキ等の有機顔料（例えば、赤色２０１号、赤色２０２号、赤色２０４号、赤色２０５号、赤色２２０号、赤色２２６号、赤色２２８号、赤色４０５号、橙色２０３号、橙色２０４号、黄色２０５号、黄色４０１号、及び青色４０４号などの有機顔料、赤色３号、赤色１０４号、赤色１０６号、赤色２２７号、赤色２３０号、赤色４０１号、赤色５０５号、橙色２０５号、黄色４号、黄色５号、黄色２０２号、黄色２０３号、緑色３号及び青色１号等）；天然色素（例えば、クロロフィル、β－カロチン等）；ワックス粉末（例えば、カルナバワックス粉末等）；デンプン粉末（例えば、トウモロコシデンプン粉末、コメデンプン粉末等）等を使用することができる。 Powders include, for example, inorganic powders (e.g., talc, kaolin, mica, sericite (sericite), muscovite, phlogopite, synthetic mica, red mica, biotite, slithiamite, calcined mica, calcined talc, vermiculite, Magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, fumed silica, zeolite, glass, barium sulfate, calcined calcium sulfate ( Calcined gypsum), calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, metal soap (e.g. zinc myristate, calcium palmitate, aluminum stearate), boron nitride, etc.); organic powder (e.g. polyamide resin powder (nylon powder) , polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, silicone resin powder, silk powder, wool powder, urethane powder etc.); inorganic white pigments (e.g., titanium dioxide, zinc oxide, etc.); inorganic red pigments (e.g., iron oxide (red iron oxide), iron titanate, etc.); inorganic brown pigments (γ-iron oxide, etc.), inorganic yellow system pigments (yellow iron oxide, ocher, etc.), inorganic black pigments (black iron oxide, carbon black, low order titanium oxide, etc.), inorganic purple pigments (e.g., manganese violet, cobalt violet, etc.); inorganic green pigments ( For example, chromium oxide, chromium hydroxide, cobalt titanate, etc.); Inorganic blue pigments (for example, ultramarine blue, Prussian blue, etc.); colored titanium oxide-coated mica, bismuth oxychloride, fish scale foil, etc.); metal powder pigments (e.g., aluminum powder, copper powder, etc.); organic pigments such as zirconium, barium, or aluminum lakes (e.g., Red No. 201, Red No. 202, Organic pigments such as Red No. 204, Red No. 205, Red No. 220, Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401, and Blue No. 404, red Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3 and Blue No. 1, etc.); natural pigments (e.g., chlorophyll, β-carotene, etc.); wax powders (e.g., carnauba wax powder, etc.); starch powders (e.g., corn starch powder, rice starch powder) etc.) can be used.
　水溶性アルコールとしては、例えば、低級アルコール、多価アルコール、多価アルコール重合体、２価のアルコールアルキルエーテル類、２価アルコールアルキルエーテル類、２価アルコールエーテルエステル、グリセリンモノアルキルエーテル、糖アルコール、単糖、オリゴ糖、多糖およびそれらの誘導体等から選ばれる少なくとも１つを挙げることができる。 Examples of water-soluble alcohols include lower alcohols, polyhydric alcohols, polyhydric alcohol polymers, dihydric alcohol alkyl ethers, dihydric alcohol alkyl ethers, dihydric alcohol ether esters, glycerin monoalkyl ethers, sugar alcohols, At least one selected from monosaccharides, oligosaccharides, polysaccharides, derivatives thereof, and the like can be mentioned.
　多価アルコールとしては、例えば、２価のアルコール（例えば、エチレングリコール、プロピレングリコール、トリメチレングリコール、１，２－ブチレングリコール、１，３－ブチレングリコール、テトラメチレングリコール、２，３－ブチレングリコール、ペンタメチレングリコール、２－ブテン－１，４－ジオール、ヘキシレングリコール、オクチレングリコール等）；３価のアルコール（例えば、グリセリン、トリメチロールプロパン等）；４価アルコール（例えば、１，２，６－ヘキサントリオール等のペンタエリスリトール等）；５価アルコール（例えば、キシリトール等）；６価アルコール（例えば、ソルビトール、マンニトール等）；多価アルコール重合体（例えば、ジエチレングリコール、ジプロピレングリコール、トリエチレングリコール、ポリプロピレングリコール、テトラエチレングリコール、ジグリセリン、ポリエチレングリコール、トリグリセリン、テトラグリセリン、ポリグリセリン等）；２価のアルコールアルキルエーテル類（例えば、エチレングリコールモノメチルエーテル、エチレングリコールモノエチルエーテル、エチレングリコールモノブチルエーテル、エチレングリコールモノフェニルエーテル、エチレングリコールモノヘキシルエーテル、エチレングリコールモノ２－メチルヘキシルエーテル、エチレングリコールイソアミルエーテル、エチレングリコールベンジルエーテル、エチレングリコールイソプロピルエーテル、エチレングリコールジメチルエーテル、エチレングリコールジエチルエーテル、エチレングリコールジブチルエーテル等）；２価アルコールアルキルエーテル類（例えば、ジエチレングリコールモノメチルエーテル、ジエチレングリコールモノエチルエーテル、ジエチレングリコールモノブチルエーテル、ジエチレングリコールジメチルエーテル、ジエチレングリコールジエチルエーテル、ジエチレングリコールブチルエーテル、ジエチレングリコールメチルエチルエーテル、トリエチレングリコールモノメチルエーテル、トリエチレングリコールモノエチルエーテル、プロピレングリコールモノメチルエーテル、プロピレングリコールモノエチルエーテル、プロピレングリコールモノブチルエーテル、プロピレングリコールイソプロピルエーテル、ジプロピレングリコールメチルエーテル、ジプロピレングリコールエチルエーテル、ジプロピレングリコールブチルエーテル等）；２価アルコールエーテルエステル（例えば、エチレングリコールモノメチルエーテルアセテート、エチレングリコールモノエチルエーテルアセテート、エチレングリコールモノブチルエーテルアセテート、エチレングリコールモノフェニルエーテルアセテート、エチレングリコールジアジベート、エチレングリコールジサクシネート、ジエチレングリコールモノエチルエーテルアセテート、ジエチレングリコールモノブチルエーテルアセテート、プロピレングリコールモノメチルエーテルアセテート、プロピレングリコールモノエチルエーテルアセテート、プロピレングリコールモノプロピルエーテルアセテート、プロピレングリコールモノフェニルエーテルアセテート等）；グリセリンモノアルキルエーテル（例えば、キミルアルコール、セラキルアルコール、バチルアルコール等）；糖アルコール（例えば、ソルビトール、マルチトール、マルトトリオース、マンニトール、ショ糖、エリトリトール、グルコース、フルクトース、デンプン分解糖、マルトース、キシリトール、デンプン分解糖還元アルコール等）；グリコリド；テトラハイドロフルフリルアルコール；ＰＯＥ－テトラハイドロフルフリルアルコール；ＰＯＰ－ブチルエーテル；ＰＯＰ・ＰＯＥ－ブチルエーテル；トリポリオキシプロピレングリセリンエーテル；ＰＯＰ－グリセリンエーテル；ＰＯＰ－グリセリンエーテルリン酸；ＰＯＰ・ＰＯＥ－ペンタンエリスリトールエーテル、ポリグリセリン等が挙げられる。 Polyhydric alcohols include, for example, dihydric alcohols (e.g., ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, 2,3-butylene glycol, pentamethylene glycol, 2-butene-1,4-diol, hexylene glycol, octylene glycol, etc.); trihydric alcohols (e.g., glycerin, trimethylolpropane, etc.); tetrahydric alcohols (e.g., 1,2,6 -pentaerythritol such as hexanetriol); pentahydric alcohols (e.g., xylitol, etc.); hexahydric alcohols (e.g., sorbitol, mannitol, etc.); polyhydric alcohol polymers (e.g., diethylene glycol, dipropylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol, diglycerin, polyethylene glycol, triglycerin, tetraglycerin, polyglycerin, etc.); dihydric alcohol alkyl ethers (e.g., ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, Ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono-2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, ethylene glycol isopropyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, etc. ); dihydric alcohol alkyl ethers (e.g., diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl Ether, Propylene Glycol Monomethyl Ether, Propylene Glycol Monoethyl Ether, Propylene Glycol Monobutyl Ether, Propylene Glycol Isopropyl Ether, Dipropylene Glycol Methyl Ether, Dipropylene Glycol Ethyl Ether, Dipropylene Glycol coal butyl ether, etc.); dihydric alcohol ether ester (e.g., ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diazibate, ethylene glycol disuccinate) , diethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propylene glycol monophenyl ether acetate, etc.); glycerin monoalkyl ether (e.g., chimyl alcohol, selachyl alcohol, batyl alcohol, etc.); sugar alcohols (e.g., sorbitol, maltitol, maltotriose, mannitol, sucrose, erythritol, glucose, fructose, starch-degrading sugar, maltose, xylitol, starch-degrading sugar reducing alcohol, etc.) ); glycolide; tetrahydrofurfuryl alcohol; POE-tetrahydrofurfuryl alcohol; POP-butyl ether; POP-POE-butyl ether; Examples include pentaneerythritol ether, polyglycerin, and the like.
　単糖としては、例えば、三炭糖（例えば、Ｄ－グリセリルアルデヒド、ジヒドロキシアセトン等）、四炭糖（例えば、Ｄ－エリトロ－ス、Ｄ－エリトルロ－ス、Ｄートレオ－ス、エリスリトール等）、五炭糖（例えば、Ｌ－アラビノ－ス、Ｄ－キシロ－ス、Ｌ－リキソ－ス、Ｄ－アラビノ－ス、Ｄ－リボ－ス、Ｄ－リブロ－ス、Ｄ－キシルロ－ス、Ｌ－キシルロ－ス等）、六炭糖（例えば、Ｄ－グルコ－ス、Ｄ－タロ－ス、Ｄ－プシコ－ス、Ｄ－ガラクト－ス、Ｄ－フルクト－ス、Ｌ－ガラクト－ス、Ｌ－マンノ－ス、Ｄ－タガト－ス等）、七炭糖（例えば、アルドヘプト－ス、ヘプツロース等）、八炭糖（例えば、オクツロース等）、デオキシ糖（例えば、２－デオキシ－Ｄ－リボ－ス、６－デオキシ－Ｌ－ガラクト－ス、６－デオキシ－Ｌ－マンノ－ス等）、アミノ糖（例えば、Ｄ－グルコサミン、Ｄ－ガラクトサミン、シアル酸、アミノウロン酸、ムラミン酸等）、ウロン酸（例えば、Ｄ－グルクロン酸、Ｄ－マンヌロン酸、Ｌ－グルロン酸、Ｄ－ガラクツロン酸、Ｌ－イズロン酸等）等から選ばれる少なくとも１つを挙げることができる。 Examples of monosaccharides include three-carbon sugars (eg, D-glycerylaldehyde, dihydroxyacetone, etc.), four-carbon sugars (eg, D-erythrose, D-erythrulose, D-threose, erythritol, etc.), Five carbon sugars (e.g., L-arabinose, D-xylose, L-lyxose, D-arabinose, D-ribose, D-ribulose, D-xylulose, L- xylulose, etc.), hexoses (e.g., D-glucose, D-talose, D-psicose, D-galactose, D-fructose, L-galactose, L- mannose, D-tagatose, etc.), heptose (e.g., aldoheptose, heptulose, etc.), heptose (e.g., octulose, etc.), deoxysugar (e.g., 2-deoxy-D-ribose) , 6-deoxy-L-galactose, 6-deoxy-L-mannose, etc.), amino sugars (e.g., D-glucosamine, D-galactosamine, sialic acid, aminouronic acid, muramic acid, etc.), uronic acid ( Examples include at least one selected from D-glucuronic acid, D-mannuronic acid, L-guluronic acid, D-galacturonic acid, L-iduronic acid, and the like.
　オリゴ糖としては、例えば、ショ糖、グンチアノース、ウンベリフェロース、ラクトース、プランテオース、イソリクノース類、α，α－トレハロース、ラフィノース、リクノース類、ウンビリシン、スタキオース、ベルバスコース類等から選ばれる少なくとも１つを挙げることができる。 Examples of oligosaccharides include at least one selected from sucrose, guntianose, umbelliferose, lactose, planteose, isoliquinoses, α,α-trehalose, raffinose, lignoses, umbilicine, stachyose, verbascoses, and the like. can be mentioned.
　多糖としては、例えば、セルロース、クインスシード、コンドロイチン硫酸、デンプン、ガラクタン、デルマタン硫酸、グリコーゲン、アラビアガム、ヘパラン硫酸、ヒアルロン酸、トラガントガム、ケラタン硫酸、コンドロイチン、キサンタンガム、ムコイチン硫酸、グアガム、デキストラン、ケラト硫酸、ローカストビーンガム、サクシノグルカン、カロニン酸等から選ばれる少なくとも１つを挙げることができる。 Examples of polysaccharides include cellulose, quince seed, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, gum arabic, heparan sulfate, hyaluronic acid, tragacanth gum, keratan sulfate, chondroitin, xanthan gum, mucoitin sulfate, guar gum, dextran, and keratosulfate. , locust bean gum, succinoglucan, caroninic acid and the like.
　その他のポリオールとしては、例えば、ポリオキシエチレンメチルグルコシド（グルカムＥ－１０）、ポリオキシプロピレンメチルグルコシド（グルカムＰ－１０）等から選ばれる少なくとも１つを挙げることができる。 Examples of other polyols include at least one selected from polyoxyethylene methyl glucoside (glucum E-10), polyoxypropylene methyl glucoside (glucum P-10), and the like.
　天然の水溶性ポリマーとしては、例えば、植物系高分子（例えば、アラビアガム、トラガカントガム、ガラクタン、グアガム、キャロブガム、カラヤガム、カラギーナン、ペクチン、カンテン、クインスシード（マルメロ）、アルゲコロイド（カッソウエキス）、デンプン（コメ、トウモロコシ、バレイショ、コムギ）、グリチルリチン酸）；微生物系高分子（例えば、キサンタンガム、デキストラン、サクシノグルカン、プルラン等）；動物系高分子（例えば、コラーゲン、カゼイン、アルブミン、ゼラチン等）等が挙げられる。 Examples of natural water-soluble polymers include plant-based polymers (e.g., gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (quince), algecolloid (cassou extract), starch ( rice, corn, potato, wheat), glycyrrhizic acid); microbial macromolecules (e.g., xanthan gum, dextran, succinoglucan, pullulan, etc.); mentioned.
　半合成の水溶性ポリマーとしては、例えば、デンプン系高分子（例えば、カルボキシメチルデンプン、メチルヒドロキシプロピルデンプン等）；セルロース系高分子（メチルセルロース、エチルセルロース、メチルヒドロキシプロピルセルロース、ヒドロキシエチルセルロース、セルロース硫酸ナトリウム、ヒドロキシプロピルセルロース、カルボキシメチルセルロース、カルボキシメチルセルロースナトリウム、結晶セルロース、セルロース末等）；アルギン酸系高分子（例えば、アルギン酸ナトリウム、アルギン酸プロピレングリコールエステル等）等が挙げられる。 Examples of semi-synthetic water-soluble polymers include starch-based polymers (e.g., carboxymethyl starch, methylhydroxypropyl starch, etc.); cellulose-based polymers (methylcellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, hydroxypropylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder, etc.); alginate-based polymers (eg, sodium alginate, propylene glycol alginate, etc.);
［水溶性ポリマー］
　本開示の油分散組成物において、油性成分の分散に水溶性ポリマーの作用を利用する必要はない。なお、本開示において、水溶性ポリマーに寒天は含まれない。水溶性ポリマーは、油分散組成物の質量に対して、例えば、１質量％以下、０．５質量％以下、０．３質量％以下、０．１質量％以下、又は０質量％（無含有）とすることができる。 [Water-soluble polymer]
In the oil dispersion composition of the present disclosure, it is not necessary to use the action of a water-soluble polymer to disperse the oily component. In the present disclosure, water-soluble polymers do not include agar. The water-soluble polymer is, for example, 1% by mass or less, 0.5% by mass or less, 0.3% by mass or less, 0.1% by mass or less, or 0% by mass (not containing ).
　保湿剤としては、例えば、ポリエチレングリコール、プロピレングリコール、グリセリン、１，３－ブチレングリコール、キシリトール、ソルビトール、マルチトール、コンドロイチン硫酸、ヒアルロン酸、ムコイチン硫酸、カロニン酸、アテロコラーゲン、コレステリル－１２－ヒドロキシステアレート、乳酸ナトリウム、胆汁酸塩、ｄｌ－ピロリドンカルボン酸塩、アルキレンオキシド誘導体、短鎖可溶性コラーゲン、ジグリセリン（ＥＯ）ＰＯ付加物、イザヨイバラ抽出物、セイヨウノコギリソウ抽出物、メリロート抽出物等が挙げられる。 Examples of moisturizing agents include polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caroninic acid, atelocollagen, and cholesteryl-12-hydroxystearate. , sodium lactate, bile salts, dl-pyrrolidone carboxylate, alkylene oxide derivatives, short-chain soluble collagen, diglycerin (EO) PO adducts, rose barra extract, yarrow extract, melilot extract and the like.
　皮膜剤としては、例えば、アニオン性皮膜剤（例えば、（メタ）アクリル酸／（メタ）アクリル酸エステル共重合体、メチルビニルエーテル／無水マレイン酸高重合体等）、カチオン性皮膜剤（例えば、カチオン化セルロース、ジメチルジアリルアンモニウムクロライド重合体、ジメチルジアリルアンモニウムクロライド／アクリルアミド共重合体等）、ノニオン性皮膜剤（例えば、ポリビニルアルコール、ポリビニルピロリドン、ポリ酢酸ビニル、ポリアクリル酸エステル共重合体、（メタ）アクリルアミド、高分子シリコーン、シリコーンレジン、トリメチルシロキシケイ酸等）が挙げられる。 Examples of film-forming agents include anionic film-forming agents (e.g., (meth)acrylic acid/(meth)acrylic acid ester copolymer, methyl vinyl ether/maleic anhydride high polymer, etc.), cationic film-forming agents (e.g., cationic cellulose, dimethyldiallylammonium chloride polymer, dimethyldiallylammonium chloride/acrylamide copolymer, etc.), nonionic film agents (e.g., polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl acetate, polyacrylate copolymer, (meth) acrylamide, polymer silicone, silicone resin, trimethylsiloxysilicate, etc.).
　水溶性紫外線吸収剤としては、例えば、ベンゾフェノン系紫外線吸収剤（例えば、２－ヒドロキシ－４－メトキシベンゾフェノン－５－スルホン酸塩等）、ベンジリデンショウノウ系紫外線吸収剤（ベンジリデンショウノウスルホン酸、テレフタリリデンジショウノウスルホン酸等）、フェニルベンゾイミダゾール系紫外線吸収剤（フェニルベンズイミダゾールスルホン酸等）等が挙げられる。 Examples of water-soluble UV absorbers include benzophenone UV absorbers (eg, 2-hydroxy-4-methoxybenzophenone-5-sulfonate), benzylidene camphor UV absorbers (benzylidene camphor sulfonic acid, terephthalyl camphor sulfonic acid, etc.), phenylbenzimidazole-based UV absorbers (phenylbenzimidazole sulfonic acid, etc.), and the like.
　金属イオン封鎖剤としては、例えば、１－ヒドロキシエタン－１，１－ジフォスホン酸、１－ヒドロキシエタン－１，１－ジフォスホン酸四ナトリウム塩、エデト酸二ナトリウム、エデト酸三ナトリウム、エデト酸四ナトリウム、クエン酸ナトリウム、ポリリン酸ナトリウム、メタリン酸ナトリウム、グルコン酸、リン酸、クエン酸、アスコルビン酸、コハク酸、エデト酸、エチレンジアミンヒドロキシエチル三酢酸３ナトリウム等が挙げられる。 Examples of sequestering agents include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, and tetrasodium edetate. , sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, trisodium ethylenediaminehydroxyethyl triacetate, and the like.
　アミノ酸としては、例えば、中性アミノ酸（例えば、スレオニン、システイン等）；塩基性アミノ酸（例えば、ヒドロキシリジン等）等が挙げられる。また、アミノ酸誘導体として、例えば、アシルサルコシンナトリウム(ラウロイルサルコシンナトリウム)、アシルグルタミン酸塩、アシルβ-アラニンナトリウム、グルタチオン、ピロリドンカルボン酸等が挙げられる。 Amino acids include, for example, neutral amino acids (eg, threonine, cysteine, etc.); basic amino acids (eg, hydroxylysine, etc.). Examples of amino acid derivatives include sodium acyl sarcosinate (sodium lauroyl sarcosinate), acyl glutamate, sodium acyl β-alanine, glutathione, pyrrolidone carboxylic acid and the like.
　有機アミンとしては、例えば、モノエタノールアミン、ジエタノールアミン、トリエタノールアミン、モルホリン、トリイソプロパノールアミン、２－アミノ－２－メチル－１,３－プロパンジオール、２－アミノ－２－メチル－１－プロパノール等が挙げられる。 Examples of organic amines include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-1-propanol, and the like. is mentioned.
　高分子エマルジョンとしては、例えば、アクリル樹脂エマルジョン、ポリアクリル酸エチルエマルジョン、アクリルレジン液、ポリアクリルアルキルエステルエマルジョン、ポリ酢酸ビニル樹脂エマルジョン、天然ゴムラテックス等が挙げられる。 Examples of polymer emulsions include acrylic resin emulsions, polyethyl acrylate emulsions, acrylic resin liquids, polyacryl alkyl ester emulsions, polyvinyl acetate resin emulsions, and natural rubber latex.
　ｐＨ調整剤としては、例えば、乳酸－乳酸ナトリウム、クエン酸－クエン酸ナトリウム、コハク酸－コハク酸ナトリウム等の緩衝剤等が挙げられる。 Examples of pH adjusters include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinic acid-sodium succinate.
　ビタミン類としては、例えば、ビタミンＡ、Ｂ１、Ｂ２、Ｂ６、Ｃ、Ｅ及びその誘導体、パントテン酸及びその誘導体、ビオチン等が挙げられる。 Examples of vitamins include vitamins A, B1, B2, B6, C, E and their derivatives, pantothenic acid and its derivatives, biotin, and the like.
　酸化防止剤としては、例えば、トコフェロール類、ジブチルヒドロキシトルエン、ブチルヒドロキシアニソール、没食子酸エステル類等が挙げられる。 Examples of antioxidants include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, and gallic acid esters.
　酸化防止助剤としては、例えば、リン酸、クエン酸、アスコルビン酸、マレイン酸、マロン酸、コハク酸、フマル酸、ケファリン、ヘキサメタフォスフェイト、フィチン酸、エチレンジアミン四酢酸等が挙げられる。 Examples of antioxidant aids include phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, cephalin, hexametaphosphate, phytic acid, and ethylenediaminetetraacetic acid.
　その他の配合可能成分としては、例えば、防腐剤（エチルパラベン、ブチルパラベン、クロルフェネシン、フェノキシエタノール等）；消炎剤（例えば、グリチルリチン酸誘導体、グリチルレチン酸誘導体、サリチル酸誘導体、ヒノキチオール、酸化亜鉛、アラントイン等）；美白剤（例えば、胎盤抽出物、ユキノシタ抽出物、アルブチン等）；各種抽出物（例えば、オウバク、オウレン、シコン、シャクヤク、センブリ、バーチ、セージ、ビワ、ニンジン、アロエ、ゼニアオイ、アイリス、ブドウ、ヨクイニン、ヘチマ、ユリ、サフラン、センキュウ、ショウキョウ、オトギリソウ、オノニス、ニンニク、トウガラシ、チンピ、トウキ、海藻等）、賦活剤（例えば、ローヤルゼリー、感光素、コレステロール誘導体等）；血行促進剤（例えば、ノニル酸ワニリルアミド、ニコチン酸ベンジルエステル、ニコチン酸β－ブトキシエチルエステル、カプサイシン、ジンゲロン、カンタリスチンキ、イクタモール、タンニン酸、α－ボルネオール、ニコチン酸トコフェロール、イノシトールヘキサニコチネート、シクランデレート、シンナリジン、トラゾリン、アセチルコリン、ベラパミル、セファランチン、γ－オリザノール等）；抗脂漏剤（例えば、硫黄、チアントール等）；抗炎症剤（例えば、トラネキサム酸、チオタウリン、ヒポタウリン等）等が挙げられる。 Other ingredients that can be blended include, for example, preservatives (ethylparaben, butylparaben, chlorphenesin, phenoxyethanol, etc.); ); whitening agent (e.g., placenta extract, saxifrage extract, arbutin, etc.); , coix seed, loofah, lily, saffron, cnidium, ginger, hypericum, ononis, garlic, red pepper, chimp, angelica, seaweed, etc.), activator (e.g., royal jelly, photosensitizer, cholesterol derivative, etc.); blood circulation promoter (e.g., , Nonylic Acid Vanillylamide, Nicotinic Acid Benzyl Ester, Nicotinic Acid β-Butoxyethyl Ester, Capsaicin, Zingerone, Cantharis Tincture, Ictamol, Tannic Acid, α-Borneol, Tocopherol Nicotinate, Inositol Hexanicotinate, Cyclanderate, Cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, etc.); antiseborrheic agents (eg, sulfur, thianthol, etc.); anti-inflammatory agents (eg, tranexamic acid, thiotaurine, hypotaurine, etc.), and the like.
　さらに、本開示の組成物は、カフェイン、タンニン、ベラパミル、トラネキサム酸及びその誘導体、甘草、カリン、イチヤクソウ等の各種生薬抽出物、酢酸トコフェロール、グリチルレジン酸、グリチルリチン酸及びその誘導体又はその塩等の薬剤、ビタミンＣ、アスコルビン酸リン酸マグネシウム、アスコルビン酸グルコシド、アルブチン、コウジ酸等の美白剤、アルギニン、リジン等のアミノ酸及びその誘導体、も適宜含有することができる。 Furthermore, the composition of the present disclosure contains caffeine, tannin, verapamil, tranexamic acid and its derivatives, various crude drug extracts such as licorice, Chinese quince, and Ichiyakuso, tocopheryl acetate, glycyrrhizic acid, glycyrrhizic acid and its derivatives or salts thereof, and the like. Pharmaceutical agents, whitening agents such as vitamin C, magnesium ascorbyl phosphate, ascorbyl glucoside, arbutin and kojic acid, amino acids such as arginine and lysine and their derivatives may also be contained as appropriate.
［粘度］
　本開示の油分散組成物は、３０℃において、２，０００ｍＰａ・ｓ以上の粘度を有すると好ましい。本開示の油分散組成物の粘度は、例えば、３０℃において、３，０００ｍＰａ・ｓ以上、５，０００ｍＰａ・ｓ以上、８，０００ｍＰａ・ｓ以上、１０，０００ｍＰａ・ｓ以上、２０，０００ｍＰａ・ｓ以上、又は３０，０００ｍＰａ・ｓ以上とすることができる。粘度が２，０００ｍＰａ・ｓ未満となると、皮膚外用剤として使用する場合に使用性が低下してしまう。本開示の油分散組成物は、３０℃において、１００，０００ｍＰａ・ｓ以下であると好ましく、８０，０００ｍＰａ・ｓ以下であるとより好ましい。本開示の油分散組成物の粘度は、例えば、３０℃において、７０，０００ｍＰａ・ｓ以下、６０，０００ｍＰａ・ｓ以下、４０，０００ｍＰａ・ｓ以下、又は２０，０００ｍＰａ・ｓ以下とすることができる。粘度が１００，０００ｍＰａ・ｓを超えると、肌への塗布容易性が低下してしまう。粘度は３０℃におけるブルックフィールド型粘度計（ローター番号２２、回転数１２ｒｐｍ）で測定開始から６０秒後の粘度とすることができる。 [viscosity]
The oil dispersion composition of the present disclosure preferably has a viscosity of 2,000 mPa·s or more at 30°C. The viscosity of the oil dispersion composition of the present disclosure is, for example, 3,000 mPa s or more, 5,000 mPa s or more, 8,000 mPa s or more, 10,000 mPa s or more, 20,000 mPa s at 30°C. or more, or 30,000 mPa·s or more. If the viscosity is less than 2,000 mPa·s, usability will be reduced when used as an external preparation for skin. The oil dispersion composition of the present disclosure preferably has a viscosity of 100,000 mPa·s or less, more preferably 80,000 mPa·s or less, at 30°C. The viscosity of the oil dispersion composition of the present disclosure can be, for example, 70,000 mPa s or less, 60,000 mPa s or less, 40,000 mPa s or less, or 20,000 mPa s or less at 30°C. . If the viscosity exceeds 100,000 mPa·s, the ease of application to the skin is reduced. The viscosity can be measured 60 seconds after the start of measurement with a Brookfield viscometer (rotor number 22, rotation speed 12 rpm) at 30°C.
　本開示の油分散組成物において、相構造、分散状態等が、組成によって直接特定することが困難であるか、又はおよそ実際的ではない場合がある。このような場合には、本開示の油分散組成物は、後述するその製造方法によって特定することが許されるべきものである。 In the oil dispersion composition of the present disclosure, it may be difficult or almost impractical to directly specify the phase structure, dispersion state, etc. by composition. In such cases, the oil dispersion composition of the present disclosure should be allowed to be identified by its manufacturing method described below.
　本開示の油分散組成物においては、寒天ゲル中に油分粒子が均一にかつ安定に分散されている。例えば、平均粒径が１０μｍ以上の大きな寒天ゲル粒子でもって、平均粒径が２００μｍを以上の大きな油分粒子を分散させることができる。これにより、界面活性剤を使用せずとも、油を均一かつ安定に分散させることができる。また、増粘剤によって増粘させなくても、油を均一かつ安定に分散させることができる。 In the oil-dispersed composition of the present disclosure, oil particles are uniformly and stably dispersed in the agar gel. For example, large oil particles with an average particle size of 200 μm or more can be dispersed using large agar gel particles with an average particle size of 10 μm or more. As a result, the oil can be uniformly and stably dispersed without using a surfactant. In addition, the oil can be uniformly and stably dispersed without thickening with a thickener.
　本開示の油分散組成物を皮膚外用剤に使用する場合には、使用者は組成物を肌に塗布した際に良好なみずみずしさを感じることができる。本開示の油分散組成物を肌に塗布した後には、使用者は、コク感、みずみずしさ及び潤い感を得ることができる。本開示にいうコク感とは、肌がしっとりとして、濃厚な印象が生じる使用感のことである。みずみずしさとは、べたつきがなく、伸びがよく、さっぱり感があることをいう。潤い感とは、乾燥せずに保湿感があることをいう。 When the oil dispersion composition of the present disclosure is used for an external skin preparation, the user can feel good freshness when applying the composition to the skin. After applying the oil dispersion composition of the present disclosure to the skin, the user can obtain richness, freshness and moisture. The full-bodied feeling referred to in the present disclosure is a feeling of use that gives a moist and rich impression to the skin. The term "freshness" refers to non-stickiness, good spreadability, and refreshing feeling. The moist feeling means that the skin has a moist feeling without drying.
　本開示の油分散組成物においては、界面活性剤の作用によらず、油性成分を分散させている。界面活性剤を使用しないことにより、肌への刺激を低減することができると共に、肌に塗布した際のべたつきを抑制することができる。また、拭き取り不要の皮膚外用剤として使用することができる。 In the oil-dispersed composition of the present disclosure, oily components are dispersed without the action of surfactants. By not using a surfactant, irritation to the skin can be reduced, and stickiness when applied to the skin can be suppressed. In addition, it can be used as an external preparation for skin that does not require wiping.
　本開示の油分散組成物を飲食料に使用する場合には、使用者は、粒径の大きな内相及び外相による食感を得ることができる。また、酸化しやすい油を使用する場合には、油の酸化を抑制することができる。 When the oil-dispersed composition of the present disclosure is used for food and drink, the user can obtain the texture of the inner and outer phases with large particle sizes. Moreover, when using an oil that is easily oxidized, oxidation of the oil can be suppressed.
［製造方法］
　本開示の油分散組成物の製造方法について説明する。まず、外相となる寒天ゲル粒子を作製する。油分散組成物の製造方法は、加熱した水に寒天を溶解する溶解工程と、寒天水溶液を冷却しながら撹拌する冷却工程と、を含むことができる。溶解工程において、水は、例えば、８５℃～９０℃に加熱することができる。溶解する寒天の量は、上述のように、水１質量部に対して、８×１０－３質量部以上とする。冷却工程において、寒天水溶液が４０℃以下になったら撹拌すると好ましい。寒天水溶液を撹拌する方法としては、寒天ゲル粒子が所望の粒径となるのであれば、いずれの方法を採用することができる。撹拌方法としては、例えば、パドル、ディスパー等を用いることができる。撹拌は、寒天ゲルの温度が室温となるまで行うと好ましい。寒天が固化する過程において寒天を撹拌（粉砕）することによって、油を分散させやすい寒天ゲル粒子とすることができる。 [Production method]
A method for producing the oil dispersion composition of the present disclosure will be described. First, agar gel particles to be the outer phase are produced. A method for producing an oil-dispersed composition can include a dissolving step of dissolving agar in heated water and a cooling step of stirring while cooling the aqueous agar solution. In the dissolving step, the water can be heated to, for example, 85°C to 90°C. The amount of dissolved agar is 8×10 −3 parts by mass or more per 1 part by mass of water, as described above. In the cooling step, it is preferable to stir when the aqueous agar solution reaches 40° C. or lower. As a method for stirring the aqueous agar solution, any method can be employed as long as the agar gel particles have a desired particle size. As a stirring method, for example, a paddle, a disper, or the like can be used. Stirring is preferably performed until the temperature of the agar gel reaches room temperature. By agitating (pulverizing) the agar in the process of solidifying the agar, it is possible to obtain agar gel particles in which the oil is easily dispersed.
　寒天ゲルは、寒天ゲルが固化した後に粒子化してもよい。例えば、上述の溶解工程後、冷却工程において、寒天溶液を静置して室温まで十分に冷却して、寒天ゲルを固化させることができる。次に、固化した寒天ゲルをディスパー、ホモジナイザ等を用いて粉砕して、寒天ゲル粒子を作製してもよい。 The agar gel may be granulated after the agar gel has solidified. For example, after the dissolving step described above, in the cooling step, the agar solution can be allowed to stand and sufficiently cooled to room temperature to solidify the agar gel. Next, the solidified agar gel may be pulverized using a disper, homogenizer, or the like to produce agar gel particles.
　油分散組成物の製造方法は、次に、外相となる寒天ゲル粒子（粒子の集合体）に、油を分散させる分散工程を含むことができる。分散工程は、いわゆるインライン混合を使用することができる。インライン混合は、動力のある駆動型撹拌であってもよいし、スタティックミキサ等を用いた静止型混合であってもよい。インライン混合装置は、送液を兼ねたポンプであってもよい。分散工程は、目的とする外相と内相の質量比±１０％で外相成分及び内相成分をインライン混合装置へ供給する供給工程と、内相が所望の平均粒子径となるようにインライン混合装置で内相を外相に分散する分散工程と、インライン混合装置から外相及び内相（すなわち、本開示の油分散組成物）を排出する排出工程と、含むことができる。供給工程、分散工程、及び排出工程は同時に行うと好ましい。内相の量及び外相の量は、上述の含有率に基づいて決定することができる。 The method for producing the oil-dispersed composition can then include a dispersing step of dispersing the oil in the agar gel particles (aggregate of particles) serving as the outer phase. The dispersion process can use so-called in-line mixing. In-line mixing may be driven stirring with power, or static mixing using a static mixer or the like. The in-line mixing device may be a pump that also serves as a liquid feeder. The dispersion step includes a supply step of supplying the external phase component and the internal phase component to the in-line mixing device at a target mass ratio of the external phase and the internal phase of ± 10%, and an in-line mixing device so that the internal phase has a desired average particle size. and a discharging step of discharging the external and internal phases (ie, the oil dispersion composition of the present disclosure) from the in-line mixing device. It is preferable to carry out the feeding step, the dispersing step and the discharging step at the same time. The amount of internal phase and the amount of external phase can be determined based on the above-mentioned content.
　油分散組成物の製造方法は、分散工程前及び／又は後に、液状水性成分を外相に添加する添加工程をさらに含むことができる。液状水性成分は、所望の成分を含むことができる。液状水性成分の添加によって、含有成分、粘度、使用感等を調整することができる。 The method for producing an oil dispersion composition can further include an addition step of adding a liquid aqueous component to the external phase before and/or after the dispersion step. The liquid aqueous component can contain any desired ingredients. By adding a liquid aqueous component, it is possible to adjust the ingredients, viscosity, feeling of use, and the like.
　油分散組成物の製造方法によれば、寒天ゲル粒子で油を均一にかつ安定に分散させることができる。特に、平均粒径が１０μｍを超える大きな寒天ゲル粒子で油を分散させることができる。また、平均粒径が２００μｍを超えるような大きな油分粒子であっても分散させることができる。 According to the method for producing the oil dispersion composition, the oil can be dispersed uniformly and stably with the agar gel particles. In particular, oil can be dispersed with large agar gel particles with an average particle size greater than 10 μm. In addition, even large oil particles with an average particle size exceeding 200 μm can be dispersed.
　本開示の油分散組成物について、以下に例を挙げて説明する。しかしながら、本開示の油分散組成物以下の例に限定されるものではない。各表に示す各成分の含有率の単位は質量％である。 The oil dispersion composition of the present disclosure will be described below with examples. However, the oil dispersion composition of the present disclosure is not limited to the following examples. The unit of the content of each component shown in each table is % by mass.
［試験例１～２］
［外相の作製］
　内相を分散させる外相（寒天ゲル粒子）を作製した。試験例１と試験例２とでは、寒天ゲル粒子の作製方法が異なっている。作製した寒天ゲルについて、寒天ゲルの粒子径範囲、寒天ゲルの含水率及び粘度を測定した。 [Test Examples 1 and 2]
[Preparation of foreign phase]
An outer phase (agar gel particles) was prepared to disperse the inner phase. Test Example 1 and Test Example 2 differ in the method of producing the agar gel particles. The particle size range of the agar gel, the water content of the agar gel, and the viscosity of the agar gel thus prepared were measured.
　試験例１においては、寒天粉末を８５℃～９０℃の水に溶解させ、寒天が水に溶解した後、寒天水溶液を室温（２５℃）～３０℃に冷却している過程において、寒天溶液を冷却しながらパドル式撹拌機（スリーワンモータ（登録商標）（新東科学社製））で撹拌して寒天ゲル粒子を形成した。表１に、組成及び測定結果を示す。 In Test Example 1, agar powder was dissolved in water at 85°C to 90°C, and after the agar was dissolved in water, the agar solution was cooled to room temperature (25°C) to 30°C. While cooling, agar gel particles were formed by stirring with a paddle type stirrer (Three One Motor (registered trademark) (manufactured by Shinto Kagaku Co., Ltd.)). Table 1 shows the composition and measurement results.
　試験例２においては、寒天粉末を８５℃～９０℃の水に溶解させ、寒天が水に溶解した後、静置した状態で室温（２５℃）℃まで冷却した後十分時間を置いて寒天ゲルを固化させた。固化後、ディスパーを用いて寒天ゲルを粉砕して寒天ゲル粒子を形成した。表２に、組成及び測定結果を示す。 In Test Example 2, agar powder was dissolved in water at 85 ° C. to 90 ° C., and after the agar was dissolved in water, it was allowed to stand still and cooled to room temperature (25 ° C.). solidified. After solidification, the agar gel was pulverized using a disper to form agar gel particles. Table 2 shows the composition and measurement results.
［寒天ゲル平均粒子径］
　油分粒子を取り囲む寒天ゲル粒子の平均粒子径は、顕微鏡観察によって、油分散組成物中における任意の１００個の寒天ゲル粒子の粒子径を測定し、その平均値を算出した。寒天ゲルの粒子径は針状部を含む最も長い部分を粒子径とした。 [Agar gel average particle size]
The average particle size of the agar gel particles surrounding the oil particles was obtained by measuring the particle size of arbitrary 100 agar gel particles in the oil-dispersed composition by microscopic observation and calculating the average value. The particle size of the agar gel was defined as the longest portion including the needle-like portion.
［寒天ゲル粒子径範囲］
　油分粒子を取り囲む寒天ゲルの粒子径範囲は、顕微鏡観察によって、油分散組成物中における任意の１００個の寒天ゲル粒子の粒子径を測定し、その最小値及び最大値を粒子径範囲とした。寒天ゲルの粒子径は針状部を含む最も長い部分を粒子径とした。 [Agar gel particle size range]
The particle size range of the agar gel surrounding the oil particles was obtained by measuring the particle size of any 100 agar gel particles in the oil dispersion composition by microscopic observation, and using the minimum and maximum values as the particle size range. The particle size of the agar gel was defined as the longest portion including the needle-like portion.
　表１及び表２に示す含水率は、配合した水分量に対する、寒天ゲルが包含している水分量の割合を示す。作製した寒天ゲルを３５０メッシュ（目開き４０μｍ）の篩にかけ、篩から落ちた水性溶媒の質量を測定した。以下の式より、含水率を算出した。
含水率（％）＝｛（配合した水性溶媒の質量－篩から落ちた水性溶媒の質量）／配合した水性溶媒の質量｝×１００ The water content shown in Tables 1 and 2 indicates the ratio of the water content contained in the agar gel to the blended water content. The prepared agar gel was sieved through a 350-mesh (40 μm mesh) sieve, and the mass of the aqueous solvent dropped from the sieve was measured. The water content was calculated from the following formula.
Moisture content (%) = {(mass of blended aqueous solvent - mass of aqueous solvent dropped from sieve) / mass of blended aqueous solvent} x 100
　寒天ゲルの粘度は、寒天ゲル粒子を作製した２４時間後に、３０℃におけるブルックフィールド型粘度計（ＴＶＢ－１５（東機産業製））でローター番号２２、回転数１２ｒｐｍで測定開始から６０秒後の粘度を測定した。 The viscosity of the agar gel was measured 24 hours after the preparation of the agar gel particles, using a Brookfield viscometer (TVB-15 (manufactured by Toki Sangyo)) at 30 ° C. with a rotor number of 22 and a rotation speed of 12 rpm 60 seconds after the start of measurement. was measured.
　一部のロットの寒天ゲル粒子には、外面から突出する複数の突出部（針状部）が存在することが確認された。 It was confirmed that some lots of agar gel particles had multiple protrusions (needles) protruding from the outer surface.
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000002
Figure JPOXMLDOC01-appb-T000002
［試験例３～４］
　試験例１及び試験例２で作製した外相（寒天ゲル粒子）を用いて油性成分を分散させた組成物を作製した。各組成物において、油分粒子を取り囲む寒天ゲル粒子の平均粒子径及び粒子径範囲、並びに寒天ゲル粒子によって取り囲まれた油分粒子の平均粒子径及び粒子径範囲を測定した。また、各組成物の分散安定性及び肌に塗布したときの使用性を評価した。測定方法及び評価基準を以下に示す。表３及び表４に、組成、測定結果及び評価を示す。 [Test Examples 3-4]
Using the outer phase (agar gel particles) prepared in Test Examples 1 and 2, compositions in which an oily component was dispersed were prepared. For each composition, the average particle size and particle size range of the agar gel particles surrounding the oil particles and the average particle size and particle size range of the oil particles surrounded by the agar gel particles were measured. In addition, the dispersion stability of each composition and usability when applied to the skin were evaluated. Measurement methods and evaluation criteria are shown below. Tables 3 and 4 show the composition, measurement results and evaluation.
［油分粒子の平均粒子径］
　寒天ゲル粒子によって取り囲まれた油分粒子の平均粒子径は、顕微鏡観察によって、任意の１００個の油分粒子の粒子径を測定し、その平均値を算出した。油分粒子の粒子径は最も長い部分を粒子径とした。 [Average particle size of oil particles]
The average particle size of the oil particles surrounded by the agar gel particles was obtained by measuring the particle size of arbitrary 100 oil particles by microscopic observation and calculating the average value. The particle size of the oil particles was defined as the particle size of the longest portion.
［油分粒子の粒子径範囲］
　寒天ゲル粒子によって取り囲まれた油分粒子の平均粒子径は、顕微鏡観察によって、任意の１００個の油分粒子の粒子径を測定し、その最小値及び最大値を粒子径範囲とした。油分粒子の粒子径は最も長い部分を粒子径とした。 [Particle size range of oil particles]
The average particle size of oil particles surrounded by agar gel particles was obtained by measuring the particle size of arbitrary 100 oil particles by microscopic observation, and using the minimum and maximum values as the particle size range. The particle size of the oil particles was defined as the particle size of the longest portion.
　油分散組成物の粘度は、３０℃におけるブルックフィールド型粘度計でスピンドル番号２２、回転数１２ｒｐｍで測定開始から６０秒後の粘度を測定した。 The viscosity of the oil dispersion composition was measured 60 seconds after the start of measurement with a Brookfield viscometer at 30°C with a spindle number of 22 and a rotation speed of 12 rpm.
［分散安定性］
　各組成物を５０℃で７日間静置し、油性成分の分散性を確認した。
Ａ：油性成分は安定に分散していた；
Ｂ：油性成分が上面に少し浮いていた；
Ｃ：油性成分は一時的に分散したが、１日後油性成分と寒天ゲルが分離していた；
Ｄ：油性成分を分散できなかった。 [Dispersion stability]
Each composition was allowed to stand at 50° C. for 7 days, and the dispersibility of the oil component was confirmed.
A: The oily component was stably dispersed;
B: The oily component slightly floated on the upper surface;
C: The oily component was temporarily dispersed, but the oily component and the agar gel were separated after one day;
D: The oil component could not be dispersed.
［使用性］
［塗布しやすさ］
　３人専門パネルが組成物を腕に塗布し、組成物を塗布しやすいかどうかについて下記の基準で総合的に評価した：
Ａ：非常に塗布しやすい；
Ｂ：塗布しやすい；
Ｃ：塗布しにくい；
Ｄ：非常に塗布しにくい。 [Usability]
[Ease of application]
A panel of three experts applied the composition to the arm and comprehensively evaluated whether it was easy to apply the composition according to the following criteria:
A: very easy to apply;
B: easy to apply;
C: difficult to apply;
D: Very difficult to apply.
［みずみずしさ］
　３人専門パネルが組成物を腕に塗布し、みずみずしさがあるかどうかについて下記の基準で総合的に評価した：
Ａ：非常にみずみずしい；
Ｂ：みずみずしい；
Ｃ：ややみずみずしい；
Ｄ：みずみずしさを感じない。 [Freshness]
A panel of three experts applied the composition to the arm and evaluated it comprehensively according to the following criteria for freshness:
A: very fresh;
B: Fresh;
C: slightly fresh;
D: No feeling of freshness.
［コク感］
　３人専門パネルが組成物を腕に塗布した後、塗布領域にコク感があるかどうかについて下記の基準で総合的に評価した：
Ａ：非常にコク感がある；
Ｂ：コク感がある；
Ｃ：ややコク感がある；
Ｄ：コク感がない。 [Richness]
After applying the composition to the arm, a panel of three experts comprehensively evaluated whether the applied area had a rich feeling according to the following criteria:
A: There is a very rich feeling;
B: There is a rich feeling;
C: Slightly full-bodied;
D: No richness.
［潤い感］
　３人専門パネルが組成物を腕に塗布した後、塗布領域に潤い感があるかどうかについて下記の基準で総合的に評価した：
Ａ：非常に潤い感がある；
Ｂ：潤い感がある；
Ｃ：やや潤い感がある；
Ｄ：潤い感がない。 [Moisturizing]
After applying the composition to the arm, a panel of three experts comprehensively evaluated whether the applied area had a moist feeling according to the following criteria:
A: Very moist feeling;
B: Moisturizing;
C: Slightly moist feeling;
D: No moist feeling.
　試験例３～４においては、インライン乳化法を用いて、寒天ゲル粒子を含む外相中に油性成分を分散させた。インライン乳化方法としては、試験例１又は試験例２において作製した寒天ゲル粒子を含む外相と油性成分とをダイナミックミキサに供給して寒天ゲルと油性成分とを混合して寒天ゲル中に油を分散させた。インライン乳化処理後の試験例３及び４の組成物における寒天ゲル粒子の平均粒子径は、表１及び表２に示す寒天ゲル粒子の平均粒子径と同じである。 In Test Examples 3 and 4, the in-line emulsification method was used to disperse the oily component in the external phase containing the agar gel particles. As an in-line emulsification method, the external phase containing the agar gel particles prepared in Test Example 1 or Test Example 2 and the oily component are supplied to a dynamic mixer, the agar gel and the oily component are mixed, and the oil is dispersed in the agar gel. let me The average particle size of the agar gel particles in the compositions of Test Examples 3 and 4 after in-line emulsification is the same as the average particle size of the agar gel particles shown in Tables 1 and 2.
　試験例１－１～１－３及び試験例２－１～２－３において作製した寒天ゲル粒子では、油性成分を安定に乳化（分散）させることができなかった。一方、試験例１－４～１－７及び試験例２－４～２－７において作製した寒天ゲル粒子によれば、油性成分を安定に乳化（分散）させることができた。これより、油分散組成物において、油分を安定に乳化させるためには、寒天は、水１質量部に対して、８×１０－３質量部以上であると好ましく、１×１０－２質量部以上であるとより好ましいことが分かった。 The agar gel particles produced in Test Examples 1-1 to 1-3 and Test Examples 2-1 to 2-3 could not stably emulsify (disperse) the oil component. On the other hand, according to the agar gel particles produced in Test Examples 1-4 to 1-7 and Test Examples 2-4 to 2-7, the oil component could be stably emulsified (dispersed). From this, in order to stably emulsify the oil in the oil dispersion composition, the amount of agar is preferably 8 × 10 -3 parts by weight or more, and 1 × 10 -2 parts by weight with respect to 1 part by weight of water It turned out that it is more preferable when it is above.
　また、試験例１－４～１－７及び試験例２－４～２－７に係る組成物は、皮膚外用剤に適用した場合に、みずみずしさ、コク感及び潤い感について良好な評価を得ることができた。これより、寒天ゲルの平均粒子径が２００μｍ以上であるとこれらの使用感を高めることができると考えられる。 In addition, the compositions according to Test Examples 1-4 to 1-7 and Test Examples 2-4 to 2-7 are highly evaluated for freshness, richness and moistness when applied to external preparations for skin. I was able to From this, it is considered that when the average particle size of the agar gel is 200 μm or more, the feeling of use can be enhanced.
　粘度が高くなった試験例４－６及び４－７においては塗布しやすさの評価が低下する傾向があった。これより、塗布容易性を高めるためには組成物の粘度は１００，０００ｍＰａ・ｓ以下が好ましいと考えられる。 In Test Examples 4-6 and 4-7, where the viscosity was high, there was a tendency for the ease of application to decline. From this, it is considered that the viscosity of the composition is preferably 100,000 mPa·s or less in order to improve the ease of application.
Figure JPOXMLDOC01-appb-T000003
Figure JPOXMLDOC01-appb-T000003
Figure JPOXMLDOC01-appb-T000004
Figure JPOXMLDOC01-appb-T000004
［試験例５］
　試験例５においては、油性成分をバッチ方式による電動撹拌によって、上記試験例で作製した外相中に分散させた。バッチ方式による電動撹拌によって、寒天ゲル粒子の平均粒子径は、試験例１及び試験例２の平均粒子径よりも小さくなった。表５に、組成及び結果を示す。 [Test Example 5]
In Test Example 5, the oily component was dispersed in the external phase prepared in the above Test Example by electric stirring in a batch system. The average particle size of the agar gel particles became smaller than the average particle sizes of Test Examples 1 and 2 due to the electric stirring by the batch method. Table 5 shows the compositions and results.
　寒天ゲルの平均粒子径を１μｍ未満とした試験例５－４及び５－５においては、寒天ゲルと油性成分とが分離してしまい、油性成分を分散させることができなかった。また、使用感の評価も低いものとなった。試験例５－３においては、寒天ゲル粒子の粒径を大きくしても油分粒子が２０μｍと小さいと寒天ゲルと油性成分とが分離してしまった。一方、寒天ゲル粒子径と油分粒子の平均粒子径を試験例５－３～５－５よりも大きくした試験例５－１及び試験例５－２においては、油分粒子の分散安定性を高めることができた。これより、寒天ゲル平均粒子径が１０μｍ以上であると好ましいと考えられる。寒天ゲル平均粒子径は１５０μｍ以下とすることができると考えられる。油分粒子の平均粒子径が２００μｍ以上であると好ましいと考えられる。油分粒子の平均粒子径は、２０００μｍ以下とすることができると考えられる。 In Test Examples 5-4 and 5-5 in which the average particle size of the agar gel was less than 1 μm, the agar gel and the oily component were separated, and the oily component could not be dispersed. In addition, the evaluation of the usability was also low. In Test Example 5-3, even if the particle size of the agar gel particles was increased, if the oil particles were as small as 20 μm, the agar gel and the oily component were separated. On the other hand, in Test Examples 5-1 and 5-2 in which the agar gel particle size and the average particle size of the oil particles were larger than those in Test Examples 5-3 and 5-5, the dispersion stability of the oil particles was improved. was made. From this, it is considered preferable that the average particle size of the agar gel is 10 μm or more. It is believed that the average particle size of the agar gel can be 150 μm or less. It is considered preferable that the average particle size of the oil particles is 200 μm or more. It is considered that the average particle size of the oil particles can be 2000 μm or less.
Figure JPOXMLDOC01-appb-T000005
Figure JPOXMLDOC01-appb-T000005
［試験例６］
　試験例６においては、液状油分の種類及び量を変えて分散組成物を作製した。表６及び表７に、組成及び結果を示す。 [Test Example 6]
In Test Example 6, dispersion compositions were prepared by changing the type and amount of the liquid oil. Tables 6 and 7 show the compositions and results.
　液状油分が炭化水素油、エステル油及びシリコーン油のいずれであっても良好に寒天ゲル粒子で分散させることができた。これより、寒天ゲル粒子で分散させる液状油分の種類は限定されないと考えられる。 Whether the liquid oil was a hydrocarbon oil, an ester oil, or a silicone oil, it was possible to disperse it well with the agar gel particles. From this, it is considered that the type of liquid oil dispersed in the agar gel particles is not limited.
　いずれの油性成分を用いても良好な使用感を得ることができた。 A good feeling could be obtained with any of the oily ingredients.
　寒天ゲルは、５質量％以上の油性成分を分散できると考えられる。寒天ゲルは４０質量％以下の油性成分を分散できると考えられる。 It is believed that agar gel can disperse 5% by mass or more of oily components. It is believed that agar gel can disperse up to 40% by weight of oily components.
　油性成分１質量部に対して、寒天ゲルは２質量部以上とすることができることが分かった。また、油性成分１質量部に対して、寒天ゲルは２０質量部以下とすることができることが分かった。 It was found that 2 parts by mass or more of agar gel can be used for 1 part by mass of the oily component. It was also found that the amount of agar gel can be 20 parts by mass or less per 1 part by mass of the oily component.
Figure JPOXMLDOC01-appb-T000006
Figure JPOXMLDOC01-appb-T000006
Figure JPOXMLDOC01-appb-T000007
Figure JPOXMLDOC01-appb-T000007
　本発明の油分散組成物は、上記実施形態及び実施例に基づいて説明されているが、上記実施形態及び実施例に限定されることなく、本発明の範囲内において、かつ本発明の基本的技術思想に基づいて、各開示要素（請求の範囲、明細書及び図面に記載の要素を含む）に対し種々の変形、変更及び改良を含むことができる。また、本発明の請求の範囲の範囲内において、各開示要素の多様な組み合わせ・置換ないし選択が可能である。 The oil dispersion composition of the present invention has been described based on the above embodiments and examples, but is not limited to the above embodiments and examples. Various modifications, changes and improvements can be made to each disclosed element (including the elements described in the claims, specification and drawings) based on the technical concept. Moreover, various combinations, replacements, or selections of each disclosed element are possible within the scope of the claims of the present invention.
　本発明のさらなる課題、目的及び形態（変更形態含む）は、請求の範囲を含む本発明の全開示事項からも明らかにされる。 Further problems, objects, and forms (including modifications) of the present invention will be made clear from the entire disclosure of the present invention, including the scope of claims.
　本書に記載した数値範囲については、別段の記載のない場合であっても、当該範囲内に含まれる任意の数値ないし範囲が本書に具体的に記載されているものと解釈されるべきである。 Regarding the numerical ranges described in this document, it should be interpreted that any numerical value or range included within the range is specifically described in this document, even if there is no particular description.
　本開示の油分散組成物は、例えば、肌に適用する皮膚外用剤、化粧料、洗浄料、飲食料等に適用することができる。例えば、本開示の油分散組成物は、下地化粧料、上地化粧料、メイクアップ化粧料、制汗剤、防臭剤、日焼け止め化粧料、スキンケア剤、洗浄料等に適用することができる。 The oil-dispersed composition of the present disclosure can be applied, for example, to skin external preparations, cosmetics, cleansers, food and drink, and the like. For example, the oil dispersion composition of the present disclosure can be applied to base cosmetics, top cosmetics, makeup cosmetics, antiperspirants, deodorants, sunscreen cosmetics, skin care agents, cleansers, and the like.
　本開示の油分散組成物は、飲食料に適用することができる。 The oil dispersion composition of the present disclosure can be applied to food and drink.
　上記実施形態の一部又は全部は、以下の付記のようにも記載されうるが、以下の記載には限定されない。各付記は、特許請求の範囲に記載の各請求項と組み合わせることもできる。
［付記１］
　本開示の油分散組成物を皮膚外用剤として使用する、油分散組成物の使用方法。
［付記２］
　本開示の油分散組成物を化粧料として使用する、油分散組成物の使用方法。
［付記３］
　本開示の油分散組成物を飲食料として使用する、油分散組成物の使用方法。
［付記４］
　寒天ゲルが、寒天を溶解させた水を冷却しながら撹拌して形成された粒子を含む、油分散組成物。
［付記５］
　内相がインライン混合によって外相中に分散された、油分散組成物。 Some or all of the above embodiments may also be described in the following supplementary remarks, but are not limited to the following description. Each appendix can also be combined with each claim listed in the claims.
[Appendix 1]
A method of using the oil dispersion composition of the present disclosure as an external skin preparation.
[Appendix 2]
A method of using the oil dispersion composition of the present disclosure as a cosmetic.
[Appendix 3]
A method of using the oil dispersion composition of the present disclosure as a food or drink.
[Appendix 4]
An oil-dispersed composition wherein the agar gel comprises particles formed by agitating water in which agar is dissolved while cooling.
[Appendix 5]
An oil dispersion composition wherein the internal phase is dispersed in the external phase by in-line mixing.

Claims (16)

  1. 　水と、
    　寒天と、
    　油分粒子と、を含み、
    　水の少なくとも一部及び前記寒天は寒天ゲル粒子を形成し、
    　前記寒天ゲル粒子の平均粒径が１０μｍ～１５０μｍであり、
    　前記油分粒子の平均粒径が２００μｍ～２，０００μｍであり、
    　複数の前記寒天ゲル粒子が１つの前記油分粒子を取り囲んでおり、
    　前記寒天が水１質量部に対して８×１０－３質量部以上である、油分散組成物。     water and,
    agar and
    and oil particles,
    at least a portion of the water and the agar form agar gel particles;
    The average particle size of the agar gel particles is 10 μm to 150 μm,
    The oil particles have an average particle size of 200 μm to 2,000 μm,
    A plurality of said agar gel particles surround one said oil particle,
    An oil-dispersed composition, wherein the agar is 8×10 −3 parts by mass or more per 1 part by mass of water.
  2. 　水の一部は前記寒天ゲル粒子の外部に存在する、請求項１に記載の組成物。 The composition according to claim 1, wherein part of the water exists outside the agar gel particles.
  3. 　前記寒天ゲル粒子は、表面から突出する少なくとも１つの針状部を有する、請求項１又は２に記載の組成物。 The composition according to claim 1 or 2, wherein the agar gel particles have at least one needle-like part protruding from the surface.
  4. 　前記寒天ゲル粒子の総量は、前記油分粒子の総量１質量部に対して２質量部以上である、請求項１～３のいずれか一項に記載の組成物。 The composition according to any one of claims 1 to 3, wherein the total amount of the agar gel particles is 2 parts by mass or more with respect to 1 part by mass of the total amount of the oil particles.
  5. 　３０℃において、２，０００ｍＰａ・ｓ～１００，０００ｍＰａ・ｓの粘度を有する、請求項１～４のいずれか一項に記載の組成物。 The composition according to any one of claims 1 to 4, which has a viscosity of 2,000 mPa·s to 100,000 mPa·s at 30°C.
  6. 　前記油分粒子を取り囲む前の複数の前記寒天ゲル粒子は、３０℃において、３，０００ｍＰａ・ｓ～１００，０００ｍＰａ・ｓの粘度を有する、請求項１～５のいずれか一項に記載の組成物。 The composition according to any one of claims 1 to 5, wherein the plurality of agar gel particles before surrounding the oil particles have a viscosity of 3,000 mPa·s to 100,000 mPa·s at 30°C. .
  7. 　前記油分粒子は、大気圧下、２５℃において液状である、請求項１～６のいずれか一項に記載の組成物。 The composition according to any one of claims 1 to 6, wherein the oil particles are liquid at 25°C under atmospheric pressure.
  8. 　前記油分粒子の含有率は、組成物の質量に対して５質量％～３５質量％である、請求項１～７のいずれか一項に記載の組成物。 The composition according to any one of claims 1 to 7, wherein the content of the oil particles is 5% by mass to 35% by mass with respect to the mass of the composition.
  9. 　界面活性剤の含有率が組成物の質量に対して１質量％以下である、請求項１～８のいずれか一項に記載の組成物。 The composition according to any one of claims 1 to 8, wherein the surfactant content is 1% by mass or less with respect to the mass of the composition.
  10. 　水溶性ポリマーの含有率が組成物の質量に対して０．１質量％以下である、請求項１～９のいずれか一項に記載の組成物。 The composition according to any one of claims 1 to 9, wherein the content of the water-soluble polymer is 0.1% by mass or less relative to the mass of the composition.
  11. 　増粘剤の含有率が組成物の質量に対して１質量％以下である、請求項１～１０のいずれか一項に記載の組成物。 The composition according to any one of claims 1 to 10, wherein the content of the thickener is 1% by mass or less relative to the mass of the composition.
  12. 　前記寒天ゲル粒子は粒子中に油性成分を内包していない、請求項１～１１のいずれか一項に記載の組成物。 The composition according to any one of claims 1 to 11, wherein the agar gel particles do not enclose an oily component in the particles.
  13. 　前記油分粒子は、炭化水素、エステル油、シリコーン油、フッ素油、高級アルコール、高級脂肪酸及び油脂からなる群から選択される少なくとも１つを含む、請求項１～１２のいずれか一項に記載の組成物。 The oil particles according to any one of claims 1 to 12, wherein the oil particles contain at least one selected from the group consisting of hydrocarbons, ester oils, silicone oils, fluorine oils, higher alcohols, higher fatty acids and fats and oils. Composition.
  14. 　皮膚外用剤に適用される、請求項１～１３のいずれか一項に記載の組成物。 The composition according to any one of claims 1 to 13, which is applied to an external skin preparation.
  15. 　前記油分粒子は、α-リノレン酸、エイコサペンタエン酸、ドコサヘキサエン酸、アラキドン酸、リノール酸、γ－リノレン酸、オレイン酸、ミリストレイン酸、エイコセン酸、ラウリン酸、リシノール酸、ステアリン酸、アラキドン酸、エイコサペンタエン酸、ドコサヘキサエン酸、オリーブオイル菜種油、アボカド、タラ肝油、イワシ油、トウモロコシ油、大豆油、サラダ油、えごま油、亜麻仁油、ビタミン類、ポリフェノール類、及びカロテノイド類からなる群から選択される少なくとも１つを含む、請求項１～１２のいずれか一項に記載の組成物。 The oil particles contain α-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid, linoleic acid, γ-linolenic acid, oleic acid, myristoleic acid, eicosenoic acid, lauric acid, ricinoleic acid, stearic acid, arachidonic acid, At least selected from the group consisting of eicosapentaenoic acid, docosahexaenoic acid, olive oil rapeseed oil, avocado, cod liver oil, sardine oil, corn oil, soybean oil, salad oil, perilla oil, linseed oil, vitamins, polyphenols, and carotenoids A composition according to any one of claims 1 to 12, comprising one.
  16. 　飲食料に適用される、請求項１～１５のいずれか一項に記載の組成物。 The composition according to any one of claims 1 to 15, which is applied to food and drink.
PCT/JP2022/026783 2021-07-20 2022-07-06 Oil dispersion composition WO2023002847A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202280043841.3A CN117545460A (en) 2021-07-20 2022-07-06 Oil dispersion composition
JP2023536681A JPWO2023002847A1 (en) 2021-07-20 2022-07-06

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2021-120020 2021-07-20
JP2021120020 2021-07-20

Publications (1)

Publication Number Publication Date
WO2023002847A1 true WO2023002847A1 (en) 2023-01-26

Family

ID=84979150

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2022/026783 WO2023002847A1 (en) 2021-07-20 2022-07-06 Oil dispersion composition

Country Status (3)

Country Link
JP (1) JPWO2023002847A1 (en)
CN (1) CN117545460A (en)
WO (1) WO2023002847A1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001342451A (en) * 2000-01-11 2001-12-14 Shiseido Co Ltd Method for manufacturing thickener and cosmetic
JP2005082527A (en) * 2003-09-08 2005-03-31 Lion Corp Cosmetic composition and method for producing the same
JP2009203200A (en) * 2008-02-28 2009-09-10 Shiseido Co Ltd Oil-in-water emulsified composition
JP2011193814A (en) * 2010-03-19 2011-10-06 Ina Food Industry Co Ltd Low-fat whipped cream, and method for producing the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001342451A (en) * 2000-01-11 2001-12-14 Shiseido Co Ltd Method for manufacturing thickener and cosmetic
JP2005082527A (en) * 2003-09-08 2005-03-31 Lion Corp Cosmetic composition and method for producing the same
JP2009203200A (en) * 2008-02-28 2009-09-10 Shiseido Co Ltd Oil-in-water emulsified composition
JP2011193814A (en) * 2010-03-19 2011-10-06 Ina Food Industry Co Ltd Low-fat whipped cream, and method for producing the same

Also Published As

Publication number Publication date
CN117545460A (en) 2024-02-09
JPWO2023002847A1 (en) 2023-01-26

Similar Documents

Publication Publication Date Title
EP2550954B1 (en) Vaseline-like composition, and cosmetic preparation
JP2010024159A (en) Fine emulsion composition and method for producing the same
JP3673924B2 (en) Topical skin preparation
WO2017159566A1 (en) Oil-in-water type composition
JP3471601B2 (en) External preparation for skin
WO2017073758A1 (en) Composition
JP5554985B2 (en) Cosmetic composition, cosmetic and method for producing the cosmetic
JP7436382B2 (en) Cosmetic manufacturing method
JP2010024161A (en) Fine emulsion composition and method for producing the same
JP7114164B2 (en) Aqueous composition containing powder and topical preparation for skin
US20230190590A1 (en) Lamellar gel-containing composition, emulsified composition, and composition for external-use skin preparation
JP7430644B2 (en) Powder dispersion composition and its manufacturing method
JP7337842B2 (en) detergent composition
JP3695710B2 (en) Skin preparation
JP2004018375A (en) Oily cosmetics
JP4349883B2 (en) Skin external composition
WO2023002847A1 (en) Oil dispersion composition
WO2023042688A1 (en) Oil-in-water composition
WO2023042687A1 (en) Oil-in-water cleanser composition
JP7316907B2 (en) oily solid cosmetics
JP2004018415A (en) Water-in-oil type emulsion cosmetic
JP2006045133A (en) Oil-in-water type emulsion composition
WO2023100661A1 (en) Oil-based composition, external preparation for skin and fragrance material
JP2010024160A (en) Fine emulsion composition and method for producing the same
JP2010100555A (en) Gel-like composition

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 22845781

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2023536681

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE