JP5231006B2 - Surface-treated powder and cosmetics containing the same - Google Patents

Description

  The present invention relates to a surface-treated powder and a cosmetic containing the same.

Hyaluronic acid, a type of mucopolysaccharide, is present in the extracellular matrix of human joints, brain, skin tissue, etc., and it is known that skin tissue works to prevent skin dryness due to its high water retention. Yes. Therefore, hyaluronic acid is widely used in cosmetics and the like as a moisturizing component.
However, since hyaluronic acid does not dissolve in an organic solvent such as ethanol, which is widely used in cosmetics, because of its high hydrophilicity, it has been necessary to devise formulation. In addition, since the stratum corneum, which is the uppermost layer of the skin, is slightly hydrophobic due to sebum and the like, it is known that extremely hydrophilic compounds such as hyaluronic acid are hardly absorbed by the skin.
In response to such problems, acetylated hyaluronic acid (AcHA) in which a hydrophobic acetyl group is introduced into a part of the structure of hyaluronic acid has been developed, and cosmetics formulated with this as an emulsifier have gained high reputation in the market. (Patent Document 1).
In addition, a powder has been proposed in which the surface of an inorganic powder is coated with a water-soluble polymer such as hyaluronic acid and a lipid so that both adhesion on the skin and moisture retention are compatible (Patent Document 2).
Japanese Patent Laid-Open No. 08-53501 JP 2002-201113 A

However, AcHA, which is an amphiphilic compound having the hydrophilicity of hyaluronic acid and the hydrophobicity of the acetyl group, has a problem in stability because the acetyl group tends to hydrolyze with time.
In addition, when high molecular weight hyaluronic acid is to be added to cosmetics, etc., it retains the moisture in the composition and becomes a highly viscous gel, so that hyaluronic acid alone can be dispersed in oil etc. It was also difficult to uniformly coat the powder.
The present invention has been made in view of the above problems, and has a surface-treated powder having excellent moisture retention, excellent dispersibility in oil and alcohol, and high affinity for skin tissue, and the powder. It aims at providing the cosmetics excellent in the usability | use mix | blended.

In order to achieve the above object, as a result of intensive studies by the present researchers, a powder obtained by modifying the primary powder with a silane coupling agent having a primary amine and condensing the primary amino group and hyaluronic acid is obtained. It has been found that it has excellent stability and can maintain the moisture retention of hyaluronic acid. Further, it has been found that by blending the powder into a cosmetic containing a non-aqueous system, it can be dispersed in an oil component of hyaluronic acid having a high hydrophilicity, and the present invention has been completed.
That is, the present invention provides a surface-treated powder in which hyaluronic acid or a derivative thereof is coated on a base powder through a silane coupling agent having a primary amino group.
In the surface-treated powder, the base powder is preferably silica gel.
Furthermore, the present invention provides a cosmetic containing the surface-treated powder.
In the cosmetic, the amount of the surface-treated powder is preferably 0.001 to 50% by mass.
In addition, the cosmetic is preferably non-aqueous.

  According to the present invention, it is possible to obtain a surface-treated powder having amphipathic properties and excellent stability and high affinity for skin tissue. Moreover, the cosmetics excellent in usability can be produced by blending the surface-treated powder.

Hereinafter, the present invention will be described in detail.
The surface-treated powder according to the present invention can be obtained by introducing a primary amino group on the surface of the base powder to obtain an aminated powder, and then amide-bonding the amino group and the carboxyl group of hyaluronic acid. . That is, the present invention is based on bonding a base powder and hyaluronic acid using a silane coupling agent having a primary amino group as a spacer.

  Examples of the powder that can be used as the base powder of the surface-treated powder according to the present invention include silicic acid, silicic anhydride (silica gel), magnesium silicate, talc, kaolin, mica, bentonite, titanium-coated mica, and oxychloride. Bismuth, zirconium oxide, magnesium oxide, zinc oxide, titanium dioxide, aluminum oxide, calcium sulfate, barium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, iron oxide, ultramarine, bitumen, chromium oxide, chromium hydroxide, carbon black and these Inorganic powder such as composite, polyamide, polyester, polyethylene, polypropylene, polystyrene, polyurethane, vinyl resin, epoxy resin, polycarbonate resin, divinylbenzene / styrene copolymer, and monomers of the above compounds Copolymer Celluloid, acetylcellulose, cellulose, polysaccharides, proteins, CI Pigment Yellow, CI Pigment Orange, organic powders such as CI Pigment Green and the like, and especially the use of silica gel. Also, the shape of the powder may be any shape such as a plate shape, a lump shape, a scale shape, a sphere shape, a porous sphere shape, and the particle size is not particularly limited.

  Furthermore, it is also possible to use the base powder that has been previously hydrophobized. Examples of the hydrophobizing treatment method include conventionally known hydrophobizing treatment methods such as silicone treatment, metal soap treatment, fatty acid treatment, surfactant treatment, and composite treatment thereof. By surface-treating the powder that has been subjected to such a hydrophobization treatment in advance, the effect of having a makeup can be improved when blended in cosmetics. Further, only one type of the base powder can be surface-treated, but two or more types can be used in combination.

In order to introduce a primary amino group to the surface of the base powder, a silane coupling agent having a primary amino group is modified.
Examples of such silane coupling agents include 3-aminopropyltriethoxysilane, 3-aminopropyltrimethoxysilane, 3- (2-aminoethyl) aminopropyltrimethoxysilane, and 3- (2-aminoethyl). Examples include alkoxysilanes such as aminopropylmethyldimethoxysilane, 3- (2-aminoethyl) aminopropyltrimethoxysilane, and N- (6-aminohexyl) aminopropyltrimethoxysilane.

Modification of the silane coupling agent to the base powder can be appropriately performed by a known powder modification technique. For example, when N- (6-aminohexyl) aminopropyltrimethoxysilane is modified on the silica gel surface, it can be carried out as follows.
<Amination of silica gel surface>
Silica gel and N- (6-aminohexyl) aminopropyltrimethoxysilane are added to a mixture of isopropanol and water, which are reaction solvents, and the reaction vessel is heated to reflux and maintained for 2 hours. After the reaction, the reaction solution is taken out from the container and the silica gel is recovered by filtration. Thereafter, the silica gel is washed with 50% isopropanol and dried under reduced pressure at 45 ° C. for 10 hours to obtain a silica gel having an amino group introduced on the surface.
By treating the base powder with the silane coupling agent as described above, amino groups can be directly introduced onto the powder surface without impairing the function of the material due to the combination with other substances.

The primary amino group modified on the base powder forms an amide bond with the carboxyl group of hyaluronic acid, whereby the surface-treated powder according to the present invention can be obtained.
In the present invention, hyaluronic acid includes its salt form. Examples of the hyaluronic acid salt include inorganic hydrochloric acid such as hydrochloric acid, sulfuric acid, phosphoric acid, hydrobromic acid; acetic acid, lactic acid, maleic acid, fumaric acid, tartaric acid, citric acid, methanesulfonic acid, p-toluenesulfonic acid, etc. Organic acid salt; sodium salt, potassium salt, ammonium salt, magnesium salt, calcium salt and the like.

Other hyaluronic acid derivatives can also be used. Specific examples include acetylated hyaluronic acid, hyaluronic acid methyl ester, and the like, and further a protective group or the like introduced into the carboxyl group or hydroxyl group of hyaluronic acid.
In the present invention, the molecular weight of the hyaluronic acid used is not particularly limited. High molecular weight hyaluronic acid is excellent in moisture retention (hydrophilicity), but has a very high viscosity and has almost no affinity for oleophilic skin. Met. Therefore, when blending hyaluronic acid into cosmetics and the like, low molecular weight hyaluronic acid that is inferior in moisture retention but has a smooth feel has been often used.
On the other hand, in the present invention, by using a lipophilic silane coupling agent for the spacer, it becomes possible to adapt hyaluronic acid to the lipophilic skin. Therefore, in the present invention, a surface-treated powder excellent in skin affinity can be obtained through a specific spacer regardless of the molecular weight of hyaluronic acid.

There is no restriction on the method of adding hyaluronic acid to the amino group on the base powder, but it is possible to add hyaluronic acid directly to the amino group of the base powder by adding a dehydrating condensation agent with carbodiimide. It is. In this case, when 1-hydroxybenzotriazole, N-hydroxysuccinimide, or the like is allowed to act on the reaction system as an additive, the carboxyl group of hyaluronic acid is esterified and efficiently forms an amide bond with the amino group on the base powder. Therefore, it is preferable.
The addition rate of hyaluronic acid to amino groups on the base powder can be adjusted as desired. That is, all the amino groups on the base powder may be condensed with hyaluronic acid, or the surface of the surface is obtained by leaving unreacted amino groups with hyaluronic acid and binding fatty acids such as oleic acid there. It is also possible to make the treated powder more familiar with the oil.

Since the surface-treated powder according to the present invention obtained above maintains the extremely high hydrophilicity of hyaluronic acid, it is highly non-aqueous based on the lipophilicity of the silane coupling agent and is extremely dispersible in oil. it can be incorporated into any cosmetic RyoNaru content including, including moisture, obtain excellent usability such as smoothness and skin familiarity cosmetics.
In addition, the surface-treated powder of the present invention is not only covered with hyaluronic acid having a high biocompatibility on the outermost surface, but is also lipophilic by the alkyl group of the spacer used to bind hyaluronic acid to the silica surface. Is granted. Therefore, the cosmetic compounded with the surface-treated powder of the present invention exhibits hyaluronic acid's original moisture retention action, and at the same time, can absorb waste products that cause makeup collapse such as sebum due to its fat solubility, It is considered that makeup is excellent.
That is, the cosmetic according to the present invention includes the surface-treated powder. The compounding amount of the surface-treated powder with respect to the cosmetic of the present invention is preferably 0.001 to 50% by mass, and more preferably 0.01 to 10% by mass. If the blending amount is less than 0.001% by mass, the effect of blending hyaluronic acid may not be sufficiently obtained. Even if blending exceeds 50% by mass, the effect commensurate with the increase in blending amount An increase is virtually undesired and may interfere with formulation formulation.

In addition to the above essential components, other moisturizing components can be blended in the cosmetic of the present invention.
Other moisturizing ingredients include, for example, polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, carolinic acid, atelocollagen, cholesteryl-12-hydroxy Examples include stearate, sodium lactate, bile salt, dl-pyrrolidone carboxylate, short-chain soluble collagen, diglycerin (EO) PO adduct, Izayobara extract, yarrow extract, merirot extract, alkylene oxide derivatives, etc. It is done.

  Further, the cosmetic of the present invention includes other components usually used in cosmetics and pharmaceuticals, for example, powder components, liquid fats and oils, solid fats and oils, waxes, hydrocarbons, higher fatty acids, as long as the effects of the present invention are not impaired. Higher alcohols, esters, silicones, anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, water-soluble polymers, thickeners, film agents, UV absorbers, sequestering agents, Lower alcohols, polyhydric alcohols, sugars, amino acids, organic amines, polymer emulsions, pH adjusters, skin nutrients, vitamins, antioxidants, antioxidant auxiliaries, fragrances, water, etc. should be added as necessary. Can do.

  Examples of the powder component include inorganic powders (for example, talc, kaolin, mica, sericite, muscovite, phlogopite, synthetic mica, saucite, biotite, permiculite, magnesium carbonate, calcium carbonate, silicic acid. Aluminum, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, zeolite, barium sulfate, calcined calcium sulfate (baked gypsum), calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder , Metal soap (eg, zinc myristate, calcium palmitate, aluminum stearate), boron nitride, etc .; organic powder (eg, polyamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, polystyrene Powder, copolymer resin powder of styrene and acrylic acid, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, etc.); inorganic white pigment (eg, titanium dioxide, zinc oxide, etc.); inorganic red pigment (eg, Iron oxide (Bengara), iron titanate, etc .; Inorganic brown pigments (eg, γ-iron oxide, etc.); Inorganic yellow pigments (eg, yellow iron oxide, loess, etc.); Inorganic black pigments (eg, black oxide) Iron, low-order titanium oxide, etc.); inorganic purple pigments (eg, mango violet, cobalt violet, etc.); inorganic green pigments (eg, chromium oxide, chromium hydroxide, cobalt titanate, etc.); inorganic blue pigments (eg, Pearl pigments (eg titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored oxidation) Tan-coated mica, bismuth oxychloride, fish scale foil, etc.); metal powder pigments (eg, aluminum powder, copper powder, etc.); organic pigments such as zirconium, barium or aluminum lake (eg, red 201, red 202, red 204) No., red 205, red 220, red 226, red 228, red 405, orange 203, orange 204, yellow 205, yellow 401, and blue 404, organic pigments such as red 3 , Red 104, Red 106, Red 227, Red 230, Red 401, Red 505, Orange 205, Yellow 4, Yellow 5, Yellow 202, Yellow 203, Green 3 and Blue No. 1 etc.); natural pigments (for example, chlorophyll, β-carotene, etc.) and the like.

  Examples of liquid oils include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, southern castor oil, castor oil, linseed oil , Safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, cinnagiri oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin and the like.

  Examples of the solid fat include cacao butter, palm oil, horse fat, hydrogenated palm oil, palm oil, beef tallow, sheep fat, hydrogenated beef tallow, palm kernel oil, pork fat, beef bone fat, owl kernel oil, hydrogenated oil, cattle Leg fats, moles, hydrogenated castor oil and the like.

  Examples of waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ibota wax, whale wax, montan wax, nuka wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugar cane wax, lanolin fatty acid isopropyl, hexyl laurate, and reduced lanolin. , Jojoballow, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, and the like.

Examples of the hydrocarbon oil include liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax, and the like.
Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, toluic acid, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid ( DHA) and the like.

  Examples of higher alcohols include linear alcohols (eg, lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol); branched chain alcohols (eg, monostearyl glycerin ether (batyl alcohol) ), 2-decyltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyl decanol, isostearyl alcohol, octyldodecanol and the like.

  Synthetic ester oils include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyl decyl dimethyloctanoate, cetyl lactate, myristyl lactate Lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, monoisostearate N-alkyl glycol, neopentyl glycol dicaprate, apple Acid diisostearyl, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, triisostearic acid trimethylo Propane, tetra-2-ethylhexanoate pentaerythritol, glycerol tri-2-ethylhexanoate, glycerol trioctanoate, glycerol triisopalmitate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmi Tate, glyceryl trimyristate, glyceride tri-2-heptylundecanoate, castor oil fatty acid methyl ester, oleyl oleate, acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, N-lauroyl-L-glutamic acid-2 -Octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate Le, diisopropyl sebacate, 2-ethylhexyl succinate, and triethyl citrate.

  Examples of the silicone oil include linear polysiloxanes (for example, dimethylpolysiloxane, methylphenylpolysiloxane, diphenylpolysiloxane, etc.); cyclic polysiloxanes (for example, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexyl). And silicone resins that form a three-dimensional network structure, various modified polysiloxanes (amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified polysiloxane, etc.) It is done.

  Anionic surfactants include, for example, fatty acid soaps (eg, sodium laurate, sodium palmitate, etc.); higher alkyl sulfates (eg, sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfates (eg, POE-lauryl sulfate triethanolamine, POE-sodium lauryl sulfate, etc.); N-acyl sarcosine acids (eg, sodium lauroyl sarcosine, etc.); higher fatty acid amide sulfonates (eg, sodium N-myristoyl-N-methyl taurate, palm Oil fatty acid methyl tauride sodium, lauryl methyl tauride sodium, etc .; phosphate ester salt (POE-oleyl ether sodium phosphate, POE-stearyl ether phosphate, etc.); sulfosuccinate (eg, di-2-ethylhexyl sulfo) Sodium succinate, monolauroyl monoethanolamide sodium polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc.); alkyl benzene sulfonates (eg, sodium linear dodecyl benzene sulfonate, triethanol amine linear dodecyl benzene sulfonate, linear dodecyl) Higher fatty acid ester sulfates (eg, hydrogenated coconut oil fatty acid sodium glycerol sulfate); N-acyl glutamate (eg, monosodium N-lauroyl glutamate, disodium N-stearoyl glutamate, N-myristoyl) -L-glutamic acid monosodium, etc.); sulfated oil (eg funnel oil); POE-alkyl ether carboxylic acid; POE-alkyl allyl ether Α-olefin sulfonates; higher fatty acid ester sulfonates; secondary alcohol sulfates; higher fatty acid alkylolamide sulfates; lauroyl monoethanolamide sodium succinate; N-palmitoyl aspartate ditriethanolamine ; Sodium caseinate and the like.

  Examples of the cationic surfactant include alkyltrimethylammonium salts (eg, stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.); alkylpyridinium salts (eg, cetylpyridinium chloride, etc.); distearyldimethylammonium dialkyldimethylammonium chloride; Poly (N, N'-dimethyl-3,5-methylenepiperidinium chloride); alkyl quaternary ammonium salt; alkyldimethylbenzylammonium salt; alkylisoquinolinium salt; dialkyl morpholinium salt; POE-alkylamine; Examples include alkylamine salts; polyamine fatty acid derivatives; amyl alcohol fatty acid derivatives; benzalkonium chloride; benzethonium chloride and the like.

  Examples of amphoteric surfactants include imidazoline-based amphoteric surfactants (eg, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide). Side-1-carboxyethyloxy disodium salt, etc.); betaine surfactants (for example, 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkylbetaine, amide betaine) , Sulfobetaine, etc.).

  Examples of the lipophilic nonionic surfactant include sorbitan fatty acid esters (for example, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, Sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate); glycerin polyglycerin fatty acids (eg mono cottonseed oil fatty acid glycerin, monoerucic acid glycerin, sesquioleate glycerin, monostearin) Glycerin acid, α, α'-oleic acid pyroglutamate glycerin, monostearic acid glycerin malic acid, etc.); propylene glycol fatty acid esters (eg monostearies) Propylene glycolate, etc.); hardened castor oil derivative; glycerin alkyl ether, etc.

  Examples of hydrophilic nonionic surfactants include POE-sorbitan fatty acid esters (for example, POE-sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate). POE sorbite fatty acid esters (eg, POE-sorbite monolaurate, POE-sorbite monooleate, POE-sorbite pentaoleate, POE-sorbite monostearate, etc.); POE-glycerin fatty acid esters (eg, POE- POE-monooleate such as glycerol monostearate, POE-glycerol monoisostearate, POE-glycerol triisostearate); POE-fatty acid esters (eg POE-distearate, POE-monodiolate, ethylene glycol distearate, etc.) POE-alkyl ethers (eg POE- Lauryl ether, POE-oleyl ether, POE-stearyl ether, POE-behenyl ether, POE-2-octyldodecyl ether, POE-cholestanol ether, etc.); Pluronic type (eg, Pluronic, etc.); POE / POP-alkyl ether (For example, POE / POP-cetyl ether, POE / POP-2-decyltetradecyl ether, POE / POP-monobutyl ether, POE / POP-hydrogenated lanolin, POE / POP-glycerin ether, etc.); Tetra POE / Tetra POP-ethylenediamine condensates (eg Tetronic, etc.); POE-castor oil hardened castor oil derivatives (eg POE-castor oil, POE-hardened castor oil, POE-hardened castor oil monoisostearate, POE-hardened castor Oil triisostearate, POE-hardened castor oil monopyroglutamic acid monoisostearic acid diester, POE-hardened castor oil maleic acid, etc.) POE-beeswax lanolin derivatives (eg POE-sorbite beeswax); alkanolamides (eg coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.); POE-propylene glycol fatty acid ester; POE-alkylamine POE-fatty acid amide; sucrose fatty acid ester; alkyl ethoxydimethylamine oxide; trioleyl phosphate and the like.

  Examples of natural water-soluble polymers include plant-based polymers (for example, gum arabic, gum tragacanth, galactan, guar gum, carob gum, caraya gum, carrageenan, pectin, agar, quince seed (malmello), alge colloid (guckweed extract), starch (Rice, corn, potato, wheat), glycyrrhizic acid); microbial polymers (eg, xanthan gum, dextran, succinoglucan, bullulan, etc.); animal polymers (eg, collagen, casein, albumin, gelatin, etc.), etc. Is mentioned.

  Semi-synthetic water-soluble polymers include, for example, starch polymers (eg, carboxymethyl starch, methylhydroxypropyl starch, etc.); cellulose polymers (methylcellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate) Hydroxypropylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder and the like); alginic acid polymers (for example, sodium alginate, propylene glycol alginate, etc.) and the like.

  Synthetic water-soluble polymers include, for example, vinyl polymers (eg, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, carboxyvinyl polymer); polyoxyethylene polymers (eg, polyethylene glycol 20,000, 40,000, 60,000). Polyoxyethylene polyoxypropylene copolymer, etc.); acrylic polymers (for example, sodium polyacrylate, polyethyl acrylate, polyacrylamide, etc.); polyethyleneimine; cationic polymers, and the like.

  Examples of the thickener include gum arabic, carrageenan, caraya gum, gum tragacanth, carob gum, quince seed (malmello), casein, dextrin, gelatin, sodium pectate, sodium alginate, methylcellulose, ethylcellulose, CMC, hydroxyethylcellulose, hydroxypropyl Cellulose, PVA, PVM, PVP, sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, cellulose dialkyldimethylammonium sulfate, xanthan gum, magnesium aluminum silicate, bentonite, hectorite, silicate A1Mg (vee gum), Examples thereof include laponite and silicic anhydride.

  Examples of UV absorbers include benzoic acid UV absorbers (eg, paraaminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester. N, N-dimethyl PABA ethyl ester, N, N-dimethyl PABA butyl ester, N, N-dimethyl PABA ethyl ester, etc.); anthranilic acid-based UV absorbers (for example, homomenthyl-N-acetyl anthranilate, etc.); Salicylic acid ultraviolet absorbers (for example, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, etc.); cinnamic acid ultraviolet absorbers (for example, octylmethoxycinnamate, ethyl) -4-Isopropylcinname , Methyl-2,5-diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p -Methoxycinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β -Phenyl cinnamate, 2-ethylhexyl-α-cyano-β-phenyl cinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxy cinnamate, etc.); benzophenone UV absorbers (for example, 2,4-dihydroxybenzophenone) 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzo Phenone, 2,2 ', 4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5- Sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4′-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc.); 3- (4'-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2 -(2'-hydroxy-5'-t-octylphenyl) benzotriazole; 2- (2'-hydroxy-5'-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 4-methoxy-4'-t-butyl Dibenzoylmethane; 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one, dimorpholino pyridazinone like.

  Examples of the sequestering agent include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, tetrasodium edetate Sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, trisodium ethylenediaminehydroxyethyl triacetate and the like.

  Examples of the lower alcohol include ethanol, propanol, isopropanol, isobutyl alcohol, t-butyl alcohol and the like.

  Examples of the polyhydric alcohol include divalent alcohols (for example, ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, 2,3-butylene glycol, Pentamethylene glycol, 2-butene-1,4-diol, hexylene glycol, octylene glycol, etc.); trivalent alcohol (eg, glycerin, trimethylolpropane, etc.); tetravalent alcohol (eg, 1,2,6) Pentaerythritol such as hexanetriol); pentahydric alcohol (eg, xylitol, etc.); hexavalent alcohol (eg, sorbitol, mannitol, etc.); polyhydric alcohol polymer (eg, diethylene glycol, dipropylene glycol, triethylene glycol, polypropylene Glycol, tetraethylene glycol, diglycerin, polyethylene glycol, triglycerin, tetraglycerin, polyglycerin, etc.); divalent alcohol alkyl ethers (for example, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene) Glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono 2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, ethylene glycol isopropyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, etc.) ; Dihydric alcohol alkyl ester Tellurium (for example, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, propylene glycol monomethyl ether , Propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether, dipropylene glycol butyl ether, etc.); divalent alcohol Ether esters (eg, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diazinate, ethylene glycol disuccinate, diethylene glycol monoethyl ether acetate, diethylene glycol) Monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propylene glycol monophenyl ether acetate, etc .; glycerin monoalkyl ether (for example, xyl alcohol, ceralkyl alcohol) Sugar alcohol (for example, sorbitol, maltitol, maltotriose, mannitol, sucrose, erythritol, glucose, fructose, amylolytic sugar, maltose, xylitolose, amylolytic sugar reducing alcohol, etc.); Solid; Tetrahydrofurfuryl alcohol; POE-Tetrahydrofurfuryl alcohol; POP-Butyl ether; POP / POE-Butyl ether; Tripolyoxypropylene glycerin ether; POP-glycerin ether; POP-glycerin ether phosphate; POP / POE-pentane erythritol Examples include ether and polyglycerin.

  Monosaccharides include, for example, tricarbon sugars (eg, D-glyceryl aldehyde, dihydroxyacetone, etc.); tetracarbon sugars (eg, D-erythrose, D-erythrulose, D-treose, erythritol, etc.); pentose sugars (eg, , L-arabinose, D-xylose, L-lyxose, D-arabinose, D-ribose, D-ribulose, D-xylulose, L-xylulose, etc .; hexose (eg, D-glucose, D-talose, D) -Bucicose, D-galactose, D-fructose, L-galactose, L-mannose, D-tagatose, etc.); pentose sugar (eg, aldheptose, heproose, etc.); octose sugar (eg, octulose, etc.); For example, 2-deoxy-D-ribose, 6-deoxy-L-galactose, 6-deoxy-L-mannose, etc .; amino sugar (eg, D-glucosamine, D-galactosamine, shea Acid, Aminouron acid, muramic acid); uronic acid (e.g., D- glucuronic acid, D- mannuronic acid, L- guluronic acid, D- galacturonic acid, L- iduronic acid) and the like.

Examples of the oligosaccharides include sucrose, gnocyanose, umbelliferose, lactose, planteose, isoliquinoses, α, α-trehalose, raffinose, lycnose, umbilicin, stachyose verbus courses and the like.
Examples of the polysaccharide include cellulose, quince seed, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, gum arabic, heparan sulfate, hyaluronic acid, tragacanth gum, keratan sulfate, chondroitin, xanthan gum, mucoitin sulfate, guar gum, dextran, kerato sulfate. , Locust bean gum, succinoglucan, caronic acid and the like.

  Examples of amino acids include neutral amino acids (eg, threonine, cysteine, etc.); basic amino acids (eg, hydroxylysine, etc.) and the like. Examples of amino acid derivatives include acyl sarcosine sodium (lauroyl sarcosine sodium), acyl glutamate, acyl β-alanine sodium, glutathione, and pyrrolidone carboxylic acid.

Examples of organic amines include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-1-propanol, and the like. Is mentioned.
Examples of the polymer emulsion include an acrylic resin emulsion, a polyethyl acrylate emulsion, an acrylic resin liquid, a polyacryl alkyl ester emulsion, a polyvinyl acetate resin emulsion, and a natural rubber latex.

Examples of the pH adjuster include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinic acid-sodium succinate.
Examples of vitamins include vitamins A, B1, B2, B6, C, E and derivatives thereof, pantothenic acid and derivatives thereof, biotin and the like.
Examples of the antioxidant include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, gallic acid esters and the like.

  Examples of the antioxidant assistant include phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, kephalin, hexametaphosphate, phytic acid, and ethylenediaminetetraacetic acid.

  Other ingredients that can be blended include, for example, preservatives (ethyl paraben, butyl paraben, etc.); anti-inflammatory agents (eg, glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, etc.); whitening agents (for example, , Placenta extract, saxifrage extract, arbutin, etc.); various extracts (eg, Dokudami extract, duckweed extract, merirot extract, nettle extract, licorice extract, peonies extract, scorpion extract, loofah extract, kina extract, yukinoshita extract, clara Extract, potato extract, fennel extract, primrose extract, rose extract, zebra extract, lemon extract, sicon extract, aloe extract, ginger root extract, eucalyptus extract, cedar extract, sage extract, thyme extract, Extract, seaweed extract, cucumber extract, clove extract, raspberry extract, melissa extract, carrot extract, maroni extract, peach extract, peach leaf extract, mulberry extract, cornflower extract, hamamelis extract, placenta extract, thymus extract, silk extract, etc.), activation Agents (for example, royal jelly, photosensitizer, cholesterol derivatives, etc.); blood circulation promoters (for example, nonyl acid wallenylamide, nicotinic acid benzyl ester, nicotinic acid β-butoxyethyl ester, capsaicin, gingerone, cantharis tincture, ictamol, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, cyclandrate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, γ-oryzano Le etc.); anti-seborrhoeic agents (e.g., sulfur, thianthol and the like); anti-inflammatory agents (e.g., tranexamic acid, thiotaurine, and a hypotaurine and the like) and the like.

  The cosmetic dosage form of the present invention can be arbitrarily selected, and includes a wide range of agents such as solution systems, solubilization systems, emulsification systems, powder dispersion systems, water-oil two-layer systems, water-oil-powder three-layer systems, and the like. Can take a mold. In particular, the surface-treated powder of the present invention can be blended with hyaluronic acid, which has been difficult in the past, into oils, alcohols, etc., and thus exhibits excellent dispersibility in non-aqueous cosmetics based on these. . Further, the product form of the cosmetics of the present invention is also optional, such as facial cosmetics such as facial cleansers, lotions, emulsions, creams and packs, makeup cosmetics such as foundations, lipsticks and eye shadows, body cosmetics, and hair cosmetics. It can be used for cosmetics, oral cosmetics, aromatic cosmetics, cleaning agents, ointments and the like.

  The present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto. Unless otherwise specified, the blending amount is expressed in mass% with respect to the system in which the component is blended.

<Preparation of hyaluronic acid-coated silica gel>
Amino group-introduced glass reaction vessel with silica gel 80 mL of isopropanol and 20 mL of water were placed therein, and 20 g of silica gel (average particle size 4.5 to 6.0 μm, specific surface area 200 to 400 m ² / g) and N- (6-amino 2.7 mL of hexyl) aminopropyltrimethoxysilane was added. Thereafter, the reaction vessel was heated until reflux occurred, and the state was maintained for 2 hours. After completion of the reaction, the reaction solution was taken out from the container, and the silica gel therein was collected by filtration. The silica gel was thoroughly washed with 50% isopropanol, and dried under reduced pressure at 45 ° C. for 10 hours to obtain an amino group-introduced silica gel.

Addition of hyaluronic acid 20 g of amino group-introduced silica gel suspended in 100 mL of water 75 mL of 5% hyaluronic acid (average molecular weight 100,000) solution 2.519 g of N-hydroxysuccinimide dissolved in 10 mL of water In 10 mL of water 4.169 g of dissolved carbodiimide was placed in a reaction vessel on an ice bath and reacted at room temperature for 24 hours with sufficient stirring. After the reaction, silica gel was removed by filtration.
In order to eliminate the possibility of non-specific electrostatic binding between hyaluronic acid and silica gel, the silica gel was washed with 500 mL of 5% sodium chloride, followed by 500 mL of 50% methanol and finally with 500 mL of 5% sodium chloride. After washing, it was dried under reduced pressure at 45 ° C. for 10 hours to obtain hyaluronic acid-coated silica gel.

<Elemental analysis>
The amount of carbon and nitrogen was analyzed for the silica gel into which amino groups were introduced by the above preparation, and the respective molar ratios were calculated from the constituent ratios. The results are shown in Table 1 below.
Further, the hyaluronic acid-coated silica gel after addition of hyaluronic acid was similarly analyzed, and the amount of hyaluronic acid bound on the silica gel was measured. The results are shown in Table 2 below.
The molal concentration (mmol / g) is calculated as the structural unit of hyaluronic acid (u) = 402, and subtracts the amount of carbon and nitrogen (%) of N- (6-aminohexyl) aminopropyltrimethoxysilane to give a unit structure. Was determined with respect to 1 g of silica gel.

(Table 1)
Composition ratio (%) Molar concentration (mmol / g)
Carbon 5.85 0.541
Nitrogen 1.39 0.495

(Table 2)
Composition ratio (%) Molar concentration (mmol / g)
Carbon 8.82 0.088
Nitrogen 1.73 0.123
From the molar concentration of carbon and nitrogen shown in Table 1, it is estimated that about 0.52 mmol / g of N- (6-aminohexyl) aminopropyltrimethoxysilane is bound to the silica gel after introduction of the amino group. It was.
From Table 2, it was found that the amount of hyaluronic acid added to the introduced amino group was 0.088 mmol / g per hyaluronic acid constituent disaccharide from the amount of carbon.
From the above, it was confirmed that in the surface-treated powder of the present invention, an amino group was introduced onto the base powder, and hyaluronic acid was added to the amino group.

<Measurement of Fourier transform infrared spectrophotometry (FT-IR)>
Furthermore, in order to confirm the hyaluronic acid bonded to the silica gel surface, FT-IR measurement was performed on the hyaluronic acid-coated silica gel obtained above and the untreated silica gel and the amino group-introduced silica gel as a comparative example. The sample was prepared by the diffuse reflection method. The measurement results are shown in FIG.

According to FIG. 1, although the amino group-introduced silica gel was observed a peak derived from a primary amino group (-NH ₂₎ in the vicinity of 3307cm ^-1 and 3369cm ^-1, the hyaluronic acid-coated silica gel and untreated silica gel observed There wasn't. This is because the amino group is not introduced into the untreated silica gel, so there is no amino group peak. In the hyaluronic acid-coated silica gel, almost all amino groups on the base powder are bonded to hyaluronic acid. This is probably because of this.
Further, in the hyaluronic acid-coated silica gel, a peak derived from the carboxyl group (—COO—) of hyaluronic acid was observed in the vicinity of 1640 cm ⁻¹ .
From the above results, in the surface-treated powder of the present invention, it was confirmed that the amino group introduced onto the base powder and hyaluronic acid reacted and the hyaluronic acid was chemically adsorbed on the powder surface.

<Measurement of water evaporation rate>
In order to examine the moisture retention of the hyaluronic acid-coated silica gel and untreated silica gel obtained above, the water evaporation rate was measured.
Both samples were dried under reduced pressure for about 16 hours at a temperature at which hyaluronic acid was not colored (85 ° C.) in order to remove moisture as much as possible. About 60 mg of each sample was taken in a polyethylene cap for a 16 mm test tube (inside diameter 15.5 mm, height 9.7 mm) weighed in advance, and the weight was measured to obtain the initial dry weight of each sample. Ten samples were prepared for each of the hyaluronic acid-coated silica gel and the untreated silica gel. The sample was allowed to stand for about 16 hours in a plastic box (length 30 cm, width 20 cm, height 6 cm) covered with 20 cm straight filter paper moistened with water to sufficiently absorb moisture. It has been confirmed by preliminary experiments that the silica gel in this state reaches the water absorption equilibrium in about 13 hours.
The sample that sufficiently reached the moisture absorption equilibrium was transferred from the plastic box to a constant temperature and humidity chamber (temperature 25 ° C., relative humidity 50%), and the weight was measured every 15 minutes until there was no fluctuation in the measured value. As the weight measurement value, a relative weight measurement value with an initial dry weight of 100 was used. The results for the hyaluronic acid coated silica gel are shown in FIG. In FIG. 2, “▲” represents an actual measurement value, and a straight line represents an exponential regression line.

All samples showed biphasic properties as shown in FIG. 2, and the evaporation stopped about 200 minutes after the start of measurement. Therefore, an exponential regression equation of 6 measurement values up to 75 minutes from the measurement start value among the weight measurement values of each sample was obtained. The general formula is as follows.
y = e ^(ax−b) = b′e ^ax
(In the formula, y represents time, x represents a weight measurement value, and a and b, or b ′ represent the slope and intercept of the exponential regression line, respectively.)

  The slope of the exponential regression line is defined as the first phase moisture evaporation rate, and the first phase moisture evaporation rate of each sample is shown in Table 3 below. Similarly, an exponential function regression equation is obtained using the measured values for 60 minutes before the end of the weight measurement, and the slope of each is taken as the second-phase moisture evaporation rate, as shown in Table 4 below.

(Table 3)
Untreated silica gel Hyaluronic acid coated silica gel
-0.00321 -0.00298
-0.00326 -0.00244
-0.00288 -0.00301
-0.00341 -0.00286
-0.00262 -0.00242
-0.00316 -0.00302
-0.00261 -0.00248
-0.00283 -0.00269
-0.00266 -0.00246
-0.00267 -0.00258
Average value -0.00293 -0.00269
Standard deviation 0.00030 0.00025

(Table 4)
Untreated silica gel Hyaluronic acid coated silica gel
-0.00030 -0.00013
-0.00043 -0.00034
-0.00065 -0.00039
-0.00097 -0.00039
-0.00114 -0.00045
-0.00141 -0.00052
-0.00150 -0.00053
-0.00160 -0.00059
-0.00162 -0.00064
-0.00177 -0.00077
Average value -0.00114 -0.00047
Standard deviation 0.00053 0.00018
According to Tables 3 and 4, the first phase moisture evaporation rate showed a higher evaporation rate than the second phase. In addition, no significant difference was observed in the average value of the first-phase moisture evaporation rate between the untreated silica gel and the hyaluronic acid-coated silica gel. On the other hand, in the second-phase water evaporation rate shown in Table 3, as a result of analysis by a non-parametric method, it was found that the evaporation rate of untreated silica gel was significantly higher than that of hyaluronic acid-coated silica gel.
From the difference in evaporation rate between the first and second phases, the first phase moisture evaporation rate indicates the evaporation rate of moisture present on the powder surface, and the second phase moisture evaporation rate indicates the evaporation of moisture present inside the powder. It is inferred that it shows speed. Therefore, the surface-treated powder of the present invention in which the second-phase moisture evaporation rate is significantly suppressed as compared with the untreated powder has a high moisture retention power inside the powder and has excellent moisture retention.

<Dispersibility test>
In order to examine the dispersibility of the surface-treated powder of the present invention in each solvent, each sample prepared as follows was subjected to a dispersibility test in oil and alcohol. The results are shown in Table 5.
Preparation of sample Test example 1-1: Hyaluronic acid-coated silica gel obtained by the above preparation method Comparative example 1-1: Mixture of 20 g of silica gel and 0.08 g of hyaluronic acid powder Comparative example 1-2: Hyaluronic acid powder 0 .08g
Comparative Example 1-3: 15 g of hyaluronic acid and 5 g of glycosphingolipid were dissolved in 900 ml of purified water to obtain a uniform solution, and 80 g of silica gel was added thereto and stirred sufficiently until evenly dispersed. Hyaluronic acid sphingoglycolipid-coated silica gel obtained by drying the obtained slurry at a temperature of 55 ° C. or less and then pulverizing it

Test method Hyaluronic acid-coated silica gel powder obtained in the above (Test Example 1-1), powder obtained by simply mixing untreated silica gel and hyaluronic acid powder (Comparative Example 1-1), hyaluronic acid powder (Comparative Example 1-2) 0.1 g of each was added to each 5 ml of water, silicone oil, and ethanol, and the dispersibility after stirring was evaluated according to the following criteria.
○: Aggregation was not observed in the powder and was uniformly dispersed in the liquid. Δ: Part of the powder was dispersed in the liquid, but aggregation was observed in the powder. X: The powder was remarkably aggregated and was not dispersed in the liquid at all.

(Table 5)
Water Silicone oil Ethanol
Test Example 1-1 ○ ○ ○
Comparative Example 1-1 ○ × ×
Comparative Example 1-2 ○ × ×
Comparative Example 1-3 △ △ △

As shown in Table 4, all the powders showed dispersibility with respect to water, but the powders of Comparative Examples 1-1 and 1-2 aggregated in the oil and alcohol and were not dispersed at all. Moreover, although Comparative Example 1-3 showed some dispersibility in any solvent, all were inferior to Test Example 1-1. On the other hand, Test Example 1, which is a powder of the present invention, showed uniform dispersion even in oil and ethanol.
From the above results, it is recognized that the surface-treated powder of the present invention has excellent amphipathic properties and excellent dispersibility in oil and alcohol.

Nonaqueous cosmetics having the formulations shown in Table 6 below were produced by a conventional method, and each sample was evaluated according to the following evaluation criteria. The results are shown in Table 6.
(1) Moisturizing effect (conductance measurement)
4 mg of the sample was applied to the forearm of 10 professional panelists so as to be 2 cm × 2 cm, and the skin conductance before and after application for 1 hour was measured with a corneometer, and the moisturizing effect was evaluated from the rate of increase.
Based on this skin conductance increase rate, the effect of the stratum corneum on the water absorption and water retention ability can be examined. That is, the greater the increase rate, the more the stratum corneum moisture increases, and it is evaluated that the moisturizing effect is high. The evaluation criteria are as follows.
◎: The average conductance increase rate of 10 panelists is 40% or more ○: The average conductance increase rate of 10 panelists is 25% or more and less than 40% △: The average conductance increase rate of 10 panelists is 10% or more and 25% Less than x: The average conductance increase rate of 10 panelists is less than 10%

(2) Smoothness (no stickiness)
Ten professional panels evaluated the smoothness of the skin during and after use of the sample. The evaluation criteria are as follows.
◎: Eight or more panel evaluated as smooth ○: Six or more and less than eight panel evaluated as smooth △: Three or more and less than six panel evaluated as smooth ×: Smooth Less than 3 panelists

(3) Familiarity with skin 10 professional panels evaluated the practicality of familiarity with the skin during and after use of the sample. The evaluation criteria are as follows.
◎: Eight or more panels evaluated as being familiar with skin ○: Six or more panels evaluated as being familiar with skin are less than 8 persons △: Three panels evaluated as being familiar with skin Less than 6 people x: Less than 3 panels evaluated as being familiar with skin

(4) Moisturizing feeling (moist)
Ten professional panelists evaluated the moisturizing feeling (moisture) on the skin during and after use of the sample. The evaluation criteria are as follows: ◎: Eight or more panels evaluated as having a moisturizing feeling ○: Six or more panelists having a moisturizing feeling and less than eight persons Δ: Three panels evaluated as having a moisturizing feeling No less than 6 people x: Less than 3 panels evaluated as moisturizing

(Table 6)

As shown in Table 6, the cosmetics of Test Examples 2-1 to 2-3 in which 0.001 to 50% by mass of hyaluronic acid-coated silica gel (powder of Test Example 1-1) were blended had a moisturizing effect and usability. All were excellent.
On the other hand, in Comparative Example 2-1 in which the hyaluronic acid-coated silica gel is not blended, the moisture retention effect and usability are inferior, and in Comparative Example 2-2 in which 60% by mass of the hyaluronic acid-coated silica gel is blended with respect to the composition, the moisture retaining effect. Slight smoothness and familiarity to the skin were slightly reduced. In addition, Comparative Example 2-3 in which hyaluronic acid glycosphingolipid-coated silica gel was blended instead of hyaluronic acid-coated silica gel and 2-4 in which untreated silica gel was blended were significantly inferior to the test examples in terms of usability.
Therefore, the cosmetics which have the outstanding moisturizing effect and usability can be obtained by mix | blending the surface treatment powder concerning this invention. Moreover, it is suitable that the compounding quantity of the surface treatment powder with respect to the said cosmetics is 0.001-50 mass%.

Although the formulation example of the cosmetics concerning this invention is described below, this invention is not limited to this. The following cosmetics were also excellent in moisturizing effect and usability according to the above evaluation criteria.
<Formulation Example 1: Moisturizing cream>
(mass%)
Hyaluronic acid coated silica gel 10
Liquid paraffin 3
Vaseline remaining

It is a graph which shows the Fourier transform infrared spectrophotometry of the surface treatment powder concerning this invention. It is a graph which shows the weight change accompanying the water | moisture content evaporation of the surface treatment powder concerning this invention.

Claims (4)

By reacting silica gel with a silane coupling agent having a primary amino group, an aminated powder is obtained,
A silane coupling agent obtained by adding the aminated powder washed and dried after filtration to a solution containing a condensing agent and hyaluronic acid, and adding hyaluronic acid to the amino group of the aminated powder. Hyaluronic acid-coated powder coated with hyaluronic acid.   A cosmetic comprising the surface-treated powder according to claim 1.   The cosmetic according to claim 2, wherein the amount of the surface-treated powder is 0.001 to 50% by mass.   The cosmetic according to claim 2 or 3, wherein the cosmetic is non-aqueous.