JP7854402B2 - 肺動脈性肺高血圧症（ｐａｈ）の処置のためのａｃｔｒｉｉタンパク質 - Google Patents

肺動脈性肺高血圧症（ｐａｈ）の処置のためのａｃｔｒｉｉタンパク質

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JP7854402B2
JP7854402B2 JP2022579737A JP2022579737A JP7854402B2 JP 7854402 B2 JP7854402 B2 JP 7854402B2 JP 2022579737 A JP2022579737 A JP 2022579737A JP 2022579737 A JP2022579737 A JP 2022579737A JP 7854402 B2 JP7854402 B2 JP 7854402B2
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patient
method relates
amino acid
seq
acid sequence
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JP2023534143A (ja
JP2023534143A5 (https=
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オリヴェイラ ペーナ， ジャネット デ
ピーター リンデ，
サチンドラ ジョシ，
ガン リー，
パトリック アンドレ，
ラビンドラ クマール，
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アクセルロン ファーマ インコーポレイテッド
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2022579737A 2020-06-23 2021-06-22 肺動脈性肺高血圧症（ｐａｈ）の処置のためのａｃｔｒｉｉタンパク質 Active JP7854402B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202063042722P 2020-06-23 2020-06-23
US63/042,722 2020-06-23
US202063084409P 2020-09-28 2020-09-28
US63/084,409 2020-09-28
US202063112513P 2020-11-11 2020-11-11
US63/112,513 2020-11-11
US202163188141P 2021-05-13 2021-05-13
US63/188,141 2021-05-13
PCT/US2021/038482 WO2021262718A1 (en) 2020-06-23 2021-06-22 Actrii proteins for the treatment of pulmonary arterial hypertension (pah)

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JP2023534143A JP2023534143A (ja) 2023-08-08
JP2023534143A5 JP2023534143A5 (https=) 2024-07-03
JP7854402B2 true JP7854402B2 (ja) 2026-05-01

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US (3) US20230226146A1 (https=)
EP (1) EP4168037A4 (https=)
JP (1) JP7854402B2 (https=)
KR (1) KR20230026435A (https=)
CN (1) CN115989035A (https=)
AU (1) AU2021296421A1 (https=)
BR (1) BR112022025644A2 (https=)
CA (1) CA3182838A1 (https=)
CL (1) CL2022003686A1 (https=)
CO (1) CO2022018719A2 (https=)
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WO2021189010A1 (en) 2020-03-20 2021-09-23 Keros Therapeutics, Inc. Methods of using activin receptor type iib variants
WO2021189019A1 (en) 2020-03-20 2021-09-23 Keros Therapeutics, Inc. Activin receptor type ii chimeras and methods of use thereof
US20230174620A1 (en) 2020-04-28 2023-06-08 Acceleron Pharma Inc. Actrii proteins and use in treating post-capillary pulmonary hypertension
JP7854402B2 (ja) * 2020-06-23 2026-05-01 アクセルロン ファーマ インコーポレイテッド 肺動脈性肺高血圧症（ｐａｈ）の処置のためのａｃｔｒｉｉタンパク質
JP2025526021A (ja) * 2022-08-10 2025-08-07 ジービー００２，インコーポレイティド 肺動脈性高血圧症（ｐａｈ）を治療するためのチロシンキナーゼ阻害剤とアクチビン２型受容体アンタゴニストの併用療法
WO2024054985A2 (en) * 2022-09-09 2024-03-14 Keros Therapeutics, Inc. Methods of administering an activin type iib variant
WO2024238263A1 (en) * 2023-05-12 2024-11-21 Merck Sharp & Dohme Llc Methods of improving lung diffusion capacity in a patient with pulmonary arterial hypertension
EP4713372A1 (en) * 2023-05-15 2026-03-25 Immunecare Biopharmaceuticals (Shanghai) Co., Ltd Recombinant fusion protein for treatment of pulmonary hypertension
WO2025122752A1 (en) * 2023-12-07 2025-06-12 Merck Sharp & Dohme Llc Methods for treating pulmonary arterial hypertension with activin receptor type iia (actriia) proteins and/or variants thereof
WO2025237307A1 (zh) * 2024-05-14 2025-11-20 苏州康宁杰瑞生物科技有限公司 凝血因子FXI/FXIa抑制剂用于治疗肺动脉高压和/或高血压
CN120888004B (zh) * 2025-09-30 2026-04-03 齐鲁制药有限公司 包含索特西普和其变体的组合物以及相关方法和应用

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JP2017533191A (ja) 2014-10-09 2017-11-09 セルジーン コーポレイション ＡｃｔＲＩＩリガンドトラップを用いた心血管疾患の治療
JP2018522579A (ja) 2015-05-20 2018-08-16 セルジーン コーポレイション アクチビンＩＩ型受容体リガンドトラップを使用するβ−サラセミアのインビトロ細胞培養法
JP2019521144A (ja) 2016-07-15 2019-07-25 アクセルロン ファーマ， インコーポレイテッド 肺高血圧症を処置するための組成物および方法

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IL320014A (en) * 2018-01-12 2025-06-01 Keros Therapeutics Inc Activin receptor type iib variants and methods of use thereof
KR20250133994A (ko) * 2018-05-09 2025-09-09 케로스 테라퓨틱스, 인크. 액티빈 수용체 유형 iia 변이체 및 그의 사용 방법
JP7854402B2 (ja) * 2020-06-23 2026-05-01 アクセルロン ファーマ インコーポレイテッド 肺動脈性肺高血圧症（ｐａｈ）の処置のためのａｃｔｒｉｉタンパク質

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JP2018522579A (ja) 2015-05-20 2018-08-16 セルジーン コーポレイション アクチビンＩＩ型受容体リガンドトラップを使用するβ−サラセミアのインビトロ細胞培養法
JP2019521144A (ja) 2016-07-15 2019-07-25 アクセルロン ファーマ， インコーポレイテッド 肺高血圧症を処置するための組成物および方法

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ClinicalTrials.gov Archive NCT03496207 on 2019_08_27，2019年，Retrieved from the Internet: ＵＲＬ，https://clinicaltrials.gov/study/NCT03496207?term=sotatercept&intr=PAH&rank=9&tab=history&a=14#version-content-panel
ClinicalTrials.gov Archive NCT03738150 on 2020_03_17，2020年03月，Retrieved from the Internet: https://clinicaltrials.gov/study/NCT03738150?term=sotatercept&intr=PAH&rank=13&page=2&limit=10&sort=@relevance&tab=history&a=9#version-content-panel
Haematologica，2019年，104(3)，pp.477-484，doi:10.3324/haematol.2018.198887
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US20250082722A1 (en) 2025-03-13
EP4168037A4 (en) 2024-07-17
JP2023534143A (ja) 2023-08-08
PE20230783A1 (es) 2023-05-11
US20250249070A1 (en) 2025-08-07
CO2022018719A2 (es) 2023-03-07
CN115989035A (zh) 2023-04-18
EP4168037A1 (en) 2023-04-26
AU2021296421A1 (en) 2023-01-19
WO2021262718A1 (en) 2021-12-30
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