CN115989035A - 用于治疗肺动脉高压(pah)的actrii蛋白 - Google Patents

用于治疗肺动脉高压(pah)的actrii蛋白 Download PDF

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Publication number
CN115989035A
CN115989035A CN202180051315.7A CN202180051315A CN115989035A CN 115989035 A CN115989035 A CN 115989035A CN 202180051315 A CN202180051315 A CN 202180051315A CN 115989035 A CN115989035 A CN 115989035A
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patient
polypeptide
kit
amino acid
seq
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CN202180051315.7A
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Chinese (zh)
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J·德奥利韦拉·佩纳
P·林德
S·乔希
G·李
P·安德烈
R·库玛尔
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Acceleron Pharma Inc
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Acceleron Pharma Inc
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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CN202180051315.7A 2020-06-23 2021-06-22 用于治疗肺动脉高压(pah)的actrii蛋白 Pending CN115989035A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202063042722P 2020-06-23 2020-06-23
US63/042,722 2020-06-23
US202063084409P 2020-09-28 2020-09-28
US63/084,409 2020-09-28
US202063112513P 2020-11-11 2020-11-11
US63/112,513 2020-11-11
US202163188141P 2021-05-13 2021-05-13
US63/188,141 2021-05-13
PCT/US2021/038482 WO2021262718A1 (en) 2020-06-23 2021-06-22 Actrii proteins for the treatment of pulmonary arterial hypertension (pah)

Publications (1)

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CN115989035A true CN115989035A (zh) 2023-04-18

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US (3) US20230226146A1 (https=)
EP (1) EP4168037A4 (https=)
JP (1) JP7854402B2 (https=)
KR (1) KR20230026435A (https=)
CN (1) CN115989035A (https=)
AU (1) AU2021296421A1 (https=)
BR (1) BR112022025644A2 (https=)
CA (1) CA3182838A1 (https=)
CL (1) CL2022003686A1 (https=)
CO (1) CO2022018719A2 (https=)
EC (1) ECSP23004827A (https=)
IL (1) IL299189A (https=)
MX (1) MX2022016237A (https=)
PE (1) PE20230783A1 (https=)
WO (1) WO2021262718A1 (https=)

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CN120888004A (zh) * 2025-09-30 2025-11-04 齐鲁制药有限公司 包含索特西普和其变体的组合物以及相关方法和应用
WO2025237307A1 (zh) * 2024-05-14 2025-11-20 苏州康宁杰瑞生物科技有限公司 凝血因子FXI/FXIa抑制剂用于治疗肺动脉高压和/或高血压

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WO2021189010A1 (en) 2020-03-20 2021-09-23 Keros Therapeutics, Inc. Methods of using activin receptor type iib variants
WO2021189019A1 (en) 2020-03-20 2021-09-23 Keros Therapeutics, Inc. Activin receptor type ii chimeras and methods of use thereof
US20230174620A1 (en) 2020-04-28 2023-06-08 Acceleron Pharma Inc. Actrii proteins and use in treating post-capillary pulmonary hypertension
JP7854402B2 (ja) * 2020-06-23 2026-05-01 アクセルロン ファーマ インコーポレイテッド 肺動脈性肺高血圧症（ｐａｈ）の処置のためのａｃｔｒｉｉタンパク質
JP2025526021A (ja) * 2022-08-10 2025-08-07 ジービー００２，インコーポレイティド 肺動脈性高血圧症（ｐａｈ）を治療するためのチロシンキナーゼ阻害剤とアクチビン２型受容体アンタゴニストの併用療法
WO2024054985A2 (en) * 2022-09-09 2024-03-14 Keros Therapeutics, Inc. Methods of administering an activin type iib variant
WO2024238263A1 (en) * 2023-05-12 2024-11-21 Merck Sharp & Dohme Llc Methods of improving lung diffusion capacity in a patient with pulmonary arterial hypertension
EP4713372A1 (en) * 2023-05-15 2026-03-25 Immunecare Biopharmaceuticals (Shanghai) Co., Ltd Recombinant fusion protein for treatment of pulmonary hypertension
WO2025122752A1 (en) * 2023-12-07 2025-06-12 Merck Sharp & Dohme Llc Methods for treating pulmonary arterial hypertension with activin receptor type iia (actriia) proteins and/or variants thereof

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JP7854402B2 (ja) * 2020-06-23 2026-05-01 アクセルロン ファーマ インコーポレイテッド 肺動脈性肺高血圧症（ｐａｈ）の処置のためのａｃｔｒｉｉタンパク質

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JOSHI, S.R.等: "ACTRIIA-Fc(Sotatercept)Reverses Pulmonary Vascular Remodeling to Attenuate Pulmonary Arterial Hypertension(PAH)by Rebalancing TGF- b/BMP Signaling in a Preclinical Model", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 199, 21 May 2019 (2019-05-21) *
JOSHI, S.R.等: "Rap-011, a Murine Ortholog of ActRIIA-Fc(Sotatercept), Improves Pulmonary Hemodynamics and Restores Right Ventricular Structure and Function in a Preclinical Model of Severe Angio-Obliterative Pulmonary Arterial Hypertension.", CIRCULATION, vol. 138, no. 1, 5 November 2018 (2018-11-05) *
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Publication number Priority date Publication date Assignee Title
WO2025237307A1 (zh) * 2024-05-14 2025-11-20 苏州康宁杰瑞生物科技有限公司 凝血因子FXI/FXIa抑制剂用于治疗肺动脉高压和/或高血压
CN120888004A (zh) * 2025-09-30 2025-11-04 齐鲁制药有限公司 包含索特西普和其变体的组合物以及相关方法和应用

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US20250249070A1 (en) 2025-08-07
CO2022018719A2 (es) 2023-03-07
EP4168037A1 (en) 2023-04-26
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