JP7830467B2 - メカニスティックイオン交換クロマトグラフィモデル較正 - Google Patents

メカニスティックイオン交換クロマトグラフィモデル較正

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Publication number
JP7830467B2
JP7830467B2 JP2023532725A JP2023532725A JP7830467B2 JP 7830467 B2 JP7830467 B2 JP 7830467B2 JP 2023532725 A JP2023532725 A JP 2023532725A JP 2023532725 A JP2023532725 A JP 2023532725A JP 7830467 B2 JP7830467 B2 JP 7830467B2
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model
dpfr
transport
column
parameters
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JP2024501406A (ja
JP2024501406A5 (https=
Inventor
グレーザー，ユリアーネ・ドロテーア
Original Assignee
アムジェン リサーチ （ミュニック） ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8693—Models, e.g. prediction of retention times, method development and validation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44743—Introducing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8624—Detection of slopes or peaks; baseline correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8827—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Electrochemistry (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Monitoring And Testing Of Nuclear Reactors (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
JP2023532725A 2020-12-09 2021-12-03 メカニスティックイオン交換クロマトグラフィモデル較正 Active JP7830467B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063123170P 2020-12-09 2020-12-09
US63/123,170 2020-12-09
PCT/IB2021/061322 WO2022123412A1 (en) 2020-12-09 2021-12-03 Mechanistic ion-exchange chromatography model calibration

Publications (3)

Publication Number Publication Date
JP2024501406A JP2024501406A (ja) 2024-01-12
JP2024501406A5 JP2024501406A5 (https=) 2026-01-06
JP7830467B2 true JP7830467B2 (ja) 2026-03-16

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JP2023532725A Active JP7830467B2 (ja) 2020-12-09 2021-12-03 メカニスティックイオン交換クロマトグラフィモデル較正

Country Status (7)

Country Link
US (1) US20250264445A1 (https=)
EP (1) EP4260060B1 (https=)
JP (1) JP7830467B2 (https=)
AU (1) AU2021397425A1 (https=)
CA (1) CA3198086A1 (https=)
MX (1) MX2023006681A (https=)
WO (1) WO2022123412A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230359888A1 (en) * 2022-05-03 2023-11-09 Accenture Global Solutions Limited Optimization and digital twin of chromatography purification process using physics-informed neural networks
CN121057616A (zh) * 2023-05-04 2025-12-02 环球生命科学解决方案德国有限公司 分离过程的跨规模工艺开发方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Lalita K. SHEKHAWAT et al.，"An overview of mechanistic modeling of liquid chromatography"，Preparative Biochemistry and Biotechnology，2019年05月20日，Vol. 49, No. 6，p.623-638，DOI: 10.1080/10826068.2019.1615504
Rosa Ma. Montesinos-Cisnreos，Breakthrough performance of linear-DNA on ion-exchange membrane columns，Bioprocess Biosyst Eng，2006年，29，91-98，DOI:10.1007/s00449-006-0055-2
Vijesh KUMAR et al.，"Mechanistic modeling of ion-exchange process chromatography of charge variants of monoclonal antibody products"，Journal of Chromatography A，2015年12月，Vol. 1426，p.140-153，DOI: 10.1016/j.chroma.2015.11.062

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Publication number Publication date
CA3198086A1 (en) 2022-06-16
WO2022123412A1 (en) 2022-06-16
MX2023006681A (es) 2023-06-22
EP4260060A1 (en) 2023-10-18
JP2024501406A (ja) 2024-01-12
AU2021397425A1 (en) 2023-05-25
AU2021397425A9 (en) 2024-10-24
US20250264445A1 (en) 2025-08-21
EP4260060B1 (en) 2026-04-08

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