JP7826215B2 - コロナウイルスｉＲＮＡ組成物およびその使用方法 - Google Patents

コロナウイルスｉＲＮＡ組成物およびその使用方法

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Publication number
JP7826215B2
JP7826215B2 JP2022557819A JP2022557819A JP7826215B2 JP 7826215 B2 JP7826215 B2 JP 7826215B2 JP 2022557819 A JP2022557819 A JP 2022557819A JP 2022557819 A JP2022557819 A JP 2022557819A JP 7826215 B2 JP7826215 B2 JP 7826215B2
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Japan
Prior art keywords
nucleotide
strand
nucleotides
antisense strand
phosphate
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JP2022557819A
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English (en)
Japanese (ja)
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JP2023519274A5 (https=
JP2023519274A (ja
Inventor
アキンク，エイキン
ディ マキニンチ，ジェイムズ
アングレロ－ロドリゲス，イェセイニア
ケイ シュリーゲル，マーク
エム ヘブナー，クリスティ
エイ レンプ，フロリアン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alnylam Pharmaceuticals Inc
Vir Biotechnology Inc
Original Assignee
Alnylam Pharmaceuticals Inc
Vir Biotechnology Inc
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Publication of JP2023519274A publication Critical patent/JP2023519274A/ja
Publication of JP2023519274A5 publication Critical patent/JP2023519274A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C12N2310/3125—Methylphosphonates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2022557819A 2020-03-26 2021-03-25 コロナウイルスｉＲＮＡ組成物およびその使用方法 Active JP7826215B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202062994907P 2020-03-26 2020-03-26
US62/994,907 2020-03-26
US202063001580P 2020-03-30 2020-03-30
US63/001,580 2020-03-30
US202063019481P 2020-05-04 2020-05-04
US63/019,481 2020-05-04
US202063124910P 2020-12-14 2020-12-14
US63/124,910 2020-12-14
PCT/US2021/024038 WO2021195307A1 (en) 2020-03-26 2021-03-25 Coronavirus irna compositions and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2023519274A JP2023519274A (ja) 2023-05-10
JP2023519274A5 JP2023519274A5 (https=) 2024-04-03
JP7826215B2 true JP7826215B2 (ja) 2026-03-09

Family

ID=77890628

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022557819A Active JP7826215B2 (ja) 2020-03-26 2021-03-25 コロナウイルスｉＲＮＡ組成物およびその使用方法

Country Status (6)

Country Link
US (2) US11208660B1 (https=)
EP (1) EP4127168A1 (https=)
JP (1) JP7826215B2 (https=)
CN (1) CN116209759A (https=)
TW (1) TW202204615A (https=)
WO (1) WO2021195307A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12006500B2 (en) * 2020-01-23 2024-06-11 Sirnaomics, Inc. Composition and methods of RNAi prophylactics and therapeutics for treatment of severe acute respiratory infection caused by 2019 novel coronavirus (2019-nCoV)
TW202204615A (zh) 2020-03-26 2022-02-01 美商阿尼拉製藥公司 冠狀病毒ｉＲＮＡ組成物及其使用方法
EP4133077A1 (en) 2020-04-07 2023-02-15 Alnylam Pharmaceuticals, Inc. Transmembrane serine protease 2 (tmprss2) irna compositions and methods of use thereof
AU2021251249A1 (en) * 2020-04-10 2022-11-10 Aligos Therapeutics, Inc. Short interfering nucleic acid (siNA) molecules and uses thereof for coronavirus diseases
US20230241202A1 (en) * 2020-05-29 2023-08-03 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Adenovirus-Based SARS-CoV-2 Vaccine
KR102272800B1 (ko) * 2020-06-30 2021-07-05 국방과학연구소 코로나바이러스 특이적 이중가닥 올리고뉴클레오티드 및 이를 포함하는 코로나바이러스 감염증-19 예방 및 치료용 조성물
JP2023536962A (ja) * 2020-08-06 2023-08-30 エフ． ホフマン－ラ ロシュ アーゲー 重症急性呼吸器症候群コロナウイルス２（ｓａｒｓ－２）、インフルエンザａ及びインフルエンザｂの検出のための組成物及び方法
WO2022087600A1 (en) * 2020-10-20 2022-04-28 Duquesne University Of The Holy Spirit Micro rna interactions as therapeutic targets for covid-19 and other viral infections
WO2022117085A1 (en) * 2020-12-03 2022-06-09 Microbio (Shanghai) Co. Ltd. Interfering rnas targeting severe acute respiratory syndrome-associated coronavirus and uses thereof for treating covid-19
EP4148131A1 (en) * 2021-09-10 2023-03-15 Charité - Universitätsmedizin Berlin Rna for inhibiting sars-cov-2 replication
WO2023094967A1 (en) * 2021-11-23 2023-06-01 Immunitor (Thailand) Co. Ltd. Oral therapeutic vaccine compositions, methods and treatment of covid
TWI816323B (zh) * 2022-03-08 2023-09-21 至善生醫股份有限公司 包含視黃酸及碳水化合物之醫藥組成物及其用途
EP4590824A1 (en) * 2022-09-21 2025-07-30 NewSouth Innovations Pty Limited Antiviral sirna therapeutic for sars-cov-2
WO2024208588A1 (en) * 2023-04-03 2024-10-10 Technische Universität Berlin Anti-viral sirna therapy
WO2025187767A1 (ja) * 2024-03-07 2025-09-12 第一三共株式会社 コロナウイルスの増殖を抑制するアンチセンスオリゴヌクレオチド

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JP2006500012A (ja) 2002-07-31 2006-01-05 ヌクレオニクス インコーポレーティッド 二本鎖ｒｎａの構造および構築物、並びにその作製法および使用法
JP2007503205A (ja) 2003-08-22 2007-02-22 ニュークレオニクス・インコーポレイテッド 多コンパートメント真核生物発現系
JP2011501742A (ja) 2007-10-02 2011-01-13 エムディーアールエヌエー，インコーポレイテッド 核酸の送達のためのリポペプチド

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