JP7824934B2 - 操作されたナチュラルキラー細胞の増殖および細胞毒性の増強およびその使用 - Google Patents

操作されたナチュラルキラー細胞の増殖および細胞毒性の増強およびその使用

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JP7824934B2
JP7824934B2 JP2023514397A JP2023514397A JP7824934B2 JP 7824934 B2 JP7824934 B2 JP 7824934B2 JP 2023514397 A JP2023514397 A JP 2023514397A JP 2023514397 A JP2023514397 A JP 2023514397A JP 7824934 B2 JP7824934 B2 JP 7824934B2
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concentration
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JP2023539361A (ja
JPWO2022051749A5 (https=
JP2023539361A5 (https=
Inventor
バーナビー トレイガー，ジェイムズ
ライダ リアナ ラゼティック，アレクサンドラ
ジャンボレツ，キャサリン
ナフィースル ラフマン，ムハンマド
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Nkarta Inc
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Nkarta Inc
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001111—Immunoglobulin superfamily
    • A61K39/001112—CD19 or B4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N5/0602—Vertebrate cells
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    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2023514397A 2020-09-02 2021-08-31 操作されたナチュラルキラー細胞の増殖および細胞毒性の増強およびその使用 Active JP7824934B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063073671P 2020-09-02 2020-09-02
US63/073,671 2020-09-02
PCT/US2021/071330 WO2022051749A1 (en) 2020-09-02 2021-08-31 Enhanced expansion and cytotoxicity of engineered natural killer cells and uses thereof

Publications (4)

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JP2023539361A JP2023539361A (ja) 2023-09-13
JPWO2022051749A5 JPWO2022051749A5 (https=) 2024-09-10
JP2023539361A5 JP2023539361A5 (https=) 2024-09-10
JP7824934B2 true JP7824934B2 (ja) 2026-03-05

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JP2023514397A Active JP7824934B2 (ja) 2020-09-02 2021-08-31 操作されたナチュラルキラー細胞の増殖および細胞毒性の増強およびその使用

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Country Link
US (1) US20230265390A1 (https=)
EP (1) EP4204560A4 (https=)
JP (1) JP7824934B2 (https=)
KR (1) KR20230058167A (https=)
CN (1) CN116568805A (https=)
AU (1) AU2021337000A1 (https=)
CA (1) CA3191047A1 (https=)
IL (1) IL300903A (https=)
WO (1) WO2022051749A1 (https=)

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AU2015259877B2 (en) 2014-05-15 2021-02-25 National University Of Singapore Modified natural killer cells and uses thereof
KR102660336B1 (ko) 2017-03-27 2024-04-26 내셔널 유니버시티 오브 싱가포르 절단된 nkg2d 키메라 수용체 및 자연 살해 세포 면역요법에서의 그의 용도
AU2019219454A1 (en) 2018-02-09 2020-08-27 National University Of Singapore Activating chimeric receptors and uses thereof in natural killer cell immunotherapy
CN112055717B (zh) 2018-04-02 2024-04-26 新加坡国立大学 用在免疫细胞中表达的膜结合抗细胞因子非信号传导粘合剂中和人细胞因子
EP3844186A4 (en) 2018-08-29 2022-08-17 National University of Singapore METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS
US12590148B2 (en) 2018-11-26 2026-03-31 Nkarta, Inc. Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy
AU2020232691B2 (en) 2019-03-05 2023-06-29 Nkarta, Inc. CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
EP4649139A1 (en) * 2023-02-01 2025-11-19 Nkarta, Inc. Methods for expanding immune cells and related compositions and uses thereof
KR102669705B1 (ko) * 2023-02-24 2024-06-10 이엔셀 주식회사 제대혈 유래 자연 살해 세포의 확장배양방법
KR20240175366A (ko) * 2023-06-12 2024-12-20 한국화학연구원 Nk 세포의 증식 촉진 또는 활성화용 조성물 및 그의 용도
KR20250153112A (ko) * 2024-04-16 2025-10-24 주식회사 유씨아이테라퓨틱스 자연살해세포의 증폭 및 형질 도입 효율 증진용 피더 세포

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CA3191047A1 (en) 2022-03-10
EP4204560A1 (en) 2023-07-05
AU2021337000A9 (en) 2023-07-13
EP4204560A4 (en) 2024-10-16
AU2021337000A1 (en) 2023-05-11
IL300903A (en) 2023-04-01
US20230265390A1 (en) 2023-08-24
KR20230058167A (ko) 2023-05-02
JP2023539361A (ja) 2023-09-13
CN116568805A (zh) 2023-08-08
WO2022051749A1 (en) 2022-03-10

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