JP7798881B2 - アテローム硬化性心血管疾患をＬＰＡ標的ＲＮＡｉ構築体により処置する方法 - Google Patents

アテローム硬化性心血管疾患をＬＰＡ標的ＲＮＡｉ構築体により処置する方法

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Publication number
JP7798881B2
JP7798881B2 JP2023526961A JP2023526961A JP7798881B2 JP 7798881 B2 JP7798881 B2 JP 7798881B2 JP 2023526961 A JP2023526961 A JP 2023526961A JP 2023526961 A JP2023526961 A JP 2023526961A JP 7798881 B2 JP7798881 B2 JP 7798881B2
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rnai construct
patient
lpa rnai
pharmaceutical composition
lpa
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JP2023549115A5 (enExample
JP2023549115A (ja
Inventor
ウィニー ソーン，
ザカリー ジョーンズ，
ヘリナ カサフン，
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Amgen Inc
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Amgen Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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JP2023526961A 2020-11-05 2021-11-04 アテローム硬化性心血管疾患をＬＰＡ標的ＲＮＡｉ構築体により処置する方法 Active JP7798881B2 (ja)

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JP2024192703A JP2025016670A (ja) 2020-11-05 2024-11-01 アテローム硬化性心血管疾患をＬＰＡ標的ＲＮＡｉ構築体により処置する方法
JP2026071764A JP2026116347A (ja) 2020-11-05 2026-04-23 アテローム硬化性心血管疾患をＬＰＡ標的ＲＮＡｉ構築体により処置する方法

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US202063110309P 2020-11-05 2020-11-05
US63/110,309 2020-11-05
PCT/US2021/058012 WO2022098841A1 (en) 2020-11-05 2021-11-04 METHODS FOR TREATING ATHEROSCLEROTIC CARDIOVASCULAR DISEASE WITH LPA-TARGETED RNAi CONSTRUCTS

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JP2024192703A Division JP2025016670A (ja) 2020-11-05 2024-11-01 アテローム硬化性心血管疾患をＬＰＡ標的ＲＮＡｉ構築体により処置する方法

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JP2023549115A JP2023549115A (ja) 2023-11-22
JP2023549115A5 JP2023549115A5 (enExample) 2024-11-12
JP7798881B2 true JP7798881B2 (ja) 2026-01-14

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JP2023526961A Active JP7798881B2 (ja) 2020-11-05 2021-11-04 アテローム硬化性心血管疾患をＬＰＡ標的ＲＮＡｉ構築体により処置する方法
JP2024192703A Pending JP2025016670A (ja) 2020-11-05 2024-11-01 アテローム硬化性心血管疾患をＬＰＡ標的ＲＮＡｉ構築体により処置する方法
JP2026071764A Pending JP2026116347A (ja) 2020-11-05 2026-04-23 アテローム硬化性心血管疾患をＬＰＡ標的ＲＮＡｉ構築体により処置する方法

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JP2026071764A Pending JP2026116347A (ja) 2020-11-05 2026-04-23 アテローム硬化性心血管疾患をＬＰＡ標的ＲＮＡｉ構築体により処置する方法

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US (1) US20230405040A1 (enExample)
EP (1) EP4240855A1 (enExample)
JP (3) JP7798881B2 (enExample)
KR (1) KR20230104200A (enExample)
CN (1) CN116456990A (enExample)
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WO2020150473A2 (en) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Pcsk9 inhibitors and methods of use thereof
BR112021013924A2 (pt) 2019-01-18 2021-09-21 Astrazeneca Ab Inibidores de pcsk9 e métodos de uso do mesmo
US20250034561A1 (en) * 2021-02-18 2025-01-30 Oneglobe Holdings Limited Novel Compositions for Conjugating Oligonucleotides and Carbohydrates
CN115851723B (zh) * 2022-10-24 2023-10-03 厦门甘宝利生物医药有限公司 一种抑制lpa基因表达的rna抑制剂及其应用
US20240226049A1 (en) * 2023-01-09 2024-07-11 Esperion Therapeutics, Inc. Methods of treatment using bempedoic acid
KR20250131826A (ko) * 2023-01-13 2025-09-03 일라이 릴리 앤드 캄파니 치료 올리고뉴클레오티드-함유 제약 조성물 및 그를 사용한 투여 요법
CN120693405A (zh) * 2023-02-03 2025-09-23 诺华股份有限公司 降低一级预防受试者中重大不良心血管事件风险的方法
WO2024240230A1 (zh) * 2023-05-24 2024-11-28 南京明德新药研发有限公司 双链sirna、其缀合物及其应用
WO2025082058A1 (zh) * 2023-10-16 2025-04-24 润佳(上海)医药技术有限公司 一种抑制LPA基因表达的dsRNA及其用途
WO2025252223A1 (zh) * 2024-06-07 2025-12-11 迈威(上海)生物科技股份有限公司 一种抑制PCSK9基因表达的RNAi制剂及其应用
WO2026026890A1 (zh) * 2024-07-31 2026-02-05 前沿生物药业(南京)股份有限公司 用于抑制LPA基因表达的siRNA及其修饰物与应用
WO2026133253A1 (en) 2024-12-20 2026-06-25 Novartis Ag Combinations of antisense agents, pharmaceutical compositions and methods of use
CN122511931A (zh) 2025-02-04 2026-08-04 丰田纺织株式会社 燃料电池系统

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