CA3199678A1 - Methods for treating atherosclerotic cardiovascular disease with lpa-targeted rnai constructs - Google Patents

Methods for treating atherosclerotic cardiovascular disease with lpa-targeted rnai constructs

Info

Publication number
CA3199678A1
CA3199678A1 CA3199678A CA3199678A CA3199678A1 CA 3199678 A1 CA3199678 A1 CA 3199678A1 CA 3199678 A CA3199678 A CA 3199678A CA 3199678 A CA3199678 A CA 3199678A CA 3199678 A1 CA3199678 A1 CA 3199678A1
Authority
CA
Canada
Prior art keywords
patient
rnai construct
lpa rnai
administration
weeks
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3199678A
Other languages
English (en)
French (fr)
Inventor
Winnie SOHN
Zachary Jones
Helina KASSAHUN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CA3199678A1 publication Critical patent/CA3199678A1/en
Pending legal-status Critical Current

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
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    • C12N2310/30—Chemical structure
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    • C12N2320/30—Special therapeutic applications
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CA3199678A 2020-11-05 2021-11-04 Methods for treating atherosclerotic cardiovascular disease with lpa-targeted rnai constructs Pending CA3199678A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063110309P 2020-11-05 2020-11-05
US63/110,309 2020-11-05
PCT/US2021/058012 WO2022098841A1 (en) 2020-11-05 2021-11-04 METHODS FOR TREATING ATHEROSCLEROTIC CARDIOVASCULAR DISEASE WITH LPA-TARGETED RNAi CONSTRUCTS

Publications (1)

Publication Number Publication Date
CA3199678A1 true CA3199678A1 (en) 2022-05-12

Family

ID=78819940

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Application Number Title Priority Date Filing Date
CA3199678A Pending CA3199678A1 (en) 2020-11-05 2021-11-04 Methods for treating atherosclerotic cardiovascular disease with lpa-targeted rnai constructs

Country Status (12)

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US (1) US20230405040A1 (enExample)
EP (1) EP4240855A1 (enExample)
JP (3) JP7798881B2 (enExample)
KR (1) KR20230104200A (enExample)
CN (1) CN116456990A (enExample)
AU (1) AU2021373780A1 (enExample)
CA (1) CA3199678A1 (enExample)
IL (1) IL302330A (enExample)
JO (1) JOP20230093A1 (enExample)
MX (1) MX2023005198A (enExample)
TW (1) TW202233837A (enExample)
WO (1) WO2022098841A1 (enExample)

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JP2026116347A (ja) 2026-07-09
JOP20230093A1 (ar) 2023-05-03
KR20230104200A (ko) 2023-07-07
IL302330A (en) 2023-06-01
EP4240855A1 (en) 2023-09-13
WO2022098841A1 (en) 2022-05-12
MX2023005198A (es) 2023-05-16
JP2023549115A (ja) 2023-11-22
CN116456990A (zh) 2023-07-18
TW202233837A (zh) 2022-09-01
JP7798881B2 (ja) 2026-01-14
JP2025016670A (ja) 2025-02-04
US20230405040A1 (en) 2023-12-21
AU2021373780A1 (en) 2023-06-08

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