JP7796047B2 - Ｕｓｐ３０阻害剤としての活性を有するｎ－シアノピロリジン - Google Patents

Ｕｓｐ３０阻害剤としての活性を有するｎ－シアノピロリジン

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Publication number
JP7796047B2
JP7796047B2 JP2022571212A JP2022571212A JP7796047B2 JP 7796047 B2 JP7796047 B2 JP 7796047B2 JP 2022571212 A JP2022571212 A JP 2022571212A JP 2022571212 A JP2022571212 A JP 2022571212A JP 7796047 B2 JP7796047 B2 JP 7796047B2
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Prior art keywords
cyano
oxazole
disease
compound
carboxamide
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Japanese (ja)
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JP2023529570A5 (enExample
JP2023529570A (ja
Inventor
アンドリュー ラックハースト クリストファー
イアン ケンプ マーク
ウィリアム トンプソン ポール
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ミッション セラピューティクス リミティド
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Priority claimed from GBGB2008401.8A external-priority patent/GB202008401D0/en
Priority claimed from GBGB2016689.8A external-priority patent/GB202016689D0/en
Priority claimed from GBGB2101935.1A external-priority patent/GB202101935D0/en
Application filed by ミッション セラピューティクス リミティド filed Critical ミッション セラピューティクス リミティド
Publication of JP2023529570A publication Critical patent/JP2023529570A/ja
Publication of JP2023529570A5 publication Critical patent/JP2023529570A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2022571212A 2020-06-04 2021-06-03 Ｕｓｐ３０阻害剤としての活性を有するｎ－シアノピロリジン Active JP7796047B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB2008401.8 2020-06-04
GBGB2008401.8A GB202008401D0 (en) 2020-06-04 2020-06-04 Novel compounds
GB2016689.8 2020-10-21
GBGB2016689.8A GB202016689D0 (en) 2020-10-21 2020-10-21 Novel compounds
GBGB2101935.1A GB202101935D0 (en) 2021-02-11 2021-02-11 Novel compounds
GB2101935.1 2021-02-11
PCT/EP2021/064897 WO2021245186A1 (en) 2020-06-04 2021-06-03 N-cyanopyrrolidines with activity as usp30 inhibitors

Publications (3)

Publication Number Publication Date
JP2023529570A JP2023529570A (ja) 2023-07-11
JP2023529570A5 JP2023529570A5 (enExample) 2025-10-30
JP7796047B2 true JP7796047B2 (ja) 2026-01-08

Family

ID=76421953

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022571212A Active JP7796047B2 (ja) 2020-06-04 2021-06-03 Ｕｓｐ３０阻害剤としての活性を有するｎ－シアノピロリジン

Country Status (13)

Country Link
US (1) US12679833B2 (enExample)
EP (1) EP4161920A1 (enExample)
JP (1) JP7796047B2 (enExample)
KR (1) KR20230019198A (enExample)
CN (1) CN115698001A (enExample)
AU (1) AU2021285130A1 (enExample)
BR (1) BR112022019722A2 (enExample)
CA (1) CA3185654A1 (enExample)
CO (1) CO2022017112A2 (enExample)
IL (1) IL298710A (enExample)
MX (1) MX2022015254A (enExample)
WO (1) WO2021245186A1 (enExample)
ZA (1) ZA202213866B (enExample)

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RS67140B1 (sr) 2020-06-08 2025-09-30 Mission Therapeutics Ltd 1-(5-(2-cijanopiridin-4-il)oksazol-2-karbonil)-4-metilheksahidropirolo[3,4-b]pirol-5(1h)-karbonitril kao usp30 inhibitor za primenu u lečenju mitohondrijske disfunkcije, kancera i fibroze
WO2023099561A1 (en) 2021-12-01 2023-06-08 Mission Therapeutics Limited Substituted n-cyanopyrrolidines with activity as usp30 inhibitors
EP4547247A4 (en) * 2022-06-30 2026-08-12 Dana Farber Cancer Inst Inc DESUBIQUITINASE INHIBITORS AND THEIR METHODS OF USE
GB202408928D0 (en) 2024-06-21 2024-08-07 Mission Therapeutics Ltd Novel compounds
GB202411060D0 (en) 2024-07-29 2024-09-11 Mission Therapeutics Ltd Novel compounds
CN119528901B (zh) * 2024-11-05 2026-05-26 上海市同济医院 噻唑类化合物、去sumo和/或去泛素化酶抑制剂及其制备方法和应用
GB202500610D0 (en) 2025-01-16 2025-03-05 Mission Therapeutics Ltd Novel compounds

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WO2017103614A1 (en) 2015-12-17 2017-06-22 Mission Therapeutics Limited Novel Compounds

Also Published As

Publication number Publication date
ZA202213866B (en) 2024-07-31
US20230303547A1 (en) 2023-09-28
IL298710A (en) 2023-02-01
CN115698001A (zh) 2023-02-03
WO2021245186A1 (en) 2021-12-09
EP4161920A1 (en) 2023-04-12
CO2022017112A2 (es) 2022-12-09
BR112022019722A2 (pt) 2022-12-20
CA3185654A1 (en) 2021-12-09
MX2022015254A (es) 2023-01-11
AU2021285130A1 (en) 2023-01-19
US12679833B2 (en) 2026-07-14
JP2023529570A (ja) 2023-07-11
KR20230019198A (ko) 2023-02-07

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