JP7784431B2 - 新規化合物 - Google Patents
新規化合物Info
- Publication number
- JP7784431B2 JP7784431B2 JP2023537724A JP2023537724A JP7784431B2 JP 7784431 B2 JP7784431 B2 JP 7784431B2 JP 2023537724 A JP2023537724 A JP 2023537724A JP 2023537724 A JP2023537724 A JP 2023537724A JP 7784431 B2 JP7784431 B2 JP 7784431B2
- Authority
- JP
- Japan
- Prior art keywords
- indazol
- acrylamide
- methyl
- alkyl
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2013731.1 | 2020-09-01 | ||
| GBGB2013731.1A GB202013731D0 (en) | 2020-09-01 | 2020-09-01 | Novel cmpounds |
| PCT/GB2021/052262 WO2022049377A1 (en) | 2020-09-01 | 2021-09-01 | Novel compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023539695A JP2023539695A (ja) | 2023-09-15 |
| JP2023539695A5 JP2023539695A5 (https=) | 2024-09-11 |
| JP7784431B2 true JP7784431B2 (ja) | 2025-12-11 |
Family
ID=72749727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023537724A Active JP7784431B2 (ja) | 2020-09-01 | 2021-09-01 | 新規化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US12497359B2 (https=) |
| EP (1) | EP4208448B1 (https=) |
| JP (1) | JP7784431B2 (https=) |
| CN (1) | CN116096712B (https=) |
| AU (1) | AU2021336750A1 (https=) |
| CA (1) | CA3190786A1 (https=) |
| GB (1) | GB202013731D0 (https=) |
| IL (1) | IL300904A (https=) |
| WO (1) | WO2022049377A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB202013728D0 (en) * | 2020-09-01 | 2020-10-14 | Nrg Therapeutics Ltd | Novel compounds |
| GB202300833D0 (en) | 2023-01-19 | 2023-03-08 | Nrg Therapeutics Ltd | Novel compounds |
| CN121866248A (zh) | 2023-09-05 | 2026-04-14 | Nrg治疗有限公司 | 作为mptp抑制剂起作用的吡啶衍生物 |
| CN118255724A (zh) * | 2024-03-27 | 2024-06-28 | 河北天成药业股份有限公司 | 盐酸利多卡因杂质的合成方法及其反应检测方法 |
| GB202410534D0 (en) | 2024-07-18 | 2024-09-04 | Nrg Therapeutics Ltd | Novel method and uses |
| CN120025281A (zh) * | 2025-04-22 | 2025-05-23 | 九洲药业(杭州)有限公司 | 一种n,n-二异丁基-1h-吲唑-4-胺的中间体及制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012506852A (ja) | 2008-10-27 | 2012-03-22 | コンジェニア・エッセエッレエッレ | ミトコンドリアの膜透過性遷移の阻害剤として有用なアクリルアミド誘導体 |
| JP2023539694A (ja) | 2020-09-01 | 2023-09-15 | エヌアールジー セラピューティクス エルティーディー | 新規化合物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1424078A4 (en) | 2001-09-04 | 2009-03-25 | Ono Pharmaceutical Co | RESPIRATORY DISEASE MEDICINES COMPRISING A SPHINGOSINE-1-PHOSPHATE RECEPTOR REGULATING AGENT |
| WO2003051876A1 (en) | 2001-12-14 | 2003-06-26 | Japan Tobacco Inc. | Pyrazolopyridine derivatives and medicinal use thereof |
| US7482488B2 (en) | 2002-08-29 | 2009-01-27 | Temple University - Of The Commonwealth System Of Higher Education | Aryl and heteroaryl propene amides, derivatives thereof and therapeutic uses thereof |
| EP1960355A1 (en) * | 2005-11-30 | 2008-08-27 | F.Hoffmann-La Roche Ag | 3-amino-1-arylpropyl indoles and aza-substituted indoles |
| US7915304B2 (en) | 2006-10-24 | 2011-03-29 | Congenia S.R.L. | Phenyl substituted maleimides as medicaments for blocking degenerative tissue damages by inhibiting MPT |
| WO2011087051A1 (ja) | 2010-01-14 | 2011-07-21 | 国立大学法人金沢大学 | S1p2受容体アンタゴニストを含む粥状動脈硬化治療薬 |
| JP2017538676A (ja) | 2014-11-05 | 2017-12-28 | ザ ユニバーシティ オブ カンザス | ミトコンドリア透過性遷移孔（ｍｔＰＴＰ）の小分子阻害剤 |
| CA2884607A1 (en) | 2015-03-11 | 2016-09-11 | Stealth Peptides International, Inc. | Therapeutic compositions including acrylamido compounds or phenyl-substiituted maleimide compounds and uses thereof to treat and prevent mitochondrial diseases and conditions |
| WO2019002624A1 (de) | 2017-06-30 | 2019-01-03 | Kleuser, Burkhard | Mittel zur therapie entzündlicher darmerkrankungen |
-
2020
- 2020-09-01 GB GBGB2013731.1A patent/GB202013731D0/en not_active Ceased
-
2021
- 2021-09-01 IL IL300904A patent/IL300904A/en unknown
- 2021-09-01 AU AU2021336750A patent/AU2021336750A1/en not_active Abandoned
- 2021-09-01 CN CN202180053586.6A patent/CN116096712B/zh active Active
- 2021-09-01 WO PCT/GB2021/052262 patent/WO2022049377A1/en not_active Ceased
- 2021-09-01 EP EP21769790.3A patent/EP4208448B1/en active Active
- 2021-09-01 CA CA3190786A patent/CA3190786A1/en active Pending
- 2021-09-01 JP JP2023537724A patent/JP7784431B2/ja active Active
- 2021-09-01 US US18/023,488 patent/US12497359B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012506852A (ja) | 2008-10-27 | 2012-03-22 | コンジェニア・エッセエッレエッレ | ミトコンドリアの膜透過性遷移の阻害剤として有用なアクリルアミド誘導体 |
| JP2023539694A (ja) | 2020-09-01 | 2023-09-15 | エヌアールジー セラピューティクス エルティーディー | 新規化合物 |
Non-Patent Citations (3)
| Title |
|---|
| Chen Mao Xiang et al.，Probing Mitochondrial Permeability Transition Pore Actvity in Nucleated Cells and Platelets by High-Throughput Screening Assays Suggests Involvement of Protein Phosphatase 2B in Mitochondrial Dynamics，Assay and DrugDevelopment Technologies，2018年，16(8)，445-455 |
| REGISTRY (STN) [online]，2009.01.23 [検索日 2025.05.08] CAS登録番号 1159511-66-6 |
| REGISTRY (STN) [online]，2014.03.06 [検索日 2025.05.08] CAS登録番号 1563253-76-8 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4208448A1 (en) | 2023-07-12 |
| IL300904A (en) | 2023-04-01 |
| US12497359B2 (en) | 2025-12-16 |
| EP4208448B1 (en) | 2025-04-23 |
| CA3190786A1 (en) | 2022-03-10 |
| GB202013731D0 (en) | 2020-10-14 |
| CN116096712B (zh) | 2026-03-17 |
| JP2023539695A (ja) | 2023-09-15 |
| CN116096712A (zh) | 2023-05-09 |
| US20230312466A1 (en) | 2023-10-05 |
| WO2022049377A1 (en) | 2022-03-10 |
| AU2021336750A1 (en) | 2023-03-02 |
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