GB202013731D0 - Novel cmpounds - Google Patents

Novel cmpounds

Info

Publication number
GB202013731D0
GB202013731D0 GBGB2013731.1A GB202013731A GB202013731D0 GB 202013731 D0 GB202013731 D0 GB 202013731D0 GB 202013731 A GB202013731 A GB 202013731A GB 202013731 D0 GB202013731 D0 GB 202013731D0
Authority
GB
United Kingdom
Prior art keywords
cmpounds
novel
novel cmpounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB2013731.1A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nrg Therapeutics Ltd
Original Assignee
Nrg Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nrg Therapeutics Ltd filed Critical Nrg Therapeutics Ltd
Priority to GBGB2013731.1A priority Critical patent/GB202013731D0/en
Publication of GB202013731D0 publication Critical patent/GB202013731D0/en
Priority to AU2021336750A priority patent/AU2021336750A1/en
Priority to CN202180053586.6A priority patent/CN116096712B/zh
Priority to IL300904A priority patent/IL300904A/en
Priority to PCT/GB2021/052262 priority patent/WO2022049377A1/en
Priority to JP2023537724A priority patent/JP7784431B2/ja
Priority to CA3190786A priority patent/CA3190786A1/en
Priority to US18/023,488 priority patent/US12497359B2/en
Priority to EP21769790.3A priority patent/EP4208448B1/en
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
GBGB2013731.1A 2020-09-01 2020-09-01 Novel cmpounds Ceased GB202013731D0 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
GBGB2013731.1A GB202013731D0 (en) 2020-09-01 2020-09-01 Novel cmpounds
AU2021336750A AU2021336750A1 (en) 2020-09-01 2021-09-01 Novel compounds
CN202180053586.6A CN116096712B (zh) 2020-09-01 2021-09-01 新型化合物
IL300904A IL300904A (en) 2020-09-01 2021-09-01 Novel compounds
PCT/GB2021/052262 WO2022049377A1 (en) 2020-09-01 2021-09-01 Novel compounds
JP2023537724A JP7784431B2 (ja) 2020-09-01 2021-09-01 新規化合物
CA3190786A CA3190786A1 (en) 2020-09-01 2021-09-01 Novel compounds
US18/023,488 US12497359B2 (en) 2020-09-01 2021-09-01 Acrylamide derivatives
EP21769790.3A EP4208448B1 (en) 2020-09-01 2021-09-01 Acrylamide derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB2013731.1A GB202013731D0 (en) 2020-09-01 2020-09-01 Novel cmpounds

Publications (1)

Publication Number Publication Date
GB202013731D0 true GB202013731D0 (en) 2020-10-14

Family

ID=72749727

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB2013731.1A Ceased GB202013731D0 (en) 2020-09-01 2020-09-01 Novel cmpounds

Country Status (9)

Country Link
US (1) US12497359B2 (https=)
EP (1) EP4208448B1 (https=)
JP (1) JP7784431B2 (https=)
CN (1) CN116096712B (https=)
AU (1) AU2021336750A1 (https=)
CA (1) CA3190786A1 (https=)
GB (1) GB202013731D0 (https=)
IL (1) IL300904A (https=)
WO (1) WO2022049377A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202013728D0 (en) * 2020-09-01 2020-10-14 Nrg Therapeutics Ltd Novel compounds
GB202300833D0 (en) 2023-01-19 2023-03-08 Nrg Therapeutics Ltd Novel compounds
CN121866248A (zh) 2023-09-05 2026-04-14 Nrg治疗有限公司 作为mptp抑制剂起作用的吡啶衍生物
CN118255724A (zh) * 2024-03-27 2024-06-28 河北天成药业股份有限公司 盐酸利多卡因杂质的合成方法及其反应检测方法
GB202410534D0 (en) 2024-07-18 2024-09-04 Nrg Therapeutics Ltd Novel method and uses
CN120025281A (zh) * 2025-04-22 2025-05-23 九洲药业(杭州)有限公司 一种n,n-二异丁基-1h-吲唑-4-胺的中间体及制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1424078A4 (en) 2001-09-04 2009-03-25 Ono Pharmaceutical Co RESPIRATORY DISEASE MEDICINES COMPRISING A SPHINGOSINE-1-PHOSPHATE RECEPTOR REGULATING AGENT
WO2003051876A1 (en) 2001-12-14 2003-06-26 Japan Tobacco Inc. Pyrazolopyridine derivatives and medicinal use thereof
US7482488B2 (en) 2002-08-29 2009-01-27 Temple University - Of The Commonwealth System Of Higher Education Aryl and heteroaryl propene amides, derivatives thereof and therapeutic uses thereof
EP1960355A1 (en) * 2005-11-30 2008-08-27 F.Hoffmann-La Roche Ag 3-amino-1-arylpropyl indoles and aza-substituted indoles
US7915304B2 (en) 2006-10-24 2011-03-29 Congenia S.R.L. Phenyl substituted maleimides as medicaments for blocking degenerative tissue damages by inhibiting MPT
EP2179984A1 (en) 2008-10-27 2010-04-28 Congenia S.r.l. Acrylamido derivatives useful as inhibitors of the mitochondrial permeability transition
WO2011087051A1 (ja) 2010-01-14 2011-07-21 国立大学法人金沢大学 S1p2受容体アンタゴニストを含む粥状動脈硬化治療薬
JP2017538676A (ja) 2014-11-05 2017-12-28 ザ ユニバーシティ オブ カンザス ミトコンドリア透過性遷移孔(mtPTP)の小分子阻害剤
CA2884607A1 (en) 2015-03-11 2016-09-11 Stealth Peptides International, Inc. Therapeutic compositions including acrylamido compounds or phenyl-substiituted maleimide compounds and uses thereof to treat and prevent mitochondrial diseases and conditions
WO2019002624A1 (de) 2017-06-30 2019-01-03 Kleuser, Burkhard Mittel zur therapie entzündlicher darmerkrankungen
GB202013728D0 (en) 2020-09-01 2020-10-14 Nrg Therapeutics Ltd Novel compounds

Also Published As

Publication number Publication date
EP4208448A1 (en) 2023-07-12
IL300904A (en) 2023-04-01
US12497359B2 (en) 2025-12-16
EP4208448B1 (en) 2025-04-23
CA3190786A1 (en) 2022-03-10
CN116096712B (zh) 2026-03-17
JP7784431B2 (ja) 2025-12-11
JP2023539695A (ja) 2023-09-15
CN116096712A (zh) 2023-05-09
US20230312466A1 (en) 2023-10-05
WO2022049377A1 (en) 2022-03-10
AU2021336750A1 (en) 2023-03-02

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)