JP7761635B6 - Ｇｐｒ５２モジュレーター化合物 - Google Patents
Ｇｐｒ５２モジュレーター化合物Info
- Publication number
- JP7761635B6 JP7761635B6 JP2023514050A JP2023514050A JP7761635B6 JP 7761635 B6 JP7761635 B6 JP 7761635B6 JP 2023514050 A JP2023514050 A JP 2023514050A JP 2023514050 A JP2023514050 A JP 2023514050A JP 7761635 B6 JP7761635 B6 JP 7761635B6
- Authority
- JP
- Japan
- Prior art keywords
- disorder
- compound
- tetrahydro
- disorders
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Amplifiers (AREA)
- Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2013558.8 | 2020-08-28 | ||
| GBGB2013558.8A GB202013558D0 (en) | 2020-08-28 | 2020-08-28 | GRP52 Modularor compounds |
| PCT/GB2021/052247 WO2022043714A1 (en) | 2020-08-28 | 2021-08-31 | Gpr52 modulator compounds |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023539336A JP2023539336A (ja) | 2023-09-13 |
| JP2023539336A5 JP2023539336A5 (enExample) | 2024-09-06 |
| JP7761635B2 JP7761635B2 (ja) | 2025-10-28 |
| JP7761635B6 true JP7761635B6 (ja) | 2025-11-27 |
Family
ID=72749711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023514050A Active JP7761635B6 (ja) | 2020-08-28 | 2021-08-31 | Ｇｐｒ５２モジュレーター化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230348416A1 (enExample) |
| EP (1) | EP4204408A1 (enExample) |
| JP (1) | JP7761635B6 (enExample) |
| KR (1) | KR20230058132A (enExample) |
| CN (1) | CN116507622B (enExample) |
| AU (1) | AU2021330379A1 (enExample) |
| BR (1) | BR112023003696A2 (enExample) |
| CA (1) | CA3193487A1 (enExample) |
| GB (1) | GB202013558D0 (enExample) |
| IL (1) | IL301007B2 (enExample) |
| MX (1) | MX2023002389A (enExample) |
| WO (1) | WO2022043714A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB202003668D0 (en) | 2020-03-13 | 2020-04-29 | Heptares Therapeutics Ltd | GPR52 Modulator compounds |
| EP4139284A1 (en) | 2020-04-22 | 2023-03-01 | Neurocrine Biosciences, Inc. | Gpr52 modulators and methods of use |
| CN122555695A (zh) * | 2023-11-29 | 2026-08-11 | 爱克堤欧生物科学股份有限公司 | 可用作kcnt1抑制剂的杂环化合物 |
| CN121313618B (zh) * | 2025-12-09 | 2026-07-21 | 杭州师范大学附属医院(杭州市第二人民医院) | 丙酸在制备治疗肝豆状核变性肠肝轴紊乱的药物中的应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016176571A1 (en) | 2015-04-29 | 2016-11-03 | Arena Pharmaceuticals, Inc. | 1-heteroaryl-indoline-4-carboxamides as modulators of gpr52 useful for the treatment or prevention of disorders related thereto |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017077280A1 (en) * | 2015-11-02 | 2017-05-11 | Sonia Lain | Tetrahydroindazoles and medical uses thereof |
| WO2021009003A1 (en) * | 2019-07-16 | 2021-01-21 | Universität Hamburg | Computer-based identification of types in the empirical sciences by tangle theory |
| CN114650992A (zh) * | 2019-11-08 | 2022-06-21 | 赫普泰雅治疗有限公司 | Gpr52调节剂化合物 |
-
2020
- 2020-08-28 GB GBGB2013558.8A patent/GB202013558D0/en not_active Ceased
-
2021
- 2021-08-31 MX MX2023002389A patent/MX2023002389A/es unknown
- 2021-08-31 KR KR1020237010457A patent/KR20230058132A/ko active Pending
- 2021-08-31 WO PCT/GB2021/052247 patent/WO2022043714A1/en not_active Ceased
- 2021-08-31 JP JP2023514050A patent/JP7761635B6/ja active Active
- 2021-08-31 EP EP21769501.4A patent/EP4204408A1/en active Pending
- 2021-08-31 BR BR112023003696A patent/BR112023003696A2/pt unknown
- 2021-08-31 CN CN202180073276.0A patent/CN116507622B/zh active Active
- 2021-08-31 US US18/023,411 patent/US20230348416A1/en active Pending
- 2021-08-31 AU AU2021330379A patent/AU2021330379A1/en active Pending
- 2021-08-31 CA CA3193487A patent/CA3193487A1/en active Pending
-
2023
- 2023-02-28 IL IL301007A patent/IL301007B2/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016176571A1 (en) | 2015-04-29 | 2016-11-03 | Arena Pharmaceuticals, Inc. | 1-heteroaryl-indoline-4-carboxamides as modulators of gpr52 useful for the treatment or prevention of disorders related thereto |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116507622B (zh) | 2026-02-24 |
| IL301007B1 (en) | 2026-04-01 |
| IL301007A (en) | 2023-05-01 |
| WO2022043714A1 (en) | 2022-03-03 |
| US20230348416A1 (en) | 2023-11-02 |
| MX2023002389A (es) | 2023-05-03 |
| BR112023003696A2 (pt) | 2023-04-04 |
| KR20230058132A (ko) | 2023-05-02 |
| EP4204408A1 (en) | 2023-07-05 |
| AU2021330379A1 (en) | 2023-03-30 |
| CN116507622A (zh) | 2023-07-28 |
| CA3193487A1 (en) | 2022-03-03 |
| IL301007B2 (en) | 2026-08-01 |
| JP2023539336A (ja) | 2023-09-13 |
| JP7761635B2 (ja) | 2025-10-28 |
| GB202013558D0 (en) | 2020-10-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
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| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
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| A61 | First payment of annual fees (during grant procedure) |
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| R150 | Certificate of patent or registration of utility model |
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