GB202013558D0 - GRP52 Modularor compounds - Google Patents

GRP52 Modularor compounds

Info

Publication number
GB202013558D0
GB202013558D0 GBGB2013558.8A GB202013558A GB202013558D0 GB 202013558 D0 GB202013558 D0 GB 202013558D0 GB 202013558 A GB202013558 A GB 202013558A GB 202013558 D0 GB202013558 D0 GB 202013558D0
Authority
GB
United Kingdom
Prior art keywords
modularor
grp52
compounds
modularor compounds
grp52 modularor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB2013558.8A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nxera Pharma UK Ltd
Original Assignee
Heptares Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heptares Therapeutics Ltd filed Critical Heptares Therapeutics Ltd
Priority to GBGB2013558.8A priority Critical patent/GB202013558D0/en
Publication of GB202013558D0 publication Critical patent/GB202013558D0/en
Priority to AU2021330379A priority patent/AU2021330379A1/en
Priority to US18/023,411 priority patent/US20230348416A1/en
Priority to EP21769501.4A priority patent/EP4204408A1/en
Priority to BR112023003696A priority patent/BR112023003696A2/pt
Priority to CN202180073276.0A priority patent/CN116507622B/zh
Priority to JP2023514050A priority patent/JP7761635B6/ja
Priority to MX2023002389A priority patent/MX2023002389A/es
Priority to CA3193487A priority patent/CA3193487A1/en
Priority to KR1020237010457A priority patent/KR20230058132A/ko
Priority to PCT/GB2021/052247 priority patent/WO2022043714A1/en
Priority to IL301007A priority patent/IL301007B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Amplifiers (AREA)
  • Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GBGB2013558.8A 2020-08-28 2020-08-28 GRP52 Modularor compounds Ceased GB202013558D0 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
GBGB2013558.8A GB202013558D0 (en) 2020-08-28 2020-08-28 GRP52 Modularor compounds
PCT/GB2021/052247 WO2022043714A1 (en) 2020-08-28 2021-08-31 Gpr52 modulator compounds
BR112023003696A BR112023003696A2 (pt) 2020-08-28 2021-08-31 Compostos moduladores de gpr52
US18/023,411 US20230348416A1 (en) 2020-08-28 2021-08-31 Gpr52 modulator compounds
EP21769501.4A EP4204408A1 (en) 2020-08-28 2021-08-31 Gpr52 modulator compounds
AU2021330379A AU2021330379A1 (en) 2020-08-28 2021-08-31 GPR52 modulator compounds
CN202180073276.0A CN116507622B (zh) 2020-08-28 2021-08-31 Gpr52调节剂化合物
JP2023514050A JP7761635B6 (ja) 2020-08-28 2021-08-31 Gpr52モジュレーター化合物
MX2023002389A MX2023002389A (es) 2020-08-28 2021-08-31 Compuestos moduladores de gpr52.
CA3193487A CA3193487A1 (en) 2020-08-28 2021-08-31 Gpr52 modulator compounds
KR1020237010457A KR20230058132A (ko) 2020-08-28 2021-08-31 Gpr52 조절인자 화합물
IL301007A IL301007B2 (en) 2020-08-28 2023-02-28 GPR52 modulator compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB2013558.8A GB202013558D0 (en) 2020-08-28 2020-08-28 GRP52 Modularor compounds

Publications (1)

Publication Number Publication Date
GB202013558D0 true GB202013558D0 (en) 2020-10-14

Family

ID=72749711

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB2013558.8A Ceased GB202013558D0 (en) 2020-08-28 2020-08-28 GRP52 Modularor compounds

Country Status (12)

Country Link
US (1) US20230348416A1 (enExample)
EP (1) EP4204408A1 (enExample)
JP (1) JP7761635B6 (enExample)
KR (1) KR20230058132A (enExample)
CN (1) CN116507622B (enExample)
AU (1) AU2021330379A1 (enExample)
BR (1) BR112023003696A2 (enExample)
CA (1) CA3193487A1 (enExample)
GB (1) GB202013558D0 (enExample)
IL (1) IL301007B2 (enExample)
MX (1) MX2023002389A (enExample)
WO (1) WO2022043714A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202003668D0 (en) 2020-03-13 2020-04-29 Heptares Therapeutics Ltd GPR52 Modulator compounds
EP4139284A1 (en) 2020-04-22 2023-03-01 Neurocrine Biosciences, Inc. Gpr52 modulators and methods of use
CN122555695A (zh) * 2023-11-29 2026-08-11 爱克堤欧生物科学股份有限公司 可用作kcnt1抑制剂的杂环化合物
CN121313618B (zh) * 2025-12-09 2026-07-21 杭州师范大学附属医院(杭州市第二人民医院) 丙酸在制备治疗肝豆状核变性肠肝轴紊乱的药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX373876B (es) * 2015-04-29 2020-03-26 Arena Pharm Inc 1-heteroaril-indolin-4-carboxamidas como moduladores de gpr52 útiles para el tratamiento o prevención de trastornos relacionados a las mismas.
WO2017077280A1 (en) * 2015-11-02 2017-05-11 Sonia Lain Tetrahydroindazoles and medical uses thereof
WO2021009003A1 (en) * 2019-07-16 2021-01-21 Universität Hamburg Computer-based identification of types in the empirical sciences by tangle theory
CN114650992A (zh) * 2019-11-08 2022-06-21 赫普泰雅治疗有限公司 Gpr52调节剂化合物

Also Published As

Publication number Publication date
CN116507622B (zh) 2026-02-24
IL301007B1 (en) 2026-04-01
IL301007A (en) 2023-05-01
WO2022043714A1 (en) 2022-03-03
US20230348416A1 (en) 2023-11-02
MX2023002389A (es) 2023-05-03
BR112023003696A2 (pt) 2023-04-04
KR20230058132A (ko) 2023-05-02
EP4204408A1 (en) 2023-07-05
AU2021330379A1 (en) 2023-03-30
CN116507622A (zh) 2023-07-28
CA3193487A1 (en) 2022-03-03
IL301007B2 (en) 2026-08-01
JP2023539336A (ja) 2023-09-13
JP7761635B2 (ja) 2025-10-28
JP7761635B6 (ja) 2025-11-27

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)