JP7746165B2 - Ｎｕｒｒ１受容体調節因子 - Google Patents

Ｎｕｒｒ１受容体調節因子

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JP7746165B2
JP7746165B2 JP2021571643A JP2021571643A JP7746165B2 JP 7746165 B2 JP7746165 B2 JP 7746165B2 JP 2021571643 A JP2021571643 A JP 2021571643A JP 2021571643 A JP2021571643 A JP 2021571643A JP 7746165 B2 JP7746165 B2 JP 7746165B2
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substituted
unsubstituted
membered
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nhc
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JP2022520907A5 (https=
JP2022520907A (ja
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イングランド，パメラ・エム
ジェイコブソン，マシュー・ピー
ベレシス，リチャード
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ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア
シャンファーマ・イノベーション・インコーポレイテッド
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106518793A (zh) 2016-10-25 2017-03-22 中国农业大学 一种含1,2,3‑三唑环的酰胺类化合物及其制备方法与应用
CN106967047A (zh) 2017-03-29 2017-07-21 山东大学 一种取代二芳基烟酰胺类衍生物及其制备方法与应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5714505A (en) * 1980-07-01 1982-01-25 Ube Ind Ltd Herbicide
GB8702613D0 (en) * 1987-02-05 1987-03-11 Ici Plc Compositions
DE10206723A1 (de) * 2002-02-18 2003-09-04 Ulrich Schraermeyer Therapie von Erkrankungen des Auges und des Zentralen Nervensystems
TW200505452A (en) * 2003-06-17 2005-02-16 Astrazeneca Ab Chemical compounds
AU2004285053B2 (en) * 2003-10-28 2010-10-21 Vertex Pharmaceuticals, Incorporated Benzimidazoles useful as modulators of ion channels
SE0401653D0 (sv) * 2004-06-24 2004-06-24 Astrazeneca Ab New compounds
WO2007120012A1 (en) * 2006-04-19 2007-10-25 Amorepacific Corporation Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same
WO2009047240A1 (en) * 2007-10-09 2009-04-16 Smithkline Beecham Corporation Indole derivatives useful as ppar activators
FR2925906B1 (fr) * 2008-01-02 2010-08-20 Sanofi Aventis COMPOSES DE N-PHENYL-IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
HRP20151367T1 (hr) * 2008-05-13 2016-01-29 Yale University Kimerne male molekule za pojaäśanje odgovora protutijela na stanice raka
JP2012529518A (ja) * 2009-06-09 2012-11-22 アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー ヘッジホッグシグナル伝達のピリジル−トリアジン阻害剤
FR2955110A1 (fr) * 2010-01-08 2011-07-15 Fournier Lab Sa Nouveaux derives de type pyrrolopyridine benzoique
US9034916B2 (en) * 2011-04-06 2015-05-19 Korea Research Institute Of Bioscience And Biotechnology Pharmaceutical composition for the prevention or treatment of a neurodegenerative disease, comprising a Daphne genkwa extract or a compound isolated therefrom
WO2015159175A1 (en) * 2014-04-15 2015-10-22 Pfizer Inc. Tropomyosin-related kinase inhibitors containing both a 1h-pyrazole and a pyrimidine moiety
WO2015170218A1 (en) * 2014-05-07 2015-11-12 Pfizer Inc. Tropomyosin-related kinase inhibitors
WO2016201354A1 (en) * 2015-06-11 2016-12-15 Globavir Biosciences, Inc. Methods and compositions for treating cancer
LU92852B1 (en) * 2015-10-20 2017-05-02 Athanasios Spathis NURR1:RXR activating compounds for simultaneous treatment of symptoms and pathology of Parkinsons disease
JP2018537502A (ja) * 2015-12-16 2018-12-20 サウザーン リサーチ インスチチュート ピロロピリミジン化合物、キナーゼｌｒｒｋ２阻害剤としての使用、及びその調製方法
US20190151289A1 (en) * 2016-05-13 2019-05-23 Yale University Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1A (JARID1A) Histone Demethylase
AU2017279027A1 (en) * 2016-06-08 2018-12-20 Glaxosmithkline Intellectual Property Development Limited Chemical Compounds
EP3612526A2 (en) * 2017-04-20 2020-02-26 The Regents of the University of California K-ras modulators
US11872236B2 (en) * 2018-04-05 2024-01-16 Calasia Pharmaceuticals, Inc. Pharmacological agents for treating ocular diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106518793A (zh) 2016-10-25 2017-03-22 中国农业大学 一种含1,2,3‑三唑环的酰胺类化合物及其制备方法与应用
CN106967047A (zh) 2017-03-29 2017-07-21 山东大学 一种取代二芳基烟酰胺类衍生物及其制备方法与应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMISTRY A European Journal，2017年，Vol.23，pp.11524-11528，DOI: 10.1002/chem.201703191
Tetrahedron Letters，2006年，Vol.47，pp.5105-5109，DOI: 10.1016/j.tetlet.2006.05.079

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