JP7734654B2 - ワクチンおよび治療ツールとしてのネオ複合糖質 - Google Patents

ワクチンおよび治療ツールとしてのネオ複合糖質

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Publication number
JP7734654B2
JP7734654B2 JP2022518356A JP2022518356A JP7734654B2 JP 7734654 B2 JP7734654 B2 JP 7734654B2 JP 2022518356 A JP2022518356 A JP 2022518356A JP 2022518356 A JP2022518356 A JP 2022518356A JP 7734654 B2 JP7734654 B2 JP 7734654B2
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antigen
carbohydrate
peptide
cancer
neoglycoconjugate
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Japanese (ja)
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JP2022549292A (ja
JP2022549292A5 (https=
Inventor
シャオ，ツェ・ジェ
モフェット，サージ
ミニャーニ，サージ
ロイ，ルネ
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コラネックス・キャピタル
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A61K39/00117—Mucins, e.g. MUC-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A61K39/001172—Sialyl-Thomson-nouvelle antigen [sTn]
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
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    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2022518356A 2019-09-23 2020-09-18 ワクチンおよび治療ツールとしてのネオ複合糖質 Active JP7734654B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962904312P 2019-09-23 2019-09-23
US62/904,312 2019-09-23
US202063060452P 2020-08-03 2020-08-03
US63/060,452 2020-08-03
PCT/CA2020/051253 WO2021056098A1 (en) 2019-09-23 2020-09-18 Neoglycoconjugates as vaccines and therapeutic tools

Publications (3)

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JP2022549292A JP2022549292A (ja) 2022-11-24
JP2022549292A5 JP2022549292A5 (https=) 2024-04-26
JP7734654B2 true JP7734654B2 (ja) 2025-09-05

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Country Link
US (3) US10973910B1 (https=)
EP (2) EP4034159A4 (https=)
JP (1) JP7734654B2 (https=)
KR (1) KR20220115556A (https=)
CN (2) CN115003330A (https=)
AU (1) AU2020353390A1 (https=)
IL (1) IL291601B2 (https=)
WO (1) WO2021056098A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115003330A (zh) * 2019-09-23 2022-09-02 科纳克斯资本 作为疫苗和诊断工具的新糖缀合物
US20240308991A1 (en) * 2021-01-15 2024-09-19 Koranex Capital Process for the synthesis of reactive carbohydrates including antigen precursors for conjugation with a carrier material
WO2022198314A1 (en) * 2021-03-23 2022-09-29 Koranex Capital Antibodies binding to o-linked carbohydrates on sars-cov-2 spike protein and uses thereof
CN113499433B (zh) * 2021-06-21 2022-03-18 复旦大学 一种具有抗肿瘤活性的GalNAc/CpG脂质体疫苗、制备方法及应用
US20230009415A1 (en) * 2021-07-01 2023-01-12 Board Of Regents, The University Of Texas System Synthetic biomarkers for differential serological diagnosis of cutaneous leishmaniasis (cl) caused by various leishmania species
CN114306586A (zh) * 2022-01-04 2022-04-12 天津科技大学 基于tf抗原和壳寡糖内源性佐剂的肿瘤疫苗、方法和应用
CN116333062B (zh) * 2022-12-23 2025-06-17 山东大学 一种SARS-CoV-2冠状病毒糖基化RBD蛋白及其制备与应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8203925D0 (sv) * 1982-06-23 1982-06-23 Svenska Sockerfabriks Ab New and novel glycosides, glycoconjugates and processes for their preparation
WO1995029927A2 (en) 1994-05-02 1995-11-09 Biomira, Inc. Process for preparation of glycosides of tumor-associated carbohydrate antigens
JPH0851998A (ja) * 1994-08-10 1996-02-27 Otsuka Pharmaceut Co Ltd 糖転移酵素の活性測定法
EP1007541B1 (en) 1997-08-28 2006-08-23 Biomira, Inc. Randomly generated glycopeptide combinatorial libraries
DE69941574D1 (de) * 1998-08-19 2009-12-03 Baxter Healthcare Sa Immunogenes beta-propionamido-gebundenes polysaccharid-protein konjugat geeignet als impfstoff und hergestellt bei verwendung von n-acryloyliertem polysaccharid
CA2434668A1 (en) * 2003-07-04 2005-01-04 Laurence Mulard Novel approach to design glycopeptides based on o-specific polysaccharide of shigella flexneri serotype 2a
US20070275007A1 (en) 2003-11-05 2007-11-29 The Government Of The United States Of America, Represented By The Secretary Of Health And Human S Carbohydrate Antigen-Nanoparticle Conjugates and Uses Thereof as Antimetastatic Agents in Treating Cancer
KR101515078B1 (ko) * 2005-12-22 2015-04-24 글락소스미스클라인 바이오로지칼즈 에스.에이. 백신
GB201108472D0 (en) * 2011-05-19 2011-07-06 Isis Innovation HIV vaccine
WO2015006740A2 (en) 2013-07-11 2015-01-15 Alnylam Pharmaceuticals, Inc. Oligonucleotide-ligand conjugates and process for their preparation
WO2016070163A1 (en) 2014-10-31 2016-05-06 Almeida Igor C Glycoconjugates and methods for their use
WO2019178699A1 (en) * 2018-03-23 2019-09-26 Koranex Capital Precision glycoconjugates as therapeutic tools
CN110064050B (zh) * 2019-04-29 2020-10-02 北京大学 含STn或F-STn的糖缀合物及其制备方法和在抗肿瘤疫苗中的应用
CN115003330A (zh) * 2019-09-23 2022-09-02 科纳克斯资本 作为疫苗和诊断工具的新糖缀合物
WO2022198314A1 (en) * 2021-03-23 2022-09-29 Koranex Capital Antibodies binding to o-linked carbohydrates on sars-cov-2 spike protein and uses thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Bioorganic & Medicinal Chemistry，2002年，Vol.10, pp.11-17
Bioorganic & Medicinal Chemistry，2016年，Vol.24, pp.915-920
Corbohydrare Research，1980年，Vol.78, C1-C3
Glycoconj J，2006年，Vol.23, pp.317-327
J. Mass Spectrom.，2014年，Vol.49, pp.1223-1233

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JP2022549292A (ja) 2022-11-24
CN115003330A (zh) 2022-09-02
KR20220115556A (ko) 2022-08-17
EP4446336A2 (en) 2024-10-16
US20240216491A1 (en) 2024-07-04
CA3152129A1 (en) 2021-04-01
CN121197385A (zh) 2025-12-26
WO2021056098A1 (en) 2021-04-01
US20210085781A1 (en) 2021-03-25
EP4446336A3 (en) 2025-06-25
IL291601B2 (en) 2026-03-01
EP4034159A4 (en) 2024-02-21
IL291601A (en) 2022-05-01
IL291601B1 (en) 2025-11-01
US20210085770A1 (en) 2021-03-25
EP4034159A1 (en) 2022-08-03
US10973910B1 (en) 2021-04-13
AU2020353390A1 (en) 2022-05-12
US11925680B2 (en) 2024-03-12

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