CN115003330A - 作为疫苗和诊断工具的新糖缀合物 - Google Patents

作为疫苗和诊断工具的新糖缀合物 Download PDF

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Publication number
CN115003330A
CN115003330A CN202080081353.2A CN202080081353A CN115003330A CN 115003330 A CN115003330 A CN 115003330A CN 202080081353 A CN202080081353 A CN 202080081353A CN 115003330 A CN115003330 A CN 115003330A
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antigen
carbohydrate
neoglycoconjugate
carbohydrate antigen
group
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CN202080081353.2A
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Chinese (zh)
Inventor
切·赫·希奥
塞尔吉·莫菲特
塞尔吉·米格纳尼
勒内·罗伊
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Conax Capital
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Conax Capital
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Priority to CN202511577141.4A priority Critical patent/CN121197385A/zh
Publication of CN115003330A publication Critical patent/CN115003330A/zh
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    • A61K39/001169Tumor associated carbohydrates
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    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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  • Toxicology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
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CN202080081353.2A 2019-09-23 2020-09-18 作为疫苗和诊断工具的新糖缀合物 Pending CN115003330A (zh)

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US201962904312P 2019-09-23 2019-09-23
US62/904,312 2019-09-23
US202063060452P 2020-08-03 2020-08-03
US63/060,452 2020-08-03
PCT/CA2020/051253 WO2021056098A1 (en) 2019-09-23 2020-09-18 Neoglycoconjugates as vaccines and therapeutic tools

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US (3) US10973910B1 (https=)
EP (2) EP4034159A4 (https=)
JP (1) JP7734654B2 (https=)
KR (1) KR20220115556A (https=)
CN (2) CN115003330A (https=)
AU (1) AU2020353390A1 (https=)
IL (1) IL291601B2 (https=)
WO (1) WO2021056098A1 (https=)

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CN116333062A (zh) * 2022-12-23 2023-06-27 山东大学 一种SARS-CoV-2冠状病毒糖基化RBD蛋白及其制备与应用

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CN115003330A (zh) * 2019-09-23 2022-09-02 科纳克斯资本 作为疫苗和诊断工具的新糖缀合物
US20240308991A1 (en) * 2021-01-15 2024-09-19 Koranex Capital Process for the synthesis of reactive carbohydrates including antigen precursors for conjugation with a carrier material
WO2022198314A1 (en) * 2021-03-23 2022-09-29 Koranex Capital Antibodies binding to o-linked carbohydrates on sars-cov-2 spike protein and uses thereof
CN113499433B (zh) * 2021-06-21 2022-03-18 复旦大学 一种具有抗肿瘤活性的GalNAc/CpG脂质体疫苗、制备方法及应用
US20230009415A1 (en) * 2021-07-01 2023-01-12 Board Of Regents, The University Of Texas System Synthetic biomarkers for differential serological diagnosis of cutaneous leishmaniasis (cl) caused by various leishmania species
CN114306586A (zh) * 2022-01-04 2022-04-12 天津科技大学 基于tf抗原和壳寡糖内源性佐剂的肿瘤疫苗、方法和应用

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Publication number Priority date Publication date Assignee Title
CN116333062A (zh) * 2022-12-23 2023-06-27 山东大学 一种SARS-CoV-2冠状病毒糖基化RBD蛋白及其制备与应用
CN116333062B (zh) * 2022-12-23 2025-06-17 山东大学 一种SARS-CoV-2冠状病毒糖基化RBD蛋白及其制备与应用

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