JP7724394B2 - イソインドリノン化合物 - Google Patents
イソインドリノン化合物Info
- Publication number
- JP7724394B2 JP7724394B2 JP2022521718A JP2022521718A JP7724394B2 JP 7724394 B2 JP7724394 B2 JP 7724394B2 JP 2022521718 A JP2022521718 A JP 2022521718A JP 2022521718 A JP2022521718 A JP 2022521718A JP 7724394 B2 JP7724394 B2 JP 7724394B2
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- membered heterocycloalkyl
- branched
- compound
- linear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH12812019 | 2019-10-09 | ||
| CH01281/19 | 2019-10-09 | ||
| PCT/EP2020/078483 WO2021069705A1 (en) | 2019-10-09 | 2020-10-09 | Isoindolinone compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022551185A JP2022551185A (ja) | 2022-12-07 |
| JPWO2021069705A5 JPWO2021069705A5 (OSRAM) | 2023-10-17 |
| JP7724394B2 true JP7724394B2 (ja) | 2025-08-18 |
Family
ID=68242216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022521718A Active JP7724394B2 (ja) | 2019-10-09 | 2020-10-09 | イソインドリノン化合物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20220242846A1 (OSRAM) |
| EP (1) | EP4041231A1 (OSRAM) |
| JP (1) | JP7724394B2 (OSRAM) |
| WO (1) | WO2021069705A1 (OSRAM) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023507590A (ja) * | 2019-12-17 | 2023-02-24 | オリオニス バイオサイエンシズ，インコーポレイテッド | タンパク質の動員および／または分解を調節する化合物 |
| US20240050428A1 (en) * | 2020-10-07 | 2024-02-15 | Cullgen (Shanghai), Inc. | Compounds and methods of treating cancers |
| US20240085421A1 (en) | 2021-01-13 | 2024-03-14 | Monte Rosa Therapeutics, Inc. | Methods for the identification of degrons |
| CA3208313A1 (en) | 2021-01-13 | 2022-07-21 | Monte Rosa Therapeutics Ag | Isoindolinone compounds |
| CN117242060A (zh) * | 2021-01-13 | 2023-12-15 | 蒙特罗萨医疗公司 | 异吲哚啉酮化合物 |
| US20240261274A1 (en) | 2021-01-13 | 2024-08-08 | Monte Rosa Therapeutics, Inc. | Treatment of myc-driven cancers with gspt1 degraders |
| WO2022200857A1 (en) * | 2021-03-22 | 2022-09-29 | Monte Rosa Therapeutics Ag | Pharmaceutical compositions for use in the prevention and treatment of a disease or disorder caused by or associated with one or more premature termination codons |
| EP4347860A1 (en) | 2021-06-04 | 2024-04-10 | Monte Rosa Therapeutics, Inc. | E3 ligase fusion proteins for proximity detection |
| CN115504963A (zh) * | 2021-06-22 | 2022-12-23 | 苏州开拓药业股份有限公司 | 一种c-Myc蛋白降解剂 |
| JP2024527628A (ja) * | 2021-07-19 | 2024-07-25 | メッドシャイン ディスカバリー インコーポレイテッド | ヘテロアリール－３－ピペリジンジオン化合物その使用 |
| WO2023069700A1 (en) * | 2021-10-22 | 2023-04-27 | Monte Rosa Therapeutics, Inc. | Compounds that mediate protein degradation and methods of use thereof |
| WO2023069708A1 (en) * | 2021-10-22 | 2023-04-27 | Monte Rosa Therapeutics, Inc. | Compounds that mediate protein degradation and uses thereof |
| WO2023069731A1 (en) * | 2021-10-22 | 2023-04-27 | Monte Rosa Therapeutics, Inc. | Compounds that mediate protein degradation and methods of use thereof |
| WO2023069720A1 (en) * | 2021-10-22 | 2023-04-27 | Monte Rosa Therapeutics, Inc. | Compounds that mediate protein degradation and methods of use thereof |
| WO2023091567A1 (en) | 2021-11-17 | 2023-05-25 | Monte Rosa Therapeutics, Inc. | Degron and neosubstrate identification |
| IL316238A (en) | 2022-04-14 | 2024-12-01 | Bristol Myers Squibb Co | Novel GSPT1 compounds and methods of using them |
| EP4554581A1 (en) | 2022-07-13 | 2025-05-21 | Monte Rosa Therapeutics AG | Combination therapy comprising gspt1-directed molecular glue degraders and pi3k/akt/mtor pathway inhibitors |
| WO2024015565A1 (en) * | 2022-07-14 | 2024-01-18 | Monte Rosa Therapeutics, Inc. | Methods of preparing an isoindolinone derivative and crystal forms thereof |
| WO2024027795A1 (zh) * | 2022-08-04 | 2024-02-08 | 苏州开拓药业股份有限公司 | 包含Myc蛋白降解剂类生物活性化合物的抗体药物偶联物及其制备方法和用途 |
| CN115636811A (zh) * | 2022-08-17 | 2023-01-24 | 成都分迪药业有限公司 | 异吲哚啉苄胺衍生物的合成方法 |
| CA3267079A1 (en) | 2022-09-09 | 2024-03-14 | Innovo Therapeutics, Inc. | CK1α AND DOUBLE CK1α/GSPT1 DEGRADATION COMPOUNDS |
| WO2024201248A1 (en) * | 2023-03-24 | 2024-10-03 | Pin Therapeutics, Inc. | Compounds and methods for degrading gspt1 |
| WO2025051180A1 (zh) * | 2023-09-06 | 2025-03-13 | 上海超阳药业有限公司 | 内酰胺类衍生物及其应用 |
| WO2025085416A1 (en) * | 2023-10-16 | 2025-04-24 | Bristol-Myers Squibb Company | Gspt1 compounds and methods of use of the compounds |
| WO2025146112A1 (en) * | 2024-01-05 | 2025-07-10 | Primelink Biotherapeutics (Shenzhen) Co., Ltd. | Gspt1 degrading compounds and compositions and uses thereof |
| WO2025179161A1 (en) | 2024-02-21 | 2025-08-28 | Innovo Therapeutics, Inc. | Protein degrading compounds |
| WO2025259615A1 (en) * | 2024-06-11 | 2025-12-18 | Triana Biomedicines, Inc. | Modulators of cdk2 and uses thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004525889A (ja) | 2000-12-27 | 2004-08-26 | セルジーン・コーポレーション | イソインドール−イミド化合物、組成物、およびそれらの使用 |
| JP2010502627A (ja) | 2006-08-30 | 2010-01-28 | セルジーン・コーポレーション | ５−置換イソインドリン化合物 |
| JP2012507541A (ja) | 2008-10-29 | 2012-03-29 | セルジーン コーポレイション | 癌の治療に使用するためのイソインドリン化合物 |
| WO2017197051A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Amine-linked c3-glutarimide degronimers for target protein degradation |
| WO2018071606A1 (en) | 2016-10-11 | 2018-04-19 | Arvinas, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| JP2018517716A (ja) | 2016-05-05 | 2018-07-05 | エランコ ティーアゲズンタイト アーゲー | ヘテロアリール−１，２，４−トリアゾール及びヘテロアリール−テトラゾール化合物 |
| WO2019148055A1 (en) | 2018-01-26 | 2019-08-01 | Yale University | Imide-based modulators of proteolysis and methods of use |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021198965A1 (en) * | 2020-03-31 | 2021-10-07 | Orum Therapeutics, Inc. | Neodegrader conjugates |
-
2020
- 2020-10-09 EP EP20789952.7A patent/EP4041231A1/en active Pending
- 2020-10-09 JP JP2022521718A patent/JP7724394B2/ja active Active
- 2020-10-09 WO PCT/EP2020/078483 patent/WO2021069705A1/en not_active Ceased
-
2022
- 2022-04-08 US US17/716,169 patent/US20220242846A1/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004525889A (ja) | 2000-12-27 | 2004-08-26 | セルジーン・コーポレーション | イソインドール−イミド化合物、組成物、およびそれらの使用 |
| JP2010502627A (ja) | 2006-08-30 | 2010-01-28 | セルジーン・コーポレーション | ５−置換イソインドリン化合物 |
| JP2012507541A (ja) | 2008-10-29 | 2012-03-29 | セルジーン コーポレイション | 癌の治療に使用するためのイソインドリン化合物 |
| JP2018517716A (ja) | 2016-05-05 | 2018-07-05 | エランコ ティーアゲズンタイト アーゲー | ヘテロアリール−１，２，４−トリアゾール及びヘテロアリール−テトラゾール化合物 |
| WO2017197051A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Amine-linked c3-glutarimide degronimers for target protein degradation |
| WO2018071606A1 (en) | 2016-10-11 | 2018-04-19 | Arvinas, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| WO2019148055A1 (en) | 2018-01-26 | 2019-08-01 | Yale University | Imide-based modulators of proteolysis and methods of use |
Non-Patent Citations (3)
| Title |
|---|
| Annual Review of Pharmacology and Toxicology，2017年，Vol.57，p.107-123 |
| Drug Discovery Today: Technologies，2019年，Volume 31，Pages 29-34 |
| Nature，2016年，Vol.535(7611)，p.252-257 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021069705A1 (en) | 2021-04-15 |
| US20220242846A1 (en) | 2022-08-04 |
| EP4041231A1 (en) | 2022-08-17 |
| JP2022551185A (ja) | 2022-12-07 |
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