JP7720646B2 - 高純度ｌ－乳酸マグネシウムの結晶化 - Google Patents
高純度ｌ－乳酸マグネシウムの結晶化Info
- Publication number
- JP7720646B2 JP7720646B2 JP2023542680A JP2023542680A JP7720646B2 JP 7720646 B2 JP7720646 B2 JP 7720646B2 JP 2023542680 A JP2023542680 A JP 2023542680A JP 2023542680 A JP2023542680 A JP 2023542680A JP 7720646 B2 JP7720646 B2 JP 7720646B2
- Authority
- JP
- Japan
- Prior art keywords
- lactate
- magnesium
- crystals
- mbar
- carried out
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0018—Evaporation of components of the mixture to be separated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/02—Preparation of carboxylic acids or their salts, halides or anhydrides from salts of carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
- C07C59/08—Lactic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/36—Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/56—Lactic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Sustainable Development (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163139894P | 2021-01-21 | 2021-01-21 | |
| US63/139,894 | 2021-01-21 | ||
| US202163280150P | 2021-11-17 | 2021-11-17 | |
| US63/280,150 | 2021-11-17 | ||
| PCT/IL2022/050081 WO2022157768A1 (en) | 2021-01-21 | 2022-01-19 | Crystallization of high-purity magnesium l-lactate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024504112A JP2024504112A (ja) | 2024-01-30 |
| JP2024504112A5 JP2024504112A5 (cg-RX-API-DMAC7.html) | 2025-01-23 |
| JP7720646B2 true JP7720646B2 (ja) | 2025-08-08 |
Family
ID=82548988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023542680A Active JP7720646B2 (ja) | 2021-01-21 | 2022-01-19 | 高純度ｌ－乳酸マグネシウムの結晶化 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20240300880A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP4736977A3 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7720646B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR102896762B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN119330822A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2022211203B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3207836A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK4281432T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES3066755T3 (cg-RX-API-DMAC7.html) |
| FI (1) | FI4281432T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL303988B2 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2023008459A (cg-RX-API-DMAC7.html) |
| PL (1) | PL4281432T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2022157768A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116829529B (zh) * | 2021-01-21 | 2024-10-18 | 三W有限公司 | 高纯度l-乳酸镁的结晶 |
| AU2023314461A1 (en) * | 2022-07-27 | 2025-02-06 | TripleW Ltd. | Enantiomeric enrichment of l-lactic acid or salt thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008502657A (ja) | 2004-06-17 | 2008-01-31 | ピュラック・バイオケム・ベスローテン・ベンノートシャップ | 乳酸マグネシウム含有媒質からの乳酸または乳酸塩の調製方法 |
| CN104789607A (zh) | 2015-04-21 | 2015-07-22 | 北京化工大学 | 一种发酵-分离耦合制备乳酸和/或乳酸盐的方法 |
| CN105018538A (zh) | 2015-07-07 | 2015-11-04 | 北京化工大学 | 一种基于结晶法发酵分离耦合生产乳酸镁的方法 |
| WO2020110108A1 (en) | 2018-11-26 | 2020-06-04 | 3Plw Ltd. | Purification of magnesium lactate from fermentation broths having high amounts of impurities |
| JP2020535826A (ja) | 2017-10-02 | 2020-12-10 | メタボリック エクスプローラー | 発酵ブロスから有機酸塩を生産する方法 |
| JP2023523490A (ja) | 2020-01-15 | 2023-06-06 | ピュラック バイオケム ビー． ブイ． | 塩化マグネシウム溶液を精製する方法 |
| JP2024530430A (ja) | 2021-08-03 | 2024-08-21 | トリプルダブリュー リミテッド | 再生乳酸塩を生成するためのプロセス |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG2013095930A (en) * | 2008-12-26 | 2015-07-30 | Toray Industries | Method for producing lactic acid and method for producing polylactic acid |
| EP2399658A1 (en) * | 2010-06-24 | 2011-12-28 | Biosyn Arzneimittel GmbH | Method for producing pharmacologically pure crystals |
| KR20130139269A (ko) | 2010-12-13 | 2013-12-20 | 도레이 카부시키가이샤 | 락트산염의 제조 방법 |
| EP2604696A1 (en) | 2011-12-16 | 2013-06-19 | PURAC Biochem BV | Process for the fermentative production of lactic acid from a plant extract in the presence of a caustic magnesium salt |
| FR2994569B1 (fr) * | 2012-08-17 | 2016-11-04 | Roquette Freres | Procede de fabrication de compositions riches en cristaux de mannitol sous forme delta, compositions et cristaux obtenus ainsi que leurs utilisations |
| PL3174988T3 (pl) | 2014-07-28 | 2023-01-02 | Purac Biochem Bv | Sposób wytwarzania kwasu mlekowego |
| UA125821C2 (uk) | 2016-04-12 | 2022-06-15 | Пурак Біокем Бв | Спосіб зброджування для отримання лактату магнію з джерела карбону та спосіб переробки одержаного лактату магнію |
| JP6884802B2 (ja) | 2016-05-30 | 2021-06-09 | ピュラック バイオケム ビー． ブイ． | 固体発酵生成物からバイオマスを分離する方法 |
| CN106083565A (zh) * | 2016-06-06 | 2016-11-09 | 宁乡新阳化工有限公司 | 乳酸镁的生产方法 |
| US12655455B2 (en) | 2020-02-19 | 2026-06-16 | TripleW Ltd. | Methods and systems for lactic acid production and polylactic acid recycling |
-
2022
- 2022-01-19 KR KR1020237027752A patent/KR102896762B1/ko active Active
- 2022-01-19 US US18/261,475 patent/US20240300880A1/en active Pending
- 2022-01-19 EP EP26163419.0A patent/EP4736977A3/en active Pending
- 2022-01-19 JP JP2023542680A patent/JP7720646B2/ja active Active
- 2022-01-19 AU AU2022211203A patent/AU2022211203B2/en active Active
- 2022-01-19 CN CN202411348765.4A patent/CN119330822A/zh active Pending
- 2022-01-19 KR KR1020257040429A patent/KR20260003312A/ko active Pending
- 2022-01-19 DK DK22742375.3T patent/DK4281432T3/da active
- 2022-01-19 EP EP22742375.3A patent/EP4281432B1/en active Active
- 2022-01-19 ES ES22742375T patent/ES3066755T3/es active Active
- 2022-01-19 MX MX2023008459A patent/MX2023008459A/es unknown
- 2022-01-19 CA CA3207836A patent/CA3207836A1/en active Pending
- 2022-01-19 IL IL303988A patent/IL303988B2/en unknown
- 2022-01-19 FI FIEP22742375.3T patent/FI4281432T3/fi active
- 2022-01-19 PL PL22742375.3T patent/PL4281432T3/pl unknown
- 2022-01-19 WO PCT/IL2022/050081 patent/WO2022157768A1/en not_active Ceased
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008502657A (ja) | 2004-06-17 | 2008-01-31 | ピュラック・バイオケム・ベスローテン・ベンノートシャップ | 乳酸マグネシウム含有媒質からの乳酸または乳酸塩の調製方法 |
| CN104789607A (zh) | 2015-04-21 | 2015-07-22 | 北京化工大学 | 一种发酵-分离耦合制备乳酸和/或乳酸盐的方法 |
| CN105018538A (zh) | 2015-07-07 | 2015-11-04 | 北京化工大学 | 一种基于结晶法发酵分离耦合生产乳酸镁的方法 |
| JP2020535826A (ja) | 2017-10-02 | 2020-12-10 | メタボリック エクスプローラー | 発酵ブロスから有機酸塩を生産する方法 |
| WO2020110108A1 (en) | 2018-11-26 | 2020-06-04 | 3Plw Ltd. | Purification of magnesium lactate from fermentation broths having high amounts of impurities |
| JP2023523490A (ja) | 2020-01-15 | 2023-06-06 | ピュラック バイオケム ビー． ブイ． | 塩化マグネシウム溶液を精製する方法 |
| JP2024530430A (ja) | 2021-08-03 | 2024-08-21 | トリプルダブリュー リミテッド | 再生乳酸塩を生成するためのプロセス |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2022211203A9 (en) | 2024-07-18 |
| EP4736977A2 (en) | 2026-05-06 |
| US20240300880A1 (en) | 2024-09-12 |
| AU2022211203A1 (en) | 2023-08-10 |
| IL303988A (en) | 2023-08-01 |
| FI4281432T3 (fi) | 2026-04-16 |
| KR20230135613A (ko) | 2023-09-25 |
| WO2022157768A1 (en) | 2022-07-28 |
| EP4736977A3 (en) | 2026-07-01 |
| EP4281432A1 (en) | 2023-11-29 |
| IL303988B2 (en) | 2024-03-01 |
| CN119330822A (zh) | 2025-01-21 |
| AU2022211203B2 (en) | 2026-06-25 |
| IL303988B1 (en) | 2023-11-01 |
| KR20260003312A (ko) | 2026-01-06 |
| CA3207836A1 (en) | 2022-07-28 |
| EP4281432B1 (en) | 2026-03-11 |
| JP2024504112A (ja) | 2024-01-30 |
| MX2023008459A (es) | 2023-07-27 |
| ES3066755T3 (en) | 2026-05-14 |
| KR102896762B1 (ko) | 2025-12-05 |
| EP4281432A4 (en) | 2024-12-25 |
| DK4281432T3 (da) | 2026-04-20 |
| PL4281432T3 (pl) | 2026-05-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108822163B (zh) | 一种d-氨基葡萄糖盐酸盐的综合循环生产方法 | |
| KR102896762B1 (ko) | 고순도 마그네슘 l-락테이트의 결정화 | |
| CN113214076A (zh) | 一种从乳酸蒸馏釜底液中回收乳酸的方法 | |
| KR102006614B1 (ko) | 프로피오네이트 생성물의 제조 방법 | |
| CN104974032B (zh) | 一种从d‑乳酸钠发酵液中分离提取d‑乳酸的方法 | |
| US12018312B2 (en) | Purification of magnesium lactate from fermentation broths having high amounts of impurities | |
| CN113045610B (zh) | 一种从n-乙酰氨基葡萄糖发酵液中提取氨基葡萄糖的方法 | |
| CN113912475B (zh) | 一种赤藓糖醇晶体的制备方法 | |
| CN116829529B (zh) | 高纯度l-乳酸镁的结晶 | |
| HK40099618A (en) | Crystallization of high-purity magnesium l-lactate | |
| CN119930403B (zh) | 一种赤藓糖醇结晶后废母液的回收利用方法 | |
| JP3321984B2 (ja) | 蛋白塩酸加水分解物製造工程での改善された食塩分離法 | |
| CN119191970A (zh) | 一种l-乳酸发酵液中菌丝体分离和乳酸净化的方法 | |
| HK40057696A (en) | Purification of magnesium lactate from fermentation broths having high amounts of impurities | |
| CN119431174A (zh) | 一种高纯度谷氨酸的提取方法 | |
| CN120192239A (zh) | 异亮氨酸发酵液的提纯方法 | |
| WO2024228199A1 (en) | Processes for the production of lactic acid with concurrent recovery and reuse of by-products thereof | |
| CN117986142A (zh) | 一种提早预警谷氨酸β结晶并改善结晶的方法 | |
| CN116969813A (zh) | 一种肌醇结晶方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20250115 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20250115 |
|
| A871 | Explanation of circumstances concerning accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A871 Effective date: 20250115 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20250311 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20250604 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20250701 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20250722 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7720646 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |