JP7711092B2 - 大血管閉塞により引き起こされる卒中についてのバイオマーカーとしてのd-ダイマー、グリア線維酸性タンパク質(gfap)、オステオプロテジェリン(opg)及びオステオポンチン(opn) - Google Patents
大血管閉塞により引き起こされる卒中についてのバイオマーカーとしてのd-ダイマー、グリア線維酸性タンパク質(gfap)、オステオプロテジェリン(opg)及びオステオポンチン(opn)Info
- Publication number
- JP7711092B2 JP7711092B2 JP2022563013A JP2022563013A JP7711092B2 JP 7711092 B2 JP7711092 B2 JP 7711092B2 JP 2022563013 A JP2022563013 A JP 2022563013A JP 2022563013 A JP2022563013 A JP 2022563013A JP 7711092 B2 JP7711092 B2 JP 7711092B2
- Authority
- JP
- Japan
- Prior art keywords
- stroke
- lvo
- individual
- biomarkers
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/02—Spray pistols; Apparatus for discharge
- B05B7/08—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point
- B05B7/0807—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point to form intersecting jets
- B05B7/0815—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point to form intersecting jets with at least one gas jet intersecting a jet constituted by a liquid or a mixture containing a liquid for controlling the shape of the latter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/02—Spray pistols; Apparatus for discharge
- B05B7/08—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point
- B05B7/0884—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point the outlet orifices for jets constituted by a liquid or a mixture containing a liquid being aligned
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
- D04H1/425—Cellulose series
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
- D04H1/4266—Natural fibres not provided for in group D04H1/425
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/54—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving
- D04H1/552—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving by applying solvents or auxiliary agents
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/58—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by applying, incorporating or activating chemical or thermoplastic bonding agents, e.g. adhesives
- D04H1/64—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by applying, incorporating or activating chemical or thermoplastic bonding agents, e.g. adhesives the bonding agent being applied in wet state, e.g. chemical agents in dispersions or solutions
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/58—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by applying, incorporating or activating chemical or thermoplastic bonding agents, e.g. adhesives
- D04H1/64—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by applying, incorporating or activating chemical or thermoplastic bonding agents, e.g. adhesives the bonding agent being applied in wet state, e.g. chemical agents in dispersions or solutions
- D04H1/645—Impregnation followed by a solidification process
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/58—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by applying, incorporating or activating chemical or thermoplastic bonding agents, e.g. adhesives
- D04H1/64—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by applying, incorporating or activating chemical or thermoplastic bonding agents, e.g. adhesives the bonding agent being applied in wet state, e.g. chemical agents in dispersions or solutions
- D04H1/655—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by applying, incorporating or activating chemical or thermoplastic bonding agents, e.g. adhesives the bonding agent being applied in wet state, e.g. chemical agents in dispersions or solutions characterised by the apparatus for applying bonding agents
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
- D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
- D04H1/732—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by fluid current, e.g. air-lay
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30 CD40 or CD95
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G01N2333/75—Fibrin; Fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2871—Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Textile Engineering (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2005632.1 | 2020-04-17 | ||
| GB2005632.1A GB2594094A (en) | 2020-04-17 | 2020-04-17 | Method for diagnosing stroke caused by large vessel occlusion |
| PCT/GB2020/053340 WO2021209732A1 (en) | 2020-04-17 | 2020-12-22 | D-dimer, glial fibrillary acidic protein (gfap), osteoprotegerin (opg) and osteopontin (opn) as biomarkers for stroke caused by large vessel occlusion |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023522066A JP2023522066A (ja) | 2023-05-26 |
| JP2023522066A5 JP2023522066A5 (cg-RX-API-DMAC7.html) | 2024-01-04 |
| JP7711092B2 true JP7711092B2 (ja) | 2025-07-22 |
Family
ID=70860060
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022563013A Active JP7711092B2 (ja) | 2020-04-17 | 2020-12-22 | 大血管閉塞により引き起こされる卒中についてのバイオマーカーとしてのd-ダイマー、グリア線維酸性タンパク質(gfap)、オステオプロテジェリン(opg)及びオステオポンチン(opn) |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11726100B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP4136458A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7711092B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20230004594A (cg-RX-API-DMAC7.html) |
| GB (3) | GB2594094A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2021209732A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220381794A1 (en) * | 2019-05-16 | 2022-12-01 | Fundació Hospital Universitari Vall D'hebron - Institut De Recerca | Method for selecting a patient for a reperfusion therapy |
| GB2594094A (en) * | 2020-04-17 | 2021-10-20 | Pockit Diagnostics Ltd | Method for diagnosing stroke caused by large vessel occlusion |
| US20240192231A1 (en) * | 2021-04-15 | 2024-06-13 | Fundació Hospital Universitari Vall D'hebron - Institut De Recerca | Markers for the diagnosis of large vessel occlusion |
| KR20250004423A (ko) * | 2023-06-29 | 2025-01-08 | 프리시젼바이오 주식회사 | 허혈성 뇌졸증 진단용 분석장치 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070005261A1 (en) | 2003-09-23 | 2007-01-04 | Joaquin Serena | Cellular fibronectin as a diagnostic marker in stroke and methods of use thereof |
| US20120040858A1 (en) | 2010-08-13 | 2012-02-16 | Morehouse School Of Medicine | Biomarkers for stroke |
| JP2016521850A (ja) | 2013-06-04 | 2016-07-25 | ランドックス ラボラトリーズ リミテッド | 脳卒中の鑑別診断を支援する方法 |
| US20200011880A1 (en) | 2018-07-09 | 2020-01-09 | Wright State University | Identification and analysis of protein biomarkers |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5660985A (en) | 1990-06-11 | 1997-08-26 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands containing modified nucleotides |
| US5707796A (en) | 1990-06-11 | 1998-01-13 | Nexstar Pharmaceuticals, Inc. | Method for selecting nucleic acids on the basis of structure |
| US5567588A (en) | 1990-06-11 | 1996-10-22 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: Solution SELEX |
| US5496938A (en) | 1990-06-11 | 1996-03-05 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands to HIV-RT and HIV-1 rev |
| US6011020A (en) | 1990-06-11 | 2000-01-04 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand complexes |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| US5683867A (en) | 1990-06-11 | 1997-11-04 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: blended SELEX |
| US5637459A (en) | 1990-06-11 | 1997-06-10 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chimeric selex |
| ES2259800T3 (es) | 1990-06-11 | 2006-10-16 | Gilead Sciences, Inc. | Procedimientos de uso de ligandos de acido nucleico. |
| EP1058736A1 (en) * | 1998-02-24 | 2000-12-13 | University Of Notre Dame Du Lac | Use of succinate as a diagnostic tool |
| WO2012009567A2 (en) * | 2010-07-15 | 2012-01-19 | The Regents Of The University Of California | Biomarkers for diagnosis of stroke and its causes |
| EP3029466A1 (en) * | 2014-12-03 | 2016-06-08 | Fundació Hospital Universitari Vall d' Hebron - Institut de Recerca | Methods for differentiating ischemic stroke from hemorrhagic stroke |
| US20220381794A1 (en) * | 2019-05-16 | 2022-12-01 | Fundació Hospital Universitari Vall D'hebron - Institut De Recerca | Method for selecting a patient for a reperfusion therapy |
| GB2594094A (en) | 2020-04-17 | 2021-10-20 | Pockit Diagnostics Ltd | Method for diagnosing stroke caused by large vessel occlusion |
-
2020
- 2020-04-17 GB GB2005632.1A patent/GB2594094A/en not_active Withdrawn
- 2020-12-22 WO PCT/GB2020/053340 patent/WO2021209732A1/en not_active Ceased
- 2020-12-22 GB GB2407291.0A patent/GB2627388B/en active Active
- 2020-12-22 GB GB2200967.4A patent/GB2600844B/en active Active
- 2020-12-22 JP JP2022563013A patent/JP7711092B2/ja active Active
- 2020-12-22 KR KR1020227039385A patent/KR20230004594A/ko active Pending
- 2020-12-22 EP EP20838261.4A patent/EP4136458A1/en active Pending
-
2022
- 2022-09-22 US US17/934,454 patent/US11726100B2/en active Active
-
2023
- 2023-06-01 US US18/327,243 patent/US12584925B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070005261A1 (en) | 2003-09-23 | 2007-01-04 | Joaquin Serena | Cellular fibronectin as a diagnostic marker in stroke and methods of use thereof |
| US20120040858A1 (en) | 2010-08-13 | 2012-02-16 | Morehouse School Of Medicine | Biomarkers for stroke |
| JP2016521850A (ja) | 2013-06-04 | 2016-07-25 | ランドックス ラボラトリーズ リミテッド | 脳卒中の鑑別診断を支援する方法 |
| US20200011880A1 (en) | 2018-07-09 | 2020-01-09 | Wright State University | Identification and analysis of protein biomarkers |
Non-Patent Citations (9)
| Title |
|---|
| Baburhan GULDIKEN et al.,Serum osteoprotegerin levels in patients with acute atherothrombotic stroke and lacunar infarct,Thrombosis Research,2007年01月25日,Vol.120, No.4,pp.511-516 |
| Christian FOERCH et al.,Diagnostic Accuracy of Plasma Glial Fibrillary Acidic Protein for Differentiating Intracerebral Hemorrhage and Cerebral Ischemia in Patients with Symptoms of Acute Stroke,Clinical Chemistry,2012年01月01日,Vol.56, No.1,pp.237-245 |
| David SKOLOUDIK et al.,D-dimer increase in acute ischemic stroke patients with the large artery occlusion, but do not depend on the time of artery recanalization,Journal of Thrombosis and Thrombolysis,2009年07月01日,Vol.29,pp.477-482 |
| M Ustundag et al.,The role of serum osteoprotegerin and S-100 protein levels in patients with acute ischaemic stroke determination of stroke subtype,severity and mortality, Journal of International Medical Research,2011年06月01日,Vol.39, No.3,pp.780-789 |
| Olena Y GLUSHAKOVA et al.,Biomarkers for acute diagnosis and management of stroke in neurointensive care units,Brain Circulation,2016年01月,Vol.2, No.1,pp.28-47 |
| OZAKI Saya et al.,Plasma thrombin-cleaved osteopontin as a potential biomarker of acute atherothrombotic ischemic stroke,Hypertension Research,2016年08月25日,Vol.40,pp.61-66 |
| Raf BROUNS et al.,Clinical and biochemical diagnosis of small-vessel disease in acute ischemic stroke,Journal of the Neurological Sciences,2009年07月19日,Vol.285,pp.185-190 |
| Sarkar PK et al.,STUDY ON PLASMA D-DIMER FOR EARLY DIAGNOSIS OF ISCHEMIC STROKE,Journal of Dhaka Medical College,2016年09月15日,Vol.24, No.2,pp.117-125 |
| Se-A AN et al.,Limited clinical value of multiple blood markers in the diagnosis of ischemic stroke,Clinical Biochemistry,2013年02月24日,Vol.46, No.9,pp.710-715 |
Also Published As
| Publication number | Publication date |
|---|---|
| US12584925B2 (en) | 2026-03-24 |
| GB2600844B (en) | 2024-07-17 |
| GB2627388B (en) | 2025-02-12 |
| GB2627388A8 (en) | 2024-12-11 |
| WO2021209732A1 (en) | 2021-10-21 |
| GB2600844A (en) | 2022-05-11 |
| US11726100B2 (en) | 2023-08-15 |
| GB202005632D0 (en) | 2020-06-03 |
| GB202200967D0 (en) | 2022-03-09 |
| GB2594094A (en) | 2021-10-20 |
| US20230048418A1 (en) | 2023-02-16 |
| GB202407291D0 (en) | 2024-07-03 |
| KR20230004594A (ko) | 2023-01-06 |
| EP4136458A1 (en) | 2023-02-22 |
| US20230393154A1 (en) | 2023-12-07 |
| JP2023522066A (ja) | 2023-05-26 |
| GB2627388A (en) | 2024-08-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7711092B2 (ja) | 大血管閉塞により引き起こされる卒中についてのバイオマーカーとしてのd-ダイマー、グリア線維酸性タンパク質(gfap)、オステオプロテジェリン(opg)及びオステオポンチン(opn) | |
| Dambinova et al. | Blood test detecting autoantibodies to N-methyl-D-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke | |
| KR101678703B1 (ko) | 갈렉틴-3 면역검정 | |
| CN114041058B (zh) | 对于再灌注疗法选择患者的方法 | |
| JP6639392B2 (ja) | 胎盤成長因子2の選択的測定法 | |
| JP2013501919A (ja) | 脳脊髄液の免疫的識別のための装置および方法 | |
| JP2014525593A (ja) | 心臓血管リスクを予測するための診断分析 | |
| CN107667294A (zh) | 用于预测慢性肾病发生风险的方法 | |
| JP2018523092A (ja) | 星状細胞トラウマトーム(traumatome)および神経外傷のバイオマーカー | |
| US20080183062A1 (en) | Method of Distinguishing Among Type a and Type B Acute Aortic Dissection and Acute Myocardial Infraction and Kit For Distinguishment | |
| EP3545311A1 (en) | Gfap derivatives for stroke diagnostics | |
| US20250035646A1 (en) | Biomarkers for prognosis of early onset preeclampsia | |
| CN111065922A (zh) | 肾上腺髓质素原作为危重病患者的肾脏替代治疗的指标 | |
| US20130252265A1 (en) | Method for testing for cerebral infarction via cartilage acidic protein 1 | |
| US9182413B2 (en) | Methods and devices for diagnosing cardiac disorders | |
| JP2016223774A (ja) | リンパ球性漏斗下垂体後葉炎検査試薬及びその用途 | |
| EP3311164A1 (en) | Methods and compositions for diagnosis and prognosis of appendicitis and differentiation of causes of abdominal pain | |
| WO2019164007A1 (ja) | 特発性側弯症マーカー | |
| WO2024121392A1 (en) | Multiple sflt-1 measurements for prognosis of early onset preeclampsia | |
| JP2024099260A (ja) | 骨強度の低下を伴う疾患検査用バイオマーカー | |
| CN117007819A (zh) | 用于辅助诊断阿尔茨海默病的试剂盒 | |
| WO2011143412A1 (en) | Methods for the detection and monitoring of acute myocardial infarction | |
| HK40029189A (en) | Proadrenomedullin as indicator for renal replacement therapy in critically ill patients |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20231221 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20231221 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20241021 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20241105 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20250205 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20250325 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20250617 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20250709 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7711092 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |