JP7692633B2 - メモリーｔ細胞の製造方法 - Google Patents

メモリーｔ細胞の製造方法 Download PDF

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JP7692633B2
JP7692633B2 JP2023518703A JP2023518703A JP7692633B2 JP 7692633 B2 JP7692633 B2 JP 7692633B2 JP 2023518703 A JP2023518703 A JP 2023518703A JP 2023518703 A JP2023518703 A JP 2023518703A JP 7692633 B2 JP7692633 B2 JP 7692633B2
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cells
naive
memory
differentiation
cell
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JPWO2022234856A5 (https=
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康人 徳元
俊英 三村
靖人 荒木
晋 大島
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0635—B lymphocytes
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/02—Atmosphere, e.g. low oxygen conditions
    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2302—Interleukin-2 (IL-2)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2304—Interleukin-4 (IL-4)
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2306—Interleukin-6 (IL-6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
    • C12N2506/115—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells from monocytes, from macrophages

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2023518703A 2021-05-07 2022-05-06 メモリーｔ細胞の製造方法 Active JP7692633B2 (ja)

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JP2021079296 2021-05-07
JP2021079296 2021-05-07
PCT/JP2022/019563 WO2022234856A1 (ja) 2021-05-07 2022-05-06 メモリーｔ細胞の製造方法

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JPWO2022234856A1 JPWO2022234856A1 (https=) 2022-11-10
JPWO2022234856A5 JPWO2022234856A5 (https=) 2024-02-09
JP7692633B2 true JP7692633B2 (ja) 2025-06-16

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160250248A1 (en) 2013-03-18 2016-09-01 Northeastern University Method for generation of broadly neutralizing anti-pathogen antibodies
WO2020081987A1 (en) 2018-10-18 2020-04-23 Board Of Regents The University Of Texas System Methods for production of tissue resident memory-like t cells and use thereof
US20200188435A1 (en) 2018-11-08 2020-06-18 Nexlmmune, Inc. T cell compositions with improved phenotypic properties
JP2020534313A (ja) 2017-09-20 2020-11-26 ネクシミューン インコーポレイテッド 養子療法のための抗原特異的ｔ細胞を含む細胞組成物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021079296A (ja) 2021-03-08 2021-05-27 株式会社三洋物産 遊技機

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160250248A1 (en) 2013-03-18 2016-09-01 Northeastern University Method for generation of broadly neutralizing anti-pathogen antibodies
JP2020534313A (ja) 2017-09-20 2020-11-26 ネクシミューン インコーポレイテッド 養子療法のための抗原特異的ｔ細胞を含む細胞組成物
WO2020081987A1 (en) 2018-10-18 2020-04-23 Board Of Regents The University Of Texas System Methods for production of tissue resident memory-like t cells and use thereof
US20200188435A1 (en) 2018-11-08 2020-06-18 Nexlmmune, Inc. T cell compositions with improved phenotypic properties

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NGUYEN DC. et al.，Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin sec，Nat Commun.，2018年，9:3698，pp.1-12，doi:10.1038/s41467-018-05853-7

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WO2022234856A1 (ja) 2022-11-10
US20240368545A1 (en) 2024-11-07
EP4321613A4 (en) 2025-04-23
EP4321613A1 (en) 2024-02-14
JPWO2022234856A1 (https=) 2022-11-10

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