JP7690284B2 - Ｉｄｏ阻害剤の非晶質形態および結晶形態 - Google Patents

Ｉｄｏ阻害剤の非晶質形態および結晶形態 Download PDF

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Publication number
JP7690284B2
JP7690284B2 JP2020500206A JP2020500206A JP7690284B2 JP 7690284 B2 JP7690284 B2 JP 7690284B2 JP 2020500206 A JP2020500206 A JP 2020500206A JP 2020500206 A JP2020500206 A JP 2020500206A JP 7690284 B2 JP7690284 B2 JP 7690284B2
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Japan
Prior art keywords
compound
free base
cancer
fluoroquinolin
amorphous
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Japanese (ja)
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JP2020526520A (ja
JP2020526520A5 (enExample
Inventor
ジェイ・パトリック・パワーズ
ヒラリー・プレイク・ベック
マクシム・オシポフ
モーリーン・ケイ・ライリー
ハンター・ポール・シュナトナ
ジェイムズ・ロス・ウォーカー
ミハイル・ジビンスキー
タマル・ローゼンバウム
イアン・スコット・ヤング
ジェニファー・ネルソン
ペティンカ・ブラホバ
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of JP2020526520A5 publication Critical patent/JP2020526520A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2020500206A 2017-06-30 2018-06-29 Ｉｄｏ阻害剤の非晶質形態および結晶形態 Active JP7690284B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762527855P 2017-06-30 2017-06-30
US62/527,855 2017-06-30
PCT/US2018/040262 WO2019006283A1 (en) 2017-06-30 2018-06-29 AMORPHOUS AND CRYSTALLINE FORMS OF IDO INHIBITORS

Publications (3)

Publication Number Publication Date
JP2020526520A JP2020526520A (ja) 2020-08-31
JP2020526520A5 JP2020526520A5 (enExample) 2025-03-14
JP7690284B2 true JP7690284B2 (ja) 2025-06-10

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JP2020500206A Active JP7690284B2 (ja) 2017-06-30 2018-06-29 Ｉｄｏ阻害剤の非晶質形態および結晶形態

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Country Link
US (2) US11236049B2 (enExample)
EP (1) EP3644993B1 (enExample)
JP (1) JP7690284B2 (enExample)
KR (1) KR102630575B1 (enExample)
CN (1) CN111093651B (enExample)
AU (1) AU2018294314B2 (enExample)
CA (1) CA3066789A1 (enExample)
EA (1) EA202090119A1 (enExample)
IL (1) IL271601B2 (enExample)
MX (2) MX391848B (enExample)
SG (1) SG11201911937UA (enExample)
WO (1) WO2019006283A1 (enExample)

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WO2019006292A1 (en) * 2017-06-30 2019-01-03 Bristol-Myers Squibb Company SUBSTITUTED QUINOLINYCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED PROCESSES FOR THE PREPARATION THEREOF
EP3711387B1 (en) * 2017-11-17 2024-06-26 Telefonaktiebolaget LM Ericsson (publ) Signaling ta-offset in nr
CN110357813A (zh) * 2018-04-09 2019-10-22 信达生物制药(苏州)有限公司 一种新型吲哚胺2,3-双加氧酶抑制剂及其制备方法和用途
CN110869351B (zh) 2018-06-27 2022-03-18 深圳仁泰医药科技有限公司 (r)-n-(4-氯苯基)-2-(顺-4-(6-氟喹啉-4-基)环己基)丙酰胺的晶型
CN114641278A (zh) * 2019-09-11 2022-06-17 百时美施贵宝公司 吲哚胺2,3-双加氧酶抑制剂的药物配制品
CA3159071A1 (en) * 2019-11-26 2021-06-03 Tamar I. ROSENBAUM Salts/cocrystals of (r)-n-(4-chlorophenyl)-2-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide
AR120935A1 (es) * 2020-01-02 2022-03-30 Hutchison Medipharma Ltd Derivados de amida y usos de los mismos

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Also Published As

Publication number Publication date
BR112019027259A2 (pt) 2020-07-14
JP2020526520A (ja) 2020-08-31
EP3644993B1 (en) 2023-08-02
MX391848B (es) 2025-03-19
WO2019006283A1 (en) 2019-01-03
KR20200020916A (ko) 2020-02-26
MX2021015656A (es) 2022-02-03
EP3644993A1 (en) 2020-05-06
IL271601A (en) 2020-02-27
SG11201911937UA (en) 2020-01-30
AU2018294314B2 (en) 2024-09-19
IL271601B2 (en) 2024-05-01
EP3644993A4 (en) 2021-03-10
US11236049B2 (en) 2022-02-01
CA3066789A1 (en) 2019-01-03
MX2019014885A (es) 2020-02-13
CN111093651B (zh) 2023-06-06
US20200115342A1 (en) 2020-04-16
US12421195B2 (en) 2025-09-23
AU2018294314A1 (en) 2020-02-06
CN111093651A (zh) 2020-05-01
KR102630575B1 (ko) 2024-01-29
IL271601B1 (en) 2024-01-01
EA202090119A1 (ru) 2020-04-21
US20220169615A1 (en) 2022-06-02

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