JP7680999B2 - サイクリン依存性キナーゼ７のインヒビターおよびそれらの使用 - Google Patents

サイクリン依存性キナーゼ７のインヒビターおよびそれらの使用 Download PDF

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JP7680999B2
JP7680999B2 JP2022504701A JP2022504701A JP7680999B2 JP 7680999 B2 JP7680999 B2 JP 7680999B2 JP 2022504701 A JP2022504701 A JP 2022504701A JP 2022504701 A JP2022504701 A JP 2022504701A JP 7680999 B2 JP7680999 B2 JP 7680999B2
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JPWO2021016388A5 (https=
JP2022541644A (ja
JP2022541644A5 (https=
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チャン，ティンフー
クィアトコウスキ，ニコラス，ポール
グレイ，ナサナエル，エス．
ヘ，ジーシャン
リアン，ヤンケ
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ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2022504701A 2019-07-23 2020-07-22 サイクリン依存性キナーゼ７のインヒビターおよびそれらの使用 Active JP7680999B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962877788P 2019-07-23 2019-07-23
US62/877,788 2019-07-23
PCT/US2020/043132 WO2021016388A1 (en) 2019-07-23 2020-07-22 Inhibitors of cyclin-dependent kinase 7 and uses thereof

Publications (4)

Publication Number Publication Date
JP2022541644A JP2022541644A (ja) 2022-09-26
JPWO2021016388A5 JPWO2021016388A5 (https=) 2023-09-26
JP2022541644A5 JP2022541644A5 (https=) 2023-09-26
JP7680999B2 true JP7680999B2 (ja) 2025-05-21

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ID=74192704

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JP2022504701A Active JP7680999B2 (ja) 2019-07-23 2020-07-22 サイクリン依存性キナーゼ７のインヒビターおよびそれらの使用

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Country Link
US (1) US20230242534A9 (https=)
EP (1) EP4003335A4 (https=)
JP (1) JP7680999B2 (https=)
CN (1) CN114401719A (https=)
AU (1) AU2020319005B2 (https=)
CA (1) CA3147106A1 (https=)
WO (1) WO2021016388A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015371251B2 (en) 2014-12-23 2020-06-11 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
HK1246645A1 (zh) 2015-03-27 2018-09-14 达纳-法伯癌症研究所股份有限公司 细胞周期蛋白依赖性激酶的抑制剂
US12187701B2 (en) 2018-06-25 2025-01-07 Dana-Farber Cancer Institute, Inc. Taire family kinase inhibitors and uses thereof
JP7660063B2 (ja) 2018-12-28 2025-04-10 ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド サイクリン依存性キナーゼ７のインヒビターおよびそれらの使用
US20230114207A1 (en) * 2019-12-24 2023-04-13 Dana-Farber Cancer Institute, Inc. The combination of cyclin dependent kinase 7 inhibitor and immunotherapy for treatment of cancer
KR20240035820A (ko) 2021-07-09 2024-03-18 플렉시움 인코포레이티드 Ikzf2를 조절하는 아릴 화합물 및 약학 조성물
WO2023107705A1 (en) 2021-12-10 2023-06-15 Incyte Corporation Bicyclic amines as cdk12 inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006514026A (ja) 2002-12-19 2006-04-27 ファルマシア・イタリア・エス・ピー・エー キナーゼ抑制物質としてのピロロ−ピラゾール置換誘導体
WO2016201370A1 (en) 2015-06-12 2016-12-15 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
JP2018502098A (ja) 2014-12-23 2018-01-25 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド サイクリン依存性キナーゼ７（ｃｄｋ７）の阻害剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2661883T3 (es) * 2012-07-09 2018-04-04 Novartis Ag Biomarcadores asociados con inhibidores de CDK
HK1246645A1 (zh) * 2015-03-27 2018-09-14 达纳-法伯癌症研究所股份有限公司 细胞周期蛋白依赖性激酶的抑制剂

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006514026A (ja) 2002-12-19 2006-04-27 ファルマシア・イタリア・エス・ピー・エー キナーゼ抑制物質としてのピロロ−ピラゾール置換誘導体
JP2018502098A (ja) 2014-12-23 2018-01-25 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド サイクリン依存性キナーゼ７（ｃｄｋ７）の阻害剤
WO2016201370A1 (en) 2015-06-12 2016-12-15 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Mei Zeng et al，eLIFE，2018年，7，39030-39049

Also Published As

Publication number Publication date
EP4003335A4 (en) 2024-01-10
AU2020319005A1 (en) 2021-12-23
JP2022541644A (ja) 2022-09-26
AU2020319005B2 (en) 2026-01-08
US20230242534A9 (en) 2023-08-03
WO2021016388A1 (en) 2021-01-28
CA3147106A1 (en) 2021-01-28
EP4003335A1 (en) 2022-06-01
CN114401719A (zh) 2022-04-26
US20220281874A1 (en) 2022-09-08

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