CN114401719A - 细胞周期蛋白依赖性激酶7的抑制剂及其用途 - Google Patents

细胞周期蛋白依赖性激酶7的抑制剂及其用途 Download PDF

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Publication number
CN114401719A
CN114401719A CN202080052924.XA CN202080052924A CN114401719A CN 114401719 A CN114401719 A CN 114401719A CN 202080052924 A CN202080052924 A CN 202080052924A CN 114401719 A CN114401719 A CN 114401719A
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substituted
compound
unsubstituted
pharmaceutically acceptable
certain embodiments
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English (en)
Chinese (zh)
Inventor
T.张
N.P.克维亚特科夫斯基
N.S.格雷
Z.何
Y.梁
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202080052924.XA 2019-07-23 2020-07-22 细胞周期蛋白依赖性激酶7的抑制剂及其用途 Pending CN114401719A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962877788P 2019-07-23 2019-07-23
US62/877,788 2019-07-23
PCT/US2020/043132 WO2021016388A1 (en) 2019-07-23 2020-07-22 Inhibitors of cyclin-dependent kinase 7 and uses thereof

Publications (1)

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CN114401719A true CN114401719A (zh) 2022-04-26

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CN202080052924.XA Pending CN114401719A (zh) 2019-07-23 2020-07-22 细胞周期蛋白依赖性激酶7的抑制剂及其用途

Country Status (7)

Country Link
US (1) US20230242534A9 (https=)
EP (1) EP4003335A4 (https=)
JP (1) JP7680999B2 (https=)
CN (1) CN114401719A (https=)
AU (1) AU2020319005B2 (https=)
CA (1) CA3147106A1 (https=)
WO (1) WO2021016388A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015371251B2 (en) 2014-12-23 2020-06-11 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
HK1246645A1 (zh) 2015-03-27 2018-09-14 达纳-法伯癌症研究所股份有限公司 细胞周期蛋白依赖性激酶的抑制剂
US12187701B2 (en) 2018-06-25 2025-01-07 Dana-Farber Cancer Institute, Inc. Taire family kinase inhibitors and uses thereof
JP7660063B2 (ja) 2018-12-28 2025-04-10 ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド サイクリン依存性キナーゼ７のインヒビターおよびそれらの使用
US20230114207A1 (en) * 2019-12-24 2023-04-13 Dana-Farber Cancer Institute, Inc. The combination of cyclin dependent kinase 7 inhibitor and immunotherapy for treatment of cancer
KR20240035820A (ko) 2021-07-09 2024-03-18 플렉시움 인코포레이티드 Ikzf2를 조절하는 아릴 화합물 및 약학 조성물
WO2023107705A1 (en) 2021-12-10 2023-06-15 Incyte Corporation Bicyclic amines as cdk12 inhibitors

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1726217A (zh) * 2002-12-19 2006-01-25 法玛西雅意大利公司 用作激酶抑制剂的取代的吡咯并吡唑衍生物
CN104487594A (zh) * 2012-07-09 2015-04-01 诺华股份有限公司 与cdk抑制剂相关的生物标志物
CN107427521A (zh) * 2015-03-27 2017-12-01 达纳-法伯癌症研究所股份有限公司 细胞周期蛋白依赖性激酶的抑制剂
US20190055248A1 (en) * 2014-12-23 2019-02-21 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclindependent kinase 7 (cdk7)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10702527B2 (en) * 2015-06-12 2020-07-07 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1726217A (zh) * 2002-12-19 2006-01-25 法玛西雅意大利公司 用作激酶抑制剂的取代的吡咯并吡唑衍生物
US20070004705A1 (en) * 2002-12-19 2007-01-04 Brasca Maria G Substituted pyrrolo-pyrazole derivatives as kinase inhibitors
CN104487594A (zh) * 2012-07-09 2015-04-01 诺华股份有限公司 与cdk抑制剂相关的生物标志物
US20150322528A1 (en) * 2012-07-09 2015-11-12 Novartis Ag Biomarkers associated with cdk inhibitors
US20190055248A1 (en) * 2014-12-23 2019-02-21 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclindependent kinase 7 (cdk7)
CN107427521A (zh) * 2015-03-27 2017-12-01 达纳-法伯癌症研究所股份有限公司 细胞周期蛋白依赖性激酶的抑制剂

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JP7680999B2 (ja) 2025-05-21
EP4003335A4 (en) 2024-01-10
AU2020319005A1 (en) 2021-12-23
JP2022541644A (ja) 2022-09-26
AU2020319005B2 (en) 2026-01-08
US20230242534A9 (en) 2023-08-03
WO2021016388A1 (en) 2021-01-28
CA3147106A1 (en) 2021-01-28
EP4003335A1 (en) 2022-06-01
US20220281874A1 (en) 2022-09-08

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