JP7676361B2 - オルガノイド組成物を作製するための改良された方法 - Google Patents

オルガノイド組成物を作製するための改良された方法 Download PDF

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JP7676361B2
JP7676361B2 JP2022507745A JP2022507745A JP7676361B2 JP 7676361 B2 JP7676361 B2 JP 7676361B2 JP 2022507745 A JP2022507745 A JP 2022507745A JP 2022507745 A JP2022507745 A JP 2022507745A JP 7676361 B2 JP7676361 B2 JP 7676361B2
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endoderm
aggregates
organoids
aggregated
gut
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JP2022544175A (ja
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ノーマン メイヒュー、クリストファー
マコーマック ウェルズ、ジェームズ
リー ピットスティック、エイミー
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Cincinnati Childrens Hospital Medical Center
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JP2022507745A 2019-08-13 2020-08-11 オルガノイド組成物を作製するための改良された方法 Active JP7676361B2 (ja)

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US201962885903P 2019-08-13 2019-08-13
US62/885,903 2019-08-13
PCT/US2020/045809 WO2021030373A1 (en) 2019-08-13 2020-08-11 Improved methods for making organoid compositions

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CN (1) CN114502721A (https=)
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US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
SG10201801654RA (en) 2014-05-28 2018-04-27 Childrens Hospital Med Ct Methods and systems for converting precursor cells into gastric tissues through directed differentiation
EP4553082A3 (en) 2016-11-04 2025-08-20 Children's Hospital Medical Center Liver organoid compositions and methods of making and using same
JP7248586B2 (ja) 2017-04-14 2023-03-29 チルドレンズ ホスピタル メディカル センター 複数ドナー幹細胞組成物およびそれを作製する方法
EP3694603B1 (en) 2017-10-10 2026-04-08 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
EP4678727A3 (en) 2018-07-26 2026-03-11 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
CA3112026A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
US12600943B2 (en) 2019-02-01 2026-04-14 The University Of Hong Kong Innervated organoid compositions and methods of making same
US12497597B2 (en) 2019-05-31 2025-12-16 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
AU2020283048A1 (en) 2019-05-31 2021-12-23 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
WO2023278676A1 (en) * 2021-07-02 2023-01-05 Children’S Hospital Medical Center Structurally complete organoids
EP4388083A4 (en) * 2021-08-19 2025-07-09 Childrens Hospital Med Ct VASCULARIZED ORGANOIDS
CN114317415B (zh) * 2022-03-07 2022-06-03 天九再生医学(天津)科技有限公司 人多能干细胞向多谱系大肠类器官定向分化的方法
EP4562127A1 (en) * 2022-07-29 2025-06-04 Children's Hospital Medical Center Population-scale organoid pools
EP4580691A1 (en) * 2022-09-22 2025-07-09 Children's Hospital Medical Center Organoid compositions having immune cells
CN119968460A (zh) * 2022-09-27 2025-05-09 庆应义塾 用于在不存在细胞外基质的条件下培养类器官的药物
WO2024206911A2 (en) 2023-03-30 2024-10-03 Children's Hospital Medical Center Clinical-grade organoids
WO2024238977A2 (en) 2023-05-18 2024-11-21 Children's Hospital Medical Center Liver organoids with intrahepatic sympathetic nerves, and methods of use thereof
EP4731750A2 (en) 2023-06-23 2026-04-29 Children's Hospital Medical Center Methods of matrix-free suspension culture
WO2025072803A1 (en) 2023-09-29 2025-04-03 Children's Hospital Medical Center Ntrk2 signaling-mediated alveolar capillary injury and repair
WO2025212920A1 (en) 2024-04-03 2025-10-09 Children's Hospital Medical Center Multi-zonal liver organoids
WO2025217202A1 (en) 2024-04-08 2025-10-16 Children's Hospital Medical Center Bile duct organoid
WO2026015589A1 (en) * 2024-07-09 2026-01-15 Children's Hospital Medical Center Pancreatic organoids and uses thereof

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US20180258400A1 (en) 2015-09-15 2018-09-13 Agency For Science, Technology And Research (A*Star) Derivation of liver organoids from human pluripotent stem cells

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US11898166B2 (en) * 2017-09-20 2024-02-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services In vitro generation of thymic organoid from human pluripotent stem cells

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US20120070419A1 (en) 2010-03-25 2012-03-22 International Stem Cell Corporation Method of altering the differentiative state of a cell and compositions thereof
US20180258400A1 (en) 2015-09-15 2018-09-13 Agency For Science, Technology And Research (A*Star) Derivation of liver organoids from human pluripotent stem cells

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CN114502721A (zh) 2022-05-13
EP4013853A4 (en) 2023-08-23
JP2025128081A (ja) 2025-09-02
JP2022544175A (ja) 2022-10-17
WO2021030373A1 (en) 2021-02-18
CA3149805A1 (en) 2021-02-18
US20220275345A1 (en) 2022-09-01
IL290544A (en) 2022-04-01
EP4013853A1 (en) 2022-06-22
AU2020329194A1 (en) 2022-02-24

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