JP7669399B2 - ナノ細孔支持構造及びその製造 - Google Patents

ナノ細孔支持構造及びその製造 Download PDF

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JP7669399B2
JP7669399B2 JP2022577455A JP2022577455A JP7669399B2 JP 7669399 B2 JP7669399 B2 JP 7669399B2 JP 2022577455 A JP2022577455 A JP 2022577455A JP 2022577455 A JP2022577455 A JP 2022577455A JP 7669399 B2 JP7669399 B2 JP 7669399B2
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nanopore
support structure
well
overhang
aperture
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JP2023531904A (ja
JP2023531904A5 (https=
Inventor
シェ，ピン
ミリス，ジャスティン
ヒーリー，ケン
アンソニー クラーク，ジェイムス
ロバート ハイド，ジェイソン
ケネス ジョン ウィルトシャー，リチャード
エドワード マッケンドリー，ジョナサン
グレイシー，ロバート
ギャビン ブラウン，クライヴ
ペラ，イオアナ
シン サンゲーラ，ガーディアル
ハイランド，マーク
バハモン，ペドロ ミゲル オルティス
デイヴィッド ジャクソン，マーク
レイモンド マケット，ポール
リース デイヴィス，ロドリ
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オックスフォード ナノポール テクノロジーズ ピーエルシー
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/308—Electrodes, e.g. test electrodes; Half-cells at least partially made of carbon
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0896—Nanoscaled

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Nanotechnology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Food Science & Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Electrochemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Exposure And Positioning Against Photoresist Photosensitive Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2022577455A 2020-06-17 2021-04-29 ナノ細孔支持構造及びその製造 Active JP7669399B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202063040455P 2020-06-17 2020-06-17
US63/040,455 2020-06-17
GB2016874.6 2020-10-23
GBGB2016874.6A GB202016874D0 (en) 2020-10-23 2020-10-23 Nanopore support structure and manufacture thereof
GBGB2105787.2A GB202105787D0 (en) 2020-06-17 2021-04-23 Nanopore support structure and manufacture thereof
GB2105787.2 2021-04-23
PCT/GB2021/051029 WO2021255414A1 (en) 2020-06-17 2021-04-29 Nanopore support structure and manufacture thereof

Publications (3)

Publication Number Publication Date
JP2023531904A JP2023531904A (ja) 2023-07-26
JP2023531904A5 JP2023531904A5 (https=) 2024-05-14
JP7669399B2 true JP7669399B2 (ja) 2025-04-28

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JP2022577455A Active JP7669399B2 (ja) 2020-06-17 2021-04-29 ナノ細孔支持構造及びその製造

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US (1) US20230228732A1 (https=)
EP (2) EP4682536A3 (https=)
JP (1) JP7669399B2 (https=)
CN (1) CN115803624A (https=)
GB (2) GB202016874D0 (https=)
WO (1) WO2021255414A1 (https=)

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CN108051578B (zh) 2011-04-04 2020-07-24 哈佛大学校长及研究员协会 通过局部电位测量进行的纳米孔感测
CN112816679B (zh) 2015-02-05 2024-05-28 哈佛大学校长及研究员协会 一种用于感测分子穿过纳米孔的移位的方法
US20250067703A1 (en) * 2021-12-27 2025-02-27 Bgi Shenzhen Membrane forming device and membrane forming method
KR102818274B1 (ko) * 2022-04-22 2025-06-10 울산과학기술원 멤브레인이 형성된 미세유체 채널 제작방법 및 그 미세유체 채널 내부에 멤브레인을 형성하는 장치
GB202302813D0 (en) 2023-02-27 2023-04-12 Oxford Nanopore Tech Plc Nanopore sensor device
GB202302812D0 (en) 2023-02-27 2023-04-12 Oxford Nanopore Tech Plc Nanopore sensor device
GB202302811D0 (en) 2023-02-27 2023-04-12 Oxford Nanopore Tech Plc Nanopore sensor device
GB202302810D0 (en) 2023-02-27 2023-04-12 Oxford Nanopore Tech Plc Nanopore sensor device
WO2025120150A1 (en) * 2023-12-08 2025-06-12 Oxford Nanopore Technologies Plc Methods and apparatus for forming apertures, methods and apparatus for unblocking apertures, methods of sensing molecular entities in apertures, and measurement systems
CN119292003B (zh) * 2024-11-12 2025-07-25 南通华核医疗科技有限公司 一种制备微孔微阀硅橡胶芯片的方法

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Publication number Publication date
EP4682536A2 (en) 2026-01-21
EP4168798A1 (en) 2023-04-26
GB202105787D0 (en) 2021-06-09
EP4682536A3 (en) 2026-03-25
JP2023531904A (ja) 2023-07-26
US20230228732A1 (en) 2023-07-20
CN115803624A (zh) 2023-03-14
GB202016874D0 (en) 2020-12-09
WO2021255414A1 (en) 2021-12-23
EP4168798B1 (en) 2025-08-06

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