JP7665529B2 - ジアミノピリミジン化合物を使用することによって咳を治療する方法 - Google Patents

ジアミノピリミジン化合物を使用することによって咳を治療する方法 Download PDF

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JP7665529B2
JP7665529B2 JP2021564189A JP2021564189A JP7665529B2 JP 7665529 B2 JP7665529 B2 JP 7665529B2 JP 2021564189 A JP2021564189 A JP 2021564189A JP 2021564189 A JP2021564189 A JP 2021564189A JP 7665529 B2 JP7665529 B2 JP 7665529B2
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cough
compound
pharma
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JPWO2020221274A5 (https=
JP2022530890A (ja
JP2022530890A5 (https=
Inventor
ヤンピン チャオ，
ホンジュン ワン，
ファイ ファン，
ユアンユアン ジアン，
フイニン リャン，
ラン アン，
チョウ ラン，
ジン ワン，
リイン チョウ，
ヤンアン リウ，
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Beijing Tide Pharmaceutical Co Ltd
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Beijing Tide Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2021564189A 2019-04-30 2020-04-29 ジアミノピリミジン化合物を使用することによって咳を治療する方法 Active JP7665529B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2019/085180 2019-04-30
CN2019085180 2019-04-30
PCT/CN2020/087686 WO2020221274A1 (zh) 2019-04-30 2020-04-29 二氨基嘧啶类化合物治疗咳嗽的方法

Publications (4)

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JP2022530890A JP2022530890A (ja) 2022-07-04
JPWO2020221274A5 JPWO2020221274A5 (https=) 2023-05-11
JP2022530890A5 JP2022530890A5 (https=) 2023-05-11
JP7665529B2 true JP7665529B2 (ja) 2025-04-21

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JP2021564189A Active JP7665529B2 (ja) 2019-04-30 2020-04-29 ジアミノピリミジン化合物を使用することによって咳を治療する方法

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US (1) US20220211703A1 (https=)
EP (1) EP3960179B1 (https=)
JP (1) JP7665529B2 (https=)
KR (1) KR102935436B1 (https=)
CN (1) CN114007619B (https=)
AU (1) AU2020265327B2 (https=)
BR (1) BR112021021600A2 (https=)
MX (1) MX2021013338A (https=)
SG (1) SG11202111877TA (https=)
TW (1) TWI736243B (https=)
WO (1) WO2020221274A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7207634B2 (ja) 2017-11-01 2023-01-18 ベイジン タイド ファーマシューティカル カンパニー リミテッド Ｐ２ｘ３及び／又はｐ２ｘ２／３受容体アンタゴニスト、それを含む医薬組成物及びその使用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019508445A (ja) 2016-03-14 2019-03-28 アファレント ファーマシューティカルズ インコーポレイテッド ピリミジンおよびそのバリアント、ならびにそのための使用
JP2019510025A (ja) 2016-03-25 2019-04-11 アファレント ファーマシューティカルズ インコーポレイテッド ピリミジンおよびそのバリアント、ならびにそのための使用
JP2021501184A (ja) 2017-11-01 2021-01-14 ベイジン タイド ファーマシューティカル カンパニー リミテッドＢｅｉｊｉｎｇ Ｔｉｄｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． Ｐ２ｘ３及び／又はｐ２ｘ２／３受容体アンタゴニスト、それを含む医薬組成物及びその使用

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
CN1930135B (zh) * 2004-03-05 2011-12-28 弗·哈夫曼-拉罗切有限公司 作为p2x3和p2x2/3拮抗剂的二氨基嘧啶
CA2619919C (en) * 2005-09-01 2014-04-01 F. Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 modulators
AU2007304280B2 (en) 2006-10-04 2013-01-31 F. Hoffmann-La Roche Ag Process for synthesis of phenoxy diaminopyrimidine derivatives
RU2650118C2 (ru) * 2013-08-23 2018-04-09 Афферент Фармасьютикалз Инк. Способ лечения острого, хронического и подострого кашля и непреодолимого желания откашляться
KR20180054843A (ko) * 2015-09-29 2018-05-24 애퍼런트 파마슈티컬스 인크. 기침 치료에 사용하기 위한 디아미노피리미딘 p2x3 및 p2x2/3 수용체 조정제

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019508445A (ja) 2016-03-14 2019-03-28 アファレント ファーマシューティカルズ インコーポレイテッド ピリミジンおよびそのバリアント、ならびにそのための使用
JP2019510025A (ja) 2016-03-25 2019-04-11 アファレント ファーマシューティカルズ インコーポレイテッド ピリミジンおよびそのバリアント、ならびにそのための使用
JP2021501184A (ja) 2017-11-01 2021-01-14 ベイジン タイド ファーマシューティカル カンパニー リミテッドＢｅｉｊｉｎｇ Ｔｉｄｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． Ｐ２ｘ３及び／又はｐ２ｘ２／３受容体アンタゴニスト、それを含む医薬組成物及びその使用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EUR. J. MED. CHEM. -CHIMICA THERAPEUTICA，1977年，12(6)，531-536
Lancet，2015年，385，1198-205

Also Published As

Publication number Publication date
EP3960179A4 (en) 2023-01-25
US20220211703A1 (en) 2022-07-07
CN114007619A (zh) 2022-02-01
SG11202111877TA (en) 2021-11-29
TW202106302A (zh) 2021-02-16
CA3138780A1 (en) 2020-11-05
KR102935436B1 (ko) 2026-03-05
EP3960179A1 (en) 2022-03-02
BR112021021600A2 (pt) 2022-01-04
EP3960179B1 (en) 2026-03-18
CN114007619B (zh) 2024-08-06
MX2021013338A (es) 2022-01-24
TWI736243B (zh) 2021-08-11
AU2020265327B2 (en) 2025-09-11
AU2020265327A1 (en) 2021-12-16
KR20220007620A (ko) 2022-01-18
JP2022530890A (ja) 2022-07-04
WO2020221274A1 (zh) 2020-11-05

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