JP7660960B2 - 標的ヌクレオチド配列の改変のための非天然型ポリヌクレオチド - Google Patents

標的ヌクレオチド配列の改変のための非天然型ポリヌクレオチド Download PDF

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JP7660960B2
JP7660960B2 JP2024551649A JP2024551649A JP7660960B2 JP 7660960 B2 JP7660960 B2 JP 7660960B2 JP 2024551649 A JP2024551649 A JP 2024551649A JP 2024551649 A JP2024551649 A JP 2024551649A JP 7660960 B2 JP7660960 B2 JP 7660960B2
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nucleotide
nucleotides
geo
lna
natural
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貴人 能見
圭子 早見
直紀 井上
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Eurus Therapeutics
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/35—Nature of the modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

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JP2024551649A 2023-04-26 2024-04-26 標的ヌクレオチド配列の改変のための非天然型ポリヌクレオチド Active JP7660960B2 (ja)

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JP2025051903A JP2025092562A (ja) 2023-04-26 2025-03-26 標的ヌクレオチド配列の改変のための非天然型ポリヌクレオチド

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JP2023071927 2023-04-26
JP2023071927 2023-04-26
PCT/JP2024/016395 WO2024225425A1 (ja) 2023-04-26 2024-04-26 標的ヌクレオチド配列の改変のための非天然型ポリヌクレオチド

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JPWO2024225425A1 JPWO2024225425A1 (https=) 2024-10-31
JPWO2024225425A5 JPWO2024225425A5 (https=) 2025-04-02
JP7660960B2 true JP7660960B2 (ja) 2025-04-14

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JP2025051903A Pending JP2025092562A (ja) 2023-04-26 2025-03-26 標的ヌクレオチド配列の改変のための非天然型ポリヌクレオチド

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EP (1) EP4703472A1 (https=)
JP (2) JP7660960B2 (https=)
KR (1) KR20250168544A (https=)
CN (1) CN121443735A (https=)
AU (1) AU2024260090A1 (https=)
IL (1) IL324176A (https=)
WO (1) WO2024225425A1 (https=)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009520495A (ja) 2005-12-22 2009-05-28 キージーン ナムローゼ フェンノートシャップ 改善された標的化ヌクレオチド交換のための代替ヌクレオチド
JP2010530750A (ja) 2007-06-22 2010-09-16 キージーン・エン・フェー 改善された修飾オリゴヌクレオチドを用いた標的ヌクレオチドの交換
JP2011062207A (ja) 2004-07-07 2011-03-31 National Institute Of Agrobiological Sciences 核酸を配列特異的に標識する方法、およびそれを利用した新規核酸検出法
JP2016517273A (ja) 2013-03-14 2016-06-16 ソマロジック, インコーポレイテッドSomaLogic, Inc. Ｉｌ−６に結合するアプタマー及びｉｌ−６介在性状態の治療または診断におけるそれらの使用
JP2020500035A (ja) 2016-11-11 2020-01-09 バイオ−ラド ラボラトリーズ，インコーポレイティド 核酸試料をプロセシングする方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102016035A (zh) * 2006-11-02 2011-04-13 犹他大学研究基金会 可用于等位基因特异pcr的寡聚核苷酸
AU2013266968B2 (en) 2012-05-25 2017-06-29 Emmanuelle CHARPENTIER Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
EP3115457B1 (en) 2014-03-05 2019-10-02 National University Corporation Kobe University Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same
DK3636753T5 (da) 2017-06-08 2024-08-26 Univ Osaka Fremgangsmåde til fremstilling af DNA-redigeret eukaryotisk celle
EP4347818A2 (en) * 2021-06-01 2024-04-10 Arbor Biotechnologies, Inc. Gene editing systems comprising a crispr nuclease and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011062207A (ja) 2004-07-07 2011-03-31 National Institute Of Agrobiological Sciences 核酸を配列特異的に標識する方法、およびそれを利用した新規核酸検出法
JP2009520495A (ja) 2005-12-22 2009-05-28 キージーン ナムローゼ フェンノートシャップ 改善された標的化ヌクレオチド交換のための代替ヌクレオチド
JP2010530750A (ja) 2007-06-22 2010-09-16 キージーン・エン・フェー 改善された修飾オリゴヌクレオチドを用いた標的ヌクレオチドの交換
JP2016517273A (ja) 2013-03-14 2016-06-16 ソマロジック, インコーポレイテッドSomaLogic, Inc. Ｉｌ−６に結合するアプタマー及びｉｌ−６介在性状態の治療または診断におけるそれらの使用
JP2020500035A (ja) 2016-11-11 2020-01-09 バイオ−ラド ラボラトリーズ，インコーポレイティド 核酸試料をプロセシングする方法

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AU2024260090A1 (en) 2025-12-04
IL324176A (en) 2025-12-01
EP4703472A1 (en) 2026-03-04
WO2024225425A1 (ja) 2024-10-31
KR20250168544A (ko) 2025-12-02
JPWO2024225425A1 (https=) 2024-10-31
JP2025092562A (ja) 2025-06-19
CN121443735A (zh) 2026-01-30

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