JP7657792B2 - メラノコルチンサブタイプ－２受容体（ｍｃ２ｒ）アンタゴニストおよびその使用 - Google Patents

メラノコルチンサブタイプ－２受容体（ｍｃ２ｒ）アンタゴニストおよびその使用 Download PDF

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JP7657792B2
JP7657792B2 JP2022525903A JP2022525903A JP7657792B2 JP 7657792 B2 JP7657792 B2 JP 7657792B2 JP 2022525903 A JP2022525903 A JP 2022525903A JP 2022525903 A JP2022525903 A JP 2022525903A JP 7657792 B2 JP7657792 B2 JP 7657792B2
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ethoxy
substituted
bipyridine
trifluoromethyl
unsubstituted
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JP2022553832A (ja
JP2022553832A5 (enExample
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ハン，シャンドン
ヒ キム，ソン
ヂウ，ユンフェイ
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クリネティックス ファーマシューティカルズ，インク．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2022525903A 2019-11-07 2020-10-30 メラノコルチンサブタイプ－２受容体（ｍｃ２ｒ）アンタゴニストおよびその使用 Active JP7657792B2 (ja)

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Application Number Priority Date Filing Date Title
JP2025050448A JP2025109202A (ja) 2019-11-07 2025-03-25 メラノコルチンサブタイプ－２受容体（ｍｃ２ｒ）アンタゴニストおよびその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962932306P 2019-11-07 2019-11-07
US62/932,306 2019-11-07
PCT/US2020/058202 WO2021091788A1 (en) 2019-11-07 2020-10-30 Melanocortin subtype-2 receptor (mc2r) antagonists and uses thereof

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JP2025050448A Division JP2025109202A (ja) 2019-11-07 2025-03-25 メラノコルチンサブタイプ－２受容体（ｍｃ２ｒ）アンタゴニストおよびその使用

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JP2022553832A JP2022553832A (ja) 2022-12-26
JP2022553832A5 JP2022553832A5 (enExample) 2023-11-07
JP7657792B2 true JP7657792B2 (ja) 2025-04-07

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JP2022525903A Active JP7657792B2 (ja) 2019-11-07 2020-10-30 メラノコルチンサブタイプ－２受容体（ｍｃ２ｒ）アンタゴニストおよびその使用
JP2025050448A Pending JP2025109202A (ja) 2019-11-07 2025-03-25 メラノコルチンサブタイプ－２受容体（ｍｃ２ｒ）アンタゴニストおよびその使用

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US (1) US12479825B2 (enExample)
EP (1) EP4054583A4 (enExample)
JP (2) JP7657792B2 (enExample)
WO (1) WO2021091788A1 (enExample)

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Publication number Priority date Publication date Assignee Title
KR102695210B1 (ko) 2018-06-05 2024-08-13 크리네틱스 파마슈티칼스, 인크. 멜라노코르틴 아형-2 수용체(mc2r) 길항제 및 이의 용도
WO2021091788A1 (en) 2019-11-07 2021-05-14 Crinetics Pharmaceuticals, Inc. Melanocortin subtype-2 receptor (mc2r) antagonists and uses thereof
JP7672406B2 (ja) * 2019-12-18 2025-05-07 クリネティックス ファーマシューティカルズ，インク． Ｇｅｍ－二置換ピペリジンメラノコルチンサブタイプ－２受容体（ｍｃ２ｒ）アンタゴニストおよびその使用
JP7651574B2 (ja) 2019-12-23 2025-03-26 クリネティックス ファーマシューティカルズ，インク． スピロ環式ピペリジンメラノコルチンサブタイプ－２受容体（ｍｃ２ｒ）アンタゴニストおよびその使用
BR112023018816A2 (pt) 2021-03-19 2023-10-31 Crinetics Pharmaceuticals Inc Antagonista do receptor de melanocortina subtipo-2 (mc2r) para o tratamento de doença
WO2023219952A1 (en) * 2022-05-10 2023-11-16 Radionetics Oncology, Inc. Melanocortin type 2 receptor (mc2r) targeted therapeutics and uses thereof
AU2024225939A1 (en) 2023-02-23 2025-08-21 Omass Therapeutics Limited Mc2r modulator compounds
GB202302629D0 (en) 2023-02-23 2023-04-12 Omass Therapeutics Ltd MC2R modulator compounds
GB202302618D0 (en) 2023-02-23 2023-04-12 Omass Therapeutics Ltd MC2R modulator compounds
WO2024237266A1 (ja) * 2023-05-16 2024-11-21 株式会社スコヒアファーマ メラノコルチン２型受容体アンタゴニスト
GB202412595D0 (en) 2024-08-28 2024-10-09 Omass Therapeutics Ltd Mc2r modulator compounds
WO2026047337A1 (en) 2024-08-28 2026-03-05 Omass Therapeutics Limited Mc2r modulator compounds
WO2026047334A1 (en) 2024-08-28 2026-03-05 Omass Therapeutics Limited Mc2r modulator compounds

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JP2012500785A (ja) 2008-08-22 2012-01-12 ノバルティス アーゲー Ｃｄｋ阻害剤としてのピロロピリミジン化合物
JP2012501317A (ja) 2008-09-02 2012-01-19 ノイロサーチ アクティーゼルスカブ トリアゾール誘導体、及びそのニコチン性アセチルコリン受容体モジュレーターとしての使用
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JP7359783B2 (ja) 2018-06-05 2023-10-11 クリネティックス ファーマシューティカルズ，インク． メラノコルチンサブタイプ－２受容体（ｍｃ２ｒ）アンタゴニストおよびその使用
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Publication number Publication date
JP2025109202A (ja) 2025-07-24
EP4054583A4 (en) 2023-10-25
JP2022553832A (ja) 2022-12-26
US20230015914A1 (en) 2023-01-19
EP4054583A1 (en) 2022-09-14
US12479825B2 (en) 2025-11-25
WO2021091788A1 (en) 2021-05-14

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