JP7650521B2 - 新規スチリペントール誘導体およびその用途 - Google Patents

新規スチリペントール誘導体およびその用途 Download PDF

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JP7650521B2
JP7650521B2 JP2022539600A JP2022539600A JP7650521B2 JP 7650521 B2 JP7650521 B2 JP 7650521B2 JP 2022539600 A JP2022539600 A JP 2022539600A JP 2022539600 A JP2022539600 A JP 2022539600A JP 7650521 B2 JP7650521 B2 JP 7650521B2
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JPWO2022025242A5 (https=
JPWO2022025242A1 (https=
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剛 井上
渚 佐田
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Okayama University NUC
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Okayama University NUC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2022539600A 2020-07-31 2021-07-30 新規スチリペントール誘導体およびその用途 Active JP7650521B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020129956 2020-07-31
JP2020129956 2020-07-31
PCT/JP2021/028307 WO2022025242A1 (ja) 2020-07-31 2021-07-30 新規スチリペントール誘導体およびその用途

Publications (3)

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JPWO2022025242A1 JPWO2022025242A1 (https=) 2022-02-03
JPWO2022025242A5 JPWO2022025242A5 (https=) 2024-08-06
JP7650521B2 true JP7650521B2 (ja) 2025-03-25

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JP2022539600A Active JP7650521B2 (ja) 2020-07-31 2021-07-30 新規スチリペントール誘導体およびその用途

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US (1) US12516043B2 (https=)
EP (1) EP4190401A4 (https=)
JP (1) JP7650521B2 (https=)
WO (1) WO2022025242A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116930368B (zh) * 2023-07-27 2024-03-29 石家庄四药有限公司 一种司替戊醇异构体的检测方法
CN118045081B (zh) * 2024-02-05 2025-04-08 中山大学孙逸仙纪念医院 司替戊醇在制备抗肿瘤药物中的应用
WO2025229111A1 (en) 2024-05-01 2025-11-06 Basf Se Pyrimidinone derivatives as pesticidal compounds
WO2026037853A1 (en) 2024-08-14 2026-02-19 Basf Se Benzoxazole derivatives as pesticidal compounds
WO2026041702A1 (en) 2024-08-21 2026-02-26 Basf Se Benzoxazole derivatives as pesticidal compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2253503A2 (en) 1973-12-10 1975-07-04 Unicler Ethylenic piperonal alcohols and ketones - anxiolytics, antidepressants, hypnotics and tranquillisers
WO2016129583A1 (ja) 2015-02-09 2016-08-18 国立大学法人岡山大学 乳酸脱水素酵素阻害剤およびそれを含有する抗てんかん剤
CN108276376A (zh) 2017-12-18 2018-07-13 北京理工大学 一种新型二苯丙烯类衍生物及其制备方法、一种药物组合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59197764A (ja) 1983-04-23 1984-11-09 ダイキン工業株式会社 冷凍装置
WO2014115764A1 (ja) 2013-01-25 2014-07-31 国立大学法人岡山大学 乳酸脱水素酵素阻害剤およびそれを含有する医薬品

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2253503A2 (en) 1973-12-10 1975-07-04 Unicler Ethylenic piperonal alcohols and ketones - anxiolytics, antidepressants, hypnotics and tranquillisers
WO2016129583A1 (ja) 2015-02-09 2016-08-18 国立大学法人岡山大学 乳酸脱水素酵素阻害剤およびそれを含有する抗てんかん剤
CN108276376A (zh) 2017-12-18 2018-07-13 北京理工大学 一种新型二苯丙烯类衍生物及其制备方法、一种药物组合物

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHANG,M. et al.，NBS-mediated cyclization of trans-cinnamic alcohols，Tetrahedron，2013年，Vol.69, No.31，p.6364-6370
KOPPOLU,S.R. et al.，Triflic Acid Promoted Direct α-Alkylation of Unactivated Ketones Using Benzylic Alcohols via in Sit，Journal of Organic Chemistry，2014年，Vol.79, No.13，p.6069-6078
KRISHNA,J. et al.，Sequential one-pot approach for the synthesis of functionalized phthalans via Heck-reduction-cycliza，RSC Advances，2015年，Vol.5, No.34， p.26749-26761
UCHIL,V.R. et al.，Selective reductions of substituted α-(1,2,4-triazol-1-yl)chalcones with NaBH4 and Al-isopropoxide:，Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry，2002年，Vol.41B, No.3，p.631-634
YUAN,Z. et al.，Tandem 1,6-addition/cyclization/vinylcyclopropane rearrangement at low temperature under metal-free，Chemical Communications(Cambridge, United Kingdom)，2017年，Vol.53, No.24，p.3485-3488

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JPWO2022025242A1 (https=) 2022-02-03
WO2022025242A1 (ja) 2022-02-03
EP4190401A1 (en) 2023-06-07
US12516043B2 (en) 2026-01-06
EP4190401A4 (en) 2023-11-29
US20230303543A1 (en) 2023-09-28

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