JP7650279B2 - トリスルフィド化合物 - Google Patents

トリスルフィド化合物 Download PDF

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Publication number
JP7650279B2
JP7650279B2 JP2022544576A JP2022544576A JP7650279B2 JP 7650279 B2 JP7650279 B2 JP 7650279B2 JP 2022544576 A JP2022544576 A JP 2022544576A JP 2022544576 A JP2022544576 A JP 2022544576A JP 7650279 B2 JP7650279 B2 JP 7650279B2
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Prior art keywords
pantethine
trisulfide
solution
equivalents
compound
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Japanese (ja)
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JPWO2022045052A1 (https=
Inventor
昌一郎 朝長
貴弘 磯部
悦男 大島
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Kyowa Pharma Chemical Co Ltd
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Kyowa Pharma Chemical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/12—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms
    • C07C321/14—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2022544576A 2020-08-27 2021-08-23 トリスルフィド化合物 Active JP7650279B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020143639 2020-08-27
JP2020143639 2020-08-27
PCT/JP2021/030755 WO2022045052A1 (ja) 2020-08-27 2021-08-23 トリスルフィド化合物

Publications (2)

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JPWO2022045052A1 JPWO2022045052A1 (https=) 2022-03-03
JP7650279B2 true JP7650279B2 (ja) 2025-03-24

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JP2022544576A Active JP7650279B2 (ja) 2020-08-27 2021-08-23 トリスルフィド化合物

Country Status (7)

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US (1) US12534432B2 (https=)
EP (1) EP4194437B1 (https=)
JP (1) JP7650279B2 (https=)
CN (1) CN115943140B (https=)
ES (1) ES3054285T3 (https=)
PL (1) PL4194437T3 (https=)
WO (1) WO2022045052A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7842033B2 (ja) 2020-05-12 2026-04-07 ザ ジェネラル ホスピタル コーポレイション 神経保護におけるグルタチオントリスルフィド（ｇｓｓｓｇ）
EP4342464A4 (en) 2021-07-08 2025-06-04 Kyowa Pharma Chemical Co., Ltd. PROPHYLACTIC OR THERAPEUTIC MEDICINE FOR PARKINSON'S DISEASE
EP4603087A1 (en) 2022-11-21 2025-08-20 Kyowa Hakko Bio Co., Ltd. Prophylactic or therapeutic agent for acute kidney injury induced by anticancer agent
CN120344503A (zh) 2022-12-27 2025-07-18 协和医药化工股份有限公司 三硫化物化合物
WO2025070464A1 (ja) 2023-09-28 2025-04-03 協和ファーマケミカル株式会社 トリスルフィド化合物を含有する医薬組成物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996000241A1 (en) 1994-06-27 1996-01-04 Pharmacia & Upjohn Ab Process for the preparation of peptide trisulfides
WO2020158894A1 (ja) 2019-01-30 2020-08-06 協和発酵バイオ株式会社 ポリスルフィド化合物を含有する組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS532931B2 (https=) * 1973-12-05 1978-02-01
JPS5819673B2 (ja) * 1976-08-26 1983-04-19 相互薬工業株式会社 パンテチンの製造方法
JP2928414B2 (ja) 1991-09-20 1999-08-03 ポーラ化成工業株式会社 皮膚外用剤
CN107652264A (zh) 2017-09-25 2018-02-02 苏州华诺医药有限公司 硫辛酸杂质a的制备方法
JP2022166333A (ja) * 2019-09-18 2022-11-02 国立大学法人 熊本大学 活性イオウ分子種生体内濃度上昇剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996000241A1 (en) 1994-06-27 1996-01-04 Pharmacia & Upjohn Ab Process for the preparation of peptide trisulfides
WO2020158894A1 (ja) 2019-01-30 2020-08-06 協和発酵バイオ株式会社 ポリスルフィド化合物を含有する組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
第一部医薬品各条 は行，第十三改正日本薬局方解説書，第１版，株式会社廣川書店 廣川 節男，1996年，C-1986～C-1990

Also Published As

Publication number Publication date
WO2022045052A1 (ja) 2022-03-03
US20230357141A1 (en) 2023-11-09
ES3054285T3 (en) 2026-02-02
CN115943140A (zh) 2023-04-07
US12534432B2 (en) 2026-01-27
PL4194437T3 (pl) 2026-02-02
EP4194437B1 (en) 2025-11-12
EP4194437A1 (en) 2023-06-14
CN115943140B (zh) 2024-10-01
EP4194437A4 (en) 2024-10-02
JPWO2022045052A1 (https=) 2022-03-03
EP4194437C0 (en) 2025-11-12

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