JP7648528B2 - モノマーおよびマルチマー抗ｈｂｖ薬 - Google Patents

モノマーおよびマルチマー抗ｈｂｖ薬 Download PDF

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JP7648528B2
JP7648528B2 JP2021544096A JP2021544096A JP7648528B2 JP 7648528 B2 JP7648528 B2 JP 7648528B2 JP 2021544096 A JP2021544096 A JP 2021544096A JP 2021544096 A JP2021544096 A JP 2021544096A JP 7648528 B2 JP7648528 B2 JP 7648528B2
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JP2022508642A5 (enExample
JP2022508642A (ja
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シナジ，レイモンド，エフ．
アンブラルド，フランク
コックス，ブライアン
チェン，チー
バシット，レダ
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Emory University
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Emory University
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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IL328538A (en) * 2018-10-05 2026-07-01 Univ Emory Monomeric and multimeric hepatitis B antivirals
IL286902B2 (en) 2019-04-03 2025-03-01 Aligos Therapeutics Inc Pyrrole compounds
KR20230021121A (ko) * 2020-06-05 2023-02-13 파티오스 테라퓨틱스 리미티드 Gpr65의 조절제로서 n-페닐아미노카보닐 피리디노-, 피리미디노 및 벤조-트로판
WO2022156758A1 (zh) * 2021-01-22 2022-07-28 广东东阳光药业有限公司 新型酰胺吡咯类化合物及其在药物中的用途
WO2023174351A1 (zh) * 2022-03-17 2023-09-21 成都微芯药业有限公司 吡咯酰胺类化合物及其制备方法和用途
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Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002539204A (ja) 1999-03-12 2002-11-19 バイオタ、サイアンティフィック、マネージメント、プロプライエタリ、リミテッド 二量体化合物およびニューラミニダーゼ阻害剤として
JP2014523901A (ja) 2011-07-01 2014-09-18 インスティテュート フォー ヘパタイティス アンド ウィルス リサーチ Ｈｂｖ感染に対する抗ウイルス剤としてのスルファモイルベンズアミド誘導体
JP2015531773A (ja) 2012-08-28 2015-11-05 ヤンセン・サイエンシズ・アイルランド・ユーシー スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用
JP2016502519A (ja) 2012-11-09 2016-01-28 インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション Ｈｂｖ集合エフェクターの代替的使用
JP2016509591A (ja) 2012-12-27 2016-03-31 ドレクセル ユニバーシティ Ｈｂｖ感染に対する新規抗ウイルス剤
JP2016525141A (ja) 2013-07-25 2016-08-22 ヤンセン・サイエンシズ・アイルランド・ユーシー グリオキサミド置換ピロールアミド誘導体およびｂ型肝炎を処置するための医薬品としてのその使用
JP2017516816A (ja) 2014-05-30 2017-06-22 メッドシャイン ディスカバリー インコーポレイテッド Ｈｂｖ阻害剤としてのジヒドロピリミジン縮環誘導体
WO2017156255A1 (en) 2016-03-09 2017-09-14 Emory University Elimination of hepatitis b virus with antiviral agents
WO2018039531A1 (en) 2016-08-26 2018-03-01 Gilead Sciences, Inc. Substituted pyrrolizine compounds and uses thereof
WO2019185016A1 (zh) 2018-03-30 2019-10-03 正大天晴药业集团股份有限公司 含有n杂五元环的衣壳蛋白装配抑制剂、其药物组合物和用途
WO2019241292A1 (en) 2018-06-11 2019-12-19 VenatoRx Pharmaceuticals, Inc. Hepatitis b capsid assembly modulators

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060100233A1 (en) * 2002-07-25 2006-05-11 Manuela Villa Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
US9242981B2 (en) * 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
WO2016109689A2 (en) * 2014-12-30 2016-07-07 Novira Therapeutics, Inc. Derivatives and methods of treating hepatitis b infections
CN106317055A (zh) * 2015-07-02 2017-01-11 中国科学院上海药物研究所 一类具有激酶抑制活性的化合物、制备方法和用途
WO2020001592A1 (zh) * 2018-06-28 2020-01-02 河南天晟泰丰医药科技有限公司 二氢嘧啶衍生物及其用途
IL328538A (en) * 2018-10-05 2026-07-01 Univ Emory Monomeric and multimeric hepatitis B antivirals

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002539204A (ja) 1999-03-12 2002-11-19 バイオタ、サイアンティフィック、マネージメント、プロプライエタリ、リミテッド 二量体化合物およびニューラミニダーゼ阻害剤として
JP2014523901A (ja) 2011-07-01 2014-09-18 インスティテュート フォー ヘパタイティス アンド ウィルス リサーチ Ｈｂｖ感染に対する抗ウイルス剤としてのスルファモイルベンズアミド誘導体
JP2015531773A (ja) 2012-08-28 2015-11-05 ヤンセン・サイエンシズ・アイルランド・ユーシー スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用
JP2016502519A (ja) 2012-11-09 2016-01-28 インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション Ｈｂｖ集合エフェクターの代替的使用
JP2016509591A (ja) 2012-12-27 2016-03-31 ドレクセル ユニバーシティ Ｈｂｖ感染に対する新規抗ウイルス剤
JP2016525141A (ja) 2013-07-25 2016-08-22 ヤンセン・サイエンシズ・アイルランド・ユーシー グリオキサミド置換ピロールアミド誘導体およびｂ型肝炎を処置するための医薬品としてのその使用
JP2017516816A (ja) 2014-05-30 2017-06-22 メッドシャイン ディスカバリー インコーポレイテッド Ｈｂｖ阻害剤としてのジヒドロピリミジン縮環誘導体
WO2017156255A1 (en) 2016-03-09 2017-09-14 Emory University Elimination of hepatitis b virus with antiviral agents
WO2018039531A1 (en) 2016-08-26 2018-03-01 Gilead Sciences, Inc. Substituted pyrrolizine compounds and uses thereof
WO2019185016A1 (zh) 2018-03-30 2019-10-03 正大天晴药业集团股份有限公司 含有n杂五元环的衣壳蛋白装配抑制剂、其药物组合物和用途
WO2019241292A1 (en) 2018-06-11 2019-12-19 VenatoRx Pharmaceuticals, Inc. Hepatitis b capsid assembly modulators

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