JP7634476B2 - 関節への送達に適した医薬組成物及びその関節痛の治療における使用 - Google Patents

関節への送達に適した医薬組成物及びその関節痛の治療における使用 Download PDF

Info

Publication number
JP7634476B2
JP7634476B2 JP2021511641A JP2021511641A JP7634476B2 JP 7634476 B2 JP7634476 B2 JP 7634476B2 JP 2021511641 A JP2021511641 A JP 2021511641A JP 2021511641 A JP2021511641 A JP 2021511641A JP 7634476 B2 JP7634476 B2 JP 7634476B2
Authority
JP
Japan
Prior art keywords
pharmaceutical composition
μmol
phospholipids
lipid mixture
therapeutic agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021511641A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2020056399A5 (https=
JP2022500364A5 (https=
JP2022500364A (ja
Inventor
ユン－ロン ツェン
シェウ－ファン シー
ポ－チュン チャン
ロー チャン
Original Assignee
ティーエルシー バイオファーマシューティカルズ、インク．
タイワン リポソーム カンパニー リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ティーエルシー バイオファーマシューティカルズ、インク．, タイワン リポソーム カンパニー リミテッド filed Critical ティーエルシー バイオファーマシューティカルズ、インク．
Publication of JP2022500364A publication Critical patent/JP2022500364A/ja
Publication of JPWO2020056399A5 publication Critical patent/JPWO2020056399A5/ja
Publication of JP2022500364A5 publication Critical patent/JP2022500364A5/ja
Application granted granted Critical
Publication of JP7634476B2 publication Critical patent/JP7634476B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021511641A 2018-09-16 2019-09-16 関節への送達に適した医薬組成物及びその関節痛の治療における使用 Active JP7634476B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862731941P 2018-09-16 2018-09-16
US62/731,941 2018-09-16
PCT/US2019/051247 WO2020056399A1 (en) 2018-09-16 2019-09-16 Pharmaceutical compositions suitable for articular delivery and use thereof in treatment of joint pain

Publications (4)

Publication Number Publication Date
JP2022500364A JP2022500364A (ja) 2022-01-04
JPWO2020056399A5 JPWO2020056399A5 (https=) 2024-07-22
JP2022500364A5 JP2022500364A5 (https=) 2024-07-22
JP7634476B2 true JP7634476B2 (ja) 2025-02-21

Family

ID=68084954

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021511641A Active JP7634476B2 (ja) 2018-09-16 2019-09-16 関節への送達に適した医薬組成物及びその関節痛の治療における使用

Country Status (15)

Country Link
US (1) US12208104B2 (https=)
EP (1) EP3849522A1 (https=)
JP (1) JP7634476B2 (https=)
KR (1) KR20210060559A (https=)
CN (1) CN112702993A (https=)
AU (1) AU2019339528B2 (https=)
BR (1) BR112021004880A2 (https=)
CA (1) CA3112234A1 (https=)
CL (1) CL2021000627A1 (https=)
IL (1) IL281513A (https=)
MX (1) MX2021003030A (https=)
SG (1) SG11202102400PA (https=)
TW (1) TWI843751B (https=)
WO (1) WO2020056399A1 (https=)
ZA (1) ZA202101688B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3187955A1 (en) 2020-08-05 2022-02-10 Sheue-Fang Shih Pharmaceutical composition of intra-articular corticosteroid for pain control
WO2024230404A1 (zh) * 2023-05-05 2024-11-14 中南大学湘雅医院 一种治疗关节疼痛的氢氧化镁纳米粒、其制备方法及应用
TW202519194A (zh) * 2023-11-03 2025-05-16 台灣微脂體股份有限公司 用於疼痛控制之關節內皮質類固醇的微脂體組成物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005534663A (ja) 2002-06-12 2005-11-17 ユニベルシテイト、ユトレヒト、ホールディング ベスローテン、フェンノートシャップ 炎症性疾患の治療用組成物
JP2015522041A (ja) 2012-07-05 2015-08-03 タイワン リポソーム カンパニー リミテッド 関節炎の処置方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050152962A1 (en) * 2002-06-12 2005-07-14 Metselaar Josbert M. Composition for treatment of inflammatory disorders
DK2797601T3 (en) 2012-02-10 2018-06-14 Taiwan Liposome Co Ltd PHARMACEUTICAL COMPOSITIONS FOR REDUCING COMPLICATIONS BY Ocular steroid

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005534663A (ja) 2002-06-12 2005-11-17 ユニベルシテイト、ユトレヒト、ホールディング ベスローテン、フェンノートシャップ 炎症性疾患の治療用組成物
JP2015522041A (ja) 2012-07-05 2015-08-03 タイワン リポソーム カンパニー リミテッド 関節炎の処置方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Ｂｒｉｔｉｓｈ Ｊｏｕｒｎａｌ ｏｆ Ｒｈｅｕｍａｔｏｌｏｇｙ，1996年，Ｖｏｌ．３５，Ｎｏ．８，ｐ７１９－７２４
Ｍｏｌｅｃｕｌａｒ Ｐｈａｒｍａｃｅｕｔｉｃｓ，2011年，Ｖｏｌ．８，Ｎｏ．４，ｐ１００２－１０１５

Also Published As

Publication number Publication date
TWI843751B (zh) 2024-06-01
US20210338688A1 (en) 2021-11-04
CL2021000627A1 (es) 2021-09-10
BR112021004880A2 (pt) 2021-06-01
IL281513A (en) 2021-04-29
SG11202102400PA (en) 2021-04-29
CN112702993A (zh) 2021-04-23
WO2020056399A1 (en) 2020-03-19
US12208104B2 (en) 2025-01-28
JP2022500364A (ja) 2022-01-04
TW202023569A (zh) 2020-07-01
ZA202101688B (en) 2024-06-26
MX2021003030A (es) 2021-05-27
AU2019339528A1 (en) 2021-04-15
AU2019339528B2 (en) 2025-01-30
CA3112234A1 (en) 2020-03-19
KR20210060559A (ko) 2021-05-26
EP3849522A1 (en) 2021-07-21

Similar Documents

Publication Publication Date Title
JP6964571B2 (ja) 関節炎の処置方法
JP7634476B2 (ja) 関節への送達に適した医薬組成物及びその関節痛の治療における使用
JP2014532697A (ja) ヒトにおける炎症性障害の治療用リポソームコルチコステロイド
AU2019301542B2 (en) Methods to reduce complications of intra-articular steroid
RU2810788C2 (ru) Фармацевтические композиции, подходящие для суставной доставки, и их применение при лечении суставной боли
RU2806023C2 (ru) Способы уменьшения осложнений от внутрисуставного стероида
HK40041739A (en) Pharmaceutical compositions suitable for articular delivery and use thereof in treatment of joint pain
US12514820B2 (en) Pharmaceutical composition of intra-articular corticosteroid for pain control
HK40041258A (en) Methods to reduce complications of intra-articular steroid
HK40087158A (zh) 用於疼痛控制的关节内皮质类固醇的药物组合物
WO2025096949A1 (en) Liposomal composition of intra-articular corticosteroid for pain control

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220819

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230704

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20231002

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240116

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20240415

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20240614

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20240711

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240910

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20241121

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20241203

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250108

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20250121

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20250210

R150 Certificate of patent or registration of utility model

Ref document number: 7634476

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150